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EVALUATION OF B7-H3 IMMUNOHISTOCHEMISTRY IN HIGH-GRADE GLIOMAS FOR CHIMERIC ANTIGEN RECEPTOR T-CELL PREDICTIVE TESTING B7-H3免疫组织化学在高级别胶质瘤中用于嵌合抗原受体T细胞预测性检测的评价 Dyson, Kyle; Zuraski, Connor; Solomon, David; Li, Gordon; Stocksdale, Brian; Song, Kun-Wei; Mahdi, Jasia; Tanner, Kelly; Bertrand, Sophie; Iv, Michael; Threlkeld, Zachary; Ramakrishna, Sneha; Sahaf, Bita; Egeler, Emily; Tunuguntla, Ramya; Therkelsen, Kate; Nagpal, Seema; Lim, Michael; Monje, Michelle; Scott, Brian; Mackall, Crystal; Charu, Vivek; Thomas, Reena 分享 收藏
Quantitative surfaceome profiling of high-risk medulloblastoma prioritizes the oncofetal antigen GPC2 for potent CAR-T cell therapy 高风险髓母细胞瘤的定量表面组分析优先考虑癌胚抗原GPC2用于有效的CAR-T细胞疗法 Usta, Diren; Gwynne, William; Suk, Yujin; Chen, Yiyun; Radosevic, Molly T.; Chernova, Daria; Delaidelli, Alberto; Feng, Yushen; Nasajpour, Emon; Trissal, Maria C.; Poetschke, Rebecca D.; Dunham, Christopher; Labanie, Louai; Van Der Lugt, Jasper; Nierkens, Stefan; Filbin, Mariella G.; Petritsch, Claudia K.; Sorensen, Poul; Ryan, Katherine J.; Venugopal, Chitra; Sotillo, Elena; Mackall, Crystal L.; Singh, Sheila K.; Heitzeneder, Sabine 分享 收藏
SINGLE-CELL LANDSCAPE OF B7H3-CAR T THERAPY IN GLIOMA: MECHANISMS OF RESISTANCE AND SIGNATURES OF LONG-TERM RESPONSE 单细胞景观揭示B7H3-CAR T疗法在胶质瘤中的抗药机制及长期应答特征 Chen, Yiyun; Song, Kun-Wei; Desai, Moksha; Ehlinger, Zach; Daghagh, Hossein; Rietberg, Skyler; Feeney, Anne-Marie; Tanner, Kelly; Dyson, Kyle; Stockdale, Brian; Dhapola, Gaurav; Lohman, Claire; Patil, Sunita; Kuo, Adam; Good, Zinaida; Prabhu, Snehit; Kong, Katherine; Egeler, Emily; Beebe, Barbara; Carr, Casey; Mahdi, Jasia; Bertrand, Sophie; Iv, Michael; Threlkeld, Zachary; Charu, Vivek; Tunuguntla, Ramya; Therkelsen, Kate; Nagpal, Seema; Monje, Michelle; Scott, Brian; Li, Gordon; Lim, Michael; Sotillo, Elena; Sahaf, Bita; Ramakrishna, Sneha; Thomas, Reena; Mackall, Crystal 分享 收藏
GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency Car-t细胞中GLUT1过表达诱导代谢重编程并增强效力 Guerrero, Justin A.; Klysz, Dorota D.; Chen, Yiyun; Malipatlolla, Meena; Lone, Jameel; Fowler, Carley; Stuani, Lucille; May, Audre; Bashti, Malek; Xu, Peng; Huang, Jing; Michael, Basil; Contrepois, Kevin; Dhingra, Shaurya; Fisher, Chris; Svensson, Katrin J.; Davis, Kara L.; Kasowski, Maya; Feldman, Steven A.; Sotillo, Elena; Mackall, Crystal L. 分享 收藏
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation PRC2-AgeIndex作为衰老和复兴的普遍生物标志物 Moqri, Mahdi; Cipriano, Andrea; Simpson, Daniel J.; Rasouli, Sajede; Murty, Tara; de Jong, Tineke Anna; Nachun, Daniel; Brandine, Guilherme de Sena; Ying, Kejun; Tarkhov, Andrei; Aberg, Karolina A.; van den Oord, Edwin; Zhou, Wanding; Smith, Andrew; Mackall, Crystal; Gladyshev, Vadim N.; Horvath, Steve; Snyder, Michael P.; Sebastiano, Vittorio 分享 收藏
CD22-directed CART-cell therapy for large B-cell lymphomas progressing after CD19-directed CART-cell therapy: a dose- finding phase 1 study Frank, Matthew J.; Baird, John H.; Kramer, Anne Marijn; Srinagesh, Hrishikesh K.; Patel, Shabnum; Brown, Annie Kathleen; Oak, Jean S.; Younes, Sheren F.; Natkunam, Yasodha; Hamilton, Mark P.; Su, Yi-Jiun; Agarwal, Neha; Chinnasamy, Harshini; Egeler, Emily; Mavroukakis, Sharon; Feldman, Steven A.; Sahaf, Bita; Mackall, Crystal L.; Muffly, Lori; Miklos, David B. 分享 收藏
Enhancing pediatric access to cell and gene therapies 提高儿科获得细胞和基因疗法的机会 Mackall, Crystal L.; Bollard, Catherine M.; Goodman, Nancy; Carr, Casey; Gardner, Rebecca; Rouce, Rayne; Sotillo, Elena; Stoner, Rich; Urnov, Fyodor D.; Wayne, Alan S.; Park, Julie; Kohn, Donald B. 分享 收藏
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome 靶向小胶质细胞中tgf β 活化激酶-1活化可降低CAR T免疫效应细胞相关神经毒性综合征 Vinnakota, Janaki Manoja; Biavasco, Francesca; Schwabenland, Marius; Chhatbar, Chintan; Adams, Rachael; Erny, Daniel; Duquesne, Sandra; El Khawanky, Nadia; Schmidt, Dominik; Fetsch, Viktor; Zaehringer, Alexander; Salie, Henrike; Athanassopoulos, Dimitrios; Braun, Lukas; Javorniczky, Nora; Ho, Jenny; Kierdorf, Katrin; Marks, Reinhard; Waesch, Ralph; Simonetta, Federico; Andrieux, Geoffroy; Pfeifer, Dietmar; Monaco, Gianni; Capitini, Christian; Fry, Terry; Blank, Thomas; Blazar, Bruce; Wagner, Eva; Theobald, Matthias; Sommer, Clemens; Stelljes, Matthias; Reicherts, Christian; Jeibmann, Astrid; Schittenhelm, Jens; Monoranu, Camelia-Maria; Rosenwald, Andreas; Kortuem, Martin; Rasche, Leo; Einsele, Hermann; Meyer, Philipp; Brumberg, Joachim; Voelkl, Simon; Mackensen, Andreas; Coras, Roland; von Bergwelt-Baildon, Michael; Albert, Nathalie; Bartos, Laura; Brendel, Matthias; Holzgreve, Adrien; Mack, Matthias; Boerries, Melanie; Mackall, Crystal; Duyster, Justus; Henneke, Philipp; Priller, Josef; Koehler, Natalie; Struebing, Felix; Bengsch, Bertram; Ruella, Marco; Subklewe, Marion; von Baumgarten, Louisa; Gill, Saar; Prinz, Marco; Zeiser, Robert 分享 收藏
Lineage tracing defines responding CAR T cells in patients with B cell malignancies Good, Zinaida; Hamilton, Mark P.; Spiegel, Jay Y.; Desai, Moksha H.; Ehlinger, Zachary J.; Quinn, Patrick J.; Chen, Yiyun; Prabhu, Snehit; Chiou, Shin-Heng; Kurra, Sreevidya; Yang, Eric; Ozawa, Michael G.; Frank, Matthew J.; Muffly, Lori; Claire, Gursharan K.; Bharadwaj, Sushma; Dahiya, Saurabh; Kong, Katherine A.; Davis, Mark M.; Plevritis, Sylvia K.; Sotillo, Elena; Sahaf, Bita; Miklos, David B.; Mackall, Crystal L. 分享 收藏
CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results Schultz, Liora M.; Jeyakumar, Nikeshan; Kramer, Anne Marijn; Sahaf, Bita; Srinagesh, Hrishi; Shiraz, Parveen; Agarwal, Neha; Hamilton, Mark; Erickson, Courtney; Jacobs, Ashley; Moon, Jennifer; Baggott, Christina; Arai, Sally; Bharadwaj, Sushma; Johnston, Laura J.; Liedtke, Michaela; Lowsky, Robert; Meyer, Everett; Negrin, Robert; Rezvani, Andrew; Shizuru, Judy; Sidana, Surbhi; Egeler, Emily; Mavroukakis, Sharon; Tunuguntla, Ramya; Gkitsas-Long, Nikolaos; Retherford, Aidan; Brown, Annie Kathleen; Gramstrap-Petersen, Anne-Louise; Ibanez, Raquel Martin; Feldman, Steven A.; Miklos, David B.; Mackall, Crystal L.; Davis, Kara L.; Frank, Matthew; Ramakrishna, Sneha; Muffly, Lori 分享 收藏
Unanswered questions following reports of secondary malignancies after CAR-T cell therapy Car-t细胞治疗后继发性恶性肿瘤报告后未解决的问题 Levine, Bruce L.; Pasquini, Marcelo C.; Connolly, John E.; Porter, David L.; Gustafson, Michael P.; Boelens, Jaap J.; Horwitz, Edwin M.; Grupp, Stephan A.; Maus, Marcela V.; Locke, Frederick L.; Ciceri, Fabio; Ruggeri, Annalisa; Snowden, John; Heslop, Helen E.; Mackall, Crystal L.; June, Carl H.; Sureda, Anna M.; Perales, Miguel-Angel 分享 收藏
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing Balke-Want, Hyatt; Keerthi, Vimal; Gkitsas, Nikolaos; Mancini, Andrew G.; Kurgan, Gavin L.; Fowler, Carley; Xu, Peng; Liu, Xikun; Asano, Kyle; Patel, Sunny; Fisher, Christopher J.; Brown, Annie K.; Tunuguntla, Ramya H.; Patel, Shabnum; Sotillo, Elena; Mackall, Crystal L.; Feldman, Steven A. 分享 收藏
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TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS Mahdi, Jasia; Dietrich, Jorg; Straathof, Karin; Roddie, Claire; Scott, Brian; Davidson, Tom Belle; Prolo, Laura; Batchelor, Tracy; Campen, Cynthia; Davis, Kara; Gust, Juliane; Lim, Michael; Majzner, Robbie; Park, Julie; Partap, Sonia; Ramakrishna, Sneha; Richards, Rebecca; Schultz, Liora; Vitanza, Nicholas; Wang, Leo; Mackall, Crystal; Monje, Michelle 分享 收藏
Tumor inflammation-associated neurotoxicity 肿瘤炎症相关神经毒性 Mahdi, Jasia; Dietrich, Jorg; Straathof, Karin; Roddie, Claire; Scott, Brian J.; Davidson, Tom Belle; Prolo, Laura M.; Batchelor, Tracy T.; Campen, Cynthia J.; Davis, Kara L.; Gust, Juliane; Lim, Michael; Majzner, Robbie G.; Park, Julie R.; Partap, Sonia; Ramakrishna, Sneha; Richards, Rebecca; Schultz, Liora; Vitanza, Nicholas A.; Wang, Leo D.; Mackall, Crystal L.; Monje, Michelle 分享 收藏
Lineage tracing of CAR T cells in patients with B cell malignancies Good, Zinaida; Hamilton, Mark P.; Spiegel, Jay Y.; Kurra, Sreevidya; Desai, Moksha H.; Prabhu, Snehit; Chiou, Shin-Heng; Yeh, Christine Y.; Chen, Yiyun; Yang, Eric; Ozawa, Michael G.; Wu, Fang; Frank, Matthew J.; Muffly, Lori; Claire, Gursharan K.; Craig, Juliana; Iglesias, Maria I.; Bharadwaj, Sushma; Kong, Katherine A.; Wagh, Dhananjay; Coller, John; Davis, Mark M.; Plevritis, Sylvia K.; Sahaf, Bita; Miklos, David B.; Mackall, Crystal L. 分享 收藏
Immune signatures of GD2 CAR T cell activity in H3K27M+diffuse midline glioma patients Ramakrishna, Sneha; Good, Zinaida; Desai, Moksha; Zamler, Daniel; Mancusi, Rebecca; Mahdi, Jasia; Majzner, Robbie; Schultz, Liora; Richards, Rebecca; Kamens, Jennifer; Barsan, Valentin; Campen, Cynthia; Partap, Sonia; Ehlinger, Zachary; Reynolds, Warren; Chen, Yiyun; Hamilton, Mark P.; Moon, Jennifer; Baggott, Christina; Kunicki, Michael; Fujimoto, Michelle; Li, Amy; Jariwala, Sneha; Mavroukakis, Sharon; Egeler, Emily; Jacobs, Ashley; Erickson, Courtney; Yamabe-Kwong, Karen; Prabhu, Snehit; Davis, Kara; Feldman, Steve; Sahaf, Bita; Mackall, Crystal L.; Monje, Michelle 分享 收藏
Harnessing macrophages, while protecting T cells, enhances anti-tumor efficacy Yamada-Hunter, Sean A.; Theruvath, Johanna; Radosevich, Molly T.; McIntosh, Brianna J.; Freitas, Katherine A.; Martinez-Velez, Naiara; Sotillo, Elena; Leruste, Amaury; Xu, Peng; Desai, Moksha H.; Sahaf, Bita; Banuelos, Allison; Wasserman, Savannah L.; Weissman, Irving L.; Cochran, Jennifer R.; Mackall, Crystal L. 分享 收藏
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