未登录 分享 收藏
Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in Staphylococcus aureus Infection ClfA002与中和抗体AZD7745复合物的结构，揭示了其在金黄色葡萄球菌感染中的广谱中和机制。 Tkaczyk, Christine; Keren-Kaplan, Tal; Gamson, Adam; Warrener, Paul; Semenova, Elena; Rosenthal, Kim; Barnes, Arnita; Ahani, Bahar; Sellman, Bret R.; Podlaha, Ondrej; Oganesyan, Vaheh 分享 收藏
NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome NTHi杀伤活性在COPD患者中降低，并与差异微生物组相关。 Gopalakrishnan, Vancheswaran; Sparklin, Ben; Kim, Jung Hwan; Bouquet, Jerome; Kehl, Margaret; Kenny, Tara; Morehouse, Christopher; Caceres, Carolina; Warrener, Paul; Hristova, Ventzislava A.; Wilson, Susan; Shandilya, Harini; Barnes, Arnita; Ruzin, Alexey; Wang, Junmin; Oberg, Lisa; Angermann, Bastian; Mccrae, Christopher; Platt, Adam; Muthas, Daniel; Hess, Sonja; Tkaczyk, Christine; Sellman, Bret R.; Ostridge, Kristoffer; Belvisi, Maria G.; Wilkinson, Tom M. A.; Staples, Karl J.; Digiandomenico, Antonio; MICA II Study Grp, Vancheswaran 分享 收藏
Characterization of mAbs against Klebsiella pneumoniae type 3 fimbriae isolated in a target-independent phage display campaign Berry, Sophia K.; Rust, Steven; Irving, Lorraine; Scott, Josefin Bartholdson; Weinert, Lucy A.; Dougan, Gordon; Christie, Graham; Warrener, Paul; Minter, Ralph; Grant, Andrew J. 分享 收藏
A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis Long, Merete B.; Gilmour, Amy; Kehl, Margaret; Tabor, David E.; Keller, Ashley E.; Warrener, Paul; Gopalakrishnan, Vancheswaran; Rosengren, Sanna; Crichton, Megan L.; McIntosh, Eve; Giam, Yan Hui; Keir, Holly R.; Brailsford, Wayne; Hughes, Rod; Belvisi, Maria G.; Sellman, Bret R.; DiGiandomenico, Antonio; Chalmers, James D. 分享 收藏
RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure Carleton, M; Mao, M; Biery, M; Warrener, P; Kim, S; Buser, C; Marshall, CG; Fernandes, C; Annis, J; Linsley, PS 分享 收藏
Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions Bartz, Steven R.; Zhang, Zhan; Burchard, Julja; Imakura, Maki; Martin, Melissa; Palmieri, Anthony; Needham, Rachel; Guo, Jie; Gordon, Marcia; Chung, Namjin; Warrener, Paul; Jackson, Aimee L.; Carleton, Michael; Oatley, Melissa; Locco, Louis; Santini, Francesca; Smith, Todd; Kunapuli, Priya; Ferrer, Marc; Strulovici, Berta; Friend, Stephen H.; Linsley, Peter S. 分享 收藏
Phenotypic whole-cell screening identifies a protective carbohydrate epitope on Klebsiella pneumoniae 表型全细胞筛选鉴定肺炎克雷伯菌的保护性碳水化合物表位 Berry, Sophia K.; Rust, Steven; Caceres, Carolina; Irving, Lorraine; Scott, Josefin Bartholdson; Tabor, David E.; Dougan, Gordon; Christie, Graham; Warrener, Paul; Minter, Ralph; Grant, Andrew J. 分享 收藏
Engraftment of Bacteria after Fecal Microbiota Transplantation Is Dependent on Both Frequency of Dosing and Duration of Preparative Antibiotic Regimen 粪便微生物群移植后细菌的植入取决于给药频率和制备性抗生素方案的持续时间 Gopalakrishnan, Vancheswaran; Dozier, Elizabeth Ashley; Glover, Matthew S.; Novick, Steven; Ford, Michael; Morehouse, Christopher; Warrener, Paul; Caceres, Carolina; Hess, Sonja; Sellman, Bret R.; Cohen, Taylor S. 分享 收藏
Antibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function Jones-Nelson, Omari; Tovchigrechko, Andrey; Glover, Matthew S.; Fernandes, Fiona; Rangaswamy, Udaya; Liu, Hui; Tabor, David E.; Boyd, Jonathan; Warrener, Paul; Martinez, Jose; Hilliard, Jamese J.; Stover, C. Ken; Yu, Wen; DAngelo, Gina; Hess, Sonja; Cohen, Taylor S.; Sellman, Bret R. 分享 收藏
Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source 走向标准饮食诱导和活检证实的非酒精性脂肪性肝炎小鼠模型: 饮食脂肪来源的影响 Boland, Michelle L.; Oro, Denise; Tolbol, Kirstine S.; Thrane, Sebastian T.; Nielsen, Jens Christian; Cohen, Taylor S.; Tabor, David E.; Fernandes, Fiona; Tovchigrechko, Andrey; Veidal, Sanne S.; Warrener, Paul; Sellman, Bret R.; Jelsing, Jacob; Feigh, Michael; Vrang, Niels; Trevaskis, James L.; Hansen, Henrik H. 分享 收藏
The Neutrophilic Response to Pseudomonas Damages the Airway Barrier, Promoting Infection by Klebsiella pneumoniae Jones-Nelson, Oman; Hilliard, Jamese J.; DiGiandomenico, Antonio; Warrener, Paul; Alfaro, Alex; Cheng, Lily; Stover, C. Kendall; Cohen, Taylor S.; Sellman, Bret R. 分享 收藏
分享 收藏
Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates Tabor, D. E.; Oganesyan, V.; Keller, A. E.; Yu, L.; McLaughlin, R. E.; Song, E.; Warrener, P.; Rosenthal, K.; Esser, M.; Qi, Y.; Ruzin, A.; Stover, C. K.; DiGiandomenico, A. 分享 收藏
A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells Kroh, Heather K.; Chandrasekaran, Ramyavardhanee; Zhang, Zhifen; Rosenthal, Kim; Woods, Rob; Jin, Xiaofang; Nyborg, Andrew C.; Rainey, G. Jonah; Warrener, Paul; Melnyk, Roman A.; Spiller, Benjamin W.; Lacy, D. Borden 分享 收藏
Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae 免疫隐形驱动的O2血清型流行率和针对多重耐药肺炎克雷伯菌的治疗性抗体的潜力 Pennini, Meghan E.; De Marco, Anna; Pelletier, Mark; Bonnell, Jessica; Cvitkovic, Romana; Beltramello, Martina; Cameroni, Elisabetta; Bianchi, Siro; Zatta, Fabrizia; Zhao, Wei; Xiao, Xiaodong; Camara, Maria M.; DiGiandomenico, Antonio; Semenova, Elena; Lanzavecchia, Antonio; Warrener, Paul; Suzich, JoAnn; Wang, Qun; Corti, Davide; Stover, C. Kendall 分享 收藏
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors Colley, Caroline S.; Popovic, Bojana; Sridharan, Sudharsan; Debreczeni, Judit E.; Hargeaves, David; Fung, Michael; An, Ling-Ling; Edwards, Bryan; Arnold, Joanne; England, Elizabeth; Eghobamien, Laura; Sivars, Ulf; Flavell, Liz; Renshaw, Jonathan; Wickson, Kate; Warrener, Paul; Zha, Jingying; Bonnell, Jessica; Woods, Rob; Wilkinson, Trevor; Dobson, Claire; Vaughan, Tristan J. 分享 收藏
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface Kroh, Heather K.; Chandrasekaran, Ramyavardhanee; Rosenthal, Kim; Woods, Rob; Jin, Xiaofang; Ohi, Melanie D.; Nyborg, Andrew C.; Rainey, G. Jonah; Warrener, Paul; Spiller, Benjamin W.; Lacy, D. Borden 分享 收藏
Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach Tkaczyk, C.; Kasturirangan, S.; Minola, A.; Jones-Nelson, O.; Gunter, V.; Shi, Y. Y.; Rosenthal, K.; Aleti, V.; Semenova, E.; Warrener, P.; Tabor, D.; Stover, C. K.; Corti, D.; Rainey, G.; Sellman, B. R. 分享 收藏
Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4 抗LPS抗体通过增强中性粒细胞介导的清除而不中和TLR4来保护肺炎克雷伯菌 Cohen, Taylor S.; Pelletier, Mark; Cheng, Lily; Pennini, Meghan E.; Bonnell, Jessica; Cvitkovic, Romana; Chang, Chew-shun; Xiao, Xiaodong; Cameroni, Elisabetta; Corti, Davide; Semenova, Elena; Warrener, Paul; Sellman, Bret R.; Suzich, JoAnn; Wang, Qun; Stover, C. Kendall 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
