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收藏Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression
Xu, Renqi; Zhou, Haibin; Bai, Longchuan; McEachern, Donna; Wu, Dimin; Acharyya, Ranjan Kumar; Wang, Mi; Tosovic, Jelena; Yang, Chao-Yie; Chinnaswamy, Krishnapriya; Meagher, Jennifer L.; Stuckey, Jeanne A.; Liu, Cai; Wang, Meilin; Wen, Bo; Sun, Duxin; Wang, Shaomeng 分享 收藏 Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC DegraderAK-1690的发现: 一种有效且高度选择性的STAT6 PROTAC降解剂Kaneshige, Atsunori; Yang, Yiqing; Bai, Longchuan; Wang, Mi; Xu, Renqi; Mallik, Leena; Chinnaswamy, Krishnapriya; Metwally, Hoda; Wang, Yu; McEachern, Donna; Tosovic, Jelena; Yang, Chao-Yie; Kirchhoff, Paul D.; Meagher, Jennifer L.; Stuckey, Jeanne A.; Wang, Shaomeng 分享 收藏 Discovery of potent, highly selective and orally efficacious SMARCA2 degradersLeng, Lingying; Yang, Lin; Tu, Wenbin; Rej, Rohan; Allu, Srinivasa Rao; Huang, Liyue; Jiang, Wei; Wang, Yu; Stuckey, Jeanne; Sarkari, Farzad R.; Wang, Meilin; Wang, Lu; Wen, Bo; Sun, Duxin; Wang, Shaomeng 分享 收藏 Development of potent, highly selective and efficacious SMARCA2 degradersYang, Lin; Tu, Wenbin; Huang, Liyue; Leng, Lingying; Jiang, Wei; Wang, Meilin; Wen, Bo; Sun, Duxin; Stuckey, Jeanne; Wang, Shaomeng 分享 收藏 分享 收藏 分享 收藏 Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor ApoptosisWubben, Thomas J.; Chaudhury, Sraboni; Watch, Brennan T.; Stuckey, Jeanne A.; Weh, Eric; Fernando, Roshini; Goswami, Moloy; Pawar, Mercy; Rech, Jason C.; Besirli, Cagri G. 分享 收藏 分享 收藏 分享 收藏 Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia在急性髓性白血病中发现具有强抗肿瘤活性的有效和选择性STAT5 PROTAC降解剂Kaneshige, Atsunori; Bai, Longchuan; Wang, Mi; McEachern, Donna; Meagher, Jennifer L.; Xu, Renqi; Kirchhoff, Paul D.; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A.; Wang, Shaomeng 分享 收藏 A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo一种能够在体内实现肿瘤消退的选择性小分子STAT5 PROTAC降解剂Kaneshige, Atsunori; Bai, Longchuan; Wang, Mi; McEachern, Donna; Meagher, Jennifer L.; Xu, Renqi; Wang, Yu; Jiang, Wei; Metwally, Hoda; Kirchhoff, Paul D.; Zhao, Lijie; Jiang, Hui; Wang, Meilin; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A.; Wang, Shaomeng 分享 收藏 Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host diseaseYuan, Xinrui; Jiang, Hua; Fu, Denggang; Robida, Aaron; Rajanayake, Krishani; Yuan, Hebao; Wen, Bo; Sun, Duxin; Watch, Brennan T.; Chinnaswamy, Krishnapriya; Stuckey, Jeanne A.; Paczesny, Sophie; Rech, Jason C.; Yang, Chao-Yie 分享 收藏 Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor RegressionRej, Rohan Kalyan; Wang, Changwei; Lu, Jianfeng; Wang, Mi; Petrunak, Elyse; Zawacki, Kaitlin P.; McEachern, Donna; Yang, Chao-Yie; Wang, Lu; Li, Ruiting; Chinnaswamy, Krishnapriya; Wen, Bo; Sun, Duxin; Stuckey, Jeanne A.; Zhou, Yunlong; Chen, Jianyong; Tang, Guozhi; Wang, Shaomeng 分享 收藏 分享 收藏 Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor RegressionZhang, Meng; Aguilar, Angelo; Xu, Shilin; Huang, Liyue; Chinnaswamy, Krishnapriya; Sleger, Taryn; Wang, Bo; Gross, Stefan; Nicolay, Brandon N.; Ronseaux, Sebastien; Harvey, Kaitlin; Wang, Yu; McEachern, Donna; Kirchhoff, Paul D.; Liu, Zhaomin; Stuckey, Jeanne; Tron, Adriana E.; Liu, Tao; Wang, Shaomeng 分享 收藏 Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicityZhou, Haibin; Lu, Jianfeng; Chinnaswamy, Krishnapriya; Stuckey, Jeanne A.; Liu, Liu; McEachern, Donna; Yang, Chao-Yie; Bernard, Denzil; Shen, Hong; Rui, Liangyou; Sun, Yi; Wang, Shaomeng 分享 收藏 SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor RegressionSD-91作为一种有效和选择性的STAT3降解剂，能够实现完全和持久的肿瘤消退Zhou, Haibin; Bai, Longchuan; Xu, Renqi; McEachern, Donna; Chinnaswamy, Krishnapriya; Li, Ruiting; Wen, Bo; Wang, Mi; Yang, Chao-Yie; Meagher, Jennifer L.; Sun, Duxin; Stuckey, Jeanne A.; Wang, Shaomeng 分享 收藏 Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity马来西亚香蕉凝集素中pi-pi堆叠的靶向破坏降低了有丝分裂性，同时保留了抗病毒活性Coves-Datson, Evelyn M.; King, Steven R.; Legendre, Maureen; Swanson, Michael D.; Gupta, Auroni; Claes, Sandra; Meagher, Jennifer L.; Boonen, Arnaud; Zhang, Lihong; Kalveram, Birte; Raglow, Zoe; Freiberg, Alexander N.; Prichard, Mark; Stuckey, Jeanne A.; Schols, Dominique; Markovitz, David M. 分享 收藏 Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor RegressionChen, Jianyong; Zhou, Yunlong; Dong, Xuyuan; Liu, Liu; Bai, Longchuan; McEachern, Donna; Przybranowski, Sally; Yang, Chao-Yie; Stuckey, Jeanne; Li, Xiaoqin; Wen, Bo; Zhao, Ting; Sun, Siwei; Sun, Duxin; Jiao, Lingling; Jing, Yu; Guo, Ming; Yang, Dajun; Wang, Shaomeng 分享 收藏 
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