未登录 Nilotinib in KIT-driven advanced melanoma: Results from the phase II single-arm NICAM trial 尼洛替尼治疗试剂盒驱动的晚期黑色素瘤: II期单臂NICAM试验的结果 Larkin, James; Marais, Richard; Porta, Nuria; de Castro, David Gonzalez; Parsons, Lisa; Messiou, Christina; Stamp, Gordon; Thompson, Lisa; Edmonds, Kim; Sarker, Sarah; Banerji, Jane; Lorigan, Paul; Evans, Thomas R. Jeffry; Corrie, Pippa; Marshall, Ernest; Middleton, Mark R.; Nathan, Paul; Nicholson, Steve; Ottensmeier, Christian; Plummer, Ruth; Bliss, Judith; Valpione, Sara; Turajlic, Samra 分享 收藏
Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways 晚期转移性黑色素瘤通过多种进化途径出现 Spain, Lavinia; Coulton, Alexander; Lobon, Irene; Rowan, Andrew; Schnidrig, Desiree; Shepherd, Scott T. C.; Shum, Benjamin; Byrne, Fiona; Goicoechea, Maria; Piperni, Elisa; Au, Lewis; Edmonds, Kim; Carlyle, Eleanor; Hunter, Nikki; Renn, Alexandra; Messiou, Christina; Hughes, Peta; Nobbs, Jaime; Foijer, Floris; van den Bos, Hilda; Wardenaar, Rene; Spierings, Diana C. J.; Spencer, Charlotte; Schmitt, Andreas M.; Tippu, Zayd; Lingard, Karla; Grostate, Lauren; Peat, Kema; Kelly, Kayleigh; Sarker, Sarah; Vaughan, Sarah; Mangwende, Mary; Terry, Lauren; Kelly, Denise; Biano, Jennifer; Murra, Aida; Korteweg, Justine; Lewis, Charlotte; O'Flaherty, Molly; Cattin, Anne-Laure; Emmerich, Max; Gerard, Camille L.; Pallikonda, Husayn Ahmed; Lynch, Joanna; Mason, Robert; Rogiers, Aljosja; Xu, Hang; Huebner, Ariana; McGranahan, Nicholas; Al Bakir, Maise; Murai, Jun; Naceur-Lombardelli, Cristina; Borg, Elaine; Mitchison, Miriam; Moore, David A.; Falzon, Mary; Proctor, Ian; Stamp, Gordon W. H.; Nye, Emma L.; Young, Kate; Furness, Andrew J. S.; Pickering, Lisa; Stewart, Ruby; Mahadeva, Ula; Green, Anna; Larkin, James; Litchfield, Kevin; Swanton, Charles; Jamal-Hanjani, Mariam; Turajlic, Samra 分享 收藏
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Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study Fu, Xiao; Zhao, Yue; Lopez, Jose I.; Rowan, Andrew; Au, Lewis; Fendler, Annika; Hazell, Steve; Xu, Hang; Horswell, Stuart; Shepherd, Scott T. C.; Spencer, Charlotte E.; Spain, Lavinia; Byrne, Fiona; Stamp, Gordon; O'Brien, Tim; Nicol, David; Augustine, Marcellus; Chandra, Ashish; Rudman, Sarah; Toncheva, Antonia; Furness, Andrew J. S.; Pickering, Lisa; Kumar, Santosh; Koh, Dow-Mu; Messiou, Christina; ap Dafydd, Derfel; Orton, Matthew R.; Doran, Simon J.; Larkin, James; Swanton, Charles; Sahai, Erik; Litchfield, Kevin; Turajlic, Samra; Bates, Paul A. 分享 收藏
Selection of metastasis competent subclones in the tumour interior Zhao, Yue; Fu, Xiao; Lopez, Jose I.; Rowan, Andrew; Au, Lewis; Fendler, Annika; Hazell, Steve; Xu, Hang; Horswell, Stuart; Shepherd, Scott T. C.; Spain, Lavinia; Byrne, Fiona; Stamp, Gordon; O'Brien, Tim; Nicol, David; Augustine, Marcellus; Chandra, Ashish; Rudman, Sarah; Toncheva, Antonia; Pickering, Lisa; Sahai, Erik; Larkin, James; Bates, Paul A.; Swanton, Charles; Turajlic, Samra; Challacombe, Ben; Chowdhury, Simon; Drake, William; Fernando, Archana; Fotiadis, Nicos; Furness, Andrew; Hatipoglu, Emine; Harrison-Phipps, Karen; Hill, Peter; Horsfield, Catherine; Marafioti, Teresa; Olsburgh, Jonathon; Polson, Alexander; Quezada, Sergio; Varia, Mary; Verma, Hema; Litchfield, Kevin 分享 收藏
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YAP drives cutaneous squamous cell carcinoma formation and progression Vincent-Mistiaen, Zoe; Elbediwy, Ahmed; Vanyai, Hannah; Cotton, Jennifer; Stamp, Gordon; Nye, Emma; Spencer-Dene, Bradley; Thomas, Gareth J.; Mao, Junhao; Thompson, Barry 分享 收藏
Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis Bellelli, Roberto; Borel, Valerie; Logan, Clare; Svendsen, Jennifer; Cox, Danielle E.; Nye, Emma; Metcalfe, Kay; O'Connell, Susan M.; Stamp, Gordon; Flynn, Helen R.; Snijders, Ambrosius P.; Lassailly, Francois; Jackson, Andrew; Boulton, Simon J. 分享 收藏
Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression 导管和腺泡来源的胰腺导管腺癌显示出明显的肿瘤进展和标志物表达 Ferreira, Rute M. M.; Sancho, Rocio; Messal, Hendrik A.; Nye, Emma; Spencer-Dene, Bradley; Stone, Richard K.; Stamp, Gordon; Rosewell, Ian; Quaglia, Alberto; Behrens, Axel 分享 收藏
Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours Blaas, Leander; Pucci, Fabio; Messal, Hendrik A.; Andersson, Agneta B.; Ruiz, E. Josue; Gerling, Marco; Douagi, Iyadh; Spencer-Dene, Bradley; Musch, Alexandra; Mitter, Richard; Bhaw, Leena; Stone, Richard; Bornhorst, Dorothee; Sesay, Abdul K.; Jonkers, Jos; Stamp, Gordon; Malanchi, Ilaria; Toftgard, Rune; Behrens, Axel 分享 收藏
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Rho-associated kinase(ROCK)function is essential for cell cycle progression, senescence and tumorigenesis Kuemper, Sandra; Mardakheh, Faraz K.; McCarthy, Afshan; Yeo, Maggie; Stamp, Gordon W.; Paul, Angela; Worboys, Jonathan; Sadok, Amine; Jorgensen, Claus; Guichard, Sabrina; Marshall, Christopher J. 分享 收藏
Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion Quetier, Ivan; Marshall, Jacqueline J. T.; Spencer-Dene, Bradley; Lachmann, Sylvie; Casamassima, Adele; Franco, Claudio; Escuin, Sarah; Worrall, Joseph T.; Baskaran, Priththivika; Rajeeve, Vinothini; Howell, Michael; Copp, Andrew J.; Stamp, Gordon; Rosewell, Ian; Cutillas, Pedro; Gerhardt, Holger; Parker, Peter J.; Cameron, Angus J. M. 分享 收藏
Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival Baenke, Franziska; Dubuis, Sebastien; Brault, Charlene; Weigelt, Britta; Dankworth, Beatrice; Griffiths, Beatrice; Jiang, Ming; Mackay, Alan; Saunders, Becky; Spencer-Dene, Bradley; Ros, Susana; Stamp, Gordon; Reis-Filho, Jorge S.; Howell, Michael; Zamboni, Nicola; Schulze, Almut 分享 收藏
Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome 通过IDH1克隆驱动程序的下降和双分染色体的宏观进化来追踪胶质母细胞瘤的适应性 Favero, F.; McGranahan, N.; Salm, M.; Birkbak, N. J.; Sanborn, J. Z.; Benz, S. C.; Becq, J.; Peden, J. F.; Kingsbury, Z.; Grocok, R. J.; Humphray, S.; Bentley, D.; Spencer-Dene, B.; Gutteridge, A.; Brada, M.; Roger, S.; Dietrich, P. -Y.; Forshew, T.; Gerlinger, M.; Rowan, A.; Stamp, G.; Eklund, A. C.; Szallasi, Z.; Swanton, C. 分享 收藏
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution Kovac, Michal; Navas, Carolina; Horswell, Stuart; Salm, Max; Bardella, Chiara; Rowan, Andrew; Stares, Mark; Castro-Giner, Francesc; Fisher, Rosalie; de Bruin, Elza C.; Kovacova, Monika; Gorman, Maggie; Makino, Seiko; Williams, Jennet; Jaeger, Emma; Jones, Angela; Howarth, Kimberley; Larkin, James; Pickering, Lisa; Gore, Martin; Nicol, David L.; Hazell, Steven; Stamp, Gordon; O'Brien, Tim; Challacombe, Ben; Matthews, Nik; Phillimore, Benjamin; Begum, Sharmin; Rabinowitz, Adam; Varela, Ignacio; Chandra, Ashish; Horsfield, Catherine; Polson, Alexander; Tran, Maxine; Bhatt, Rupesh; Terracciano, Luigi; Eppenberger-Castori, Serenella; Protheroe, Andrew; Maher, Eamonn; El Bahrawy, Mona; Fleming, Stewart; Ratcliffe, Peter; Heinimann, Karl; Swanton, Charles; Tomlinson, Ian 分享 收藏
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High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer Veeriah, Selvaraju; Leboucher, Pierre; de Naurois, Julien; Jethwa, Nirmal; Nye, Emma; Bunting, Tamara; Stone, Richard; Stamp, Gordon; Calleja, Veronique; Jeffrey, Stefanie S.; Parker, Peter J.; Larijani, Banafshe 分享 收藏
Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution Fisher, Rosalie; Horswell, Stuart; Rowan, Andrew; Salm, Maximilian P.; de Bruin, Elza C.; Gulati, Sakshi; McGranahan, Nicholas; Stares, Mark; Gerlinger, Marco; Varela, Ignacio; Crockford, Andrew; Favero, Francesco; Quidville, Virginie; Andre, Fabrice; Navas, Carolina; Groenroos, Eva; Nicol, David; Hazell, Steve; Hrouda, David; O'Brien, Tim; Matthews, Nik; Phillimore, Ben; Begum, Sharmin; Rabinowitz, Adam; Biggs, Jennifer; Bates, Paul A.; McDonald, Neil Q.; Stamp, Gordon; Spencer-Dene, Bradley; Hsieh, James J.; Xu, Jianing; Pickering, Lisa; Gore, Martin; Larkin, James; Swanton, Charles 分享 收藏
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