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Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies 改良的C型利钠肽使肿瘤血管正常化，重振抗肿瘤免疫力，并改善实体瘤治疗 Lu, Zhen; Verginadis, Ioannis; Kumazoe, Motofumi; Castillo, Gerardo M.; Yao, Yao; Guerra, Rebecca E.; Bicher, Sandra; You, Menghao; Mcclung, George; Qiu, Rong; Xiao, Zebin; Miao, Zhen; George, Subin S.; Beiting, Daniel P.; Nojiri, Takashi; Tanaka, Yasutake; Fujimura, Yoshinori; Onda, Hiroaki; Hatakeyama, Yui; Nishimoto-Ashfield, Akiko; Bykova, Katrina; Guo, Wei; Fan, Yi; Buynov, Nikolay M.; Diehl, J. Alan; Stanger, Ben Z.; Tachibana, Hirofumi; Gade, Terence P.; Pure, Ellen; Koumenis, Constantinos; Bolotin, Elijah M.; Fuchs, Serge Y. 分享 收藏
PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies Basavaraja, Raghavendra; Zhang, Hongru; Holczbauer, Agnes; Lu, Zhen; Radaelli, Enrico; Assenmacher, Charles-Antoine; George, Subin S.; Nallamala, Vamshidhar C.; Beiting, Daniel P.; Meyer-Ficca, Mirella L.; Meyer, Ralph G.; Guo, Wei; Fan, Yi; Modzelewski, Andrew J.; Spiegelman, Vladimir S.; Cohen, Michael S.; Fuchs, Serge Y. 分享 收藏
An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma 免疫抑制性血管生态位驱动胶质母细胞瘤中的巨噬细胞极化和免疫治疗抵抗 Yang, Fan; Akhtar, Md Naushad; Zhang, Duo; El-Mayta, Rakan; Shin, Junyoung; Dorsey, Jay F.; Zhang, Lin; Xu, Xiaowei; Guo, Wei; Bagley, Stephen J.; Fuchs, Serge Y.; Koumenis, Constantinos; Lathia, Justin D.; Mitchell, Michael J.; Gong, Yanqing; Fan, Yi 分享 收藏
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment ATR抑制剂ceralasertib通过调节肿瘤微环境来增强癌症检查点免疫治疗 Hardaker, Elizabeth L.; Sanseviero, Emilio; Karmokar, Ankur; Taylor, Devon; Milo, Marta; Michaloglou, Chrysis; Hughes, Adina; Mai, Mimi; King, Matthew; Solanki, Anisha; Magiera, Lukasz; Miragaia, Ricardo; Kar, Gozde; Standifer, Nathan; Surace, Michael; Gill, Shaan; Peter, Alison; Talbot, Sara; Tohumeken, Sehmus; Fryer, Henderson; Mostafa, Ali; Mulgrew, Kathy; Lam, Carolyn; Hoffmann, Scott; Sutton, Daniel; Carnevalli, Larissa; Calero-Nieto, Fernando J.; Jones, Gemma N.; Pierce, Andrew J.; Wilson, Zena; Campbell, David; Nyoni, Lynet; Martins, Carla P.; Baker, Tamara; de Almeida, Gilberto Serrano; Ramlaoui, Zainab; Bidar, Abdel; Phillips, Benjamin; Boland, Joseph; Iyer, Sonia; Barrett, J. Carl; Loembe, Arsene-Bienvenu; Fuchs, Serge Y.; Duvvuri, Umamaheswar; Lou, Pei-Jen; Nance, Melonie A.; Gomez Roca, Carlos Alberto; Cadogan, Elaine; Critichlow, Susan E.; Fawell, Steven; Cobbold, Mark; Dean, Emma; Valge-Archer, Viia; Lau, Alan; Gabrilovich, Dmitry I.; Barry, Simon T. 分享 收藏
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Tumor-Derived Small Extracellular Vesicles Inhibit the Efficacy of CAR T Cells against Solid Tumors 肿瘤来源的小胞外囊泡抑制CAR T细胞抗实体瘤的功效 Zhong, Wenqun; Xiao, Zebin; Qin, Zhiyuan; Yang, Jingbo; Wen, Yi; Yu, Ziyan; Li, Yumei; Sheppard, Neil C.; Fuchs, Serge Y.; Xu, Xiaowei; Herlyn, Meenhard; June, Carl H.; Pure, Ellen; Guo, Wei 分享 收藏
Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress Buschmann, T; Potapova, O; Bar-Shira, A; Ivanov, VN; Fuchs, SY; Henderson, S; Fried, VA; Minamoto, T; Alarcon-Vargas, D; Pincus, MR; Gaarde, WA; Holbrook, NJ; Shiloh, Y; Ronai, Z 分享 收藏
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Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway Varghese, Bentley; Barriere, Herve; Carbone, Christopher J.; Banerjee, Anamika; Swaminathan, Gayathri; Plotnikov, Alexander; Xu, Ping; Peng, Junmin; Goffin, Vincent; Lukacs, Gergely L.; Fuchs, Serge Y. 分享 收藏
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Mammalian Casein Kinase 1α and Its Leishmanial Ortholog Regulate Stability of IFNAR1 and Type I Interferon Signaling Liu, Jianghuai; Carvalho, Lucas P.; Bhattacharya, Sabyasachi; Carbone, Christopher J.; Kumar, K. G. Suresh; Leu, N. Adrian; Yau, Peter M.; Donald, Robert G. K.; Weiss, Mitchell J.; Baker, Darren P.; McLaughlin, K. John; Scott, Phillip; Fuchs, Serge Y. 分享 收藏
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Type I Interferons Control Proliferation and Function of the Intestinal Epithelium Katlinskaya, Yuliya V.; Katlinski, Kanstantsin V.; Lasri, Audrey; Li, Ning; Beiting, Daniel P.; Durham, Amy C.; Yang, Ting; Pikarsky, Eli; Lengner, Christopher J.; Johnson, F. Brad; Ben-Neriah, Yinon; Fuchs, Serge Y. 分享 收藏
PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy Zhang, Duo; Li, Albert M.; Hu, Guanghui; Huang, Menggui; Yang, Fan; Zhang, Lin; Wellen, Kathryn E.; Xu, Xiaowei; Conn, Crystal S.; Zou, Wei; Kahn, Mark; Rhoades, Seth D.; Weljie, Aalim M.; Fuchs, Serge Y.; Amankulor, Nduka; Yoshor, Daniel; Ye, Jiangbin; Koumenis, Constantinos; Gong, Yanqing; Fan, Yi 分享 收藏
Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells McBrearty, Noreen; Cho, Christina; Chen, Jinyun; Zahedi, Farima; Peck, Amy R.; Radaelli, Enrico; Assenmacher, Charles-Antoine; Pavlak, Clarice; Devine, Anne; Yu, Pengfei; Lu, Zhen; Zhang, Hongru; Li, Jinyang; Pitarresi, Jason R.; Astsaturov, Igor; Cukierman, Edna; Rustgi, Anil K.; Stanger, Ben Z.; Rui, Hallgeir; Fuchs, Serge Y. 分享 收藏
Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer Lu, Zhen; Chen, Jinyun; Yu, Pengfei; Atherton, Matthew J.; Gui, Jun; Tomar, Vivek S.; Middleton, Justin D.; Sullivan, Neil T.; Singhal, Sunil; George, Subin S.; Woolfork, Ashley G.; Weljie, Aalim M.; Hai, Tsonwin; Eruslanov, Evgeniy B.; Fuchs, Serge Y. 分享 收藏
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation Mucha, Bartosz; Qie, Shuo; Bajpai, Sagar; Tarallo, Vincenzo; Diehl, J. Nathaniel; Tedeschi, Frank; Zhou, Gao; Gao, Zhaofeng; Flashner, Samuel; Klein-Szanto, Andres J.; Hibshoosh, Hanina; Masataka, Shimonosono; Chajewski, Olga S.; Majsterek, Ireneusz; Pytel, Dariusz; Hatzoglou, Maria; Der, Channing J.; Nakagawa, Hiroshi; Bass, Adam J.; Wong, Kwok-Kin; Fuchs, Serge Y.; Rustgi, Anil K.; Jankowsky, Eckhard; Diehl, J. Alan 分享 收藏
ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes Lu, Zhen; McBrearty, Noreen; Chen, Jinyun; Tomar, Vivek S.; Zhang, Hongru; De Rosa, Gianluca; Tan, Aiwen; Weljie, Aalim M.; Beiting, Daniel P.; Miao, Zhen; George, Subin S.; Berger, Allison; Saggu, Gurpanna; Diehl, J. Alan; Koumenis, Constantinos; Fuchs, Serge Y. 分享 收藏
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression Verginadis, Ioannis I.; Avgousti, Harris; Monslow, James; Skoufos, Giorgos; Chinga, Frank; Kim, Kyle; Leli, Nektaria Maria; Karagounis, Ilias V.; Bell, Brett I.; Velalopoulou, Anastasia; Salinas, Carlo Salas; Wu, Victoria S.; Li, Yang; Ye, Jiangbin; Scott, David A.; Osterman, Andrei L.; Sengupta, Arjun; Weljie, Aalim; Huang, Menggui; Zhang, Duo; Fan, Yi; Radaelli, Enrico; Tobias, John W.; Rambow, Florian; Karras, Panagiotis; Marine, Jean-Christophe; Xu, Xiaowei; Hatzigeorgiou, Artemis G.; Ryeom, Sandra; Diehl, J. Alan; Fuchs, Serge Y.; Pure, Ellen; Koumenis, Constantinos 分享 收藏
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