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Chronic pain recruits hypothalamic dynorphin/kappa opioid receptor signalling to promote wakefulness and vigilance Ito, Hisakatsu; Navratilova, Edita; Vagnerova, Barbora; Watanabe, Moe; Kopruszinski, Carol; de Souza, Luiz H. Moreira; Yue, Xu; Ikegami, Daigo; Moutal, Aubin; Patwardhan, Amol; Khanna, Rajesh; Yamazaki, Mitsuaki; Guerrero, Miguel; Rosen, Hugh; Roberts, Ed; Neugebauer, Volker; Dodick, David W.; Porreca, Frank 分享 收藏
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S1P1 Contributes to Endotoxin-enhanced B-Cell Functions Involved in Hypersensitivity Pneumonitis Huppe, Carole-Ann; Blais-Lecours, Pascale; Bernatchez, Emilie; Lauzon-Joset, Jean-Francois; Duchaine, Caroline; Rosen, Hugh; Dion, Genevieve; McNagny, Kelly M.; Blanchet, Marie-Renee; Morissette, Mathieu C.; Marsolais, David 分享 收藏
Stabilization of amyloidogenic immunoglobulin light chains by small molecules Morgan, Gareth J.; Yan, Nicholas L.; Mortenson, David E.; Rennella, Enrico; Blundon, Joshua M.; Gwin, Ryan M.; Lin, Chung-Yon; Stanfield, Robyn L.; Brown, Steven J.; Rosen, Hugh; Spicer, Timothy P.; Fernandez-Vega, Virneliz; Merlini, Giampaolo; Kay, Lewis E.; Wilson, Ian A.; Kelly, Jeffery W. 分享 收藏
Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) Guerrero, Miguel; Urbano, Mariangela; Kim, Eun-Kyong; Gamo, Ana M.; Riley, Sean; Abgaryan, Lusine; Leaf, Nora; Van Orden, Lori Jean; Brown, Steven J.; Xie, Jennifer Y.; Porreca, Frank; Cameron, Michael D.; Rosen, Hugh; Roberts, Edward 分享 收藏
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo Ogasawara, Daisuke; Ichu, Taka-Aki; Vartabedian, Vincent F.; Benthuysen, Jacqueline; Jing, Hui; Reed, Alex; Ulanovskaya, Olesya A.; Hulce, Jonathan J.; Roberts, Amanda; Brown, Steven; Rosen, Hugh; Teijaro, John R.; Cravatt, Benjamin F. 分享 收藏
A sphingosine-1-phosphate receptor 1 agonist inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung Huppe, C. A.; Lecours, P. Blais; Lechasseur, A.; Gendron, D. R.; Lemay, A. M.; Bissonnette, E. Y.; Blanchet, M. R.; Duchaine, C.; Morissette, M. C.; Rosen, H.; Marsolais, D. 分享 收藏
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Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention Xie, Jennifer Y.; De Felice, Milena; Kopruszinski, Caroline M.; Eyde, Nathan; LaVigne, Justin; Remeniuk, Bethany; Hernandez, Pablo; Yue, Xu; Goshima, Naomi; Ossipov, Michael; King, Tamara; Streicher, John M.; Navratilova, Edita; Dodick, David; Rosen, Hugh; Roberts, Ed; Porreca, Frank 分享 收藏
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Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection Yung, Bryan S.; Brand, Cameron S.; Xiang, Sunny Y.; Gray, Charles B. B.; Means, Christopher K.; Rosen, Hugh; Chun, Jerold; Purcell, Nicole H.; Brown, Joan Heller; Miyamoto, Shigeki 分享 收藏
Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease Karuppuchamy, T.; Behrens, E-H; Gonzalez-Cabrera, P.; Sarkisyan, G.; Gima, L.; Boyer, J. D.; Bamias, G.; Jedlicka, P.; Veny, M.; Clark, D.; Peach, R.; Scott, F.; Rosen, H.; Rivera-Nieves, J. 分享 收藏
Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation DRUGGABILITY OF THE SMALL GTPase Rab27a Johnson, Jennifer L.; Ramadass, Mahalakshmi; He, Jing; Brown, Steven J.; Zhang, Jinzhong; Abgaryan, Lusine; Biris, Nikolaos; Gavathiotis, Evripidis; Rosen, Hugh; Catz, Sergio D. 分享 收藏
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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Plate, Lars; Cooley, Christina B.; Chen, John J.; Paxman, Ryan J.; Gallagher, Ciara M.; Madoux, Franck; Genereux, Joseph C.; Dobbs, Wesley; Garza, Dan; Spicer, Timothy P.; Scampavia, Louis; Brown, Steven J.; Rosen, Hugh; Powers, Evan T.; Walter, Peter; Hodder, Peter; Wiseman, R. Luke; Kelly, Jeffery W. 分享 收藏
Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activity Scott, F. L.; Clemons, B.; Brooks, J.; Brahmachary, E.; Powell, R.; Dedman, H.; Desale, H. G.; Timony, G. A.; Martinborough, E.; Rosen, H.; Roberts, E.; Boehm, M. F.; Peach, R. J. 分享 收藏
Inflammation Modulates the Sphingosine-1-Phosphate Pathway in Inflammatory Bowel Disease (IBD) Karuppuchamy, Thangaraj; Behrens, En-hui; Gonzalez-Cabrera, Pedro; Sarkisyan, Gor; Gima, Lauren; Boyer, Joshua; Bamias, Giorgos; Jedlicka, Paul; Veny, Marisol; Clark, David; Peach, Robert; Scott, Fiona; Rosen, Hugh; Rivera-Nieves, Jesus 分享 收藏
S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification Teijaro, John R.; Studer, Sean; Leaf, Nora; Kiosses, William B.; Nguyen, Nhan; Matsuki, Kosuke; Negishi, Hideo; Taniguchi, Tadatsugu; Oldstone, Michael B. A.; Rosen, Hugh 分享 收藏
Bitopic Sphingosine 1-Phosphate Receptor 3 (S1P3) Antagonist Rescue from Complete Heart Block: Pharmacological and Genetic Evidence for Direct S1P3 Regulation of Mouse Cardiac Conduction Sanna, M. Germana; Vincent, Kevin P.; Repetto, Emanuela; Nhan Nguyen; Brown, Steven J.; Abgaryan, Lusine; Riley, Sean W.; Leaf, Nora B.; Cahalan, Stuart M.; Kiosses, William B.; Kohno, Yasushi; Brown, Joan Heller; McCulloch, Andrew D.; Rosen, Hugh; Gonzalez-Cabrera, Pedro J. 分享 收藏
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