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K

Kalkunte S. Srivenugopal

Texas Tech University System
H指数:31
被引数:3,148
浏览量:0

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工作经历

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荣誉奖项

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Novel Pathways of Oxidative and Nitrosative Inactivation of the Human MGMT Protein in Colon Cancer and Glioblastoma Cells: Increased Efficacy of Alkylating Agents In Vitro and In Vivo

氧化和亚硝化导致人MGMT蛋白失活的新型通路：结肠癌和胶质母细胞瘤细胞中烷化剂在体外和体内的增强效果

DISEASES
IF3
2025-01-250
OA
Basak, Debasish; Mostofa, Agm; Madala, Hanumantha Rao; Srivenugopal, Kalkunte S.
Human NQO1 as a Selective Target for Anticancer Therapeutics and Tumor Imaging
CELLS
IF5.2
2024-07-293
OAAI
Khan, A. E. M. Adnan; Arutla, Viswanath; Srivenugopal, Kalkunte S.
Characterization of novel NQO1-targeted therapeutic and theranostic compounds for tumor selective chemotherapy
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Srivenugopal, Kalkunte S.; Punganuru, Surendra R.; Arutla, Viswanath; Khan, Aem Adnan
Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action
CELLS
IF5.2
2020-07-0117
OAAI
Punganuru, Surendra R.; Arutla, Viswanath; Zhao, Wei; Rajaei, Mehrdad; Deokar, Hemantkumar; Zhang, Ruiwen; Buolamwini, John K.; Srivenugopal, Kalkunte S.; Wang, Wei
Structure and activity relationship of disulfiram in inactivating the O6-methylguanine DNA methyltransferase (MGMT) and potentiation of alkylation DNA damage in brain tumors
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Arutla, Viswanath; Punganuru, Surendra R.; Srivenugopal, Kalkunte S.
A near-infrared, highly specific NQO1-activated turn-on fluorescent probe for the detection and imaging of cancer cells in vivo
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Punganuru, Surendra Reddy; Arutla, Viswanath; Srivenugopal, Kalkunte S.
Synthesis and preclinical evaluation of dual-stimuli responsive doxorubicin prodrug activated by histone deacetylases and cathepsin L
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Punganuru, Surendra R.; Madala, Hanumantha Rao; Arutla, Viswanath; Srivenugopal, Kalkunte S.
Characterization of a highly specific NQO1-activated near- infrared fluorescent probe and its application for in vivo tumor imaging
SCIENTIFIC REPORTS
IF3.9
2019-06-1236
OAAI
Punganuru, Surendra Reddy; Madala, Hanumantha Rao; Arutla, Viswanath; Zhang, Ruiwen; Srivenugopal, Kalkunte S.
Selective killing of human breast cancer cells by the styryl lactone (R)-goniothalamin is mediated by glutathione conjugation, induction of oxidative stress and marked reactivation of the R175H mutant p53 protein
CARCINOGENESIS
IF2.9
2018-07-1312
OAAI
Punganuru, Surendra R.; Madala, Hanumantha Rao; Arutla, Viswanath; Srivenugopal, Kalkunte S.
Design and development of a parthenolide-combretastatin hybrid drug (VA-11) with highly potent antimicrotubule and NF-kB inhibitory activities
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Arutla, Viswanath; Punganuru, Surendra R.; Madala, Hanumantharao; Srivenugopal, Kalkunte S.
Structure-based drug design to overcome temozolomide resistance in glioblastoma (GBM) through a dual inhibition of MGMT and base excision repair
CANCER RESEARCH
IF16.6
2018-07-011
PRE
Madala, Hanumantha Rao; Arutla, Viswanath; Punganuru, Surendra; Srivenugopal, Kalkunte
Design and characterization of an NQO1-activated spiroisoindolinone derivative for glioma treatment
CANCER RESEARCH
IF16.6
2018-07-011
PRE
Punganuru, Surendra R.; Madala, Hanumantha Rao; Arutla, Viswanath; Srivenugopal, Kalkunte S.
Allele-specific restoration of biological function of the mutant p53 by Baylis-Hillman adducts
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Punganuru, Surendra R.; Arutla, Viswanath; Madala, Hanumantha Rao; Srivenugopal, Kalkunte S.
S-phase Specific Downregulation of Human O 6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21 cip1 Proteins in Glioma Cells
NEOPLASIA
IF7.7
2018-04-0123
OAAI
Mostofa, A. G. M.; Punganuru, Surendra R.; Madala, Hanumantha Rao; Srivenugopal, Kalkunte S.
IDH1 mutation-inspired α-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Madala, Hanumantha Rao; Punganuru, Surendra Reddy; Srivenugopal, Kalkunte S.
Induction of mild oxidative stress as a strategy for reactivation of mutant p53 proteins: KSS72, a small molecule derived from ethacrynic acid restores the biological functions of R248W/Q mutant
CANCER RESEARCH
IF16.6
2017-07-011
PRE
Punganuru, Surendra R.; Madala, Hanumantha Rao; Srivenugopal, Kalkunte S.
Redox-mediated inactivation of MGMT DNA repair through thiolation or nitrosylation of the active site cysteine145 sensitizes human gliomas to alkylating agents in vitro and in xenograft models
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Basak, Debasish; Srivenugopal, Kalkunte S.
Development of a novel non-diuretic brain-penetrating ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Punganuru, Surendra R.; Madala, Hanumantha Rao; Srivenugopal, Kalkunte S.
Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Madala, Hanumantha Rao; Punganuru, Surendra R.; Ali-Osman, Francis; Srivenugopal, Kalkunte S.
The S-phase checkpoint function of MGMT provides an unexpected rational route to profoundly increase the efficacy of anticancer antimetabolites in cell culture and xenograft models
CANCER RESEARCH
IF16.6
2017-07-010
PRE
Mostofa, A. G. M.; Basak, Debasish; Madala, Hanumantha; Punganuru, Surendra R.; Srivenugopal, Kalkunte S.

研究方向

暂未获取到该数据
S
Surendra R. Punganuru
H 指数:13论文数:51被引数:544
H
Hanumantha Rao Madala
H 指数:13论文数:94被引数:558
V
Viswanath Arutla
H 指数:17论文数:60被引数:929
F
Francis Ali‐Osman
H 指数:51论文数:311被引数:9,291
D
Debasish Basak
H 指数:12论文数:30被引数:938
A
Ameya Paranjpe
H 指数:5论文数:19被引数:261
S
Santhi D. Konduri
H 指数:23论文数:114被引数:2,003
A
AGM Mostofa
H 指数:13论文数:24被引数:651
R
Ruiwen Zhang
H 指数:59论文数:497被引数:1.1万
G
George C. Bobustuc
H 指数:13论文数:77被引数:1,608