未登录 Development of conditionally active IL-10 INDUKINE TM molecules for the treatment of inflammatory bowel disease Sullivan, Jenna; Aderhold, Pamela; Brodkin, Heather; Nagy-Domonkos, Celesztina; Economides, Kyriakos; Hicklin, Daniel; Lewis, Yuka; Magness, Leigh; Siedel-Dugan, Cynthia; Steuert, Zoe; Stieglitz, Jessica; Winston, William; Salmerson, Andres 分享 收藏
Discovery of WTX-518, an IL-18 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models Morris, Kristin R.; Brodkin, Heather; Economides, Kyriakos; Hicklin, Daniel J.; LePrevost, Julie; Nagy-Domonkos, Celesztina; Nirschl, Christopher; Salmeron, Andres; Seidel-Dugan, Cynthia; Spencer, Cierra; Steuert, Zoe; Winston, William M. 分享 收藏
WTX-712, a conditionally active IL-21 INDUKINETM molecule, induces a strong anti-tumor phenotype through a differentiated mechanism Sullivan, Jenna M.; Aderhold, Pamela A.; Brodkin, Heather R.; Nagy-Domonkos, Celesztina; Economides, Kyriakos; Hicklin, Daniel J.; Ismail, Nesreen; Lewis, Yuka; Seidel-Dugan, Cynthia; Winston, William M.; Salmeron, Andres 分享 收藏
Discovery of WTX-330, a clinical stage conditionally activated IL-12 INDUKINE™ therapeutic with potent antitumor activity in murine syngeneic tumor models resistant to checkpoint blockade Nirschl, Christopher J.; Brodkin, Heather R.; Chopra, Sameer S.; Dwyer, Connor J.; Hicklin, Daniel J.; Isaacs, Randi; Ismail, Nesreen; Seidel-Dugan, Cynthia; Steuert, Zoe; Sullivan, Jenna M.; Winston, William M.; Salmeron, Andres 分享 收藏
Generation of IL-21 INDUKINE™ molecules for the treatment of cancer Sullivan, Jenna M.; Aderhold, Pamela A.; Brodkin, Heather R.; Economides, Kyriakos; Hicklin, Daniel J.; Ismail, Nesreen; Lewis, Yuka; Seidel-Dugan, Cynthia; Spencer, Cierra; Winston, William M.; Salmeron, Andres 分享 收藏
WTX-613, (JZP898) a selectively activated IFNα INDUKINE™ molecule, reprograms the tumor microenvironment and generates robust anti-tumor immunity as a monotherapy and in combination with checkpoint inhibitors Nirschl, Christopher J.; Brodkin, Heather R.; Domonkos, Celesztina; Economides, Kyriakos; Hicklin, Daniel J.; Ismail, Nesreen; Seidel-Dugan, Cynthia; Steiner, Philipp; Steuert, Zoe; Winston, William M.; Salmeron, Andres 分享 收藏
MWTX-330, AN IL-12 INDUKINE MOLECULE, SELECTIVELY ACTIVATES TUMOR INFILTRATING LYMPHOCYTES AND REPROGRAMS THE TUMOR MICROENVIRONMENT IN MURINE SYNGENEIC TUMOR MODELS Nirschl, Christopher; Brodkin, Heather; Dwyer, Connor; Hicklin, Daniel; Ismail, Nesreen; Domonkos, Celesztina; Seidel-Dugan, Cynthia; Steiner, Philipp; Steuert, Zoe; Sullivan, Jenna; Winston, William; Salmeron, Andres 分享 收藏
The discovery and characterization of PTZ-201, a fully-human, high affinity, antagonistic anti-TIGIT monoclonal antibody Abbott, Sandra; Anderson, Ana C.; Brodkin, Heather; Hicklin, Daniel J.; Ismail, Nesreen; Nielson, Nels; Nirschl, Christopher; Salmeron, Andres; Seidel-Dugan, Cynthia; Steiner, Philipp; Winston, William 分享 收藏
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors Bogen, Stephane L.; Pan, Weidong; Gibeau, Craig R.; Lahue, Brian R.; Ma, Yao; Nair, Latha G.; Seigel, Elise; Shipps, Gerald W., Jr.; Tian, Yuan; Wang, Yaolin; Lin, Yinghui; Liu, Ming; Liu, Suxing; Mirza, Asra; Wang, Xiaoying; Lipar, Philip; Seidel-Dugan, Cynthia; Hicklin, Daniel J.; Bishop, W. Robert; Rindgen, Diane; Nomeir, Amin; Prosise, Winifred; Reichert, Paul; Scapin, Giovanna; Strickland, Corey; Doll, Ronald J. 分享 收藏
Discovery of a Novel ERK Inhibitor with Activity in Models of Acquired Resistance to BRAF and MEK Inhibitors 在对BRAF和MEK抑制剂的获得性耐药模型中发现具有活性的新型ERK抑制剂 Morris, Erick J.; Jha, Sharda; Restaino, Clifford R.; Dayananth, Priya; Zhu, Hugh; Cooper, Alan; Carr, Donna; Deng, Yongi; Jin, Weihong; Black, Stuart; Long, Brian; Liu, Jenny; DiNunzio, Edward; Windsor, William; Zhang, Rumin; Zhao, Shuxia; Angagaw, Minilik H.; Pinheiro, Elaine M.; Desai, Jagdish; Xiao, Li; Shipps, Gerald; Hruza, Alan; Wang, James; Kelly, Joe; Paliwal, Sunil; Gao, Xiaolei; Babu, Boga Sobhana; Zhu, Liang; Daublain, Pierre; Zhang, Ling; Lutterbach, Bart A.; Pelletier, Marc R.; Philippar, Ulrike; Siliphaivanh, Phieng; Witter, David; Kirschmeier, Paul; Bishop, W. Robert; Hicklin, Daniel; Gilliland, D. Gary; Jayaraman, Lata; Zawel, Leigh; Fawell, Stephen; Samatar, Ahmed A. 分享 收藏
Discovery of a novel HDM2 inhibitor with potent in vivo anti-tumor activity Wang, Yaolin; Lipari, Philip; Mirza, Asra; Lin, Yinghui; Zhang, Rumin; Bogen, Stephane; Bogen, Stephane; Ma, Yao; Hicklin, Daniel J.; Seidel-Dugan, Cynthia; Liu, Suxing; Wang, Xiaoying; Doll, Ronald; Shipps, Gerald; Bishop, Walter Robert 分享 收藏
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TMPRSS2-ERG gene fusion sensitizes VCaP human prostate tumors to the fully human anti-IGF-IR monoclonal antibody SCH 717454 Long, Brian J.; Groothuis, Patrick; Taylor, Stacey; Liu, Gongjie; Terracina, Gaby; Liu, Ming; Layerty, Maureen; Gustafson, Eric L.; Wang, Yaolin; Wang, Yan; Seidel-Dugan, Cynthia; Hicklin, Daniel 分享 收藏
SCH 2047069, a Novel Oral Kinesin Spindle Protein Inhibitor, Shows Single-Agent Antitumor Activity and Enhances the Efficacy of Chemotherapeutics Basso, Andrea D.; Liu, Ming; Dai, Chaoyang; Gray, Kimberly; Nale, Lissette; Tevar, Seema; Lee, Suining; Liang, Lianzhu; Ponery, Abdul; Yaremko, Bohdan; Smith, Elizabeth; Tang, Huadong; Sheth, Payal R.; Siddiqui, M. Arshad; Hicklin, Daniel J.; Kirschmeier, Paul 分享 收藏
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Cetuximab-induced anaphylaxis and IgE specific for galactose-α-1,3-galactose 西妥昔单抗诱导的过敏反应和对半乳糖-α-1，3-半乳糖特异性的IgE Chung, Christine H.; Mirakhur, Beloo; Chan, Emily; Le, Quynh-Thu; Berlin, Jordan; Morse, Michael; Murphy, Barbara A.; Satinover, Shama M.; Hosen, Jacob; Mauro, David; Slebos, Robbert J.; Zhou, Qinwei; Gold, Diane; Hatley, Tina; Hicklin, Daniel J.; Platts-Mills, Thomas A. E. 分享 收藏
Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system Stoeltzing, Oliver; Liu, Wenbiao; Fan, Fan; Wagner, Christine; Stengel, Kathrin; Somcio, Ray J.; Reinmuth, Niels; Parikh, Alexander A.; Hicklin, Daniel J.; Ellis, Lee M. 分享 收藏
Effect of molecular therapeutics on liver regeneration in a murine model Van Buren, George, II; Yang, Anthony D.; Dallas, Nikolaos A.; Gray, Michael J.; Lim, Sherry J.; Xia, Ling; Fan, Fan; Wn, Yan; Hicklin, Daniel J.; Ellis, Lee M. 分享 收藏
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