Geoffrey P. Margison - Publications, H-index & Citations

Geoffrey P. Margison

university of london

49H指数

255论文数

8.4K被引数

收录论文 79

发表时间

Bracken Fern Carcinogen, Ptaquiloside, Forms a Guanine O 6-Adduct in DNA

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

IF6.2

2025-01-07

OAAI

Keskin, Fourat; Noone, Hannah; Dickman, Mark J.; Allen, Esther; Mulcrone, William D.; Rasmussen, Lars Holm; Hansen, Hans Christian Bruun; O'Connor, Peter J.; Povey, Andrew C.; Margison, Geoffrey P.; Williams, David M.

Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O6-Alkylated Guanine Bases in DNA

TOXICS

IF4.1

2024-09-04

OAAI

Yaakub, Hanum; Howell, Anthony; Margison, Geoffrey P.; Povey, Andrew C.

Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O 6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O 6-Alkylguanine Adductome

CHEMICAL RESEARCH IN TOXICOLOGY

IF3.8

2023-11-20

OAAI

Abdelhady, Rasha; Senthong, Pattama; Eyers, Claire E.; Reamtong, Onrapak; Cowley, Elizabeth; Cannizzaro, Luca; Stimpson, Joanna; Cain, Kathleen; Wilkinson, Oliver J.; Williams, Nicholas H.; Barran, Perdita E.; Margison, Geoffrey P.; Williams, David M.; Povey, Andrew C.

QSAR and Chemical Read-Across Analysis of 370 Potential MGMT Inactivators to Identify the Structural Features Influencing Inactivation Potency

PHARMACEUTICS

IF5.5

2023-08-21

OAAI

Sun, Guohui; Bai, Peiying; Fan, Tengjiao; Zhao, Lijiao; Zhong, Rugang; Mcelhinney, R. Stanley; Mcmurry, T. Brian H.; Donnelly, Dorothy J.; Mccormick, Joan E.; Kelly, Jane; Margison, Geoffrey P.

Increased susceptibility to streptozotocin-induced β-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Cardinal, JW; Margison, GP; Mynett, KJ; Yates, AP; Cameron, DP; Elder, RH

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

130

OAAI

Elder, RH; Jansen, JG; Weeks, RJ; Willington, MA; Deans, B; Watson, PJ; Mynett, KJ; Bailey, JA; Cooper, DP; Rafferty, JA; Heeran, MC; Wijnhoven, SWP; van Zeeland, AA; Margison, GP

Developing a screen for O6-alkylguanines in human DNA using the damage-specific binding protein, Atl1

CANCER RESEARCH

IF16.6

2020-08-15

PREAI

Yaakub, Hanum; Howell, Anthony; Margison, Geoffrey; Povey, Andrew

PON1 increases cellular DNA damage by lactone substrates

ARCHIVES OF TOXICOLOGY

IF6.9

2019-06-17

OAAI

Shangula, S.; Noori, M.; Ahmad, I.; Margison, G. P.; Liu, Y.; Siahmansur, T.; Soran, H.; Povey, A. C.

O6-methylguanine-induced transcriptional mutagenesis reduces p53 tumor-suppressor function O6-methylguanine-induced转录突变降低p53肿瘤抑制功能

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2018-04-17

OAAI

Ezerskyte, Monika; Paredes, Joao A.; Malvezzi, Stefano; Burns, John A.; Margison, Geoffrey P.; Olsson, Magnus; Scicchitano, David A.; Dreij, Kristian

ASSOCIATIONS BETWEEN PLACENTAL O6-METHYLGUANINE DNA METHYLTRANSFERASE (MGMT) ACTIVITY, AIR POLLUTANTS AND BIRTH OUTCOMES

PLACENTA

IF2.5

2017-09-01

PREAI

Yatim, Nurulshyha Md; Margison, Geoffrey; Johnstone, Edward; Povey, Andrew

L-β-N-methylamino-L-alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease

NEUROTOXICOLOGY

IF3.9

2017-03-01

OAAI

Potjewyd, G.; Day, P. J.; Shangula, S.; Margison, G. P.; Povey, A. C.

MGMT Expression Predicts PARP-Mediated Resistance to Temozolomide

MOLECULAR CANCER THERAPEUTICS

IF5.5

2015-05-05

OAAI

Erice, Oihane; Smith, Michael P.; White, Rachel; Goicoechea, Ibai; Barriuso, Jorge; Jones, Chris; Margison, Geoffrey P.; Acosta, Juan C.; Wellbrock, Claudia; Arozarena, Imanol

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity

DNA REPAIR

IF2.7

2015-04-01

OAAI

Tomaszowski, Karl-Heinz; Aasland, Dorthe; Margison, Geoffrey P.; Williams, Emma; Pinder, Sarah I.; Modesti, Mauro; Fuchs, Robert P.; Kaina, Bernd

Inhibition of type 1 insulin-like growth factor receptor (IGF-1R) influences processing of replication-associated DNA double-strand breaks (DSBs) and induces schedule-dependent sensitization of human melanoma to temozolomide (TMZ)

CANCER RESEARCH

IF16.6

2014-10-01

PREAI

Ramcharan, Roger N.; Aleksic, Tamara; Gao, Shan; Tanner, Jordan; Darvill, Nicholas; Bridges, Esther; Asher, Ruth; Watson, Amanda J.; Margison, Geoffrey P.; Repapi, Emmanouela; Li, Ji-Liang; Middleton, Mark R.; Macaulay, Valentine M.

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

MOLECULAR CANCER

IF33.9

2014-01-01

OAAI

Arozarena, Imanol; Goicoechea, Ibai; Erice, Oihane; Ferguson, Jennnifer; Margison, Geoffrey P.; Wellbrock, Claudia

Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations

NUCLEIC ACIDS RESEARCH

IF13.1

2013-04-10

OAAI

Zhang, Fang; Tsunoda, Masaru; Suzuki, Kaoru; Kikuchi, Yuji; Wilkinson, Oliver; Millington, Christopher L.; Margison, Geoffrey P.; Williams, David M.; Morishita, Ella Czarina; Takenaka, Akio

Triazene Compounds in the Treatment of Acute Myeloid Leukemia: A Short Review and a Case Report

CURRENT MEDICINAL CHEMISTRY

IF3.5

2013-04-01

PREAI

Bonmassar, L.; Marchesi, F.; Pascale, E.; Franzese, O.; Margison, G. P.; Bianchi, A.; D'Atri, S.; Bernardini, S.; Lattuada, D.; Bonmassar, E.; Aquino, A.

The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase

NUCLEIC ACIDS RESEARCH

IF13.1

2013-01-17

OAAI

Senthong, Pattama; Millington, Christopher L.; Wilkinson, Oliver J.; Marriott, Andrew S.; Watson, Amanda J.; Reamtong, Onrapak; Eyers, Claire E.; Williams, David M.; Margison, Geoffrey P.; Povey, Andrew C.

Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-10-29

OAAI

Wilkinson, Oliver J.; Latypov, Vitaly; Tubbs, Julie L.; Millington, Christopher L.; Morita, Rihito; Blackburn, Hannah; Marriott, Andrew; McGown, Gail; Thorncroft, Mary; Watson, Amanda J.; Connolly, Bernard A.; Grasby, Jane A.; Masui, Ryoji; Hunter, Christopher A.; Tainer, John A.; Margison, Geoffrey P.; Williams, David M.

Atl1 Regulates Choice between Global Genome and Transcription-Coupled Repair of O6-Alkylguanines

MOLECULAR CELL

IF16.6

2012-07-01

OAAI

Latypov, Vitaly F.; Tubbs, Julie L.; Watson, Amanda J.; Marriott, Andrew S.; McGown, Gail; Thorncroft, Mary; Wilkinson, Oliver J.; Senthong, Pattama; Butt, Amna; Arvai, Andrew S.; Millington, Christopher L.; Povey, Andrew C.; Williams, David M.; Santibanez-Koref, Mauro F.; Tainer, John A.; Margison, Geoffrey P.

研究方向