未登录 The discovery and structural basis of two distinct state-dependent inhibitors of BamA Sun, Dawei; Storek, Kelly M.; Tegunov, Dimitry; Yang, Ying; Arthur, Christopher P.; Johnson, Matthew; Quinn, John G.; Liu, Weijing; Han, Guanghui; Girgis, Hany S.; Alexander, Mary Kate; Murchison, Austin K.; Shriver, Stephanie; Tam, Christine; Ijiri, Hiroshi; Inaba, Hiroko; Sano, Tatsuya; Yanagida, Hayato; Nishikawa, Junichi; Heise, Christopher E.; Fairbrother, Wayne J.; Tan, Man-Wah; Skelton, Nicholas; Sandoval, Wendy; Sellers, Benjamin D.; Ciferri, Claudio; Smith, Peter A.; Reid, Patrick C.; Cunningham, Christian N.; Rutherford, Steven T.; Payandeh, Jian 分享 收藏
Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability Wu, Hao; Murray, Jeremy; Ishisoko, Noriko; Frommlet, Alexandra; Deshmukh, Gauri; Dipasquale, Antonio; Mulvihill, Melinda M.; Zhang, Donglu; Quinn, John G.; Blake, Robert A.; Fairbrother, Wayne J.; Fuhrmann, Jakob 分享 收藏
Targeted degradation via direct 26S proteasome recruitment Bashore, Charlene; Prakash, Sumit; Johnson, Matthew C.; Conrad, Ryan J.; Kekessie, Ivy A.; Scales, Suzie J.; Ishisoko, Noriko; Kleinheinz, Tracy; Liu, Peter S.; Popovych, Nataliya; Wecksler, Aaron T.; Zhou, Lijuan; Tam, Christine; Zilberleyb, Inna; Srinivasan, Rajini; Blake, Robert A.; Song, Aimin; Staben, Steven T.; Zhang, Yingnan; Arnott, David; Fairbrother, Wayne J.; Foster, Scott A.; Wertz, Ingrid E.; Ciferri, Claudio; Dueber, Erin C. 分享 收藏
IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition Alicke, Bruno; Varfolomeev, Eugene; Lee, Shi Hui Kaylee; Frommlet, Alexandra; Ubhayakar, Savita; Quinn, John G.; Fairbrother, Wayne J.; Jones, Robert; Gould, Stephen E.; Vucic, Domagoj 分享 收藏
Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif Ultsch, Mark; Holliday, Michael J.; Gerhardy, Stefan; Moran, Paul; Scales, Suzie J.; Gupta, Nidhi; Oltrabella, Francesca; Chiu, Cecilia; Fairbrother, Wayne; Eigenbrot, Charles; Kirchhofer, Daniel 分享 收藏
分享 收藏
Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein den Besten, Willem; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M.; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J.; Wertz, Ingrid; Yu, Kebing; Staben, Steven T. 分享 收藏
分享 收藏
Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XL Inhibitor Wang, Le; Doherty, George A.; Judd, Andrew S.; Tao, Zhi-Fu; Hansen, T. Matthew; Frey, Robin R.; Song, Xiaohong; Bruncko, Milan; Kunzer, Aaron R.; Wang, Xilu; Wendt, Michael D.; Flygare, John A.; Catron, Nathaniel D.; Judge, Russell A.; Park, Chang H.; Shekhar, Shashank; Phillips, Darren C.; Nimmer, Paul; Smith, Morey L.; Tahir, Stephen K.; Xiao, Yu; Xue, John; Zhang, Haichao; Le, Phuong N.; Mitten, Michael J.; Boghaert, Erwin R.; Gao, Wenqing; Kovar, Peter; Choo, Edna F.; Diaz, Dolores; Fairbrother, Wayne J.; Elmore, Steven W.; Sampath, Deepak; Leverson, Joel D.; Souers, Andrew James 分享 收藏
Heterobifunctional Molecules Induce Dephosphorylation of Kinases-A Proof of Concept Study 异双功能分子诱导激酶的去磷酸化-概念研究的证明 Yamazoe, Sayumi; Tom, Jeffrey; Fu, Yue; Wu, Wenqiong; Zeng, Liang; Sun, Changlei; Liu, Qi; Lin, Jie; Lin, Kui; Fairbrother, Wayne J.; Staben, Steven T. 分享 收藏
分享 收藏
Cyclodextrin Reduces Intravenous Toxicity of a Model Compound Mantik, Priscilla; Xie, Minli; Wong, Harvey; La, Hank; Steigerwalt, Ronald W.; Devanaboyina, Uday; Ganem, Geoffrey; Shih, Danny; Flygare, John A.; Fairbrother, Wayne J.; Chakravarty, Paroma; Russell, David; Fernandez, Gilberto E.; Narang, Ajit S. 分享 收藏
分享 收藏
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (vol 14, pg 582, 2018) Nile, Aaron H.; de Sousa e Melo, Felipe; Mukund, Susmith; Piskol, Robert; Hansen, Simon; Zhou, Lijuan; Zhang, Yingnan; Fu, Yue; Gogol, Emily B.; Komuves, Laszlo G.; Modrusan, Zora; Angers, Stephane; Franke, Yvonne; Koth, Christopher; Fairbrother, Wayne J.; Wang, Weiru; de Sauvage, Frederic J.; Hannoush, Rami N. 分享 收藏
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells Nile, Aaron H.; de Sousa e Melo, Felipe; Mukund, Susmith; Piskol, Robert; Hansen, Simon; Zhou, Lijuan; Zhang, Yingnan; Fu, Yue; Gogol, Emily B.; Komuves, Laszlo G.; Modrusan, Zora; Angers, Stephane; Franke, Yvonne; Koth, Christopher; Fairbrother, Wayne J.; Wang, Weiru; de Sauvage, Frederic J.; Hannoush, Rami N. 分享 收藏
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling Goncharov, Tatiana; Hedayati, Stefanie; Mulvihill, Melinda M.; Izrael-Tomasevic, Anita; Zobel, Kerry; Jeet, Surinder; Fedorova, Anna V.; Eidenschenk, Celine; deVoss, Jason; Yu, Kebing; Shaw, Andrey S.; Kirkpatrick, Donald S.; Fairbrother, Wayne J.; Deshayes, Kurt; Vucic, Domagoj 分享 收藏
分享 收藏
BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab Huet, Sarah; Szafer-Glusman, Edith; Tesson, Bruno; Xerri, Luc; Fairbrother, Wayne J.; Mukhyala, Kiran; Bolen, Chris; Punnoose, Elizabeth; Tonon, Laurie; Chassagne-Clement, Catherine; Feugier, Pierre; Viari, Alain; Jardin, Fabrice; Salles, Gilles; Sujobert, Pierre 分享 收藏
分享 收藏
Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models Punnoose, Elizabeth A.; Leverson, Joel D.; Peale, Franklin; Boghaert, Erwin R.; Belmont, Lisa D.; Tan, Nguyen; Young, Amy; Mitten, Michael; Ingalla, Ellen; Darbonne, Walter C.; Oleksijew, Anatol; Tapang, Paul; Yue, Peng; Oeh, Jason; Lee, Leslie; Maiga, Sophie; Fairbrother, Wayne J.; Amiot, Martine; Souers, Andrew J.; Sampath, Deepak 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
