高睿 (Rui Gao)

Changchun University of Chinese Medicine青百A岗/长聘副教授

H指数:22

被引数:1,730

个人简介

"高睿博士，同济大学青百A岗，博士生导师，入选国家高层次人才特殊支持计划青年拔尖人才。现于高绍荣教授团队，聚焦表观遗传如何精准调控人类生殖系细胞发育这一核心科学问题，以生殖细胞发生及早期胚胎发育为研究系统，系统解析DNA甲基化与组蛋白修饰为代表的表观遗传修饰，串联转录调控因子进而调控生殖系细胞有序发育的分子机制，鉴定并操纵关键表观遗传修饰提升胚胎发育效率和质量。个人代表性成果以第一或通讯（含共同）作者在Cell Stem Cell、Developmental Cell等国际知名学术期刊发表。主持国家自然科学基金项目（面上2项、青年1项），上海市自然科学基金项目（面上1项）等。以课题组长（1项）和骨干（2项）参与科技部国家重点研发计划“干细胞及转化研究”、“发育编程及其代谢调节”等专项。获得上海市东方英才计划青年项目、博士后创新人才支持计划等省部级人才项目资助。授权中国发明专利2项。担任Life Medicine杂志青年编委。\n发表论文\n#第一作者 *通讯作者\n1. Zhang W#, Le C#, Yi S#, Liu W, Liu X, Yin Z, Wang H, Gao R*, Gao S*, Chen J*. Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation. Life Medicine. 2026, 5(2): lnag010. doi: 10.1093/lifemedi/lnag010.\n2. Gao R#,*, Yang G#, Wang M#, Xiao J#, Yi S, Huang Y, Guo Z, Kang Y, Fu Q, Wang M, Xu B, Shen S, Zhu Q, Liu M, Wang L, Cui X, Yi S, Kou X, Zhao Y, Gu L, Wang H, Gao S*, Jiang C*, Chen J*. Defining a TFAP2C-centered transcription factor network during murine peri-implantation. Developmental Cell. 2024, 59(9): 1146-1158.e6. doi:10.1016/j.devcel.2024.03.015\n3. Shen S#, Wang M#, Li X#,*, Wang B#, Hong W#, Li W, Xu B, Guo Z, Han R, Yi S, Wu Z, He X, Wang L, Zhu Q, Yang G, Wang H, Deng Q, Chen J*, Gao S*, Jiang C*, Gao R*. The gonadal niche safeguards human fetal germline cell development following maternal SARS-CoV-2 infection. Cell Reports Medicine. 2024, 5(5): 101515. doi:10.1016/j.xcrm.2024.101515\n4. Wang L#, Yi S#, Cui X#, Guo Z, Wang M, Kou X, Zhao Y, Wang H, Jiang C, Gao S*, Yang G*, Chen J*, Gao R*. Chromatin landscape instructs precise transcription factor regulome during embryonic lineage specification. Cell Reports. 2024, 43(5): 114136. doi:10.1016/j.celrep.2024.114136\n5. Wang W#, Gao R#, Yang D#, Ma M#, Zang R, Wang X, Chen C, Kou X, Zhao Y, Chen J, Liu X, Lu J, Xu B, Liu J, Huang Y, Chen C, Wang H, Gao S*, Zhang Y*, Gao Y*. ADNP modulates SINE B2-derived CTCF-binding sites during blastocyst formation in mice. Genes & Development. 2024, 38(3-4): 168-188. doi:10.1101/gad.351189.123\n6. Gao R#, Zeng S#, Yang D#, Li X#, Liu W, Gao Y, Bai D, Zhang L, Chen C, Kang Y, Wang B, Hong W, Wang M, Yin J, Wang H, Deng Q, Gao S*, Zhang Y*, Chen J*. Resetting histone modifications during human prenatal germline development. Cell Discovery. 2023, 9(1): 14. doi:10.1038/s41421-023-00519-1\n7. Liu W#, Chen C, Gao Y, Cui X, Zhang Y, Gu L, He Y, Li J, Gao S, Gao R*, Jiang C*. Transcriptome dynamics and cell dialogs between oocytes and granulosa cells in mouse follicle development. Genomics, Proteomics & Bioinformatics. 2024, 22(2): qzad001. doi:10.1093/gpbjnl/qzad001\n8. Sun J#, Zheng W#, Liu W, Kou X, Zhao Y, Liang Z, Wang L, Zhang Z, Xiao J, Gao R*, Gao S*, Jiang C*. Differential transcriptomes and methylomes of trophoblast stem cells from naturally-fertilized and somatic cell nuclear-transferred embryos. Frontiers in Cell and Developmental Biology. 2021, 9:664178. doi:10.3389/fcell.2021.664178\n9. Gao H#, Gao R#, Zhang L#, Xiu W, Zang R, Wang H, Zhang Y, Chen J*, Gao Y*, Gao S*. Esrrb plays important roles in maintaining self-renewal of trophoblast stem cells (TSCs) and reprogramming somatic cells to induced TSCs. Journal of Molecular Cell Biology. 2019, 11(6): 463-473. doi:10.1093/jmcb/mjy054\n10. Gao R#, Wang C#, Gao Y#, Xiu W, Chen J, Kou X, Zhao Y, Liao Y, Bai D, Qiao Z, Yang L, Wang M, Zang R, Liu X, Jia Y, Li Y, Zhang Y, Yin J, Wang H, Wan X, Liu W*, Zhang Y*, Gao S*. Inhibition of aberrant DNA re-methylation improves post-implantation development of somatic cell nuclear transfer embryos. Cell Stem Cell. 2018, 23(3): 426-435.e5. doi:10.1016/j.stem.2018.07.017\n11. Gao R#, Xiu W#, Zhang L, Zang R, Yang L, Wang C, Wang M, Wang M, Yi L, Tang Y, Gao Y, Wang H, Xi J, Liu W, Wang Y, Wen X, Yu Y, Zhang Y, Chen L*, Chen J*, Gao S*. Direct induction of neural progenitor cells transiently passes through a partially reprogrammed state. Biomaterials. 2017, 119: 53-67. doi:10.1016/j.biomaterials.2016.12.007\n12. Gao R#, Liu X, Gao S*. Progress in understanding epigenetic remodeling during induced pluripotency. Science Bulletin. 2015, 60(20): 1713-1721."