David H. MacLennan - Publications, H-index & Citations

David H. MacLennan

princess margaret cancer centre

97H指数

340论文数

3.4W被引数

收录论文 95

发表时间

Online searching of patients is a complement, not a workaround

BMJ-BRITISH MEDICAL JOURNAL

IF42.7

2023-11-27

PREAI

Maclennan, David

Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease

BIOCHEMICAL JOURNAL

IF4.3

2017-08-07

OAAI

Chen, Wenqian; Koop, Andrea; Liu, Yingjie; Guo, Wenting; Wei, Jinhong; Wang, Ruiwu; MacLennan, David H.; Dirksen, Robert T.; Chen, Sui Rong Wayne

Metformin increases degradation of phospholamban via autophagy in cardiomyocytes 二甲双胍通过自噬增加心肌细胞对磷化氢的降解

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-05-26

OAAI

Teng, Allen C. T.; Miyake, Tetsuaki; Yokoe, Shunichi; Zhang, Liyong; Rezende, Luis Mario, Jr.; Sharma, Parveen; MacLennan, David H.; Liu, Peter P.; Gramolini, Anthony O.

Variably Protease-Sensitive Prionopathy, a Unique Prion Variant with Inefficient Transmission Properties

EMERGING INFECTIOUS DISEASES

IF6.6

2014-12-01

OAAI

Diack, Abigail B.; Ritchie, Diane L.; Peden, Alexander H.; Brown, Deborah; Boyle, Aileen; Morabito, Laura; Maclennan, David; Burgoyne, Paul; Jansen, Casper; Knight, Richard S.; Piccardo, Pedro; Ironside, James W.; Manson, Jean C.

CASQ1 Gene Is an Unlikely Candidate for Malignant Hyperthermia Susceptibility in the North American Population

ANESTHESIOLOGY

IF9.1

2013-02-01

OAAI

Kraeva, Natalia; Zvaritch, Elena; Frodis, Wanda; Sizova, Olga; Kraev, Alexander; MacLennan, David H.; Riazi, Sheila

Structural determination of the phosphorylation domain of the ryanodine receptor

FEBS JOURNAL

IF4.2

2012-09-11

OAAI

Sharma, Parveen; Ishiyama, Noboru; Nair, Usha; Li, Wenping; Dong, Aiping; Miyake, Tetsuaki; Wilson, Aaron; Ryan, Tim; MacLennan, David H.; Kislinger, Thomas; Ikura, Mitsuhiko; Dhe-Paganon, Sirano; Gramolini, Anthony O.

Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2011-12-27

OAAI

De Crescenzo, Valerie; Fogarty, Kevin E.; Lefkowitz, Jason J.; Bellve, Karl D.; Zvaritch, Elena; MacLennan, David H.; Walsh, John V., Jr.

Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice 肌脂素缺失小鼠骨骼肌中Ca2转运增强和肌肉松弛

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2011-10-01

OAAI

Tupling, A. Russell; Bombardier, Eric; Gupta, Subash C.; Hussain, Dawar; Vigna, Chris; Bloemberg, Darin; Quadrilatero, Joe; Trivieri, Maria G.; Babu, Gopal J.; Backx, Peter H.; Periasamy, Muthu; MacLennan, David H.; Gramolini, Anthony O.

Identification of Novel Ryanodine Receptor 1 (RyR1) Protein Interaction with Calcium Homeostasis Endoplasmic Reticulum Protein (CHERP)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-05-01

OAAI

Ryan, Timothy; Sharma, Parveen; Ignatchenko, Alex; MacLennan, David H.; Kislinger, Thomas; Gramolini, Anthony O.

Ryanodine receptor type 1 gene mutations found in the Canadian malignant hyperthermia population

CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE

IF3.3

2011-03-31

OAAI

Kraeva, Natasha; Riazi, Sheila; Loke, Julian; Frodis, Wanda; Crossan, Mary Lou; Nolan, Kevin; Kraev, Alexander; MacLennan, David H.

Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum

JOURNAL OF GENERAL PHYSIOLOGY

IF2.9

2010-12-13

OAAI

Loy, Ryan E.; Orynbayev, Murat; Xu, Le; Andronache, Zoita; Apostol, Simona; Zvaritch, Elena; MacLennan, David H.; Meissner, Gerhard; Melzer, Werner; Dirksen, Robert T.

Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by α-crystallin-B

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2010-10-11

OAAI

Bousette, Nicolas; Chugh, Shaan; Fong, Vincent; Isserlin, Ruth; Kim, Kyoung-Han; Volchuk, Allen; Backx, Peter H.; Liu, Peter; Kislinger, Thomas; MacLennan, David H.; Emili, Andrew; Gramolini, Anthony O.

Does Central Core Disease have a Neuronal Component?

BIOPHYSICAL JOURNAL

IF3.1

2010-01-01

OAAI

De Crescenzo, Valerie; Fogarty, Kevin E.; Bellve, Karl D.; Tuft, Richard A.; Zvaritch, Elena; Maclennan, David H.; Walsh, John V.

Ca2+ dysregulation in Ryr1I4895T/wt mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2009-12-22

OAAI

Zvaritch, Elena; Kraeva, Natasha; Bombardier, Eric; McCloy, Robert A.; Depreux, Frederic; Holmyard, Douglas; Kraev, Alexander; Seidman, Christine E.; Seidman, J. G.; Tupling, A. Russell; MacLennan, David H.

Crystal structure of type 1 ryanodine receptor amino-terminal β-trefoil domain reveals a disease-associated mutation hot spot loop

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2009-07-07

OAAI

Amador, Fernando J.; Liu, Shuang; Ishiyama, Noboru; Plevin, Michael J.; Wilson, Aaron; MacLennan, David H.; Ikura, Mitsuhiko

A new role for type 1 ryanodine receptor

BIOPHYSICAL JOURNAL

IF3.1

2009-02-01

OAAI

De Crescenzo, Valerie; Zvaritch, Elena; Fogarty, Kevin E.; MacLennan, David H.; Allen, Paul D.; Walsh, John V.

Deficits in Ca2+Release and in vivo Muscle Strength in Heterozygous I4895T RyR1 Knock-In Mice

BIOPHYSICAL JOURNAL

IF3.1

2009-02-01

OAAI

Loy, Ryan E.; Apostol, Simona; Orynbayev, Murat; Andronache, Zoita; Zvaritch, Elena; MacLennan, David H.; Melzer, Werner; Dirksen, Robert T.

Alterations of Phospholamban Function Can Exhibit Cardiotoxic Effects Independent of Excessive Sarcoplasmic Reticulum Ca2+-ATPase Inhibition

CIRCULATION

IF38.6

2009-01-27

OAAI

Schmitt, Joachim P.; Ahmad, Ferhaan; Lorenz, Kristina; Hein, Lutz; Schulz, Stefan; Asahi, Michio; MacLennan, David H.; Seidman, Christine E.; Seidman, J. G.; Lohse, Martin J.

Tbx5-dependent pathway regulating diastolic function in congenital heart disease

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2008-04-08

OAAI

Zhu, Yonghong; Gramolini, Anthony O.; Walsh, Mark A.; Zhou, Yu-Qing; Slorach, Cameron; Friedberg, Mark K.; Takeuchi, Jun K.; Sun, Hui; Henkelman, R. Mark; Backx, Peter H.; Redington, Andrew N.; MacLennan, David H.; Bruneau, Benoit G.

Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses

MOLECULAR & CELLULAR PROTEOMICS

IF5.5

2008-03-01

104

OAAI

Gramolini, Anthony O.; Kislinger, Thomas; Alikhani-Koopaei, Rasoul; Fong, Vincent; Thompson, Natalie J.; Isserlin, Ruth; Sharma, Parveen; Oudit, Gavin Y.; Trivieri, Maria G.; Fagan, Ailis; Kannan, Anitha; Higgins, Desmond G.; Huedig, Hendrik; Hess, George; Arab, Sara; Seidman, Jonathan G.; Seidman, Christine E.; Frey, Brendan; Perry, Marc; Backx, Peter H.; Liu, Peter P.; MacLennan, David H.; Emili, Andrew

研究方向