未登录 Updated results of surufatinib plus transarterial embolization versus surufatinib monotherapy in neuroendocrine tumor with liver metastasis: A prospective, randomized, controlled trial 神经内分泌肿瘤肝转移患者中，舒尼替尼联合经动脉栓塞与舒尼替尼单药治疗更新的结果：一项前瞻性、随机、对照试验 Cao, D.; Li, X.; You, X.; Li, R.; Xiang, J.; Lan, H.; Wang, J.; Ke, N. 分享 收藏
Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7 Marineau, Jason J.; Hamman, Kristin B.; Hu, Shanhu; Alnemy, Sydney; Mihalich, Janessa; Kabro, Anzhelika; Whitmore, Kenneth Matthew; Winter, Dana K.; Roy, Stephanie; Ciblat, Stephane; Ke, Nan; Savinainen, Anneli; Wilsily, Ashraf; Malojcic, Goran; Zahler, Robert; Schmidt, Darby; Bradley, Michael J.; Waters, Nigel J.; Chuaqui, Claudio 分享 收藏
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Preclinical evaluation of intermittent dosing regimens on antitumor and PD activity of SY-5609, a potent and selective oral CDK7 inhibitor, in ovarian cancer xenografts Johannessen, L.; Dworakowski, W.; Sawant, P.; Ke, N.; Lefkovith, A.; D'Ippolito, A.; Eaton, M.; Henry, S. H.; Hodgson, G. 分享 收藏
Tolerability and preliminary clinical activity of SY-5609, a highly potent and selective oral CDK7 inhibitor, in patients with advanced solid tumors Sharma, M.; Bashir, B.; Hamilton, E.; Juric, D.; Papadopoulos, K.; Richardson, D.; Shapiro, G.; Hodgson, G.; Ke, N.; D'Ippolito, A.; Henry, S.; Zhu, L.; Rosario, M.; Jolin, H.; Roth, D.; Klimek, V.; Madigan, C.; Kelly, M. 分享 收藏
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Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clinical development in multiple solid tumor indications Johannessen, Liv H.; Hu, Shanhu; Ke, Nan; D'Ippolito, Anthony; Rajagopal, Nisha; Marineau, Jason; Savinainen, Anneli; Zamboni, William; Hodgson, Graeme 分享 收藏
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7 CDK7的选择性共价抑制剂SY-1365的发现和表征 Hu, Shanhu; Marineau, Jason J.; Rajagopal, Nisha; Hamman, Kristin B.; Choi, Yoon Jong; Schmidt, Darby R.; Ke, Nan; Johannessen, Liv; Bradley, Michael J.; Orlando, David A.; Alnemy, Sydney R.; Ren, Yixuan; Ciblat, Stephane; Winter, Dana K.; Kabro, Anzhelika; Sprott, Kevin T.; Hodgson, J. Graeme; Fritz, Christian C.; Carulli, John P.; di Tomaso, Emmanuelle; Olson, Eric R. 分享 收藏
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Kinase-independent function of E-type cyclins in liver cancer E型细胞周期蛋白在肝癌中的激酶非依赖性功能 Geng, Yan; Michowski, Wojciech; Chick, Joel M.; Wang, Yaoyu E.; Jecrois, M. Emmanuelle; Sweeney, Katharine E.; Liu, Lijun; Han, Richard C.; Ke, Nan; Zagozdzon, Agnieszka; Sicinska, Ewa; Bronson, Roderick T.; Gygi, Steven P.; Sicinski, Piotr 分享 收藏
SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors Hu, Shanhu; Ke, Nan; Ren, Yixuan; Miljovska, Sofija; Rajagopal, Nisha; McKeown, Michael; Orlando, David; Sprott, Kevin; Choi, Yoon J.; Olson, Eric; Fritz, Christian C. 分享 收藏
Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer Bradley, Michael; Marineau, Jason; Choi, Yoon; Hamman, Kristin; Malojcic, Goran; Orlando, David; Ren, Yixuan; Ke, Nan; Hu, Shanhu; Olson, Eric; Fritz, Christian; Roberts, Christopher 分享 收藏
Selective CDK7 inhibitors suppress super enhancer-genes, induce massive apoptosis in acute myeloid leukemia and demonstrate durable in vivo efficacy Hu, Shanhu; Ke, Nan; Ren, Yixuan; Lopez, Jeremy; Miljovska, Sofija; Orlando, David; Schmidt, Darby; Bradley, Michael; Sprott, Kevin; Olson, Eric; Fritz, Christian C.; Choi, Yoon Jong 分享 收藏
Cyclin C is a haploinsufficient tumour suppressor Li, Na; Fassl, Anne; Chick, Joel; Inuzuka, Hiroyuki; Li, Xiaoyu; Mansour, Marc R.; Liu, Lijun; Wang, Haizhen; King, Bryan; Shaik, Shavali; Gutierrez, Alejandro; Ordureau, Alban; Otto, Tobias; Kreslavsky, Taras; Baitsch, Lukas; Bury, Leah; Meyer, Clifford A.; Ke, Nan; Mulry, Kristin A.; Kluk, Michael J.; Roy, Moni; Kim, Sunkyu; Zhang, Xiaowu; Geng, Yan; Zagozdzon, Agnieszka; Jenkinson, Sarah; Gale, Rosemary E.; Linch, David C.; Zhao, Jean J.; Mullighan, Charles G.; Harper, J. Wade; Aster, Jon C.; Aifantis, Iannis; von Boehmer, Harald; Gygi, Steven P.; Wei, Wenyi; Look, A. Thomas; Sicinski, Piotr 分享 收藏
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