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TRIM21 facilitates inflammasome assembly and contributes to autoinflammatory disease TRIM21促进炎症小体组装并导致自身炎症性疾病 Carriere, Jessica; Yun, Chawon; Khare, Sonal; Ismaeel, Sana; Jager, Elisabeth; Dantas Martins, Vinicius; Sims, Kaiden A.; Chu, Lan H.; Nguyen, Huyen; de Almeida, Lucia; Onyuru, Janset; Ruiz, Justin; Khatri, Hemisha; Devi, Savita; Chae, Jae Jin; Kastner, Daniel L.; Broderick, Lori; Hoffman, Hal M.; Dorfleutner, Andrea; Stehlik, Christian 分享 收藏
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The human milk oligosaccharide 3′sialyllactose reduces low-grade inflammation and atherosclerosis development in mice Pessentheiner, Ariane R.; Spann, Nathanael J.; Autran, Chloe A.; Oh, Tae Gyu; Grunddal, Kaare, V; Coker, Joanna K. C.; Painter, Chelsea D.; Ramms, Bastian; Chiang, Austin W. T.; Wang, Chen-Vi; Hsiao, Jason; Wang, Viwen; Quach, Anthony; Booshehri, Laela M.; Hammond, Alexandra; Tognaccini, Chiara; Latasiewicz, Joanna; Willemsen, Lisa; Zengler, Karsten; Winther, Menno P. J. de; Hoffman, Hal M.; Philpott, Martin; Cribbs, Adam P.; Oppermann, Udo; Lewis, Nathan E.; Witztum, Joseph L.; Vu, Ruth; Atkins, Annette R.; Downes, Michael; Evans, Ron M.; Glass, Christopher K.; Bode, Lars; Gordts, Philip L. S. M. 分享 收藏
Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells Yu, Juan; Meneses-Salas, Elsa; Johnson, Jennifer L.; Manenti, Susanna; Kbaich, Mouad Ait; Chen, Danni; Askari, Kasra; He, Jing; Shukla, Aparna; Shaji, Binchu; Gonzalez-Quintial, Rosana; Croker, Ben A.; Zhang, Jinzhong; Hoffman, Hal; Kiosses, William B.; Hedrick, Catherine; Pestonjamasp, Kersi; Wineinger, Nathan; Baccala, Roberto; Catz, Sergio D. 分享 收藏
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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis (vol 23, e54446, 2022) Kaufmann, Benedikt; Leszczynska, Aleksandra; Reca, Agustina; Booshehri, Laela M.; Onyuru, Janset; Tan, Zhehao; Wree, Alexander; Friess, Helmut; Hartmann, Daniel; Papouchado, Bettina; Broderick, Lori; Hoffman, Hal M.; Croker, Ben A.; Zhu, Yanfang Peipei; Feldstein, Ariel E. 分享 收藏
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NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils Zhu, Yanfang Peipei; Speir, Mary; Tan, ZheHao; Lee, Jamie Casey; Nowell, Cameron J.; Chen, Alyce A.; Amatullah, Hajera; Salinger, Ari J.; Huang, Carolyn J.; Wu, Gio; Peng, Weiqi; Askari, Kasra; Griffis, Eric; Ghassemian, Majid; Santini, Jennifer; Gerlic, Motti; Kiosses, William B.; Catz, Sergio D.; Hoffman, Hal M.; Greco, Kimberly F.; Weller, Edie; Thompson, Paul R.; Wong, Lai Ping; Sadreyev, Ruslan; Jeffrey, Kate L.; Croker, Ben A. 分享 收藏
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders Ambrus-Aikelin, Geza; Takeda, Katsuyuki; Joetham, Anthony; Lazic, Milos; Povero, Davide; Santini, Angelina M.; Pranadinata, Rama; Johnson, Casey D.; McGeough, Matthew D.; Beasley, Federico C.; Stansfield, Ryan; McBride, Christopher; Trzoss, Lynnie; Hoffman, Hal M.; Feldstein, Ariel E.; Stafford, Jeffrey A.; Veal, James M.; Bain, Gretchen; Gelfand, Erwin W. 分享 收藏
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis Povero, Davide; Lazic, Milos; McBride, Christopher; Ambrus-Aikelin, Geza; Stansfield, Ryan; Johnson, Casey D.; Santini, Angelina M.; Pranadinata, Rama F.; McGeough, Matthew D.; Stafford, Jeffrey A.; Hoffman, Hal M.; Feldstein, Ariel E.; Veal, James M.; Bain, Gretchen 分享 收藏
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Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation (vol 6, 578, 2023) Cabral, Angela; Cabral, Julia Elise; Wang, Angelina; Zhang, Yiyang; Liang, Hailin; Nikbakht, Donya; Corona, Leslie; Hoffman, Hal M. M.; McNulty, Reginald 分享 收藏
Constitutive IL-1RA production by modified immune cells protects against IL-1-mediated inflammatory disorders Colantuoni, Mariasilvia; Hernandez, Raisa Jofra; Pettinato, Emanuela; Basso-Ricci, Luca; Magnani, Laura; Andolfi, Grazia; Rigamonti, Chiara; Finardi, Annamaria; Romeo, Valentina; Soldi, Monica; Sergi, Lucia Sergi; Rocchi, Martina; Scala, Serena; Hoffman, Hal M.; Gregori, Silvia; Kajaste-Rudnitski, Anna; Sanvito, Francesca; Muzio, Luca; Naldini, Luigi; Aiuti, Alessandro; Mortellaro, Alessandra 分享 收藏
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