未登录 SETBP1 overexpression acts in the place of class-defining mutations to drive FLT3-ITD-mutant AML Pacharne, Suruchi; Dovey, Oliver M.; Cooper, Jonathan L.; Gu, Muxin; Friedrich, Mathias J.; Rajan, Sandeep S.; Barenboim, Maxim; Collord, Grace; Vijayabaskar, M. S.; Ponstingl, Hannes; De Braekeleer, Etienne; Bautista, Ruben; Mazan, Milena; Rad, Roland; Tzelepis, Konstantinos; Wright, Penny; Gozdecka, Malgorzata; Vassiliou, George S. 分享 收藏
Genetic perturbation of PU.1 binding and chromatin looping at neutrophil enhancers associates with autoimmune disease Watt, Stephen; Vasquez, Louella; Walter, Klaudia; Mann, Alice L.; Kundu, Kousik; Chen, Lu; Sims, Ying; Ecker, Simone; Burden, Frances; Farrow, Samantha; Farr, Ben; Iotchkova, Valentina; Elding, Heather; Mead, Daniel; Tardaguila, Manuel; Ponstingl, Hannes; Richardson, David; Datta, Avik; Flicek, Paul; Clarke, Laura; Downes, Kate; Pastinen, Tomi; Fraser, Peter; Frontini, Mattia; Javierre, Biola-Maria; Spivakov, Mikhail; Soranzo, Nicole 分享 收藏
PiggyBac mutagenesis and exome sequencing identify genetic driver landscapes and potential therapeutic targets of EGFR-mutant gliomas PiggyBac诱变和外显子组测序鉴定EGFR突变胶质瘤的遗传驱动景观和潜在治疗靶点 Noorani, Imran; de la Rosa, Jorge; Choi, Yoonha; Strong, Alexander; Ponstingl, Hannes; Vijayabaskar, M. S.; Lee, Jusung; Lee, Eunmin; Richard-Londt, Angela; Friedrich, Mathias; Furlanetto, Federica; Fuente, Rocio; Banerjee, Ruby; Yang, Fengtang; Law, Frances; Watts, Colin; Rad, Roland; Vassiliou, George; Kim, Jong Kyoung; Santarius, Thomas; Brandner, Sebastian; Bradley, Allan 分享 收藏
A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection Yeung, Amy T. Y.; Choi, Yoon Ha; Lee, Amy H. Y.; Hale, Christine; Ponstingl, Hannes; Pickard, Derek; Goulding, David; Thomas, Mark; Gill, Erin; Kim, Jong Kyoung; Bradley, Allan; Hancock, Robert E. W.; Dougan, Gordon 分享 收藏
Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming Yang, Jian; Rajan, Sandeep S.; Friedrich, Mathias J.; Lan, Guocheng; Zou, Xiangang; Ponstingl, Hannes; Garyfallos, Dimitrios A.; Liu, Pentao; Bradley, Allan; Metzakopian, Emmanouil 分享 收藏
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks Balmus, Gabriel; Pilger, Domenic; Coates, Julia; Demir, Mukerrem; Sczaniecka-Clift, Matylda; Barros, Ana C.; Woods, Michael; Fu, Beiyuan; Yang, Fengtang; Chen, Elisabeth; Ostermaier, Matthias; Stankovic, Tatjana; Ponstingl, Hannes; Herzog, Mareike; Yusa, Kosuke; Martinez, Francisco Munoz; Durant, Stephen T.; Galanty, Yaron; Beli, Petra; Adams, David J.; Bradley, Allan; Metzakopian, Emmanouil; Forment, Josep, V; Jacksom, Stephen P. 分享 收藏
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4 Tzelepis, Konstantinos; De Braekeleer, Etienne; Aspris, Demetrios; Barbieri, Isaia; Vijayabaskar, M. S.; Liu, Wen-Hsin; Gozdecka, Malgorzata; Metzakopian, Emmanouil; Toop, Hamish D.; Dudek, Monika; Robson, Samuel C.; Hermida-Prado, Francisco; Yang, Yu Hsuen; Babaei-Jadidi, Roya; Garyfallos, Dimitrios A.; Ponstingl, Hannes; Dias, Joao M. L.; Gallipoli, Paolo; Seiler, Michael; Buonamici, Silvia; Vick, Binje; Bannister, Andrew J.; Rad, Roland; Prinjha, Rab K.; Marioni, John C.; Huntly, Brian; Batson, Jennifer; Morris, Jonathan C.; Pina, Cristina; Bradley, Allan; Jeremias, Irmela; Bates, David O.; Yusa, Kosuke; Kouzarides, Tony; Vassiliou, George S. 分享 收藏
Modulation of splicing by inhibiting the kinase SRPK1 as a novel therapeutic strategy in myeloid leukemia Tzelepis, Konstantinos; De Braekeleer, Etienne; Seiler, Michael; Barbieri, Isaia; Robson, Sam; Yang, Yu Hsuen; Gozdecka, Malgorzata; Dudek, Monika; Collord, Grace; Dovey, Oliver M.; Metzakopian, Emmanouil; Garyfallos, Dimitrios; Cooper, Jonathan L.; Buonamici, Silvia; Ponstingl, Hannes; Stratton, Michael R.; Bradley, Allan; Huntly, Brian J.; Pina, Cristina; Kouzarides, Tony; Yusa, Kosuke; Vassiliou, George S. 分享 收藏
JAK2 V617F hematopoietic clones are present several years prior to MPN diagnosis and follow different expansion kinetics McKerrell, Thomas; Park, Naomi; Chi, Jianxiang; Collord, Grace; Moreno, Thaidy; Ponstingl, Hannes; Dias, Joao M. L.; Gerasimou, Petroula; Melanthiou, Kiki; Prokopiou, Chrystalla; Antoniades, Marios; Varela, Ignacio; Costeas, Paul A.; Vassiliou, George S. 分享 收藏
A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes de la Rosa, Jorge; Weber, Julia; Friedrich, Mathias Josef; Li, Yilong; Rad, Lena; Ponstingl, Hannes; Liang, Qi; de Quiros, Sandra Bernaldo; Noorani, Imran; Metzakopian, Emmanouil; Strong, Alexander; Li, Meng Amy; Astudillo, Aurora; Fernadez-Garcia, Mara Teresa; Fernandez-Garcia, Maria Soledad; Hoffman, Gary J.; Fuente, Rocio; Vassiliou, George S.; Rad, Roland; Lopez-Otin, Carlos; Bradley, Allan; Cadinanos, Juan 分享 收藏
Genome-wide transposon screening and quantitative insertion site sequencing for cancer gene discovery in mice Friedrich, Mathias J.; Rad, Lena; Bronner, Iraad F.; Strong, Alexander; Wang, Wei; Weber, Julia; Mayho, Matthew; Ponstingl, Hannes; Engleitner, Thomas; Grove, Carolyn; Pfaus, Anja; Saur, Dieter; Cadinanos, Juan; Quail, Michael A.; Vassiliou, George S.; Liu, Pentao; Bradley, Allan; Rad, Roland 分享 收藏
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia CRISPR Dropout筛选确定了急性髓系白血病的遗传脆弱性和治疗靶点 Tzelepis, Konstantinos; Koike-Yusa, Hiroko; De Braekeleer, Etienne; Li, Yilong; Metzakopian, Emmanouil; Dovey, Oliver M.; Mupo, Annalisa; Grinkevich, Vera; Li, Meng; Mazan, Milena; Gozdecka, Malgorzata; Ohnishi, Shuhei; Cooper, Jonathan; Patel, Miten; McKerrell, Thomas; Chen, Bin; Domingues, Ana Filipa; Gallipoli, Paolo; Teichmann, Sarah; Ponstingl, Hannes; McDermott, Ultan; Saez-Rodriguez, Julio; Huntly, Brian J. P.; Iorio, Francesco; Pina, Cristina; Vassiliou, George S.; Yusa, Kosuke 分享 收藏
Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis McKerrell, Thomas; Park, Naomi; Moreno, Thaidy; Grove, Carolyn S.; Ponstingl, Hannes; Stephens, Jonathan; Crawley, Charles; Craig, Jenny; Scott, Mike A.; Hodkinson, Clare; Baxter, Joanna; Rad, Roland; Forsyth, Duncan R.; Quail, Michael A.; Zeggini, Eleftheria; Ouwehand, Willem; Varela, Ignacio; Vassiliou, George S. 分享 收藏
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer Rad, Roland; Rad, Lena; Wang, Wei; Strong, Alexander; Ponstingl, Hannes; Bronner, Iraad F.; Mayho, Matthew; Steiger, Katja; Weber, Julia; Hieber, Maren; Veltkamp, Christian; Eser, Stefan; Geumann, Ulf; Oellinger, Rupert; Zukowska, Magdalena; Barenboim, Maxim; Maresch, Roman; Cadinanos, Juan; Friedrich, Mathias; Varela, Ignacio; Constantino-Casas, Fernando; Sarver, Aaron; ten Hoeve, Jelle; Prosser, Haydn; Seidler, Barbara; Bauer, Judith; Heikenwaelder, Mathias; Metzakopian, Emmanouil; Krug, Anne; Ehmer, Ursula; Schneider, Guenter; Knoesel, Thomas; Ruemmele, Petra; Aust, Daniela; Gruetzmann, Robert; Pilarsky, Christian; Ning, Zemin; Wessels, Lodewyk; Schmid, Roland M.; Quail, Michael A.; Vassiliou, George; Esposito, Irene; Liu, Pentao; Saur, Dieter; Bradley, Allan 分享 收藏
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity Mueller, Thomas; Hess, Michael W.; Schiefermeier, Natalia; Pfaller, Kristian; Ebner, Hannes L.; Heinz-Erian, Peter; Ponstingl, Hannes; Partsch, Joachim; Roellinghoff, Barbara; Koehler, Henrik; Berger, Thomas; Lenhartz, Henning; Schlenck, Barbara; Houwen, Roderick J.; Taylor, Christopher J.; Zoller, Heinz; Lechner, Silvia; Goulet, Olivier; Utermann, Gerd; Ruemmele, Frank M.; Huber, Lukas A.; Janecke, Andreas R. 分享 收藏
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Glutaredoxin-3 from Escherichia coli - Amino acid sequence, H-1 and N-15 NMR assignments, and structural analysis Aslund, F; Nordstrand, K; Berndt, KD; Nikkola, M; Bergman, T; Ponstingl, H; Jornvall, H; Otting, G; Holmgren, A 分享 收藏
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