未登录A Strategy for Simultaneous Engineering of Interspecies Cross-Reactivity, Thermostability, and Expression of a Bispecific 5T4 x CD3 DART® Molecule for Treatment of Solid Tumors
Huang, Renhua R.; Spliedt, Michael; Kaufman, Tom; Gorlatov, Sergey; Barat, Bhaswati; Shah, Kalpana; Gill, Jeffrey; Stahl, Kurt; Dichiara, Jennifer; Wang, Qian; Li, Jonathan C.; Alderson, Ralph; Moore, Paul A.; Brown, Jennifer G.; Tamura, James; Zhang, Xiaoyu; Bonvini, Ezio; Diedrich, Gundo .png)
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收藏Preclinical development of MGC028, an ADAM9-targeted, glycan-linked, exatecan-based antibody-drug conjugate for the treatment of solid cancersScribner, Juniper A.; Brown, Jennifer G.; Son, Thomas; Jin, Linda; McKenzie, Carroll; Nam, Viktoriya; Bush, Curtis; Quinonez, Dienis; Ford, Delta; Gonzalez, Verlene; Tamura, James; Gorlatov, Sergey; Li, Hua; Butler, Shelley; Bonvini, Ezio; Loo, Deryk 分享 收藏 Preclinical development of MGC026, a glycan-linked, exatecan-based antibodydrug conjugate (ADC) targeting B7-H3 for solid cancerScribner, Juniper A.; Brown, Jennifer G.; Son, Thomas; Jin, Linda; McKenzie, Carroll; Nam, Viktoriya; Bush, Curtis; Quinonez, Dienis; Tamura, James; Gorlatov, Sergey; Li, Hua; Butler, Shelley; Bonvini, Ezio; Loo, Deryk 分享 收藏 Anti-tumor activity of vobramitamab duocarmazine (MGC018), an investigational duocarmycin-based anti-B7-H3 antibody- drug conjugate (ADC), in preclinical neuroblastoma modelsBrignole, Chiara; Bensa, Veronica; Calarco, Enzo; Giusto, Elena; Ciampi, Eleonora; Perri, Patrizia; Corrias, Maria Valeria; Astigiano, Simonetta; Cilli, Michele; Loo, Deryk; Bonvini, Ezio; Pastorino, Fabio; Ponzoni, Mirco 分享 收藏 分享 收藏 Membrane raft-dependent regulation of phospholipase Cγ-1 activation in T lymphocytesVerí, MC; DeBell, KE; Seminario, MC; DiBaldassarre, A; Reischl, I; Rawat, R; Graham, L; Noviello, C; Rellahan, BL; Miscia, S; Wange, RL; Bonvini, E 分享 收藏 Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing TumorsScribner, Juniper A.; Hicks, Stuart W.; Sinkevicius, Kerstin W.; Yoder, Nicholas C.; Diedrich, Gundo; Brown, Jennifer G.; Lucas, Jacquelynn; Fuller, Megan E.; Son, Thomas; Dastur, Anahita; Hooley, Jeff; Espelin, Christopher; Themeles, Marian; Chen, Francine Z.; Li, Ying; Chiechi, Michael; Lee, Jenny; Barat, Bhaswati; Widjaja, Lusiana; Gorlatov, Sergey; Tamura, James; Ciccarone, Valentina; Ab, Olga; McEachem, Kerry A.; Koenig, Scott; Westin, Eric H.; Moore, Paul A.; Chittenden, Thomas; Gregory, Richard J.; Bonvini, Ezio; Loo, Deryk 分享 收藏 分享 收藏 Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART MoleculeBerezhnoy, Alexey; Sumrow, Bradley J.; Stahl, Kurt; Shah, Kalpana; Liu, Daorong; Li, Jonathan; Hao, Su-Shin; De Costa, Anushka; Kaul, Sanjeev; Bendell, Johanna; Cote, Gregory M.; Luke, Jason J.; Sanborn, Rachel E.; Sharma, Manish R.; Chen, Francine; Li, Hua; Diedrich, Gundo; Bonvini, Ezio; Moore, Paul A. 分享 收藏 Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid CancerScribner, Juniper A.; Brown, Jennifer G.; Son, Thomas; Chiechi, Michael; Li, Pam; Sharma, Sharad; Li, Hua; De Costa, Anushka; Li, Ying; Chen, Yan; Easton, Ann; Yee-Toy, Nicholas C.; Chen, Francine Z.; Gorlatov, Sergey; Barat, Bhaswati; Huang, Ling; Wolff, Christina R.; Hooley, Jeff; Hotaling, Tim E.; Gaynutdinov, Timur; Ciccarone, Valentina; Tamura, James; Koenig, Scott; Moore, Paul A.; Bonvini, Ezio; Loo, Deryk 分享 收藏 A phase I, first-in-human, open-label, dose escalation study of MGD019, an investigational bispecific PD-1 x CTLA-4 DART® molecule in patients with advanced solid tumoursSharma, M.; Sanborn, R. E.; Cote, G. M.; Bendell, J. C.; Kaul, S.; Chen, F.; Berezhnoy, A.; Moore, P.; Bonvini, E.; Sumrow, B. J.; Luke, J. J. 分享 收藏 MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3, exhibits immunomodulatory activity and enhanced antitumor activity in combination with checkpoint inhibitorsScribner, Juniper A.; Chiechi, Michael; Li, Pam; Son, Thomas; Hooley, Jeff; Li, Ying; De Costa, Anushka; Lung, Peter; Yee-Toy, Nicholas; Chen, Francine; Barat, Bhaswati; Wolff, Christina; Ciccarone, Valentina; Tamura, James; Koenig, Scott; Bohac, Chet; Wigginton, Jon; Moore, Paul A.; Bonvini, Ezio; Loo, Deryk 分享 收藏 Investigational CD25 x CTLA-4 bispecific DART® molecule for depletion of tumor infiltrating Tregs via an enhanced Fc-dependent effector mechanismBerezhnoy, Alexey; Shah, Kalpana; Liu, Daorong; Jill, Rillema; Fieger, Claudia; Smith, Douglas; Chen, Francine; Tamura, James; Bonvini, Ezio; Diedrich, Gundo; Moore, Paul A. 分享 收藏 Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal CancerMoore, Paul A.; Shah, Kalpana; Yang, Yinhua; Alderson, Ralph; Roberts, Penny; Long, Vatana; Liu, Daorong; Li, Jonathan C.; Burke, Steve; Ciccarone, Valentina; Li, Hua; Fieger, Claudia B.; Hooley, Jeff; Easton, Ann; Licea, Monica; Gorlatov, Sergey; King, Kathy L.; Young, Peter; Adami, Arash; Loo, Deryk; Chichili, Gurunadh R.; Liu, Liqin; Smith, Douglas H.; Brown, Jennifer G.; Chen, Francine Z.; Koenig, Scott; Mather, Jennie; Bonvini, Ezio; Johnson, Syd 分享 收藏 Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancerScribner, Juniper A.; Brown, Jennifer G.; Sharma, Sharad; Li, Hua; Chiechi, Michael; Li, Pam; Son, Thomas; De Costa, Anushka; Chen, Yan; Chen, Francine; Barat, Bhaswati; Huang, Ling; Wolff, Christina; Hooley, Jeff; Hotaling, Tim E.; Gaynutdinov, Timur; Ciccarone, Valentina; Tamura, James; Koenig, Scott; Johnson, Syd; Moore, Paul A.; Bonvini, Ezio; Loo, Deryk 分享 收藏 Immunotherapy of colorectal cancer by the T-cell targeted DART® protein MGD007: Cellular mechanisms of actionMoore, Paul A.; Yang, Yinhua; Shah, Kalpana; Liu, Daorong; Long, Vatana; Smith, Douglas H.; Pan, Zhuangyu; Alderson, Ralph; Liu, Liqin; Johnson, Syd; Bonvini, Ezio 分享 收藏 Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasmsCircosta, Paola; Elia, Angela Rita; Landra, Indira; Machiorlatti, Rodolfo; Todaro, Maria; Aliberti, Sabrina; Brusa, Davide; Deaglio, Silvia; Chiaretti, Sabina; Bruna, Riccardo; Gottardi, Daniela; Massaia, Massimo; Di Giacomo, Filomena; Guarini, Anna Rita; Foa, Robin; Kyriakides, Peter W.; Bareja, Rohan; Elemento, Olivier; Chichili, Gurunadh R.; Monteleone, Emanuele; Moore, Paul A.; Johnson, Syd; Bonvini, Ezio; Cignetti, Alessandro; Inghirami, Giorgio 分享 收藏 Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumorsScribner, Juniper A.; Barat, Bhaswati; Hicks, Stuart W.; Yoder, Nicholas C.; Son, Thomas; Widjaja, Lusiana; Diedrich, Gundo; Gorlatov, Sergey; Hooley, Jeff; Easton, Ann; Lung, Peter; De Costa, Anushka; Chen, Francine; Chiechi, Michael; Li, Pam; Licea, Monica; Hotaling, Timothy E.; Spliedt, Michael; Ciccarone, Valentina; Gantt, Nadia; Tamura, James; Fuller, Megan E.; McShea, Molly; Koenig, Scott; Johnson, Syd; Moore, Paul A.; Bonvini, Ezio; Loo, Deryk 分享 收藏 Co-targeting of PD-1 and CTLA-4 inhibitory pathways with bispecific DART® and TRIDENT™ moleculesChichili, Gurunadh R.; Shah, Kalpana; La Motte-Mohs, Ross; Berezhnoy, Alex; Liu, Daorong; Hill, Jessica; He, Leilei; Shoemaker, Christine; Brown, Jennifer; Stahl, Kurt; Li, Hua; Li, Jonathan; Gorlatov, Sergey; Tamura, Jim; Ciccarone, Valentina; Alderson, Ralph; Bonvini, Ezio; Moore, Paul A.; Johnson, Syd 分享 收藏 A 5T4 x CD3 bispecific DART® molecule with extended half-life for T-cell immunotherapy of cancersHuang, Ling; Chichili, Gurunadh; Alderson, Ralph; Chen, Francine; Brown, Jennifer; Li, Hua; Ciccarone, Valentina; Tamura, Jim; Liu, Daorong; Liu, Liqin; Johnson, Syd; Bonvini, Ezio; Moore, Paul 分享 收藏 
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