未登录 Digital pathology based prognostic & predictive biomarkers in metastatic non-small cell lung cancer Qamra, Aditi; Srivastava, Minu K.; Fuentes, Eloisa; Ben Trotter; Biju, Raymond; Chhor, Guillaume; Cowan, James; Gendreau, Steven; Lincoln, Webster; McGinnis, Lisa; Molinero, Luciana; Patil, Namrata S.; Schedlbauer, Amber; Schulze, Katja; Stanford-Moore, Adam; Chambre, Laura; Wapinski, Ilan; Shames, David S.; Koeppen, Hartmut; Hennek, Stephanie; Fridlyand, Jane; Giltnane, Jennifer M.; Amitai, Assaf 分享 收藏
Exploratory analysis of hormone receptor-positive (HR plus ), human epidermal growth factor receptor 2-negative (HER-2) PIK3CA mutated (mut) advanced breast cancer (aBC) treated with taselisib (TAS) and/or fulvestrant (FUL) reveals increased CCNE2 expression with poor outcome to placebo (PBO) plus FUL but not TAS plus FUL in SANDPIPER Johnson, Radia M.; Liu, Bonnie; Cortes, Javier; Dent, Susan; Harbeck, Nadia; Krop, Ian E.; Jacot, William; Yauch, Robert L.; Stout, Thomas J.; Schimmoller, Frauke; Gendreau, Steven; Wilson, Timothy R. 分享 收藏
Clinical outcomes and exploratory gene expression analysis of OPPORTUNE: a phase II window-of-opportunity study to evaluate pictilisib plus anastrozole versus anastrozole alone in ER-positive breast cancer Chibly, Alejandro Martinez; Shia, Alice; Johnson, Radia; Hwang, Michael S.; Hafner, Marc; Metcalfe, Ciara; Shah, Kalpit; Slyper, Michal; Bolen, Chris; Pinder, Sarah E.; Thompson, Alastair M.; Gendreau, Steven; Schmid, Peter 分享 收藏
Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors ipatasertib联合化疗的抗肿瘤活性: 实体瘤Ib期研究的结果 Isakoff, S. J.; Tabernero, J.; Molife, L. R.; Soria, J. -C.; Cervantes, A.; Vogelzang, N. J.; Patel, M. R.; Hussain, M.; Baron, A.; Argiles, G.; Conkling, R.; Sampath, D.; Maslyar, D.; Patel, P.; Chan, W.; Gendreau, S.; Musib, L.; Xu, N.; Ma, H.; Lin, K.; Bendell, J. 分享 收藏
A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-9545, in postmenopausal women with estrogen receptor-positive (ER+) HER2-negative (HER2-) metastatic breast cancer Jhaveri, Komal; Winer, Eric Paul; Lim, Elgene; Fidalgo, Jose AlejandroPerez; Bellet, Meritxell; Mayer, Ingrid Alina; Boni, Valentina; Patel, Jaymin M.; Bardia, Aditya; Garcia, Jose Manuel; Kabos, Peter; Gates, Mary; Chen, Ya-Chi; Fredrickson, Jill; Wang, Xiaojing; Friedman, Lori Sickels; Spoerke, Jill; Gendreau, Steven; Metcalfe, Ciara; Liu, Lichuan; Chang, Ching-Wei; Monemi, Sharareh; Gonzalez, Monica; McCurry, Ursula; Milan, Sandra; Humke, Eric William; Loi, Sherene 分享 收藏
ER pathway activity signature as a biomarker for endocrine agent GDC-9545 Daemen, Anneleen; Spoerke, Jill M.; Zhou, Wei; Guan, Jane; Ingalla, Ellen; Young, Amy; Hafner, Marc; Aimi, Junko; Chang, Ching-Wei; Giltnane, Jennifer M.; Gates, Mary; Mayer, Ingrid A.; Azaro, Analia; Winer, Eric P.; Loi, Sherene; Jhaveri, Komal; Lauchle, Jennifer; Gendreau, Steven; Humke, Eric W.; Metcalfe, Ciara 分享 收藏
Gene expression analysis of paired baseline (BL) and on-treatment tumor samples from FAIRLANE, a double-blind placebo (PBO)-controlled randomized phase II trial of neoadjuvant ipatasertib (IPAT) plus paclitaxel (PAC) in early triple-negative breast cancer (eTNBC) Shi, Zhen; Isakoff, Steven J.; Saura, Cristina; Nuciforo, Paolo; Calvo, Isabel; Andersen, Jay; Passos Coelho, Jose Luis; Gil Gil, Miguel; Bermejo, Begona; Patt, Debra A.; Ciruelos, Eva; Wongchenko, Matthew J.; Singel, Stina M.; Xu, Na; de la Pena, Lorena; Baselga, Jose; Gendreau, Steven; Oliveira, Mafalda 分享 收藏
Interaction of PIK3CA mutation subclasses with response to preoperative treatment with the PI3K inhibitor pictilisib in patients with estrogen receptor-positive breast cancer Schmid, P.; Pinder, S.; Wheatley, D.; Zummit, C.; Macaskill, E. J.; Hu, J.; Price, R.; Bundred, N.; Hadad, S.; Shia, A.; Sarker, S-J; Lim, L.; Mousa, K.; O'Brien, C.; Wilson, T. R.; Lackner, M. R.; Gendreau, S.; Gazinska, P.; Korbie, D.; Trau, M.; Mainwaring, P.; Thompson, A.; Purushotham, A. 分享 收藏
Exploratory biomarker analyses of FAIRLANE, a double-blind placebo (PBO)-controlled randomized phase II trial of neoadjuvant ipatasertib (IPAT) plus paclitaxel (PAC) for early triple-negative breast cancer (TNBC) Wongchenko, M. J.; Oliveira, M.; Saura, C.; Nuciforo, P.; Calvo, I.; Andersen, J.; Coelho, J. I. Passos; Gil, M. Gil; Bermejo, B.; Patt, D. A.; Ciruelos, E.; Singel, S. M.; Maslyar, D. J.; Xu, N.; de la Pena, L.; Baselga, J.; Gendreau, S.; Isakoff, S. J. 分享 收藏
A phase II, randomised study of mFOLFOX6 with or without the Akt inhibitor ipatasertib in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer Bang, Y-J; Kang, Y-K; Ng, M.; Chung, H. C.; Wainberg, Z. A.; Gendreau, S.; Chan, W. Y.; Xu, N.; Maslyar, D.; Meng, R.; Chau, I; Ajani, J. A. 分享 收藏
A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer Schoffski, Patrick; Cresta, Sara; Mayer, Ingrid A.; Wildiers, Hans; Damian, Silvia; Gendreau, Steven; Rooney, Isabelle; Morrissey, Kari M.; Spoerke, Jill M.; Ng, Vivian W.; Singel, Stina M.; Winer, Eric 分享 收藏
Analytical Validation of a Hybrid Capture-Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA Clark, Travis A.; Chung, Jon H.; Kennedy, Mark; Hughes, Jason D.; Chennagiri, Niru; Lieber, Daniel S.; Fendler, Bernard; Young, Lauren; Zhao, Mandy; Coyne, Michael; Breese, Virginia; Young, Geneva; Donahue, Amy; Pavlick, Dean; Tsiros, Alyssa; Brennan, Timothy; Zhong, Shan; Mughal, Tariq; Bailey, Mark; He, Jie; Roels, Steven; Frampton, Garrett M.; Spoerke, Jill M.; Gendreau, Steven; Lackner, Mark; Schleifman, Erica; Peters, Eric; Ross, Jeffrey S.; Ali, Siraj M.; Miller, Vincent A.; Gregg, Jeffrey P.; Stephens, Philip J.; Welsh, Allison; Otto, Geoff A.; Lipson, Doron 分享 收藏
A novel PI3K/Aktpathway activation biomarker using comprehensive genomic profiling (CGP) for clinical trial assay He, Yuting; Wongchenko, Matthew; Skoletsky, Joel; Burns, Christine; Li, Yali; Maness, Paula; Kim, Doris; Lipson, Doron; Stephens, Philip; Miller, Vincent; Ross, Jeffrey; Gendreau, Steven; Sun, James 分享 收藏
On-treatment changes in circulating tumor DNA (ctDNA) level as an early predictor of clinical outcome in the LOTUS randomized phase 2 trial of 1st-line ipatasertib (IPAT) plus paclitaxel (PAC) for metastatic triple-negative breast cancer (mTNBC) Wongchenko, Matthew J.; Lipson, Doron; Clark, Travis; Kennedy, Mark; Greene, Mandy; Breese, Virginia; Tsiros, Alyssa; Kim, Sung-Bae; Saura, Cristina; Oliveira, Mafalda; Baselga, Jose; Kapp, Amy V.; Chan, Wai Y.; Singel, Stina M.; Gendreau, Steven; Dent, Rebecca 分享 收藏
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The complete spectrum of ESR1 mutations from 7590 breast cancer tumor samples Spoerke, J. M.; Schleifman, E.; Clark, T. A.; Young, G.; Nahas, M.; Kennedy, M.; Young, L.; Chmielecki, J.; Otto, G. A.; Lipson, D.; Wilson, T. R.; Gendreau, S.; Lackner, M. R. 分享 收藏
Pictilisib PI3Kinase inhibitor (a phosphatidylinositol 3-kinase [PI3K] inhibitor) plus paclitaxel for the treatment of hormone receptor-positive, HER2-negative, locally recurrent, or metastatic breast cancer: interim analysis of the multicentre, placebo-controlled, phase II randomised PEGGY study Pictilisib pi3激酶抑制剂 (一种磷脂酰肌醇3-激酶 [PI3K] 抑制剂) 联合紫杉醇治疗激素受体阳性、HER2-negative、局部复发或转移性乳腺癌: 多中心、安慰剂对照、II期随机PEGGY研究的中期分析 Vuylsteke, P.; Huizing, M.; Petrakova, K.; Roylance, R.; Laing, R.; Chan, S.; Abell, F.; Gendreau, S.; Rooney, I.; Apt, D.; Zhou, J.; Singel, S.; Fehrenbacher, L. 分享 收藏
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant Spoerke, Jill M.; Gendreau, Steven; Walter, Kimberly; Qiu, Jiaheng; Wilson, Timothy R.; Savage, Heidi; Aimi, Junko; Derynck, Mika K.; Chen, Meng; Chan, Iris T.; Amler, Lukas C.; Hampton, Garret M.; Johnston, Stephen; Krop, Ian; Schmid, Peter; Lackner, Mark R. 分享 收藏
Transcript analysis of PI3K and immune-related genes and gene signatures in the pre- and post-treatment samples from the window of opportunity study of anastrozole and anastrozole with pictilisib (GDC-0941) in patients with HR-positive early breast cancer (OPPORTUNE study) Schmid, P.; Pinder, S. E.; Bundred, N.; Wheatley, D.; Macaskill, J.; Zammit, C.; Hu, J.; Price, R.; Shia, A.; Lim, L.; Parker, P.; Molinero, L.; Yu, J.; O'Brien, C.; Wilson, T.; Savage, H.; Derynck, M.; Lackner, M. R.; Amler, L.; Purushotham, A.; Thompson, A.; Gendreau, S. 分享 收藏
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