Inger Lauritzen - Publications, H-index & Citations

Inger Lauritzen

cnrs

36H指数

63论文数

5.7K被引数

收录论文 32

发表时间

PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains PRKN/parkin介导的SNCA（突触核蛋白α）和分子伴侣介导的自噬在细胞模型、小鼠模型及帕金森病受影响脑部中存在缺陷

Autophagy

IF14.3

2026-05-13

OAAI

Lígia Ramos dos Santos; Eric Duplan; Juliane Debord; Gwendoline Fremont; Julien Minniti; Inger Lauritzen; Eugenie Mutez; Coline Leghay; Marie Christine Chartier-Harlin; Frédéric Checler; Cristine Alves da Costa

Functional relationships linking C99/APP-βCTF dimerization, proteostasis disruption, and organelle dysfunction C99/APP-βCTF二聚化、蛋白质稳态紊乱和细胞器功能障碍之间的功能关系

Cell Communication and Signaling

IF8.9

2026-05-07

OAAI

Céline Badot; Anaïs Bini; Eric Duplan; Frédéric Checler; Inger Lauritzen

Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion Presenilins作为控制内吞和自噬通路以及小细胞外囊泡分泌的枢纽蛋白

JOURNAL OF EXTRACELLULAR VESICLES

IF14.5

2025-01-16

OAAI

Lauritzen, Inger; Bini, Anais; Becot, Anais; Gay, Anne-Sophie; Badot, Celine; Pagnotta, Sophie; Chami, Mounia; Checler, Frederic

Correction to: Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology (vol 132, 257, 2016)

ACTA NEUROPATHOLOGICA

IF9.3

2023-08-04

OAAI

Lauritzen, Inger; Pardossi-Piquard, Raphaelle; Bourgeois, Alexandre; Pagnotta, Sophie; Biferi, Maria-Grazia; Barkats, Martine; Lacor, Pascale; Klein, William; Bauer, Charlotte; Checler, Frederic

The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2023-03-17

OAAI

Afram, Elissa; Lauritzen, Inger; Bourgeois, Alexandre; El Manaa, Wejdane; Duplan, Eric; Chami, Mounia; Valverde, Audrey; Charlotte, Bauer; Pardossi-Piquard, Raphaelle; Checler, Frederic

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology XBP1s和PINK1之间的功能相互作用的转录和磷酸化依赖性控制线粒体自噬并可能影响帕金森病的病理生理

AUTOPHAGY

IF14.3

2021-05-24

OAAI

El Manaa, Wejdane; Duplan, Eric; Goiran, Thomas; Lauritzen, Inger; Vaillant Beuchot, Loan; Lacas-Gervais, Sandra; Morais, Vanessa Alexandra; You, Han; Qi, Ling; Salazar, Mario; Ozcan, Umut; Chami, Mounia; Checler, Frederic; Alves da Costa, Cristine

Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

OAAI

Checler, Frederic; Afram, Elissa; Pardossi-Piquard, Raphaelle; Lauritzen, Inger

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains 淀粉样前体蛋白C末端片段的积累触发了阿尔茨海默氏病模型和人脑中的线粒体结构，功能和线粒体自噬缺陷

ACTA NEUROPATHOLOGICA

IF9.3

2020-10-20

159

OAAI

Vaillant-Beuchot, Loan; Mary, Arnaud; Pardossi-Piquard, Raphaelle; Bourgeois, Alexandre; Lauritzen, Inger; Eysert, Fanny; Kinoshita, Paula Fernanda; Cazareth, Julie; Badot, Celine; Fragaki, Konstantina; Bussiere, Renaud; Martin, Cecile; Mary, Rosanna; Bauer, Charlotte; Pagnotta, Sophie; Paquis-Flucklinger, Veronique; Buee-Scherrer, Valerie; Buee, Luc; Lacas-Gervais, Sandra; Checler, Frederic; Chami, Mounia

The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer's Disease Models

CELLS

IF5.2

2020-05-12

OAAI

Becot, Anais; Pardossi-Piquard, Raphaelle; Bourgeois, Alexandre; Duplan, Eric; Xiao, Qingli; Diwan, Abhinav; Lee, Jin-Moo; Lauritzen, Inger; Checler, Frederic

Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models

TRANSLATIONAL NEURODEGENERATION

IF15.2

2019-12-05

OAAI

Lauritzen, Inger; Becot, Anais; Bourgeois, Alexandre; Pardossi-Piquard, Raphaelle; Biferi, Maria-Grazia; Barkats, Martine; Checler, Frederic

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3 x TgAD and 2 x TgAD mice

NEUROBIOLOGY OF AGING

IF3.5

2018-11-01

OAAI

Bourgeois, Alexandre; Lauritzen, Inger; Lorivel, Thomas; Bauer, Charlotte; Checler, Frederic; Pardossi-Piquard, Raphaelle

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

BIOLOGICAL PSYCHIATRY

IF9

2018-03-01

OAAI

Goiran, Thomas; Duplan, Eric; Chami, Mounia; Bourgeois, Alexandre; El Manaa, Wejdane; Rouland, Lila; Dunys, Julie; Lauritzen, Inger; You, Han; Stambolic, Vuk; Biferi, Maria-Grazia; Barkats, Martine; Pimplikar, Sanjay W.; Sergeant, Nicolas; Colin, Morvane; Morais, Vanessa A.; Pardossi-Piquard, Raphaelle; Checler, Frederic; da Costa, Cristine Alves

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

CELL DEATH AND DIFFERENTIATION

IF15.4

2018-01-19

OAAI

Goiran, Thomas; Duplan, Eric; Rouland, Lila; el Manaa, Wejdane; Lauritzen, Inger; Dunys, Julie; You, Han; Checler, Frederic; da Costa, Cristine Alves

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits

ACTA NEUROPATHOLOGICA

IF9.3

2017-06-19

125

OAAI

Lacampagne, Alain; Liu, Xiaoping; Reiken, Steven; Bussiere, Renaud; Meli, Albano C.; Lauritzen, Inger; Teich, Andrew F.; Zalk, Ran; Saint, Nathalie; Arancio, Ottavio; Bauer, Charlotte; Duprat, Fabrice; Briggs, Clark A.; Chakroborty, Shreaya; Stutzmann, Grace E.; Shelanski, Michael L.; Checler, Frederic; Chami, Mounia; Marks, Andrew R.

The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model

MOLECULAR PSYCHIATRY

IF10.1

2016-09-20

OAAI

Cisse, M.; Duplan, E.; Lorivel, T.; Dunys, J.; Bauer, C.; Meckler, X.; Gerakis, Y.; Lauritzen, I.; Checler, F.

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

ACTA NEUROPATHOLOGICA

IF9.3

2016-04-30

160

OAAI

Lauritzen, Inger; Pardossi-Piquard, Raphaelle; Bourgeois, Alexandre; Pagnotta, Sophie; Biferi, Maria-Grazia; Barkats, Martine; Lacor, Pascale; Klein, William; Bauer, Charlotte; Checler, Frederic

Study on Aβ34 biology and detection in transgenic mice brains

NEUROBIOLOGY OF AGING

IF3.5

2014-07-01

PREAI

Caillava, Celine; Ranaldi, Sebastien; Lauritzen, Inger; Bauer, Charlotte; Fareh, Jeannette; Abraham, Jean-Daniel; Checler, Frederic

Evidence that the Amyloid-β Protein Precursor Intracellular Domain, AICD, Derives From β-Secretase-Generated C-Terminal Fragment

JOURNAL OF ALZHEIMERS DISEASE

IF3.1

2012-05-04

PREAI

Flammang, Brice; Pardossi-Piquard, Raphaelle; Sevalle, Jevan; Debayle, Delphine; Dabert-Gay, Anne-Sophie; Thevenet, Aurelie; Lauritzen, Inger; Checler, Frederic

Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension

LABORATORY INVESTIGATION

IF4.2

2011-01-01

PREAI

Hassane, Sabrine; Claij, Nanna; Jodar, Martine; Dedman, Alexandra; Lauritzen, Inger; Duprat, Fabrice; Koenderman, Jorine S.; van der Wal, Annemieke; Breuning, Martijn H.; de Heer, Emile; Honore, Eric; DeRuiter, Marco C.; Peters, Dorien J. M.

The TASK background K2P channels:: chemo- and nutrient sensors

TRENDS IN NEUROSCIENCES

IF15.1

2007-11-01

PREAI

Duprat, Fabrice; Lauritzen, Inger; Patel, Amanda; Honore, Eric

研究方向