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CBL-B inhibition overcomes PD-1/LAG-3 mediated resistance in lung cancer CBL-B抑制克服了PD-1/LAG-3介导的肺癌耐药性 Chocarro, L. D. E.; Blanco, E.; Fenandez-Rubio, L.; Garnica, M.; Zuazo, M.; Garcia Granda, M. J.; Bocanegra, A.; Echaide, M.; Johnston, C.; Edwards, C. J.; Legg, J.; Pierce, A.; Arasanz, H.; Fernandez-Hinojal, G.; Vera, R.; Ausin, K.; Santamaria, E.; Fernandez-Irigoyen, J.; Kochan, G.; Escors, D. 分享 收藏
PD-1/LAG-3 co-signaling profiling uncovers CBL ubiquitin ligases as key immunotherapy targets PD-1/LAG-3共信号分析揭示了CBL泛素连接酶作为关键的免疫治疗靶标 Chocarro, Luisa; Blanco, Ester; Fernandez-Rubio, Leticia; Garnica, Maider; Zuazo, Miren; Garcia, Maria Jesus; Bocanegra, Ana; Echaide, Miriam; Johnston, Colette; Edwards, Carolyn J.; Legg, James; Pierce, Andrew J.; Arasanz, Hugo; Fernandez-Hinojal, Gonzalo; Vera, Ruth; Ausin, Karina; Santamaria, Enrique; Fernandez-Irigoyen, Joaquin; Kochan, Grazyna; Escors, David 分享 收藏
Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies Blanco, Ester; Silva-Pilipich, Noelia; Bocanegra, Ana; Chocarro, Luisa; Procopio, Antonio; Ausin, Karina; Fernandez-Irigoyen, Joaquin; Fernandez, Leticia; Razquin, Nerea; Igea, Ana; Garnica, Maider; Echaide, Miriam; Arasanz, Hugo; Vera, Ruth; Escors, David; Smerdou, Cristian; Kochan, Grazyna 分享 收藏
CBL E3 ubiquitin ligases are key inhibitory regulators in PD-1/LAG-3 co-signaling in human cancers, targeted through bispecific co-blockade Chocarro, L.; Fernandez-Rubio, L.; Garcia Granda, M. J.; Blanco Palmeiro, E.; Bocanegra Gondan, A. I.; Echaide, M.; Garnica, M.; Zuazo, M.; Johnston, C.; Edwards, C. J.; Leggs, J.; Pierce, A.; Arasanz, H.; Vera, R.; Ausin, K.; Santamaria, E.; Fernandez-Irigoyen, J.; Kochan, G.; Escors, D. 分享 收藏
Plasma fractalkine contributes to systemic myeloid diversity and PD-L1/PD-1 blockade in lung cancer Bocanegra, Ana; Fernandez-Hinojal, Gonzalo; Ajona, Daniel; Blanco, Ester; Zuazo, Miren; Garnica, Maider; Chocarro, Luisa; Alfaro-Arnedo, Elvira; Pineiro-Hermida, Sergio; Morente, Pilar; Fernandez, Leticia; Remirez, Ana; Echaide, Miriam; Martinez-Aguillo, Maite; Morilla, Idoia; Tavira, Beatriz; Roncero, Alejandra; Gotera, Carolina; Ventura, Alfonso; Recalde, Nerea; Pichel, Jose G.; Lasarte, Juan Jose; Montuenga, Luis; Vera, Ruth; Pio, Ruben; Escors, David; Kochan, Grazyna 分享 收藏
Cutting-Edge CAR Engineering: Beyond T Cells Chocarro, Luisa; Blanco, Ester; Fernandez-Rubio, Leticia; Arasanz, Hugo; Bocanegra, Ana; Echaide, Miriam; Garnica, Maider; Ramos, Pablo; Pineiro-Hermida, Sergio; Vera, Ruth; Kochan, Grazyna; Escors, David 分享 收藏
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions Lachen-Montes, Mercedes; Mendizuri, Naroa; Ausin, Karina; Echaide, Miriam; Blanco, Ester; Chocarro, Luisa; de Toro, Maria; Escors, David; Fernandez-Irigoyen, Joaquin; Kochan, Grazyna; Santamaria, Enrique 分享 收藏
Cutting-Edge: Preclinical and Clinical Development of the First Approved Lag-3 Inhibitor Chocarro, Luisa; Bocanegra, Ana; Blanco, Ester; Fernandez-Rubio, Leticia; Arasanz, Hugo; Echaide, Miriam; Garnica, Maider; Ramos, Pablo; Pineiro-Hermida, Sergio; Vera, Ruth; Escors, David; Kochan, Grazyna 分享 收藏
TNF-α-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy De Ridder, Kirsten; Locy, Hanne; Piccioni, Elisa; Zuazo, Miren Ibarra; Awad, Robin Maximilian; Verhulst, Stefaan; Van Bulck, Mathias; De Vlaeminck, Yannick; Lecocq, Quentin; Reijmen, Eva; De Mey, Wout; De Beck, Lien; Ertveldt, Thomas; Pintelon, Isabel; Timmermans, Jean-Pierre; Escors, David; Keyaerts, Marleen; Breckpot, Karine; Goyvaerts, Cleo 分享 收藏
CAR-T Cells for the Treatment of Lung Cancer Car-t细胞治疗肺癌的研究进展 Chocarro, Luisa; Arasanz, Hugo; Fernandez-Rubio, Leticia; Blanco, Ester; Echaide, Miriam; Bocanegra, Ana; Teijeira, Lucia; Garnica, Maider; Morilla, Idoia; Martinez-Aguillo, Maite; Pineiro-Hermida, Sergio; Ramos, Pablo; Lasarte, Juan Jose; Vera, Ruth; Kochan, Grazyna; Escors, David 分享 收藏
Characterization of the lung tumor microenvironment upon anti-PD-L1 therapy reveals an ambiguous role for TNF-α De Ridder, K.; Locy, H.; Piccioni, E.; Zuazo, M. Ibarra; Awad, R. M.; Verhulst, S.; van Bulck, M.; De Vlaeminck, Y.; Lecocq, Q.; Reijmen, E.; De Mey, W.; De Beck, L.; Ertveldt, T.; Pintelon, I.; Timmermans, J-P.; Escors, D.; Keyaerts, M.; Breckpot, K.; Goyvaerts, C. 分享 收藏
Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis Ortiz-Espinosa, Sergio; Morales, Xabier; Senent, Yaiza; Alignani, Diego; Tavira, Beatriz; Macaya, Irati; Ruiz, Borja; Moreno, Haritz; Remirez, Ana; Sainz, Cristina; Rodriguez-Pena, Alejandro; Oyarbide, Alvaro; Ariz, Mikel; Andueza, Maria P.; Valencia, Karmele; Teijeira, Alvaro; Hoehlig, Kai; Vater, Axel; Rolfe, Barbara; Woodruff, Trent M.; Maria Lopez-Picazo, Jose; Vicent, Silvestre; Kochan, Grazyna; Escors, David; Gil-Bazo, Ignacio; Luis Perez-Gracia, Jose; Montuenga, Luis M.; Lambris, John D.; Ortiz de Solorzano, Carlos; Lecanda, Fernando; Ajona, Daniel; Pio, Ruben 分享 收藏
The multi-specific VH-based Humabody CB213 co-targets PD1 and LAG3 on T cells to promote anti-tumour activity Edwards, Carolyn J.; Sette, Angelica; Cox, Carl; Di Fiore, Barbara; Wyre, Chris; Sydoruk, Daniela; Yadin, David; Hayes, Philip; Stelter, Szymon; Bartlett, Phillip D.; Zuazo, Miren; Jesus Garcia-Granda, Maria; Benedetti, Giovanni; Fiaska, Stratoniki; Birkett, Neil R.; Teng, Yumin; Enever, Carrie; Arasanz, Hugo; Bocanegra, Ana; Chocarro, Luisa; Fernandez, Gonzalo; Vera, Ruth; Archer, Bethan; Osuch, Isabelle; Lewandowska, Martyna; Surani, Yasmin M.; Kochan, Grazyna; Escors, David; Legg, James; Pierce, Andrew J. 分享 收藏
Clinical landscape of LAG-3-targeted therapy Chocarro, L.; Blanco, E.; Arasanz, H.; Bocanegra, A.; Fernandez-Rubio, L.; Echaide, M.; Garnica, M.; Ramos, P.; Fernandez-Hinojal, G.; Vera, R.; Kochan, G.; Escors, D. 分享 收藏
Comparison of different hyperprogressive disease criteria in non-small cell lung cancer patients treated with immunotherapy and correlation with somatic mutations in driver genes Zuazo, M.; Arasanz, H.; Chocarro, L.; Bocanegra Gondan, A. I.; Martinez-Aguillo, M.; Morilla Ruiz, I.; Teijeira, L.; Guerrero, D.; Nova, L. M.; Zudaire, T.; Arriola, M.; Patino-Garcia, A.; Pio, R.; Kochan, G.; Escors, D.; Vera, R. 分享 收藏
Peripheral low-density neutrophils in the response to immunotherapy in untreated non-small cell lung cancer Arasanz, H.; Bocanegra Gondan, A. I.; Palmeiro, E. B.; Zuazo, M.; Morilla Ruiz, I.; Martinez-Aguillo, M.; Teijeira, L.; Fernandez-Hinojal, G.; Chocarro, L.; Morente Sancho, P.; Escors, D.; Vera, R.; Kochan, G. 分享 收藏
The STAT3 phosphorylation status discriminates tumor associated populations in myeloid cell tumor-infiltrating model Palmeiro, E. B.; Ibanez, M.; Hernandez, C.; Chocarro, L.; Arasanz, H.; Bocanegra, A.; Fernandez, J.; Santamaria, E.; Vera, R.; Smerdou, C.; Escors, D.; Kochan, G. 分享 收藏
PD-1 and LAG-3 immune checkpoints constitutive activators exhibit differential expression phenotypes Chocarro, L.; Palmeiro, E. B.; Arasanz, H.; Bocanegra, A.; Zuazo, M.; Echaide, M.; Morente, P.; Fernandez-Rubio, L.; Fernandez-Hinojal, G.; Garnica, M.; Ramos, P.; Garcia-Granda, M. J.; Vera, R.; Kochan, G.; Escors, D. 分享 收藏
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