未登录 ST-2560, a selective inhibitor of the NaV1.7 sodium channel, affects nocifensive and cardiovascular reflexes in non-human primates ST-2560是NaV1.7钠通道的选择性抑制剂，会影响非人类灵长类动物的神经反射和心血管反射 Mulcahy, John V.; Beckley, Jacob T.; Klas, Sheri D.; Odink, Debra A.; Delwig, Anton; Pajouhesh, Hassan; Monteleone, Dennis; Zhou, Xiang; Du Bois, Justin; Yeomans, David C.; Luu, George; Hunter, John C. 分享 收藏
Discovery of Selective Inhibitors of NaV1.7 Templated on Saxitoxin as Therapeutics for Pain 发现以Saxitoxin为模板的NaV1.7选择性抑制剂作为疼痛治疗剂 Pajouhesh, Hassan; Delwig, Anton; Beckley, Jacob T.; Klas, Sheri; Monteleone, Dennis; Zhou, Xiang; Luu, George; Du Bois, J.; Hunter, John C.; Mulcahy, John V. 分享 收藏
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Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain Beckley, Jacob T.; Pajouhesh, Hassan; Luu, George; Klas, Sheri; Delwig, Anton; Monteleone, Dennis; Zhou, Xiang; Giuvelis, Denise; Meng, Ian D.; Yeomans, David C.; Hunter, John C.; Mulcahy, John, V 分享 收藏
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Structure-guided development of covalent TAK1 inhibitors Tan, Li; Gurbani, Deepak; Weisberg, Ellen L.; Hunter, John C.; Li, Lianbo; Jones, Douglas S.; Ficarro, Scott B.; Mowafy, Samar; Tam, Chun-Pong; Rao, Suman; Du, Guangyan; Griffin, James D.; Sorger, Peter K.; Marto, Jarrod A.; Westover, Kenneth D.; Gray, Nathanael S. 分享 收藏
Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine Harshbarger, Wayne; Gondi, Sudershan; Ficarro, Scott B.; Hunter, John; Udayakumar, Durga; Gurbani, Deepak; Singer, William D.; Liu, Yan; Li, Lianbo; Marto, Jarrod A.; Westover, Kenneth D. 分享 收藏
Covalent Guanosine Mimetic Inhibitors of G12C KRAS G12C KRAS的共价鸟苷模拟抑制剂 Xiong, Yuan; Lu, Jia; Hunter, John; Li, Lianbo; Scott, David; Choi, Hwan Geun; Lim, Sang Min; Manandhar, Anuj; Gondi, Sudershan; Sim, Taebo; Westover, Kenneth D.; Gray, Nathanael S. 分享 收藏
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Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2) Tan, Li; Nomanbhoy, Tyzoon; Gurbani, Deepak; Patricelli, Matthew; Hunter, John; Geng, Jiefei; Herhaus, Lina; Zhang, Jianming; Pauls, Eduardo; Ham, Youngjin; Choi, Hwan Geun; Xie, Ting; Deng, Xianming; Buhrlage, Sara J.; Sim, Taebo; Cohen, Philip; Sapkota, Gopal; Westover, Kenneth D.; Gray, Nathanael S. 分享 收藏
Treatment of acute lung injury by targeting MG53-mediated cell membrane repair Jia, Yanlin; Chen, Ken; Lin, Peihui; Lieber, Gissela; Nishi, Miyuki; Yan, Rosalie; Wang, Zhen; Yao, Yonggang; Li, Yu; Whitson, Bryan A.; Duann, Pu; Li, Haichang; Zhou, Xinyu; Zhu, Hua; Takeshima, Hiroshi; Hunter, John C.; McLeod, Robbie L.; Weisleder, Noah; Zeng, Chunyu; Ma, Jianjie 分享 收藏
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C Hunter, John C.; Gurbani, Deepak; Ficarro, Scott B.; Carrasco, Martin A.; Lim, Sang Min; Choi, Hwan Geun; Xie, Ting; Marto, Jarrod A.; Chen, Zhe; Gray, Nathanael S.; Westover, Kenneth D. 分享 收藏
Pharmacological Evaluation of Selective α2c-Adrenergic Agonists in Experimental Animal Models of Nasal Congestion Jia, Yanlin; Mingo, Garfield G.; Hunter, John C.; Lieber, Gissela B.; Palamanda, Jairam R.; Mei, Hong; Boyce, Christopher W.; Koss, Michael C.; Yu, Yongxin; Cicmil, Milenko; Hey, John A.; McLeod, Robbie L. 分享 收藏
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Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor 共价催化位点抑制剂对致癌k-ras的治疗靶向 Lim, Sang Min; Westover, Kenneth D.; Ficarro, Scott B.; Harrison, Rane A.; Choi, Hwan Geun; Pacold, Michael E.; Carrasco, Martin; Hunter, John; Kim, Nam Doo; Xie, Ting; Sim, Taebo; Jaenne, Pasi A.; Meyerson, Matthew; Marto, Jarrod A.; Engen, John R.; Gray, Nathanael S. 分享 收藏
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