未登录High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation对100 000个小分子进行高通量筛选，在C9ORF72 ALS神经元中鉴定出可促使G4C2重复RNA进入核输出并引发与重复相关的非规范翻译的剪接体调节剂。
Luteijn, Maartje J.; Bhaskar, Varun; Trojer, Dominic; Schuerz, Melanie; Mahboubi, Hicham; Handl, Cornelia; Pizzato, Nicolas; Pfeifer, Martin; Dafinca, Ruxandra; Voshol, Hans; Giorgetti, Elisa; Manneville, Carole; Garnier, Isabelle P. M.; Mueller, Matthias; Zeng, Fanning; Buntin, Kathrin; Markwalder, Roger; Schroeder, Harald; Weiler, Jan; Khar, Dora; Schuhmann, Tim; Groot-Kormelink, Paul J.; Keller, Caroline Gubser; Farmer, Pierre; MacKay, Angela; Beibel, Martin; Roma, Guglielmo; D'Ario, Giovanni; Merkl, Claudia; Schebesta, Michael; Hild, Marc; Elwood, Fiona; Vahsen, Bjoern F.; Ripin, Nina; Clery, Antoine; Allain, Frederic; Labow, Mark; Gabriel, Daniela; Chao, Jeffrey A.; Talbot, Kevin; Nash, Mark; Hunziker, Juerg; Meisner-Kober, Nicole C. .png)
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收藏Integrative Proteogenomics for Differential Expression and Splicing Variation in a DM1 Mouse ModelSolovyeva, Elizaveta M.; Utzinger, Stephan; Vissieres, Alexandra; Mitchelmore, Joanna; Ahrne, Erik; Hermes, Erwin; Poetsch, Tania; Ronco, Marie; Bidinosti, Michael; Merkl, Claudia; Serluca, Fabrizio C.; Fessenden, James; Naumann, Ulrike; Voshol, Hans; Meyer, Angelika S.; Hoersch, Sebastian 分享 收藏 Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instabilityCortes-Cros, Marta; Moebitz, Henrik; Barbe, Stephanie; Blank, Jutta; Bordas, Vincent; Clementi, Giorgia; Dammassa, Ernesta; Decker, Andrea; Di Nanni, Noemi; de Kanter, Ruben; Dourdoigne, Marion; Gavioli, Elena; Ferretti, Stephane; Hattenberger, Marc; Hemmerlin, Christelle; Hamon, Jacques; Hinrichs, Juergen; Jaco, Isabel; Jankovic, Dragana; Nunez, Eloisa Jimenez; Li, Yifang; Martus, Hans-Joerg; Moschetta, Michele; Quadt, Cornelia; Reschke, Markus; Romanet, Vincent; Scheufler, Clemens; Schoepfer, Joseph; Strang, Ross; Therier, Maxime; Voshol, Hans; Wartmann, Markus; Welly, Sarah; Pham, Monica; Laborde, Laurent 分享 收藏 CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung CancerPrahallad, Anirudh; Weiss, Andreas; Voshol, Hans; Kerr, Grainne; Sprouffske, Kathleen; Yuan, Tina; Ruddy, David; Meistertzheim, Morgane; Kazic-Legueux, Malika; Kottarathil, Tina; Piquet, Michelle; Cao, Yichen; Martinuzzi-Duboc, Laetitia; Buhles, Alexandra; Adler, Flavia; Mannino, Salvatore; Tordella, Luca; Sansregret, Laurent; Maira, Sauveur-Michel; Graus Porta, Diana; Fedele, Carmine; Brachmann, Saskia M. 分享 收藏 JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid TumorsLorthiois, Edwige; Gerspacher, Marc; Beyer, Kim S.; Vaupel, Andrea; Leblanc, Catherine; Stringer, Rowan; Weiss, Andreas; Wilcken, Rainer; Guthy, Daniel A.; Lingel, Andreas; Bomio-Confaglia, Claudio; Machauer, Rainer; Rigollier, Pascal; Ottl, Johannes; Arz, Dorothee; Bernet, Pascal; Desjonqueres, Gaelle; Dussauge, Solene; Kazic-Legueux, Malika; Lozac'h, Marie-Anne; Mura, Christophe; Sorge, Mickael; Todorov, Milen; Warin, Nicolas; Zink, Florence; Voshol, Hans; Zecri, Frederic J.; Sedrani, Richard C.; Ostermann, Nils; Brachmann, Saskia M.; Cotesta, Simona 分享 收藏 Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12CWeiss, Andreas; Lorthiois, Edwige; Barys, Louise; Beyer, Kim S.; Bomio-Confaglia, Claudio; Burks, Heather; Chen, Xueying; Cui, Xiaoming; de Kanter, Ruben; Dharmarajan, Lekshmi; Fedele, Carmine; Gerspacher, Marc; Guthy, Daniel Alexander; Head, Victoria; Jaeger, Ashley; Nunez, Eloisa Jimenez; Kearns, Jeffrey D.; Leblanc, Catherine; Maira, Sauveur-Michel; Murphy, Jason; Oakman, Helen; Ostermann, Nils; Ottl, Johannes; Rigollier, Pascal; Roman, Danielle; Schnell, Christian; Sedrani, Richard; Shimizu, Toshio; Stringer, Rowan; Vaupel, Andrea; Voshol, Hans; Wessels, Peter; Widmer, Toni; Wilcken, Rainer; Xu, Kun; Zecri, Frederic; Farago, Anna F.; Cotesta, Simona; Brachmann, Saskia M. 分享 收藏 The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factorsMesrouze, Yannick; Aguilar, Gustavo; Meyerhofer, Marco; Bokhovchuk, Fedir; Zimmermann, Catherine; Fontana, Patrizia; Vissieres, Alexandra; Voshol, Hans; Erdmann, Dirk; Affolter, Markus; Chene, Patrick 分享 收藏 Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex (vol 85, pg 231, 2019)Bussiere, Dirksen E.; Xie, Lili; Srinivas, Honnappa; Shu, Wei; Burke, Ashley; Be, Celine; Zhao, Junping; Godbole, Adarsh; King, Dan; Karki, Rajeshri G.; Hornak, Viktor; Xu, Fangmin; Cobb, Jennifer; Carte, Nathalie; Frank, Andreas O.; Frommlet, Alexandra; Graff, Patrick; Knapp, Mark; Fazal, Aleem; Okram, Barun; Jiang, Songchun; Michellys, Pierre-Yves; Beckwith, Rohan; Voshol, Hans; Wiesmann, Christian; Solomon, Jonathan M.; Paulk, Joshiawa 分享 收藏 Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complexBussiere, Dirksen E.; Xie, Lili; Srinivas, Honnappa; Shu, Wei; Burke, Ashley; Be, Celine; Zhao, Junping; Godbole, Adarsh; King, Dan; Karki, Rajeshri G.; Hornak, Viktor; Xu, Fangmin; Cobb, Jennifer; Carte, Nathalie; Frank, Andreas O.; Frommlet, Alexandra; Graff, Patrick; Knapp, Mark; Fazal, Aleem; Okram, Barun; Jiang, Songchun; Michellys, Pierre-Yves; Beckwith, Rohan; Voshol, Hans; Wiesmann, Christian; Solomon, Jonathan M.; Paulk, Joshiawa 分享 收藏 分享 收藏 Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R InhibitionHerkert, Barbara; Kauffmann, Audrey; Molle, Sandra; Schnell, Christian; Ferrat, Thomas; Voshol, Hans; Juengert, Janina; Erasimus, Helene; Marszalek, Gregory; Kazic-Legueux, Malika; Billy, Eric; Ruddy, David; Stump, Mark; Guthy, Daniel; Ristov, Mitko; Calkins, Keith; Maira, Sauveur-Michel; Sellers, William R.; Hofmann, Francesco; Hall, Michael N.; Brachmann, Saskia M. 分享 收藏 CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinasesLeroy, C.; Shen, Q.; Strande, V.; Meyer, R.; McLaughlin, M. E.; Lezan, E.; Bentires-Alj, M.; Voshol, H.; Bonenfant, D.; Gaither, L. Alex 分享 收藏 Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinasesSausgruber, N.; Coissieux, M-M; Britschgi, A.; Wyckoff, J.; Aceto, N.; Leroy, C.; Stadler, M. B.; Voshol, H.; Bonenfant, D.; Bentires-Alj, M. 分享 收藏 分享 收藏 Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode DependentJAK抑制剂对激活环磷酸化的调节是结合模式依赖性的Andraos, Rita; Qian, Zhiyan; Bonenfant, Debora; Rubert, Joelle; Vangrevelinghe, Eric; Scheufler, Clemens; Marque, Fanny; Regnier, Catherine H.; De Pover, Alain; Ryckelynck, Hugues; Bhagwat, Neha; Koppikar, Priya; Goel, Aviva; Wyder, Lorenza; Tavares, Gisele; Baffert, Fabienne; Pissot-Soldermann, Carole; Manley, Paul W.; Gaul, Christoph; Voshol, Hans; Levine, Ross L.; Sellers, William R.; Hofmann, Francesco; Radimerski, Thomas 分享 收藏 Inhibition of Dengue Virus Polymerase by Blocking of the RNA TunnelNiyomrattanakit, Pornwaratt; Chen, Yen-Liang; Dong, Hongping; Yin, Zheng; Qing, Min; Glickman, J. Frasier; Lin, Kai; Mueller, Dieter; Voshol, Hans; Lim, Joanne Y. 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Fraser; Voshol, Hans; Mueller, Dieter; Spanka, Carsten; Dressler, Sigmar; Nilar, Shahul; Vasudevan, Subhash G.; Shi, Pei-Yong; Keller, Thomas H. 分享 收藏 Triggering the succinate receptor GPR91 on dendritic cells enhances immunity触发树突状细胞上的琥珀酸受体GPR91增强免疫力Rubic, Tina; Lametschwandtner, Guenther; Jost, Sandra; Hinteregger, Sonja; Kund, Julia; Carballido-Perrig, Nicole; Schwaerzler, Christoph; Junt, Tobias; Voshol, Hans; Meingassner, Josef G.; Mao, Xiaohong; Werner, Gudrun; Rot, Antal; Carballido, Jose M. 分享 收藏 From proteomics to systems biology of bacterial pathogens:: Approaches, tools, and applicationsPlikat, Uwe; Voshol, Hans; Dangendorf, Yvonne; Wiedmann, Brigitte; Devay, Piroska; Mueller, Dieter; Wirth, Urs; Szustakowski, Joseph; Chirn, Gung-Wei; Inverardi, Bruno; Puyang, Xiaoling; Brown, Kara; Kamp, Heather; Hoving, Sjouke; Ruchti, Alexandra; Brendlen, Nathalie; Peterson, Ron; Buco, Jennifer; van Oostrum, Jan; Peitsch, Manuel C. 分享 收藏 
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