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A Growth Differentiation Factor 15 Receptor Agonist in Randomized Placebo-Controlled Trials in Healthy or Obese Persons Smith, William B.; Nguyen, David; Clough, Timothy; Schofield, Jul; Kagan, Mark R.; Kompa, Jill; He, YanLing; Maratos-Flier, Eleftheria; Jamontt, Joanna; Vong, Linh; Schwartzkopf, Chad D.; Layne, Joseph D.; Usera, Aimee R.; O'Donnell, Christopher J.; Heldwein, Kurt A.; Streeper, Ryan S.; Goldfine, Allison B. 分享 收藏
ALN-KHK, an Investigational RNA Interference Therapeutic, Successfully Targets Hepatic Ketohexokinase in a Single Ascending Dose Study of Overweight to Obese Adults Maratos-Flier, Eleftheria; Nandi, Tirtha; Boyle, Katherine; Li, Xingyu; Wu, Yuanfeng; Noetzli, Leila; Kajbaf, Farshad; Morelli, Gaetano 分享 收藏
Preclinical Development of ALNKHK, an Investigational RNAi Therapeutic for Type 2 Diabetes Mellitus Noetzli, Leila; Borodovsky, Anna; Chua, Xien Yu; Tymon, Roxanne; Darcy, Justin; Belozerova, Sabrina; Keibler, Mark; Tu, Ho-Chou; Maratos-Flier, Eleftheria 分享 收藏
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Weight Loss Outcomes Among Early High Responders to Exenatide Treatment: A Randomized, Placebo Controlled Study in Overweight and Obese Women Rodgers, Megan; Migdal, Alexandra L.; Rodriguez, Tahereh Ghorbani; Chen, Zsu-Zsu; Nath, Anjali K.; Gerszten, Robert E.; Kasid, Natasha; Toschi, Elena; Tripaldi, Juliet; Heineman, Brent; Phan, Minh; Ngo, Long; Maratos-Flier, Eleftheria; Dushay, Jody 分享 收藏
LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in Obese Adults With Modest Hypertriglyceridemia LLF580，一种FGF21类似物，可降低中度高甘油三酯血症肥胖成人的甘油三酯和肝脂肪 Rader, Daniel J.; Maratos-Flier, Eleftheria; Nguyen, Amanda; Hom, Doug; Ferriere, Michael; Li, Yifang; Kompa, Jill; Martic, Miljen; Hinder, Markus; Basson, Craig T.; Yowe, David; Diener, John; Goldfine, Allison B.; Bajaj, Archna; Escalon, Maricer; Fein, Melanie; Hunt, Allen; Kankam, Martin K.; Koren, Michael; Smith, William; Wilson, Jessica 分享 收藏
Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism Sandhu, Bynvant; Perez-Matos, Maria C.; Tran, Stephanie; Singhal, Garima; Syed, Ismail; Feldbruegge, Linda; Mitsuhashi, Shuji; Pelletier, Julie; Huang, Jinhe; Yalcin, Yusuf; Csizmadia, Eva; Tiwari-Heckler, Shilpa; Enjyoji, Keiichi; Sevigny, Jean; Maratos-Flier, Eleftheria; Robson, Simon C.; Jiang, Z. Gordon 分享 收藏
Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis 肝源性FGF21对于完全适应生酮饮食至关重要，但不能调节葡萄糖稳态 Watanabe, Mikiko; Singhal, Garima; Fisher, Ffolliott M.; Beck, Thomas C.; Morgan, Donald A.; Socciarelli, Fabio; Mather, Marie L.; Risi, Renata; Bourke, Jared; Rahmouni, Kamal; McGuinness, Owen P.; Flier, Jeffrey S.; Maratos-Flier, Eleftheria 分享 收藏
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Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury 成纤维细胞生长因子21 (FGF21) 被乙醇强烈诱导，对乙醇相关肝损伤具有保护作用 Desai, Bhavna N.; Singhal, Garima; Watanabe, Mikiko; Stevanovic, Darko; Lundasen, Thomas; Fisher, ffolliott M.; Mather, Marie L.; Vardeh, Hilde G.; Douris, Nicholas; Adams, Andrew C.; Nasser, Imad A.; FitzGerald, Garret A.; Flier, Jeffrey S.; Skarke, Carsten; Maratos-Flier, Eleftheria 分享 收藏
The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans ter Horst, Kasper W.; Gilijamse, Pim W.; Demirkiran, Ahmet; van Wagensveld, Bart A.; Ackermans, Marlette T.; Verheij, Joanne; Romijn, Johannes A.; Nieuwdorp, Max; Maratos-Flier, Eleftheria; Herman, Mark A.; Serlie, Mireille J. 分享 收藏
Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice Douris, Nicholas; Desai, Bhavna N.; Fisher, Ffolliott M.; Cisu, Theodore; Fowler, Alan J.; Zarebidaki, Eleen; Nguyen, Ngoc Ly T.; Morgan, Donald A.; Bartness, Timothy J.; Rahmouni, Kamal; Flier, Jeffrey S.; Maratos-Flier, Eleftheria 分享 收藏
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A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism Fisher, Ffolliott M.; Kim, MiSung; Doridot, Ludivine; Cunniff, Jeremy C.; Parker, Thomas S.; Levine, Daniel M.; Hellerstein, Marc K.; Hudgins, Lisa C.; Maratos-Flier, Eleftheria; Herman, Mark A. 分享 收藏
iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy Lynch, Lydia; Hogan, Andrew E.; Duquette, Danielle; Lester, Chantel; Banks, Alexander; LeClair, Katherine; Cohen, David E.; Ghosh, Abhisek; Lu, Bing; Corrigan, Michelle; Stevanovic, Darko; Maratos-Flier, Eleftheria; Drucker, Daniel J.; O'Shea, Donal; Brenner, Michael 分享 收藏
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