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Multi-omic analysis of Huntington's disease reveals a compensatory astrocyte state Paryani, Fahad; Kwon, Ji-Sun; Ng, Christopher W.; Jakubiak, Kelly; Madden, Nacoya; Ofori, Kenneth; Tang, Alice; Lu, Hong; Xia, Shengnan; Li, Juncheng; Mahajan, Aayushi; Davidson, Shawn M.; Basile, Anna O.; Mchugh, Caitlin; Vonsattel, Jean Paul; Hickman, Richard; Zody, Michael C.; Housman, David E.; Goldman, James E.; Yoo, Andrew S.; Menon, Vilas; Al-Dalahmah, Osama 分享 收藏
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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons Al-Dalahmah, Osama; Lam, Matti; McInvale, Julie J.; Qu, Wenhui; Nguyen, Trang; Mun, Jeong-Yeon; Kwon, Sam; Ifediora, Nkechime; Mahajan, Aayushi; Humala, Nelson; Winters, Tristan; Angeles, Ellen; Jakubiak, Kelly A.; Kuhn, Rebekka; Kim, Yoon A.; De Rosa, Maria Caterina; Doege, Claudia A.; Paryani, Fahad; Flowers, Xena; Dovas, Athanassios; Mela, Angeliki; Lu, Hong; DeTure, Michael A.; Vonsattel, Jean Paul; Wszolek, Zbigniew K.; Dickson, Dennis W.; Kuhlmann, Tanja; Zaehres, Holm; Schoeler, Hans R.; Sproul, Andrew A.; Siegelin, Markus D.; De Jager, Philip L.; Goldman, James E.; Menon, Vilas; Canoll, Peter; Hargus, Gunnar 分享 收藏
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Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy Miller, Katherine E.; Rivaldi, Adithe C.; Shinagawa, Noriyuki; Sran, Sahib; Navarro, Jason B.; Westfall, Jesse J.; Miller, Anthony R.; Roberts, Ryan D.; Akkari, Yassmine; Supinger, Rachel; Hester, Mark E.; Marhabaie, Mohammad; Gade, Meethila; Lu, Jinfeng; Rodziyevska, Olga; Bhattacharjee, Meenakshi B.; Von Allmen, Gretchen K.; Yang, Edward; Lidov, Hart G. W.; Harini, Chellamani; Shah, Manish N.; Leonard, Jeffrey; Pindrik, Jonathan; Shaikhouni, Ammar; Goldman, James E.; Pierson, Christopher R.; Thomas, Diana L.; Boue, Daniel R.; Ostendorf, Adam P.; Mardis, Elaine R.; Poduri, Annapurna; Koboldt, Daniel C.; Heinzen, Erin L.; Bedrosian, Tracy A. 分享 收藏
The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina Pruvost, Mathilde; Patzig, Julia; Yattah, Camila; Selcen, Ipek; Hernandez, Marylens; Park, Hye-Jin; Moyon, Sarah; Liu, Shibo; Morioka, Malia S.; Shopland, Lindsay; Al-Dalahmah, Osama; Bendl, Jaroslav; Fullard, John F.; Roussos, Panos; Goldman, James; He, Ye; Dupree, Jeffrey L.; Casaccia, Patrizia 分享 收藏
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TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury Shafit-Zagardo, Bridget; Sidoli, Simone; Goldman, James E.; DuBois, Juwen C.; Corboy, John R.; Strittmatter, Stephen M.; Guzik, Hillary; Edema, Ukuemi; Arackal, Anita G.; Botbol, Yair M.; Merheb, Emilio; Nagra, Rashed M.; Graff, Sarah 分享 收藏
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation Lim, Ryan G.; Al-Dalahmah, Osama; Wu, Jie; Gold, Maxwell P.; Reidling, Jack C.; Tang, Guomei; Adam, Miriam; Dansu, David K.; Park, Hye-Jin; Casaccia, Patrizia; Miramontes, Ricardo; Reyes-Ortiz, Andrea M.; Lau, Alice; Hickman, Richard A.; Khan, Fatima; Paryani, Fahad; Tang, Alice; Ofori, Kenneth; Miyoshi, Emily; Michael, Neethu; McClure, Nicolette; Flowers, Xena E.; Vonsattel, Jean Paul; Davidson, Shawn; Menon, Vilas; Swarup, Vivek; Fraenkel, Ernest; Goldman, James E.; Thompson, Leslie M. 分享 收藏
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Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death Aber, Etan R.; Griffey, Christopher J.; Davies, Tim; Li, Alice M.; Yang, Young Joo; Croce, Katherine R.; Goldman, James E.; Grutzendler, Jaime; Canman, Julie C.; Yamamoto, Ai 分享 收藏
COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis 新型冠状病毒肺炎诱导中枢神经系统细胞因子表达和海马神经发生丧失 Soung, Allison L.; Vanderheiden, Abigail; Nordvig, Anna S.; Sissoko, Cheick A.; Canoll, Peter; Mariani, Madeline B.; Jiang, Xiaoping; Bricker, Traci; Rosoklija, Gorazd B.; Arango, Victoria; Underwood, Mark; Mann, J. John; Dwork, Andrew J.; Goldman, James E.; Boon, Adrianus C. M.; Boldrini, Maura; Klein, Robyn S. 分享 收藏
Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex Wu, Xiaoping; Sosunov, Alexander A.; Lado, Wudu; Teoh, Jia Jie; Ham, Ahrom; Li, Hongyu; Al-Dalahmah, Osama; Gill, Brian J. A.; Arancio, Ottavio; Schevon, Catherine A.; Frankel, Wayne N.; McKhann, Guy M.; Sulzer, David; Goldman, James E.; Tang, Guomei 分享 收藏
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Somatic variants in diverse genes leads to a spectrum of focal cortical malformations 不同基因的体细胞变异导致一系列局灶性皮质畸形 Lai, Dulcie; Gade, Meethila; Yang, Edward; Koh, Hyun Yong; Lu, Jinfeng; Walley, Nicole M.; Buckley, Anne F.; Sands, Tristan T.; Akman, Cigdem, I; Mikati, Mohamad A.; McKhann, Guy M.; Goldman, James E.; Canoll, Peter; Alexander, Allyson L.; Park, Kristen L.; Von Allmen, Gretchen K.; Rodziyevska, Olga; Bhattacharjee, Meenakshi B.; Lidov, Hart G. W.; Vogel, Hannes; Grant, Gerald A.; Porter, Brenda E.; Poduri, Annapurna H.; Crino, Peter B.; Heinzen, Erin L. 分享 收藏
Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis Heaven, Michael R.; Herren, Anthony W.; Flint, Daniel L.; Pacheco, Natasha L.; Li, Jiangtao; Tang, Alice; Khan, Fatima; Goldman, James E.; Phinney, Brett S.; Olsen, Michelle L. 分享 收藏
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