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收藏An orally available P1′-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier
Higashi-Kuwata, Nobuyo; Bulut, Haydar; Hayashi, Hironori; Tsuji, Kohei; Ogata-Aoki, Hiromi; Kiso, Maki; Takamune, Nobutoki; Kishimoto, Naoki; Hattori, Shin-ichiro; Ishii, Takahiro; Kobayakawa, Takuya; Nakano, Kenta; Shimizu, Yukiko; Das, Debananda; Saruwatari, Junji; Hasegawa, Kazuya; Murayama, Kazutaka; Sukenaga, Yoshikazu; Takamatsu, Yuki; Yoshimura, Kazuhisa; Aoki, Manabu; Furusawa, Yuri; Okamura, Tadashi; Yamayoshi, Seiya; Kawaoka, Yoshihiro; Misumi, Shogo; Tamamura, Hirokazu; Mitsuya, Hiroaki
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收藏Structural and virologic mechanism of the emergence of resistance to M pro inhibitors in SARS-CoV-2
Hattori, Shin-ichiro; Bulut, Haydar; Hayashi, Hironori; Kishimoto, Naoki; Takamune, Nobutoki; Hasegawa, Kazuya; Furusawa, Yuri; Yamayoshi, Seiya; Murayama, Kazutaka; Tamamura, Hirokazu; Li, Mi; Wlodawer, Alexander; Kawaoka, Yoshihiro; Misumi, Shogo; Mitsuya, Hiroaki
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收藏Structural analyses of the GI.4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies
Kimura-Someya, Tomomi; Katsura, Kazushige; Kato-Murayama, Miyuki; Hosaka, Toshiaki; Uchikubo-Kamo, Tomomi; Ihara, Kentaro; Hanada, Kazuharu; Sato, Shin; Murayama, Kazutaka; Kataoka, Michiyo; Shirouzu, Mikako; Someya, Yuichi
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收藏Helix-based screening with structure prediction using artificial intelligence has potential for the rapid development of peptide inhibitors targeting class I viral fusion
Suzuki, Satoshi; Kuroda, Mio; Aoki, Keisuke; Kawaji, Kumi; Hiramatsu, Yoshiki; Sasano, Mina; Nishiyama, Akie; Murayama, Kazutaka; Kodama, Eiichi N.; Oishi, Shinya; Hayashi, Hironori
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收藏GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants
Aoki, Manabu; Aoki-Ogata, Hiromi; Bulut, Haydar; Hayashi, Hironori; Takamune, Nobutoki; Kishimoto, Naoki; Tanaka, Hiroki; Higashi-Kuwata, Nobuyo; Hattori, Shin-ichiro; Das, Debananda; Rao, Kalapala Venkateswara; Iwama, Kazuya; Davis, David A.; Hasegawa, Kazuya; Murayama, Kazutaka; Yarchoan, Robert; Ghosh, Arun K.; Pau, Alice K.; Machida, Shinichi; Misumi, Shogo; Mitsuya, Hiroaki
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收藏Autocitrullination and Changes in the Activity of Peptidylarginine Deiminase 3 Induced by High Ca2+ Concentrations
Sawata, Mizuki; Shima, Hiroki; Murayama, Kazutaka; Matsui, Toshitaka; Igarashi, Kazuhiko; Funabashi, Kazumasa; Ite, Kenji; Kizawa, Kenji; Takahara, Hidenari; Unno, Masaki
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收藏Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors
Makino, Yuko; Oe, Chihiro; Iwama, Kazuya; Suzuki, Satoshi; Nishiyama, Akie; Hasegawa, Kazuya; Okuda, Haruka; Hirata, Kazushige; Ueno, Mariko; Kawaji, Kumi; Sasano, Mina; Usui, Emiko; Hosaka, Toshiaki; Yabuki, Yukako; Shirouzu, Mikako; Katsumi, Makoto; Murayama, Kazutaka; Hayashi, Hironori; Kodama, Eiichi N.
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收藏Conformational alterations in unidirectional ion transport of a light-driven chloride pump revealed using X-ray free electron lasers
Hosaka, Toshiaki; Nomura, Takashi; Kubo, Minoru; Nakane, Takanori; Luo Fangjia; Sekine, Shun-ichi; Ito, Takuhiro; Murayama, Kazutaka; Ihara, Kentaro; Ehara, Haruhiko; Kashiwagi, Kazuhiro; Katsura, Kazushige; Akasaka, Ryogo; Hisano, Tamao; Tanaka, Tomoyuki; Tanaka, Rie; Arima, Toshi; Yamashita, Ayumi; Sugahara, Michihiro; Naitow, Hisashi; Matsuura, Yoshinori; Yoshizawa, Susumu; Tono, Kensuke; Owada, Shigeki; Nureki, Osamu; Kimura-Someya, Tomomi; Iwata, So; Nango, Eriko; Shirouzu, Mikako
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收藏Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
Shimizu, Kanako; Iyoda, Tomonori; Sanpei, An; Nakazato, Hiroshi; Okada, Masahiro; Ueda, Shogo; Kato-Murayama, Miyuki; Murayama, Kazutaka; Shirouzu, Miyako; Harada, Naoko; Hidaka, Michihiro; Fujii, Shin-ichiro
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收藏Anthocyanin 5,3′-aromatic acyltransferase from Gentiana triflora, a structural insight into biosynthesis of a blue anthocyanin
Murayama, Kazutaka; Kato-Murayama, Miyuki; Sato, Tomohiro; Hosaka, Toshiaki; Ishiguro, Kanako; Mizuno, Takayuki; Kitao, Kazunori; Honma, Teruki; Yokoyama, Shigeyuki; Tanaka, Yoshikazu; Shirouzu, Mikako
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收藏A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Hattori, Shin-ichiro; Higashi-Kuwata, Nobuyo; Hayashi, Hironori; Allu, Srinivasa Rao; Raghavaiah, Jakka; Bulut, Haydar; Das, Debananda; Anson, Brandon J.; Lendy, Emma K.; Takamatsu, Yuki; Takamune, Nobutoki; Kishimoto, Naoki; Murayama, Kazutaka; Hasegawa, Kazuya; Li, Mi; Davis, David A.; Kodama, Eiichi N.; Yarchoan, Robert; Wlodawer, Alexander; Misumi, Shogo; Mesecar, Andrew D.; Ghosh, Arun K.; Mitsuya, Hiroaki
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