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Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27Kip1 Phosphorylation on Thr187 and Accumulates p27Kip1 in the Nucleus: Implications for Breast Cancer Therapy Kazi, Aslamuzzaman; Carie, Adam; Blaskovich, Michelle A.; Bucher, Cynthia; Thai, Van; Moulder, Stacy; Peng, Hairuo; Carrico, Dora; Pusateri, Erin; Pledger, Warren J.; Berndt, Norbert; Hamilton, Andrew; Sebti, Said M. 分享 收藏
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Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function 蛋白质模拟淀粉样蛋白抑制剂有效消除癌症相关的突变型p53聚集并恢复肿瘤抑制功能 Palanikumar, L.; Karpauskaite, Laura; Al-Sayegh, Mohamed; Chehade, Ibrahim; Alam, Maheen; Hassan, Sarah; Maity, Debabrata; Ali, Liaqat; Kalmouni, Mona; Hunashal, Yamanappa; Ahmed, Jemil; Houhou, Tatiana; Karapetyan, Shake; Falls, Zackary; Samudrala, Ram; Pasricha, Renu; Esposito, Gennaro; Afzal, Ahmed J.; Hamilton, Andrew D.; Kumar, Sunil; Magzoub, Mazin 分享 收藏
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Antimicrobial Peptide Mimetics Based on a Diphenylacetylene Scaffold: Synthesis, Conformational Analysis, and Activity 基于二苯乙炔支架的抗菌肽模拟物: 合成,构象分析和活性 Peacock, Hayden; Henriques, Sonia Troeira; Benfield, Aurelie H.; Elliott, Alysha G.; Luo, Jinghui; Luccarelli, James; Nagano, Masanobu; Craik, David J.; Hamilton, Andrew D. 分享 收藏
Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity Henning-Knechtel, Anja; Kumar, Sunil; Wallin, Cecilia; Krol, Sylwia; Warmlander, Sebastian K. T. S.; Jarvet, Juri; Esposito, Gennaro; Kirmizialtin, Serdal; Graslund, Astrid; Hamilton, Andrew D.; Magzoub, Mazin 分享 收藏
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Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors Kazi, Aslamuzzaman; Xiang, Shengyan; Yang, Hua; Chen, Liwei; Kennedy, Perry; Ayaz, Muhammad; Fletcher, Steven; Cummings, Christopher; Lawrence, Harshani; Beato, Francisca; Yang, Ya'an; Kim, Michael P.; Delitto, Andrea; Underwood, Patrick; Fleming, Jason B.; Trevino, Jose; Hamilton, Andrew D.; Sebti, Said M. 分享 收藏