未登录 T-type calcium channels regulate medulloblastoma and can be targeted for therapy T型钙通道调节髓母细胞瘤，可作为靶向治疗 Dube, Collin J.; Lai, Michelle; Zhang, Ying; Saha, Shekhar; Yener, Ulas; Hanif, Farina; Hudson, Kadie; Gibert Jr, Myron K.; Marcinkiewicz, Pawel; Sun, Yunan; Vegiraju, Tanvika; Xu, Esther; Sorot, Aditya; Gallagher, Rosa I.; Wulfkuhle, Julia D.; Vernon, Ashley; Dell'Olio, Lily; Anbu, Rajitha; Mulcahy, Elizabeth; Kefas, Benjamin; Guessous, Fadila; Petricoin, Emanuel F.; Abounader, Roger 分享 收藏
Targeted Dynamic Phospho-Proteogenomic Analysis of Gastric Cancer Cells Suggests Host Immunity Provides Survival Benefit 胃癌细胞的靶向动态磷酸化蛋白质组学分析表明宿主免疫可提供生存益处 Kume, Kohei; Iida, Midori; Iwaya, Takeshi; Yashima-Abo, Akiko; Koizumi, Yuka; Endo, Akari; Wade, Kaitlin; Hiraki, Hayato; Calvert, Valerie; Wulfkuhle, Julia; Espina, Virginia; Siwak, Doris R.; Lu, Yiling; Takemoto, Kazuhiro; Suzuki, Yutaka; Sasaki, Yasushi; Tokino, Takashi; Petricoin Iii, Emanuel; Liotta, Lance A.; Mills, Gordon B.; Nishizuka, Satoshi S. 分享 收藏
Clinical and immune responses to neoadjuvant fulvestrant with or without enzalutamide in ER+/Her2- breast cancer Elias, Anthony D.; Staley, Alyse W.; Fornier, Monica; Vidal, Gregory A.; Alami, Vida; Sams, Sharon; Spoelstra, Nicole S.; Goodspeed, Andrew; Kabos, Peter; Diamond, Jennifer R.; Shagisultanova, Elena; Gallagher, Rosa I.; Wulfkuhle, Julia D.; Petricoin, Emanuel F.; Zolman, Kathryn L.; McSpadden, Tessa; Jordan, Kimberly R.; Slansky, Jill E.; Borges, Virginia F.; Gao, Dexiang; Richer, Jennifer K. 分享 收藏
PDAC tumors from patients treated with combination MEK and autophagy inhibition reveal a treatment sensitive epithelial subtype that is enriched in murine models Labadie, Brian W.; Obradovic, Aleksandar Z.; Ana, Sarah Sta; May, Michael; Sender, Naomi; Ross, Isabelle V.; Rodriguez-Mendez, Monica; Wasko, Urszula; Tomassoni, Lorenzo; Li, Li; Vij, Manan; Abuzaid, Sinan; Wulfkuhle, Julia; Wong, Winston; Pellicciotta, Ilenia; Izar, Benjamin; Petricoin, Emanuel F.; Tan, Aik Choon; Olive, Kenneth P.; Raufi, Alex G.; Manji, Gulam A. 分享 收藏
Investigating mechanisms of tumor eradication by blocking SIAH E3 ligase, a major tumor vulnerability, in EGFR/RAS-driven human cancer Baker, Jonathan M.; Howell, Andrew; Hannah, Ashleigh; Wulfkuhle, Julia; Stahr, Natalie; Gallagher, Rosa; Petricoin, Emanuel; Tang, Amy 分享 收藏
p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs Grit, Jamie L.; Mcgee, Lauren E.; Tovar, Elizabeth A.; Essenburg, Curt J.; Wolfrum, Emily; Beddows, Ian; Williams, Kaitlin; Sheridan, Rachael T. C.; Schipper, Joshua L.; Adams, Marie; Arumugam, Menusha; Vander Woude, Thomas; Gurunathan, Sharavana; Field, Jeffrey M.; Wulfkuhle, Julia; Petricoin, Emanuel F.; Graveel, Carrie R.; Steensma, Matthew R. 分享 收藏
Global and TNBC-specific biomarkers of sensitivity and resistance in early stage breast cancer from the I-SPY2 biomarker data compendium Bui, Tam Binh V.; Wolf, Denise M.; Gallagher, Rosa I.; Wulfkuhle, Julia; Yau, Christina; Brown-Swigart, Lamorna; Rosenbluth, Jennifer; Yee, Douglas; Hirst, Gillian L.; Esserman, Laura J.; Petricoin, Emanuel F.; Van't Veer, Laura J. 分享 收藏
IGF-1R protein pathway activation is associated with pathologic complete response to an anti-IGF-1R regimen (paclitaxel, ganitumab, and metformin) in the I-SPY2 neoadjuvant breast cancer trial Petricoin, Emanuel F.; Wolf, Denise M.; Yau, Christina; Wulfkuhle, Julia; Veer, Laura van T.; Gallagher, Rosa I.; Hirst, Gillian L.; Brown-Swigart, Lamorna; Esserman, Laura J.; Yee, Douglas 分享 收藏
An alternative to HER2 IHC 0/1+/2+status to predict which clinically HER2-negative patients will respond to anti-HER2 therapies: A rationale for the likely superiority of quantitative HER2 pathway RPPA measurements Wulfkuhle, Julia; Wolf, Denise M.; DeMichele, Angela; Yau, Christina; Veer, Laura van T.; Rugo, Hope S.; Pusztai, Lajos; Brown-Swigart, Lamorna; Hirst, Gillian L.; Gallagher, Rosa I.; Delson, Amy L.; Borowsky, Alexander D.; Esserman, Laura J.; Pohlmann, Paula R.; Petricoin, Emanuel F. 分享 收藏
Protein signaling and drug target activation signatures to guide therapy prioritization: Therapeutic resistance and sensitivity in the I-SPY 2 Trial 蛋白质信号和药物靶标激活特征以指导治疗优先顺序: i-spy 2试验中的治疗抗性和敏感性 Gallagher, Rosa I.; Wulfkuhle, Julia; Wolf, Denise M.; Brown-Swigart, Lamorna; Yau, Christina; O'Grady, Nicholas; Basu, Amrita; Lu, Ruixiao; Campbell, Michael J.; Magbanua, Mark J.; Coppe, Jean-Philippe; Asare, Smita M.; Sit, Laura; Matthews, Jeffrey B.; Perlmutter, Jane; Hylton, Nola; Liu, Minetta C.; Symmans, W. Fraser; Rugo, Hope S.; Isaacs, Claudine; Demichele, Angela M.; Yee, Douglas; Pohlmann, Paula R.; Hirst, Gillian L.; Esserman, Laura J.; van 't Veer, Laura J.; Petricoin, Emanuel F. 分享 收藏
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance Zahavi, David J.; Erbe, Rossin; Zhang, Yong-Wei; Guo, Theresa; Malchiodi, Zoe X.; Maynard, Rachael; Lekan, Alexander; Gallagher, Rosa; Wulfkuhle, Julia; Petricoin, Emanuel; Jablonski, Sandra A.; Fertig, Elana J.; Weiner, Louis M. 分享 收藏
Establishment and characterization of patient-derived xenograft of a rare pediatric anaplastic pleomorphic xanthoastrocytoma (PXA) bearing a CDC42SE2-BRAF fusion Damayanti, Nur P.; Saadatzadeh, M. Reza; Dobrota, Erika; Ordaz, Josue D.; Bailey, Barbara J.; Pandya, Pankita H.; Bijangi-Vishehsaraei, Khadijeh; Shannon, Harlan E.; Alfonso, Anthony; Coy, Kathy; Trowbridge, Melissa; Sinn, Anthony L.; Zhang, Zhong-Yin; Gallagher, Rosa I.; Wulfkuhle, Julia; Petricoin, Emanuel; Richardson, Angela M.; Marshall, Mark S.; Lion, Alex; Ferguson, Michael J.; Balsara, Karl E.; Pollok, Karen E. 分享 收藏
Phase II trial of fulvestrant plus enzalutamide in ER+/HER2- advanced breast cancer Elias, Anthony D.; Spoelstra, Nicole S.; Staley, Alyse W.; Sams, Sharon; Crump, Lyndsey S.; Vidal, Gregory A.; Borges, Virginia F.; Kabos, Peter; Diamond, Jennifer R.; Shagisultanova, Elena; Afghahi, Anosheh; Mayordomo, Jose; McSpadden, Tessa; Crawford, Gloria; D'Alessandro, Angelo; Zolman, Kathryn L.; van Bokhoven, Adrie; Zhuang, Yonghua; Gallagher, Rosa I.; Wulfkuhle, Julia D.; Petricoin III, Emanuel F.; Gao, Dexiang; Richer, Jennifer K. 分享 收藏
Hexyl-(cuban-1-yl-methyl)-biguanide (HCB) suppresses N-glycosylation of immune checkpoint proteins B7-H3 and B7-H4, reverses tumor hypoxia, decreases intratumoral regulatory T cells, and increases intratumoral CD8+T cells in the ovarian dependent ER+HER2-SSM2ucd mammary cancer allograft model Guo, Zhijun; Lei, Jianxun; Venkatesh, Hrishi; Owen, David; Bass, Adam; Cannon, Christine; McCarra, Joshua; Koniar, Brenda; Flory, Craig; Norris, Beverly; Schumacher, Robert J.; Jayaraman, Swaathi; Hawse, John; Antonarakis, Emmanuel S.; Petricoin, Emanuel F.; Wulfkuhle, Julia; Cardiff, Robert D.; Ambrose, Elizabeth A.; Georg, Gunda I.; Schwertfeger, Kaylee L.; Farrar, Michael A.; Croix, Brad St.; Goetz, Matthew P.; Potter, David A. 分享 收藏
Randomized phase II trial of preoperative fulvestrant with or without enzalutamide for ER+/Her2-breast cancer Elias, Anthony D.; Staley, Alyse; Fornier, Monica; Vidal, Gregory A.; Sams, Sharon; Spoelstra, Nicole; Kabos, Peter; Diamond, Jennifer R.; Shagisultanova, Elena; Gallagher, Rosa I.; Wulfkuhle, Julia; Petricoin, Emanuel; Zolman, Kathryn; Biller, Stephanie; Alami, Vida; McSpadden, Tessa; Borges, Virginia; Crump, Lyndsey S.; Gao, Dexiang; Richer, Jennifer K. 分享 收藏
SHP2 inhibition enhances antitumor effect of mirdametinib in a pediatric brain tumor model bearing CDC42SE2BRAF fusion by rewiring the proteome and phosphoproteome landscape Damayanti, Nur P.; Alfonso, Anthony; Ordaz, Josue D.; Dobrota, Erika; Saadatzadeh, M. Reza; Pandya, Pankita; Bailey, Barbara J.; Bijangi-Vishehsaraei, Khadijeh; Shannon, Harlan E.; Coy, Kathy; Trowbridge, Melissa; Sinn, Anthony L.; Gallager, Rosa; Wulfkuhle, Julia; Petricoin, Emanuel; Mosley, Amber; Marshall, Mark S.; Lion, Alex; Fergusson, Michael J.; Balsara, Karl; Pollok, Karen E. 分享 收藏
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Characterizing the HER2-/Immune/DNA repair (DRD-) response predictive breast cancer subtype: the hunt for new protein targets in a high-needs population with low response to all I-SPY2 agents Wolf, Denise M.; Yau, Christina; Wulfkuhle, Julia; Gallagher, Rosa I.; Swigart, Lamorna A. Brown; Hirst, Gillian L.; Coppe, Jean-Philippe; Magbanua, Mark Jesus M.; Sit, Laura; Hylton, Nola M.; DeMichele, Angela; Berry, Donald A.; Pusztai, Lajos; Yee, Douglas; Esserman, Laura J.; Petricoin, Emanuel F.; Van 't Veer, Laura 分享 收藏
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An Organoid Model System to Study Resistance Mechanisms, Predictive Biomarkers, and New Strategies to Overcome Therapeutic Resistance in Early-Stage Triple-Negative Breast Cancer Bui, Tam Binh V.; Wolf, Denise M.; Moore, Kaitlin; Harris, Isaac S.; Phadatare, Pravin; Yau, Christina; Swigart, Lamorna A. Brown; Esserman, Laura J.; Coppe, Jean-Philippe; Wulfkuhle, Julia; Petricoin, Emanuel F.; Campbell, Michael; Selfors, Laura M.; Dillon, Deborah A.; Overmoyer, Beth; Lynce, Filipa; Van 't Veer, Laura; Rosenbluth, Jennifer 分享 收藏
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