王巍 (Wei Wang)

peking university副教授邮箱:wangwei83427@bjmu.edu.cn

H指数:10

被引数:1,685

个人简介

"长期聚焦代谢—免疫交互调控的问题，研究肿瘤代谢紊乱，特别是氧化应激和糖酵解对浸润T细胞的功能调节和重塑。一系列研究为破除肿瘤微环境中的代谢掣肘，增强免疫治疗提供了新的理论基础和应用靶点。主持基金委面上项目，北京市自然科学基金面上项目等4项。以通讯（含共同）在 Nat. Immunol. 、 Sci. Immunol. 、 Nat. Commun. 、 PNAS 、 Redox Biol. 等权威期刊发表学术论文 30 余篇。申请专利 5 项，授权 3 项； Google引用 600 余次。\n近年代表性文章\n1.Oxidative stress-mediated abnormal polarization of decidual macrophages promotes the occurrence of atonic postpartum hemorrhage, Redox Biol., 2025 Apr;81:103530.\n2.The PRAK-NRF2 axis promotes the differentiation of Th17 cells by mediating the redox homeostasis and glycolysis. Proc. Natl. Acad. Sci. U.S.A. 2023 May 9;120(19):e2212613120.\n3.The essential role of PRAK in tumor metastasis and its therapeutic potential. Nat Commun. 2021 Mar 19;12(1):1736.\n4.KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28239-28250.\n5.Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Sci Immunol. 2017 Nov 17;2(17):eaan4631.\n6.Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nat Immunol. 2017 Dec;18(12):1332-1341."