未登录 Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety EvaluationS 二价金属转运蛋白1的有效肠道限制性抑制剂: 抗铁过载的临床前疗效和安全性评估 Cutts, Alison; Chowdhury, Sultan; Ratkay, Laszlo G.; Eyers, Maryanne; Young, Clint; Namdari, Rostam; Cadieux, Jay A.; Chahal, Navjot; Grimwood, Michael; Zhang, Zaihui; Lin, Sophia; Tietjen, Ian; Xie, Zhiwei; Robinette, Lee; Sojo, Luis; Waldbrook, Matthew; Hayden, Michael; Mansour, Tarek; Pimstone, Simon; Goldberg, Y. Paul; Webb, Michael; Cohen, Charles J. 分享 收藏
Genomic characterization of SARS-CoV-2 in Egypt: insights into spike protein thermodynamic stability Jalal, Deena; Samir, Omar; Elzayat, Mariam G.; El-Shqanqery, Hend E.; Diab, Aya A.; ElKaialy, Lamiaa; Mohammed, Aya M.; Hamdy, Donia; Matar, Islam K.; Amer, Khaled; Elnakib, Mostafa; Hassan, Wael; Mansour, Tarek; Soliman, Sonia; Hassan, Reem; Al-Toukhy, Ghada M.; Hammad, Mahmoud; Abdo, Ibrahim; Sayed, Ahmed A. 分享 收藏
SARS-CoV-2 genome variations and evolution patterns in Egypt: a multi-center study Jalal, Deena; Elzayat, Mariam G.; El-Shqanqery, Hend E.; Diab, Aya A.; Yahia, Abdelrahman; Samir, Omar; Bakry, Usama; Amer, Khaled; ElNaqeeb, Mostafa; Hassan, Wael; Talat, Hala S.; Farawela, Hala M.; Hamdy, Mona S.; Soliman, May S.; El Sissy, Maha H.; Ezzelarab, Moushira H.; El Khateeb, Sara M.; Soliman, Lamyaa H.; Haddad, Sara E.; Hatem, Ashraf; Ismail, Mohamed S.; Hossam, Maha; Mansour, Tarek; Shalaby, Lobna; Soliman, Sonia; Hassan, Reem; Hammad, Mahmoud; Abdo, Ibrahim; Magdeldin, Sameh; ElHaddad, Alaa; Abouelnaga, Sherif; Sayed, Ahmed A. 分享 收藏
Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models 发现芳基磺胺类药物作为NaV1.7的同工型选择性抑制剂，在啮齿动物疼痛模型中有效 Focken, Thilo; Liu, Shifeng; Chahal, Navjot; Dauphinais, Maxim; Grimwood, Michael E.; Chowdhury, Sultan; Hemeon, Ivan; Bichler, Paul; Bogucki, David; Waldbrook, Matthew; Bankar, Girish; Sojo, Luis E.; Young, Clint; Lin, Sophia; Shuart, Noah; Kwan, Rainbow; Pang, Jodie; Chang, Jae H.; Safina, Brian S.; Sutherlin, Daniel P.; Johnson, J. P., Jr.; Dehnhardt, Christoph M.; Mansour, Tarek S.; Oballa, Renata M.; Cohen, Charles J.; Robinette, C. Lee 分享 收藏
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PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors Yu, K; Lucas, J; Zhu, TM; Zask, A; Gaydos, C; Toral-Barza, L; Gu, JX; Li, FB; Chaudhary, I; Cai, P; Lotvin, J; Petersen, R; Ruppen, M; Fawzi, M; Ayral-Kaloustian, S; Skotnicki, J; Mansour, T; Frost, P; Gibbons, J 分享 收藏
Discovery of Isoquinolinone Indole Acetic Acids as Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases Kaila, Neelu; Follows, Bruce; Leung, Louis; Thomason, Jennifer; Huang, Adrian; Moretto, Alessandro; Janz, Kristin; Lowe, Michael; Mansour, Tarek S.; Hubeau, Cedric; Page, Karen; Morgan, Paul; Fish, Susan; Xu, Xin; Williams, Cara; Saiah, Eddine 分享 收藏
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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes Wan, Zhao-Kui; Chenail, Eva; Li, Huan-Qiu; Ipek, Manus; Xiang, Jason; Suri, Vipin; Hahm, Seung; Bard, Joel; Svenson, Kristine; Xu, Xin; Tian, Xianbin; Wang, Mengmeng; Li, Xiangping; Johnson, Christian E.; Qadri, Ariful; Panza, Darrell; Perreault, Mylene; Mansour, Tarek S.; Tobin, James F.; Saiah, Eddine 分享 收藏
Diazine Indole Acetic Acids as Potent, Selective, and Orally Bioavailable Antagonists of Chemoattractant Receptor Homologous Molecule Expressed on Th2 Cells (CRTH2) for the Treatment of Allergic Inflammatory Diseases Kaila, Neelu; Huang, Adrian; Moretto, Alessandro; Follows, Bruce; Janz, Kristin; Lowe, Michael; Thomason, Jennifer; Mansour, Tarek S.; Hubeau, Cedric; Page, Karen; Morgan, Paul; Fish, Susan; Xu, Xin; Williams, Cara; Saiah, Eddine 分享 收藏
Beyond temsirolimus: Discovery of PKI-587 a highly efficacious dual PI3K/mTOR inhibitor Venkatesan, Aranapakam M.; Dehnhardt, Christoph M.; Delos Santos, Efren; Chen, Zecheng; Dos Santos, Osvaldo; Ayral-Kaloustian, Semiramis; Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Yu, Ker; Brooijmans, Natasja; Bard, Joel; Gibbons, James; Abraham, Robert T.; Mansour, Tarek S. 分享 收藏
Synthesis and SAR of Novel 4-Morpholinopyrrolopyrimidine Derivatives as Potent Phosphatidylinositol 3-Kinase Inhibitors Chen, Zecheng; Venkatesan, Aranapakam M.; Dehnhardt, Christoph M.; Ayral-Kaloustian, Semiramis; Brooijmans, Natasja; Mallon, Robert; Feldberg, Larry; Hollander, Irwin; Lucas, Judy; Yu, Ker; Kong, Fangming; Mansour, Tarek S. 分享 收藏
Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor 双 (morpholino-1，3，5-三嗪) 衍生物: 有效的腺苷5 ′-三磷酸竞争性Phosphatidylinositol-3-kinase/雷帕霉素抑制剂的哺乳动物靶标: 发现化合物26 (PKI-587)，一种高效的双重抑制剂 Venkatesan, Aranapakam M.; Dehnhardt, Christoph M.; Delos Santos, Efren; Chen, Zecheng; Dos Santos, Osvaldo; Ayral-Kaloustian, Semiramis; Khafizova, Gulnaz; Brooijmans, Natasja; Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Yu, Ker; Gibbons, James; Abraham, Robert T.; Chaudhary, Inder; Mansour, Tarek S. 分享 收藏
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Beyond Rapalog Therapy: Preclinical Pharmacology and Antitumor Activity of WYE-125132, an ATP-Competitive and Specific Inhibitor of mTORC1 and mTORC2 Yu, Ker; Shi, Celine; Toral-Barza, Lourdes; Lucas, Judy; Shor, Boris; Kim, Jae Eun; Zhang, Wei-Guo; Mahoney, Robert; Gaydos, Christine; Tardio, LuAnna; Kim, Sung Kyoo; Conant, Roger; Curran, Kevin; Kaplan, Joshua; Verheijen, Jeroen; Ayral-Kaloustian, Semiramis; Mansour, Tarek S.; Abraham, Robert T.; Zask, Arie; Gibbons, James J. 分享 收藏
Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition Dehnhardt, Christoph M.; Venkatesan, Aranapakam M.; Chen, Zecheng; Ayral-Kaloustian, Semiramis; Dos Santos, Osvaldo; Delos Santos, Efren; Curran, Kevin; Follettie, Max T.; Diesl, Veronica; Lucas, Judy; Geng, Yi; DeJoy, Susan Quinn; Petersen, Rosanne; Chaudhary, Inder; Brooijmans, Natasja; Mansour, Tarek S.; Arndt, Kim; Chen, Lei 分享 收藏
Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402 Dehnhardt, Christoph M.; Venkatesan, Aranapakam M.; Delos Santos, Efren; Chen, Zecheng; Santos, Osvaldo; Ayral-Kaloustian, Semiramis; Brooijmans, Natasja; Mallon, Robert; Hollander, Irwin; Feldberg, Larry; Lucas, Judy; Chaudhary, Inder; Yu, Ker; Gibbons, Jay; Abraham, Robert; Mansour, Tarek S. 分享 收藏
Neuroprotective Profile of Novel Src Kinase Inhibitors in Rodent Models of Cerebral Ischemia Liang, Shi; Pong, Kevin; Gonzales, Cathleen; Chen, Yi; Ling, Huai-Ping; Mark, Robert J.; Boschelli, Frank; Boschelli, Diane H.; Ye, Fei; Sosa, Ana Carolina Barrios; Mansour, Tarek S.; Frost, Philip; Wood, Andrew; Pangalos, Menelas N.; Zaleska, Margaret M. 分享 收藏
Hybrid Inhibitors of Phosphatidylinositol 3-Kinase (PI3K) and the Mammalian Target of Rapamycin (mTOR): Design, Synthesis, and Superior Antitumor Activity of Novel Wortmannin-Rapamycin Conjugates Ayral-Kaloustian, Semiramis; Gu, Jianxin; Lucas, Judy; Cinque, Michael; Gaydos, Christine; Zask, Arie; Chaudhary, Inder; Wang, Jianyao; Di, Li; Young, Mairead; Ruppen, Mark; Mansour, Tarek S.; Gibbons, James J.; Yu, Ker 分享 收藏
Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent Verheijen, Jeroen C.; Richard, David J.; Curran, Kevin; Kaplan, Joshua; Lefever, Mark; Nowak, Pawel; Malwitz, David J.; Brooijmans, Natasja; Toral-Barza, Lourdes; Zhang, Wei-Guo; Lucas, Judy; Hollander, Irwin; Ayral-Kaloustian, Semiramis; Mansour, Tarek S.; Yu, Ker; Zask, Arie 分享 收藏
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