Robert J. Lutz - Publications, H-index & Citations

Robert J. Lutz

immunogen, inc.

47H指数

193论文数

1.1W被引数

收录论文 46

发表时间

IKS012, a novel ADC design with favorable efficacy and safety for treatment of Folate Receptor Alpha-positive cancers

EUROPEAN JOURNAL OF CANCER

IF7.1

2024-10-01

PREAI

Lodge, A.; Bousis, S.; Stephenson, J.; Robinson, S.; Stanley, W. A.; Mysliwy, J.; Deckert, J.; Thirlway, J.; Lutz, R. J.

IKS01, a next generation antibody drug conjugate, shows target-dependent efficacy in a platinum-resistant tumor model with low levels of folate receptor α expression

MOLECULAR CANCER THERAPEUTICS

IF5.5

2019-12-01

PREAI

Thirlway, Jenny; Lodge, Adam; Pelava, Andria; Williamson, Daniel J.; Carta, Davide; Al Nakeeb, Majid; Mysliwy, Justyna; Jackson, Paul J. M.; Thurston, David E.; Lutz, Robert J.

Bicyclic peptides for PET imaging of MT1-MMP expressing tumors

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Teufel, Daniel; Harrison, Helen; Campbell, Spencer; Stace, Catherine; Walker, Edward; Lutz, Robert J.; Park, Peter; Eder, Matthias; Bauder-Wust, Ulrike; Schierbaum, Ursula; Leotta, Karin; Kopka, Klaus; Haberkorn, Uwe

BT1718, a novel bicyclic peptide-maytansinoid conjugate targeting MT1-MMP for the treatment of solid tumors: Design of bicyclic peptide and linker selection

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Harrison, Helen; Bennett, Gavin; Blakeley, Diane; Brown, Amy; Campbell, Spencer; Chen, Liuhong; Lutz, Robert J.; Pavan, Silvia; van Rietschoten, Katerine; Teufel, Daniel; Park, Peter U.; Lee, Kevin

IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors

MOLECULAR CANCER THERAPEUTICS

IF5.5

2015-07-06

187

OAAI

Ab, Olga; Whiteman, Kathleen R.; Bartle, Laura M.; Sun, Xiuxia; Singh, Rajeeva; Tavares, Daniel; LaBelle, Alyssa; Payne, Gillian; Lutz, Robert J.; Pinkas, Jan; Goldmacher, Victor S.; Chittenden, Thomas; Lambert, John M.

Antibody-maytansinoid conjugates for the treatment of myeloma

MABS

IF7.3

2014-10-27

OAAI

Lutz, Robert J.; Whiteman, Kathleen R.

IMGN289, an EGFR-targeting antibody-drug conjugate, is effective against tumor cells that are resistant to EGFR tyrosine kinase inhibitors

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Setiady, Yulius Y.; Dong, Ling; Skaletskaya, Anna; Pinkas, Jan; Lutz, Robert J.; Lambert, John M.; Chittenden, Thomas

Development of modified dosing approaches to achieve specific pharmacokinetic (PK) objectives in the first-inhuman phase I clinical trial of IMGN853, a folate receptor α-targeting antibody drug conjugate

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Ponte, Jose F.; Running, Kelli L.; Kirby, Maurice; Chan, Julie; Pinkas, Jan; O'Leary, James J.; Lutz, Robert J.

Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models Lorvotuzumab mertansine，一种CD56-targeting抗体-药物缀合物，在人类异种移植模型中对小细胞肺癌具有有效的抗肿瘤活性

MABS

IF7.3

2014-01-08

OAAI

Whiteman, Kathleen R.; Johnson, Holly A.; Mayo, Michele F.; Audette, Charlene A.; Carrigan, Christina N.; LaBelle, Alyssa; Zukerberg, Lawrence; Lambert, John M.; Lutz, Robert J.

The anti-EGFR ADC, IMGN289 displays favorable pharmacokinetic properties

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Ponte, Jose F.; Sun, Xiuxia; Yoder, Nicholas C.; Fishkin, Nathan; Wilhelm, Sharon; Hawes, Susan J.; Widdison, Wayne; Mastico, Robert A.; Pinkas, Jan; Chari, Ravi J.; Lutz, Robert J.; Erickson, Hans K.

Development of a novel antibody-maytansinoid conjugate, IMGN289, for the treatment of EGFR-expressing solid tumors.

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Setiady, Yulius Y.; Park, Peter U.; Ponte, Jose F.; Dong, Ling; Skaletskaya, Anna; Coccia, Jennifer A.; Hong, Erica; Clancy, Lauren; Rui, Lingyun; Pinkas, Jan; Lutz, Robert J.; Lambert, John M.; Chittenden, Thomas D.

A method for quantifying soluble folate receptor 1 in IMGN853 0401 clinical trial patients

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Testa, Nathan; Bartle, Laura; Ab, Olga; Cheng, Judy; Payne, Gillian; Lutz, Robert J.; Wolf, Ben; Carrigan, Christina

Preclinical evaluation of IMGN289, an anti-EGFR antibody-maytansinoid conjugate for the treatment of squamous cell carcinoma of the head and neck

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Ponte, Jose F.; Setiady, Yulius Y.; Dong, Ling; Skaletskaya, Anna; Carrigan, Christina N.; Anderson-Villaluz, Alfred; Lutz, Robert J.; Pinkas, Jan

IMGN289, an EGFR-targeting antibody-maytansinoid conjugate with potent activity against non-small cell lung cancer (NSCLC) regardless of dependency on EGFR pathway.

CANCER RESEARCH

IF16.6

2013-04-01

PREAI

Chittenden, Thomas D.; Setiady, Yulius Y.; Park, Peter U.; Ponte, Jose F.; Dong, Ling; Skaletskaya, Anna; Carrigan, Christina N.; Villaluz, Alfred A.; Pinkas, Jan; Lutz, Robert J.; Lambert, John M.

Evaluation of CD37 expression by calibrated IHC identifies non-Hodgkin's lymphoma as a therapeutic target for IMGN529, an anti-CD37-maytansinoid conjugate

CANCER RESEARCH

IF16.6

2012-04-01

PREAI

Xu, Shanqin; Payne, Gillian; Pinkas, Jan; Deckert, Jutta; Li, Min; Lutz, Robert J.; Carrigan, Christina N.

IMGN529, a CD37-directed antibody-drug conjugate for the treatment of B-cell malignancies, has a favorable in vitro safety profile

CANCER RESEARCH

IF16.6

2012-04-01

PREAI

Deckert, Jutta; Yi, Yong; Chicklas, Sharon; Pinkas, Jan; Chittenden, Thomas; Lutz, Robert J.; Park, Peter U.

IMGN529: A therapeutic maytansinoid conjugate of an anti-CD37 antibody with multiple mechanisms of action for B-cell lymphoma and leukemia

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Deckert, Jutta; Mayo, Michele F.; Yi, Yong; Li, Min; ChickIas, Sharon; Tavares, Daniel J.; Pinkas, Jan; Chittenden, Thomas D.; Lutz, Robert J.; Lambert, John M.; Park, Peter U.

Lorvotuzumab mertansine (IMGN901) immune effector activity and its effect on human NK cells

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Skaletskaya, Anna; Setiady, Yulius Y.; Park, Peter U.; Lutz, Robert J.

IMGN529 is an anti-CD37-maytansinoid conjugate with potent in vitro and in vivo activity against NHL and CLL cell lines

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Mayo, Michele F.; Li, Min; Yi, Yong; Xu, Shanqin; Lai, Katharine C.; Erickson, Hans K.; Deckert, Jutta; Park, Peter U.; Lutz, Robert J.; Pinkas, Jan