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LDHB contributes to the regulation of lactate levels and basal insulin secretion in human pancreatic βcells LDHB有助于调节人胰腺 β 细胞的乳酸水平和基础胰岛素分泌 Cuozzo, Federica; Viloria, Katrina; Shilleh, Ali H.; Nasteska, Daniela; Frazer-Morris, Charlotte; Tong, Jason; Jiao, Zicong; Boufersaoui, Adam; Marzullo, Bryan; Rosoff, Daniel B.; Smith, Hannah R.; Bonner, Caroline; Kerr-Conte, Julie; Pattou, Francois; Nano, Rita; Piemonti, Lorenzo; Johnson, Paul R. V.; Spiers, Rebecca; Roberts, Jennie; Lavery, Gareth G.; Clark, Anne; Ceresa, Carlo D. L.; Ray, David W.; Hodson, Leanne; Davies, Amy P.; Rutter, Guy A.; Oshima, Masaya; Scharfmann, Raphael; Merrins, Matthew J.; Akerman, Ildem; Tennant, Daniel A.; Ludwig, Christian; Hodson, David J. 分享 收藏
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A Pilot Study Using Machine-learning Algorithms and Wearable Technology for the Early Detection of Postoperative Complications After Cardiothoracic Surgery Beqari, Jorind; Powell, Joseph R.; Hurd, Jacob; Potter, Alexandra L.; Mccarthy, Meghan L.; Srinivasan, Deepti; Wang, Danny; Cranor, James; Zhang, Lizi; Webster, Kyle; Kim, Joshua; Rosenstein, Allison; Zheng, Zeyuan; Lin, Tung Ho; Fang, Zhengyu; Zhang, Yuhang; Anderson, Alex; Madsen, James; Anderson, Jacob; Clark, Anne; Yang, Margaret E.; Nurko, Andrea; Li, Jing; El-Jawahri, Areej R.; Sundt, Thoralf M.; Melnitchouk, Serguei; Jassar, Arminder S.; D'Alessandro, David; Panda, Nikhil; Schumacher, Lana Y.; Wright, Cameron D.; Auchincloss, Hugh G.; Sachdeva, Uma M.; Lanuti, Michael; Colson, Yolonda L.; Langer, Nathaniel B.; Osho, Asishana; Yang, Chi-Fu Jeffrey; Li, Xiao 分享 收藏
GLP-1 metabolite GLP-1(9-36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion GLP-1代谢物GLP-1(9-36) 是小鼠和人胰岛胰高血糖素分泌的全身性抑制剂 Gandasi, Nikhil R.; Gao, Rui; Kothegala, Lakshmi; Pearce, Abigail; Santos, Cristiano; Acreman, Samuel; Basco, Davide; Benrick, Anna; Chibalina, Margarita V.; Clark, Anne; Guida, Claudia; Harris, Matthew; Johnson, Paul R. V.; Knudsen, Jakob G.; Ma, Jinfang; Miranda, Caroline; Shigeto, Makoto; Tarasov, Andrei I.; Yeung, Ho Yan; Thorens, Bernard; Asterholm, Ingrid W.; Zhang, Quan; Ramracheya, Reshma; Ladds, Graham; Rorsman, Patrik 分享 收藏
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Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca2+ sensitivity but has limited effect on systemic metabolism McLaughlin, Kerry; Acreman, Samuel; Nawaz, Sameena; Cutteridge, Joseph; Clark, Anne; Knudsen, Jakob G.; Denwood, Geoffrey; Spigelman, Aliya F.; Fox, Jocelyn E. Manning; Singh, Sumeet Pal; MacDonald, Patrick E.; Hastoy, Benoit; Zhang, Quan 分享 收藏
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Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells Hastoy, Benoit; Godazgar, Mandieh; Clark, Anne; Nylander, Vibe; Spiliotis, Ioannis; van de Bunt, Martijn; Chibalina, Margarita, V; Barrett, Amy; Burrows, Carla; Tarasov, Andrei, I; Scharfmann, Raphael; Gloyn, Anna L.; Rorsman, Patrik 分享 收藏
Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells PAM中的2型糖尿病风险等位基因影响人胰腺 β 细胞的胰岛素释放 Thomsen, Soren K.; Raimondo, Anne; Hastoy, Benoit; Sengupta, Shahana; Dai, Xiao-Qing; Bautista, Austin; Censin, Jenny; Payne, Anthony J.; Umapathysivam, Mahesh M.; Spigelman, Aliya F.; Barrett, Amy; Groves, Christopher J.; Beer, Nicola L.; Fox, Jocelyn E. Manning; McCarthy, Mark I.; Clark, Anne; Mahajan, Anubha; Rorsman, Patrik; MacDonald, Patrick E.; Gloyn, Anna L. 分享 收藏
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Sitagliptin and Roux-en-Y gastric bypass modulate insulin secretion via regulation of intra-islet PYY Guida, Claudia; McCulloch, Laura J.; Godazgar, Mahdieh; Stephen, Sam D.; Baker, Charlotte; Basco, Davide; Dong, Jiawen; Chen, Duan; Clark, Anne; Ramracheya, Reshma D. 分享 收藏
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Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes Adam, Julie; Ramracheya, Reshma; Chibalina, Margarita V.; Ternette, Nicola; Hamilton, Alexander; Tarasov, Andrei I.; Zhang, Quan; Rebelato, Eduardo; Rorsman, Nils J. G.; Martin-del-Rio, Rafael; Lewis, Amy; Ozkan, Gizem; Do, Hyun Woong; Spegel, Peter; Saitoh, Kaori; Kato, Keiko; Igarashi, Kaori; Kessler, Benedikt M.; Pugh, Christopher W.; Tamarit-Rodriguez, Jorge; Mulder, Hindrik; Clark, Anne; Frizzell, Norma; Soga, Tomoyoshi; Ashcroft, Frances M.; Silver, Andrew; Pollard, Patrick J.; Rorsman, Patrik 分享 收藏
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Increased vimentin in human α- and β-cells in type 2 diabetes Roefs, Maaike M.; Carlotti, Francoise; Jones, Katherine; Wills, Hannah; Hamilton, Alexander; Verschoor, Michael; Durkin, Joanna M. Williams; Garcia-Perez, Laura; Brereton, Melissa F.; McCulloch, Laura; Engelse, Marten A.; Johnson, Paul R. V.; Hansen, Barbara C.; Docherty, Kevin; de Koning, Eelco J. P.; Clark, Anne 分享 收藏
Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells Brereton, Melissa F.; Rohm, Maria; Shimomura, Kenju; Holland, Christian; Tornovsky-Babeay, Sharona; Dadon, Daniela; Iberl, Michaela; Chibalina, Margarita V.; Lee, Sheena; Glaser, Benjamin; Dor, Yuval; Rorsman, Patrik; Clark, Anne; Ashcroft, Frances M. 分享 收藏
PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery Ramracheya, Reshma D.; McCulloch, Laura J.; Clark, Anne; Wiggins, David; Johannessen, Helene; Olsen, Magnus Kringstad; Cai, Xing; Zhao, Chun-Mei; Chen, Duan; Rorsman, Patrik 分享 收藏
Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits Spijker, H. Siebe; Song, Heein; Ellenbroek, Johanne H.; Roefs, Maaike M.; Engelse, Marten A.; Bos, Erik; Koster, Abraham J.; Rabelink, Ton J.; Hansen, Barbara C.; Clark, Anne; Carlotti, Francoise; de Koning, Eelco J. P. 分享 收藏
Reversible changes in pancreatic islet structure and function produced by elevated blood glucose Brereton, Melissa F.; Iberl, Michaela; Shimomura, Kenju; Zhang, Quan; Adriaenssens, Alice E.; Proks, Peter; Spiliotis, Ioannis I.; Dace, William; Mattis, Katia K.; Ramracheya, Reshma; Gribble, Fiona M.; Reimann, Frank; Clark, Anne; Rorsman, Patrik; Ashcroft, Frances M. 分享 收藏
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