Jochen Schacht - Publications, H-index & Citations

Jochen Schacht

Kresge Hearing Research Institute

75H指数

335论文数

1.7W被引数

收录论文 32

发表时间

Correction: Histone deacetylase inhibitors are protective in acute but not in chronic models of ototoxicity 更正：组蛋白去乙酰化酶抑制剂在急性但非慢性耳毒性模型中具有保护作用。

Frontiers in Cellular Neuroscience

IF4

2026-04-03

OAAI

CY Chao-Hui Yang; ZL Zhiqi Liu; DD Deanna Dong; JS Jochen Schacht; DA Dev Arya; SS Su-Hua Sha

An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity

CHEMMEDCHEM

IF3.4

2020-10-23

OAAI

Sonousi, Amr; Quirke, Jonathan C. K.; Waduge, Prabuddha; Janusic, Tanja; Gysin, Marina; Haldimann, Klara; Xu, Shan; Hobbie, Sven N.; Sha, Su-Hua; Schacht, Jochen; Chow, Christine S.; Vasella, Andrea; Boettger, Erik C.; Crich, David

Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-12-02

OAAI

Quirke, Jonathan C. K.; Rajasekaran, Parasuraman; Sarpe, Vikram; Sonousi, Amr; Osinnii, Ivan; Gysin, Marina; Haldimann, Klara; Fang, Qiao-Jun; Shcherbakov, Dimitri; Hobbie, Sven N.; Sha, Su-Hua; Schacht, Jochen; Vasella, Andrea; Boettger, Erik C.; Crich, David

Auditory metabolomics, an approach to identify acute molecular effects of noise trauma

SCIENTIFIC REPORTS

IF3.9

2019-06-25

OAAI

Ji, Lingchao; Lee, Ho-Joon; Wan, Guoqiang; Wang, Guo-Peng; Zhang, Li; Sajjakulnukit, Peter; Schacht, Jochen; Lyssiotis, Costas A.; Corfas, Gabriel

Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-02-22

OAAI

Matsushita, Takahiko; Sati, Girish C.; Kondasinghe, Nuwan; Pirrone, Michael G.; Kato, Takayuki; Waduge, Prabuddha; Kumar, Harshitha Santhosh; Sanchon, Adrian Cortes; Dobosz-Bartoszek, Malgorzata; Shcherbakov, Dimitri; Juhas, Mario; Hobbie, Sven N.; Schrepfer, Thomas; Chow, Christine S.; Polikanov, Yury S.; Schacht, Jochen; Vasella, Andrea; Bottger, Erik C.; Crich, David

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations

EMBO REPORTS

IF6.2

2018-09-20

OAAI

Akbergenov, Rashid; Duscha, Stefan; Fritz, Ann-Kristina; Juskeviciene, Reda; Oishi, Naoki; Schmitt, Karen; Shcherbakov, Dimitri; Teo, Youjin; Boukari, Heithem; Freihofer, Pietro; Isnard-Petit, Patricia; Oettinghaus, Bjorn; Frank, Stephan; Thiam, Kader; Rehrauer, Hubert; Westhof, Eric; Schacht, Jochen; Eckert, Anne; Wolfer, David; Bottger, Erik C.

Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics

ACS INFECTIOUS DISEASES

IF3.8

2018-04-30

OAAI

Sonousi, Amr; Sarpe, Vikram A.; Brilkova, Margarita; Schacht, Jochen; Vasella, Andrea; Boettger, Erik C.; Crich, David

Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

FRONTIERS IN CELLULAR NEUROSCIENCE

IF4

2017-10-24

OAAI

Yang, Chao-Hui; Liu, Zhiqi; Dong, Deanna; Schacht, Jochen; Arya, Dev; Sha, Su-Hua

Emerging therapeutic interventions against noise-induced hearing loss

EXPERT OPINION ON INVESTIGATIONAL DRUGS

IF4.1

2016-12-14

103

OAAI

Sha, Su-Hua; Schacht, Jochen

Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics

NUCLEIC ACIDS RESEARCH

IF13.1

2015-08-11

OAAI

Shalev, Moran; Rozenberg, Haim; Smolkin, Boris; Nasereddin, Abedelmajeed; Kopelyanskiy, Dmitry; Belakhov, Valery; Schrepfer, Thomas; Schacht, Jochen; Jaffe, Charles L.; Adir, Noam; Baasov, Timor

XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death

CELL DEATH & DISEASE

IF9.6

2015-05-14

OAAI

Oishi, N.; Duscha, S.; Boukari, H.; Meyer, M.; Xie, J.; Wei, G.; Schrepfer, T.; Roschitzki, B.; Boettger, E. C.; Schacht, J.

Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics

MBIO

IF4.7

2014-10-31

OAAI

Duscha, Stefan; Boukari, Heithem; Shcherbakov, Dimitri; Salian, Sumantha; Silva, Sandrina; Kendall, Ann; Kato, Takayuki; Akbergenov, Rashid; Perez-Fernandez, Deborah; Bernet, Bruno; Vaddi, Swapna; Thommes, Pia; Schacht, Jochen; Crich, David; Vasella, Andrea; Boettger, Erik C.

Synthetic Aminoglycosides Efficiently Suppress Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations and Are Enhanced by Ivacaftor

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2014-04-01

145

OAAI

Xue, Xiaojiao; Mutyam, Venkateshwar; Tang, Liping; Biswas, Silpak; Du, Ming; Jackson, Laura A.; Dai, Yanying; Belakhov, Valery; Shalev, Moran; Chen, Fuquan; Schacht, Jochen; Bridges, Robert J.; Baasov, Timor; Hong, Jeong; Bedwell, David M.; Rowe, Steven M.

Designer Aminoglycosides That Selectively Inhibit Cytoplasmic Rather than Mitochondrial Ribosomes Show Decreased Ototoxicity A STRATEGY FOR THE TREATMENT OF GENETIC DISEASES

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-01-01

OAAI

Shulman, Eli; Belakhov, Valery; Wei, Gao; Kendall, Ann; Meyron-Holtz, Esther G.; Ben-Shachar, Dorit; Schacht, Jochen; Baasov, Timor

Alleles that modulate late life hearing in genetically heterogeneous mice

NEUROBIOLOGY OF AGING

IF3.5

2012-08-01

OAAI

Schacht, Jochen; Altschuler, Richard; Burke, David T.; Chen, Shu; Dolan, David; Galecki, Andrzej T.; Kohrman, David; Miller, Richard A.

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-06-14

185

OAAI

Matt, Tanja; Ng, Chyan Leong; Lang, Kathrin; Sha, Su-Hua; Akbergenov, Rashid; Shcherbakov, Dmitri; Meyer, Martin; Duscha, Stefan; Xie, Jing; Dubbaka, Srinivas R.; Perez-Fernandez, Deborah; Vasella, Andrea; Ramakrishnan, V.; Schacht, Jochen; Boettger, Erik C.

Antioxidant-enriched diet does not delay the progression of age-related hearing loss

NEUROBIOLOGY OF AGING

IF3.5

2012-05-01

OAAI

Sha, Su-Hua; Kanicki, Ariane; Halsey, Karin; Wearne, Kimberly Anne; Schacht, Jochen

Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice

AGING CELL

IF7.1

2011-02-01

OAAI

Miller, Richard A.; Dolan, David; Han, Melissa; Kohler, William; Schacht, Jochen

Development of Novel Aminoglycoside (NB54) with Reduced Toxicity and Enhanced Suppression of Disease-Causing Premature Stop Mutations

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2009-03-23

175

OAAI

Nudelman, Igor; Rebibo-Sabbah, Annie; Cherniavsky, Marina; Belakhov, Valery; Hainrichson, Mariana; Chen, Fuquan; Schacht, Jochen; Pilch, Daniel S.; Ben-Yosef, Tamar; Baasov, Timor

Preparation of liposomes with asymmetric distribution of phosphatidylinositol 4,5-bisphosphate across the bilayer

JOURNAL OF LIPOSOME RESEARCH

IF4.3

2008-09-28

PREAI

Vardhanabhuti, N; Ramachandran, C; Schacht, J; Weiner, N

研究方向