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Pharmacodynamic biomarkers responsive to mutant huntingtin lowering in a Huntington's disease mouse model 对降低亨廷顿病小鼠模型中突变亨廷顿蛋白反应的药效学生物标志物 Marchionini, Deanna M.; De Lombaerde, Stef; van Rijswijk, Joelle; Zajicek, Franziska; Everix, Liesbeth; Miranda, Alan; Aaltonen, Mari J.; Kluger, Carleen M.; Wild, Thomas; Kakoulidou, Aglaia; Gundelach, Jannis; Fieblinger, Tim; Fentz, Joachim; Rosinski, Jim; Obenauer, John; Greene, Jonathan R.; Liu, Longbin; Munoz-Sanjuan, Ignacio; Verhoye, Marleen; Verhaeghe, Jeroen; Bard, Jonathan; Staelens, Steven; Bertoglio, Daniele 分享 收藏
Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease Zajicek, Franziska; Verhaeghe, Jeroen; De Lombaerde, Stef; Van Eetveldt, Annemie; Miranda, Alan; Munoz-Sanjuan, Ignacio; Dominguez, Celia; Khetarpal, Vinod; Bard, Jonathan; Liu, Longbin; Staelens, Steven; Bertoglio, Daniele 分享 收藏
Longitudinal alterations in brain perfusion and vascular reactivity in the zQ175DN mouse model of Huntington's disease Vasilkovska, Tamara; Salajeghe, Somaie; Vanreusel, Verdi; Van Audekerke, Johan; Verschuuren, Marlies; Hirschler, Lydiane; Warnking, Jan; Pintelon, Isabel; Pustina, Dorian; Cachope, Roger; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Barbier, Emmanuel L.; De Vos, Winnok H.; van der Linden, Annemie; Verhoye, Marleen 分享 收藏
Diffusion MRI marks progressive alterations in fiber integrity in the zQ175DN mouse model of Huntington's disease Vidas-Guscic, Nicholas; van Rijswijk, Joelle; Van Audekerke, Johan; Jeurissen, Ben; Nnah, Israel; Tang, Haiying; Munoz-Sanjuan, Ignacio; Pustina, Dorian; Cachope, Roger; Van der Linden, Annemie; Bertoglio, Daniele; Verhoye, Marleen 分享 收藏
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease Liu, Longbin; Malagu, Karine; Haughan, Alan F.; Khetarpal, Vinod; Stott, Andrew J.; Esmieu, William; Vater, Huw D.; Webster, Stephen J.; van de Poel, Amanda J.; Clissold, Cole; Cosgrove, Brett; Sutton, Benjamin; Spencer, Jonathan A.; Breccia, Perla; Gancia, Emanuela; Bonomo, Silvia; Ladduwahetty, Tammy; Lazari, Ovadia; Patel, Hiral; Atton, Helen C.; Clifton, Steve; Mota, Daniel M.; Magnani, Dario; O'Neill, Amy; Stebbeds, Marta; Macabuag, Natsuko; Todd, Daniel; Herva, Maria E.; Mitchell, Philip; Visser, Mijke; Compte Sancerni, Sara; Grand Moursel, Laure; da Silva, Marta; Kritikou, Eva; Heikkinen, Taneli T.; Bolkvadze, Tamuna; Fodale, Valentina; Spadafora, Debora; Daldin, Manuel; Bresciani, Alberto; Mangette, John E.; Doherty, Elizabeth M.; Lee, Matthew R.; Herbst, Todd; Monteagudo, Edith; Macdonald, Douglas; Plotnikov, Nikolay V.; Chambers, Mark; Mcallister, George; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using 11C-CHDI-180R PET in a Nonhuman Primate Model of Huntington Disease Bertoglio, Daniele; Weiss, Alison R.; Liguore, William; Martin, Lauren Drew; Hobbs, Theodore; Templon, John; Srinivasan, Sathya; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Khetarpal, Vinod; Verhaeghe, Jeroen; Staelens, Steven; Link, Jeanne; Liu, Longbin; Bard, Jonathan A.; McBride, Jodi L. 分享 收藏
Longitudinal investigation of changes in resting-state co-activation patterns and their predictive ability in the zQ175 DN mouse model of Huntington's disease Adhikari, Mohit H.; Vasilkovska, Tamara; Cachope, Roger; Tang, Haiying; Liu, Longbin; Keliris, Georgios A.; Munoz-Sanjuan, Ignacio; Pustina, Dorian; Van der Linden, Annemie; Verhoye, Marleen 分享 收藏
Resting-state fMRI reveals longitudinal alterations in brain network connectivity in the zQ175DN mouse model of Huntington?s disease 静息态功能磁共振成像揭示了亨廷顿舞蹈病zQ175DN小鼠模型中脑网络连接的纵向变化 Vasilkovska, Tamara; Adhikari, Mohit H.; Van Audekerke, Johan; Salajeghe, Somaie; Pustina, Dorian; Cachope, Roger; Tang, Haiying; Liu, Longbin; Munoz-Sanjuan, Ignacio; Van der Linden, Annemie; Verhoye, Marleen 分享 收藏
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Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Brown, Christopher J.; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P.; Esposito, Simone; Gadouleau, Elise; Giles, Paul R.; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E.; Marriner, Gwendolyn A.; Marston, Richard W.; Mills, Matthew R.; Monteagudo, Edith; Forsberg-Moren, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A.; Vecchi, Andrea; Veneziano, Maria; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia 分享 收藏
Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model Marchionini, Deanna M.; Liu, Jeh-Ping; Ambesi-Impiombato, Alberto; Kerker, Kimberly; Cirillo, Kim; Bansal, Mukesh; Mushlin, Rich; Brunner, Daniela; Ramboz, Sylvie; Kwan, Mei; Kuhlbrodt, Kirsten; Tillack, Karsten; Peters, Finn; Rauhala, Leena; Obenauer, John; Greene, Jonathan R.; Hartl, Christopher; Khetarpal, Vinod; Lager, Brenda; Rosinski, Jim; Aaronson, Jeff; Alam, Morshed; Signer, Ethan; Munoz-Sanjuan, Ignacio; Howland, David; Zeitlin, Scott O. 分享 收藏
A HUNTINGTON'S DISEASE EMBRYONIC STEM CELL PHENOTYPIC HTS TO IDENTIFY SMALL MOLECULE MODULATORS OF MUTANT HUNTINGTIN Todd, Daniel; Stebbeds, Marta; Thatcher, Emma; Barnard, Amy; Anton, Jeremy; Sienerth, Arnold; Visser, Mijke; Mitchell, Philip; Breccia, Perla; Smith, David; McAllister, George; Haque, Tasir; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio 分享 收藏
Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [11C]CHDI-00485180-R and [11C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin Delva, Aline; Koole, Michel; Serdons, Kim; Bormans, Guy; Liu, Longbin; Bard, Jonathan; Khetarpal, Vinod; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Wood, Andrew; Skinbjerg, Mette; Wang, Yuchuan; Vandenberghe, Wim; Van Laere, Koen 分享 收藏
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease Ladduwahetty, Tammy; Lee, Matthew R.; Maillard, Michel C.; Cachope, Roger; Todd, Daniel; Barnes, Michael; Beaumont, Vahri; Chauhan, Alka; Gallati, Caroline; Haughan, Alan F.; Kempf, Georg; Luckhurst, Christopher A.; Matthews, Kim; McAllister, George; Mitchell, Philip; Patel, Hiral; Rose, Mark; Saville-Stones, Elizabeth; Steinbacher, Stefan; Stott, Andrew J.; Thatcher, Emma; Tierney, Jason; Urbonas, Liudvikas; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Validation, kinetic modeling, and test-retest reproducibility of [18F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice Bertoglio, Daniele; Zajicek, Franziska; De Lombaerde, Stef; Miranda, Alan; Stroobants, Sigrid; Wang, Yuchuan; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Liu, Longbin; Verhaeghe, Jeroen; Staelens, Steven 分享 收藏
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease Bertoglio, Daniele; Bard, Jonathan; Hessmann, Manuela; Liu, Longbin; Gaertner, Annette; De Lombaerde, Stef; Huscher, Britta; Zajicek, Franziska; Miranda, Alan; Peters, Finn; Herrmann, Frank; Schaertl, Sabine; Vasilkovska, Tamara; Brown, Christopher J.; Johnson, Peter D.; Prime, Michael E.; Mills, Matthew R.; Van der Linden, Annemie; Mrzljak, Ladislav; Khetarpal, Vinod; Wang, Yuchuan; Marchionini, Deanna M.; Skinbjerg, Mette; Verhaeghe, Jeroen; Dominguez, Celia; Staelens, Steven; Munoz-Sanjuan, Ignacio 分享 收藏
Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington's disease Bertoglio, Daniele; Verhaeghe, Jeroen; Miranda, Alan; Wyffels, Leonie; Stroobants, Sigrid; Mrzljak, Ladislav; Khetarpal, Vinod; Skinbjerg, Mette; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Staelens, Steven 分享 收藏
Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem Bertoglio, Daniele; Verhaeghe, Jeroen; Wyffels, Leonie; Miranda, Alan; Stroobants, Sigrid; Mrzljak, Ladislav; Dominguez, Celia; Skinbjerg, Mette; Bard, Jonathan; Liu, Longbin; Munoz-Sanjuan, Ignacio; Staelens, Steven 分享 收藏
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