未登录 Intratumoral Injection of mRNA-2752 and Pembrolizumab for High-Risk Ductal Carcinoma In Situ A Phase 1 Nonrandomized Clinical Trial mRNA-2752和Pembrolizumab瘤内注射治疗高危导管原位癌：一项1期非随机临床试验 Ramalingam, Kirithiga; Woody, Rachel; Glencer, Alexa; Schwartz, Christopher J.; Mori, Hidetoshi; Wong, Jasmine; Hirst, Gillian; Rosenbluth, Jennifer; Onishi, Natsuko; Gibbs, Jessica; Hylton, Nola; Borowsky, Alexander D.; Campbell, Michael; Esserman, Laura J. 分享 收藏
Gut and oral microbial compositional differences in women with breast cancer, women with ductal carcinoma in situ, and healthy women McCune, Emma; Sharma, Anukriti; Johnson, Breanna; O'Meara, Tess; Theiner, Sarah; Campos, Maribel; Heditsian, Diane; Brain, Susie; Gilbert, Jack A.; Esserman, Laura; Campbell, Michael J. 分享 收藏
Multi-platform biomarkers of response to an immune checkpoint inhibitor in the neoadjuvant I-SPY 2 trial for early-stage breast cancer Campbell, Michael J.; Wolf, Denise M.; Yau, Christina; Brown-Swigart, Lamorna; Wulfkuhle, Julie; Gallagher, Isela R.; Zhu, Zelos; Bolen, Jennifer; Vandenberg, Scott; Hoyt, Clifford; Mori, Hidetoshi; Borowsky, Alexander; Sit, Laura; Perlmutter, Jane; Asare, Smita M.; Nanda, Rita; Liu, Minetta C.; Yee, Douglas; Demichele, Angela M.; Hylton, Nola M.; Pusztai, Lajos; Berry, Donald A.; Hirst, Gillian L.; Petricoin, Emanuel F.; van't Veer, Laura; Esserman, Laura 分享 收藏
Magnetic resonance imaging insights from active surveillance of women with ductal carcinoma in situ Greenwood, Heather I.; Rodas, Cristian K. Maldonado; Freimanis, Rita I.; Glencer, Alexa C.; Miller, Phoebe N.; Mukhtar, Rita A.; Brabham, Case; Yau, Christina; Rosenbluth, Jennifer M.; Hirst, Gillian L.; Campbell, Michael J.; Borowsky, Alexander; Hylton, Nola; Esserman, Laura J.; Basu, Amrita 分享 收藏
High IL12family levels are associated with pathologic complete response amongst HER2-patients in the neoadjuvant I-SPY2 TRIAL Chow, Kingsley V.; Al Khafaji, Silver; Wolf, Denise; Yau, Christina; Dubinsky, Kailey; Tsopurashvili, Elene; Ramalingam, Kirthiga; van Nouhuijs, Fluorentine; Xun, Zheyun; van Montfort, Anna; Heditsian, Diane; Yee, Douglas; Esserman, Laura; Campbell, Michael; van't Veer, Laura; Sayaman, Rosalyn W. 分享 收藏
Immune subtyping identifies a subset of HR+HER2-early-stage breast cancer patients with a very high likelihood of response to neoadjuvant immunotherapy (IO): Results from 5 IO arms of the I-SPY2 TRIAL Wolf, Denise M.; Yau, Christina; Pusztai, Lajos; Nanda, Rita; Chien, Jo; Stringer-Reasor, Erica; Shatsky, Rebecca; Isaacs, Claudine; Liu, MInetta; Han, Hyo; Soliman, Hatem; Campbell, Michael; Glas, Annuska; Barcaru, Andrei; Mittempergher, Lorenza; Kuilman, Midas; Swigart, Lamorna Brown; Hirst, Gillian; Yu, Hongmei; Beineke, Philip; Basu, Amrita; Yee, Douglas; Symmans, W. Fraser; DeMichele, Angela; Perlmutter, Jane; Delson, Amy; Huppert, Laura; Rugo, Hope; Clark, Amy; Hylton, Nola; Pohlmann, Paula; Esserman, Laura; van 't Veer, Laura 分享 收藏
Subtype-specific signaling dynamics during treatment in non-responding breast cancer patients in the neoadjuvant I-SPY2 TRIAL: are there clues on how to overcome resistance? Wolf, Denise M.; Yau, Christina; Magbanua, Mark Jesus M.; Sayaman, Rosalyn; Wulfkhule, Julia; Gallagher, Rosa I.; Brown-Swigart, Lamorna; Campbell, Michael J.; Basu, Amrita; Hirst, Gillian L.; Perlmutter, Jane; DeMichele, Angela; Yee, Doug; Pusztai, Lajos; Pohlmann, Paula R.; Clark, Amy S.; Rugo, Hope S.; Petricoin, Emanuel F.; Esserman, Laura J.; van't Veer, Laura 分享 收藏
Serum levels of immune markers associated with pathological complete response (pCR) and immune-related adverse events (irAEs) in early-stage breast cancer patients receiving immune checkpoint inhibitor plus chemotherapy in the I-SPY 2 trial Alkhafaji, Silver; Wolf, Denise M.; Basu, Amrita; Brown-Swigart, Lamorna; Nanda, Rita; Liu, Minneta; Hirst, Gillian L.; Esserman, Laura J.; van't Veer, Laura; Campbell, Michael 分享 收藏
Intratumoral injection of mRNA-2752 and anti-PD-1 results in rapid regression of HER2 positive and or Hormone Receptor Negative DCIS: Phase 1 study results Esserman, Laura J.; Ramalingam, Kirithiga; Woody, Rachel; Glencer, Alexa; Schwartz, Christopher; Mori, Hidetoshi; Wong, Jasmine; Hirst, Gillian; Rosenbluth, Jennifer; Hylton, Nola; Onishi, Natsuko; Borowsky, Alexander D.; Campbell, Michael J. 分享 收藏
Protein signaling and drug target activation signatures to guide therapy prioritization: Therapeutic resistance and sensitivity in the I-SPY 2 Trial 蛋白质信号和药物靶标激活特征以指导治疗优先顺序: i-spy 2试验中的治疗抗性和敏感性 Gallagher, Rosa I.; Wulfkuhle, Julia; Wolf, Denise M.; Brown-Swigart, Lamorna; Yau, Christina; O'Grady, Nicholas; Basu, Amrita; Lu, Ruixiao; Campbell, Michael J.; Magbanua, Mark J.; Coppe, Jean-Philippe; Asare, Smita M.; Sit, Laura; Matthews, Jeffrey B.; Perlmutter, Jane; Hylton, Nola; Liu, Minetta C.; Symmans, W. Fraser; Rugo, Hope S.; Isaacs, Claudine; Demichele, Angela M.; Yee, Douglas; Pohlmann, Paula R.; Hirst, Gillian L.; Esserman, Laura J.; van 't Veer, Laura J.; Petricoin, Emanuel F. 分享 收藏
B-cells and regulatory T-cells in the microenvironment of HER2+breast cancer are associated with decreased survival: a real-world analysis of women with HER2+metastatic breast cancer HER2乳腺癌微环境中的b细胞和调节性T细胞与生存率降低相关: 对HER2转移性乳腺癌女性的真实世界分析 Steenbruggen, Tessa G.; Wolf, Denise M.; Campbell, Michael J.; Sanders, Joyce; Cornelissen, Sten; Thijssen, Bram; Salgado, Roberto A.; Yau, Christina; O-Grady, Nick; Basu, Amrita; Bhaskaran, Rajith; Mittempergher, Lorenza; Hirst, Gillian L.; Coppe, Jean-Philippe; Kok, Marleen; Sonke, Gabe S.; van't Veer, Laura J.; Horlings, Hugo M. 分享 收藏
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An Organoid Model System to Study Resistance Mechanisms, Predictive Biomarkers, and New Strategies to Overcome Therapeutic Resistance in Early-Stage Triple-Negative Breast Cancer Bui, Tam Binh V.; Wolf, Denise M.; Moore, Kaitlin; Harris, Isaac S.; Phadatare, Pravin; Yau, Christina; Swigart, Lamorna A. Brown; Esserman, Laura J.; Coppe, Jean-Philippe; Wulfkuhle, Julia; Petricoin, Emanuel F.; Campbell, Michael; Selfors, Laura M.; Dillon, Deborah A.; Overmoyer, Beth; Lynce, Filipa; Van 't Veer, Laura; Rosenbluth, Jennifer 分享 收藏
Immune signatures and MammaPrint (ultra) high risk class (MP2) as predictors of response to pembrolizumab combined with the TLR9 agonist SD101 in the neoadjuvant I-SPY 2 TRIAL Wolf, Denise M.; Yau, Christina; Campbell, Michael; Soliman, Hatem; Magbanua, Mark; Lu, Ruixiao; O'Grady, Nicholas; Brown-Swigart, Lamorna; Hirst, Gillian; Sit, Laura; Florence, Yvonne M.; Asare, Smita; Yee, Doug; DeMichele, Angie; Berry, Don; Esserman, Laura; Chien, Jo; van't Veer, Laura 分享 收藏
The tumor immune microenvironment and HER2 landscape of high-risk ductal carcinoma in situ: The DEFENSE study Glencer, Alexa; Borowsky, Alexander; Mori, Hidetoshi; Campbell, Michael; Harismendy, Olivier; Stein, Janet; Ghule, Prachi; Evans, Mark; West, Robert; Hirst, Gillian; Schindler, Nicole; Miller, Phoebe; Lee, Kyra; Weaver, Donald; Esserman, Laura 分享 收藏
Modulation of the immune microenvironment of high-risk ductal carcinoma in situ by intralesional pembrolizumab injection Glencer, Alexa C.; Wong, Jasmine M.; Hylton, Nola M.; Krings, Gregor; McCune, Emma; Rothschild, Harriet T.; Loveday, Tristan A.; Alvarado, Michael D.; Esserman, Laura J.; Campbell, Michael J. 分享 收藏
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Germline genetic contribution to the immune landscape of cancer Sayaman, Rosalyn W.; Saad, Mohamad; Thorsson, Vesteinn; Hu, Donglei; Hendrickx, Wouter; Roelands, Jessica; Porta-Pardo, Eduard; Mokrab, Younes; Farshidfar, Farshad; Kirchhoff, Tomas; Sweis, Randy F.; Bathe, Oliver F.; Heimann, Carolina; Campbell, Michael J.; Stretch, Cynthia; Huntsman, Scott; Graff, Rebecca E.; Syed, Najeeb; Radvanyi, Laszlo; Shelley, Simon; Wolf, Denise; Marincola, Francesco M.; Ceccarelli, Michele; Galon, Jerome; Ziv, Elad; Bedognetti, Davide 分享 收藏
Modulation of the immune microenvironment in high risk DCIS Campbell, Michael; Wong, Jasmine; McCune, Emma; Rothschild, Harriet; Loveday, Tristan; Bolen, Jennifer; Hoyt, Cliff; VandenBerg, Scott; Chien, Jo; Esserman, Laura 分享 收藏
Lack of background parenchymal enhancement suppression in breast MRI during neoadjuvant chemotherapy may be associated with inferior treatment response in hormone receptor positive breast cancer Onishi, Natsuko; Li, Wen; Newitt, David C.; Harnish, Roy; Gibbs, Jessica; Jones, Ella F.; Nguyen, Alex; Wilmes, Lisa; Joe, Bonnie N.; Campbell, Michael J.; Basu, Amrita; van't Veer, Laura J.; DiMichele, Angela; Yee, Douglas; Berry, Donald A.; Albain, Kathy S.; Boughey, Judy C.; Chien, A. Jo; Clark, Amy S.; Edmiston, Kirsten K.; Elias, Anthony D.; Ellis, Erin D.; Euhus, David M.; Han, Heather S.; Isaacs, Claudine; Khan, Qamar J.; Lang, Julie E.; Lu, Janice; Meisel, Jane L.; Mitri, Zaha; Nanda, Rita; Northfelt, Donald W.; Sanft, Tara; Stringer-Reasor, Erica; Viscusi, Rebecca K.; Wallace, Anne M.; Yung, Rachel; Melisko, Michelle E.; Perlmutter, Jane; Rugo, Hope S.; Schwab, Richard; Symmans, W. Fraser; Asare, Smita M.; Yau, Julie E.; Yau, Christina; Esserman, Laura J.; Hylton, Nola M. 分享 收藏
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