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A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients 单核和空间转录组图谱揭示了COVID-19患者肝脏中的拓扑结构、功能及再生性器官损伤 Pita-Juarez, Yered; Karagkouni, Dimitra; Kalavros, Nikolaos; Melms, Johannes C.; Niezen, Sebastian; Delorey, Toni M.; Essene, Adam L.; Brook, Olga R.; Pant, Deepti; Skelton-Badlani, Disha; Naderi, Pourya; Huang, Pinzhu; Pan, Liuliu; Hether, Tyler; Andrews, Tallulah S.; Ziegler, Carly G. K.; Reeves, Jason; Myloserdnyy, Andriy; Chen, Rachel; Nam, Andy; Phelan, Stefan; Liang, Yan; Gregory, Mark; He, Shanshan; Patrick, Michael; Rane, Tushar; Wardhani, Aster; Amin, Amit Dipak; Biermann, Jana; Hibshoosh, Hanina; Veregge, Molly; Kramer, Zachary; Jacobs, Christopher; Yalcin, Yusuf; Phillips, Devan; Slyper, Michal; Subramanian, Ayshwarya; Ashenberg, Orr; Bloom-Ackermann, Zohar; Tran, Victoria M.; Gomez, James; Sturm, Alexander; Zhang, Shuting; Fleming, Stephen J.; Warren, Sarah; Beechem, Joseph; Hung, Deborah; Babadi, Mehrtash; Padera Jr, Robert F.; Macparland, Sonya A.; Bader, Gary D.; Imad, Nasser; Solomon, Isaac H.; Miller, Eric; Riedel, Stefan; Porter, Caroline B. M.; Villani, Alexandra-Chloe; Tsai, Linus T. -Y.; Hide, Winston; Szabo, Gyongyi; Hecht, Jonathan; Rozenblatt-Rosen, Orit; Shalek, Alex K.; Izar, Benjamin; Popov, Yury V.; Jiang, Z. Gordon; Vlachos, Ioannis S. 分享 收藏
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Integrated clinical and single-cell profiling analysis reveals cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma Hajkarim, Morteza Chalabi; May, Michael; Amin, Amit Dipak; Jamison, Jacob; Tagore, Somnath; Caprio, Lindsay; Walsh, Zachary; Shah, Parin; Abuzaid, Sinan; Michel, Alissa; Sun Dajiang; Wong, Winston; Shaikh, Neha; Ramaradj, Priyanka; Bakir, Basil; Kluger, Michael D.; Chabot, John; Hibshoosh, Hanina; Rustgi, Anil K.; Raufi, Alexander; Manji, Gulam A.; Izar, Benjamin 分享 收藏
FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer 癌细胞FLT1激活促进乳腺癌PARP抑制剂耐药 Tai, Yifan; Chow, Angela; Han, Seoyoung; Coker, Courtney; Ma, Wanchao; Gu, Yifan; Navarro, Valeria Estrada; Kandpal, Manoj; Hibshoosh, Hanina; Kalinsky, Kevin; Manova-Todorova, Katia; Safonov, Anton; Walsh, Elaine M.; Robson, Mark; Norton, Larry; Baer, Richard; Merghoub, Taha; Biswas, Anup K.; Acharyya, Swarnali 分享 收藏
Fatal COVID-19 pulmonary disease involves ferroptosis Qiu, Baiyu; Zandkarimi, Fereshteh; Saqi, Anjali; Castagna, Candace; Tan, Hui; Sekulic, Miroslav; Miorin, Lisa; Hibshoosh, Hanina; Toyokuni, Shinya; Uchida, Koji; Stockwell, Brent R. 分享 收藏
Metformin Overcomes the Consequences of NKX3.1 Loss to Suppress Prostate Cancer Progression 二甲双胍克服了NKX3.1丢失的后果，从而抑制了前列腺癌的进展 Papachristodoulou, Alexandros; Heidegger, Isabel; Virk, Renu K.; Di Bernardo, Matteo; Kim, Jaime Y.; Laplaca, Caroline; Picech, Florencia; Schafer, Georg; Castro, Guarionex Joel De; Hibshoosh, Hanina; Loda, Massimo; Klocker, Helmut; Rubin, Mark A.; Zheng, Tian; Benson, Mitchell C.; Mckiernan, James M.; Dutta, Aditya; Abate-Shen, Cory 分享 收藏
Relief of chromosomal instability-induced cGAS-STING signaling sensitizes STK11-mutant non-small cell lung cancer to immune checkpoint blockade Caprio, Lindsay A.; Hong, Christy; Amin, Amit D.; Tagore, Somnath; Duran, Mercedes; Rogava, Meri; Cai, Luke; Ebel, Leon; Melms, Johannes; Hibshoosh, Hanina; Bakhoum, Samuel; Izar, Benjamin 分享 收藏
RNA- based precision medicine predicts sensitivity to selinexor in select pancreatic ductal adenocarcinoma patients Curiel-Garcia, Alvaro; Tomassoni, Lorenzo; Dalton, Tanner C.; Decker-Farrell, Amanda R.; Palermo, Carmine F.; Ross, Daniel R.; Sastra, Stephen A.; Wasko, Urszula N.; Goncalves, Isabel M.; Mundi, Prabhot; Bakir, Basil S.; Safyan, Rachael A.; Hibshoosh, Hanina; Manji, Gulam A.; Califano, Andrea; Olive, Kenneth P. 分享 收藏
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Tumor Explants Elucidate a Cascade of Paracrine SHH, WNT, and VEGF Signals Driving Pancreatic Cancer Angiosuppression 肿瘤外植体阐明了驱动胰腺癌血管抑制的旁分泌SHH，WNT和VEGF信号的级联 Hasselluhn, Marie C.; Decker-Farrell, Amanda R.; Vlahos, Lukas; Thomas, Dafydd H.; Curiel-Garcia, Alvaro; Maurer, H. Carlo; Wasko, Urszula N.; Tomassoni, Lorenzo; Sastra, Stephen A.; Palermo, Carmine F.; Dalton, Tanner C.; Ma, Alice; Li, Fangda; Tolosa, Ezequiel J.; Hibshoosh, Hanina; Fernandez-Zapico, Martin E.; Muir, Alexander; Califano, Andrea; Olive, Kenneth P. 分享 收藏
Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer 通过Rb降解和c-myc顺序激活E2F驱动乳腺癌对CDK4/6抑制剂的抗性 Kim, Sungsoo; Armand, Jessica; Safonov, Anton; Zhang, Mimi; Soni, Rajesh K.; Schwartz, Gary; McGuinness, Julia E.; Hibshoosh, Hanina; Razavi, Pedram; Kim, Minah; Chandarlapaty, Sarat; Yang, Hee Won 分享 收藏
A Transcriptome-Based Precision Oncology Platform for Patient-Therapy Alignment in a Diverse Set of Treatment-Resistant Malignancies Mundi, Prabhjot S.; Cruz, Filemon S. Dela; Grunn, Adina; Diolaiti, Daniel; Mauguen, Audrey; Rainey, Allison R.; Guillan, Kristina; Siddiquee, Armaan; You, Daoqi; Realubit, Ronald; Karan, Charles; Ortiz, Michael V.; Douglass, Eugene F.; Accordino, Melissa; Mistretta, Suzanne; Brogan, Frances; Bruce, Jeffrey N.; Caescu, Cristina I.; Carvajal, Richard D.; Crew, Katherine D.; Decastro, Guarionex; Heaney, Mark; Henick, Brian S.; Hershman, Dawn L.; Hou, June Y.; Iwamoto, Fabio M.; Jurcic, Joseph G.; Kiran, Ravi P.; Kluger, Michael D.; Kreisl, Teri; Lamanna, Nicole; Lassman, Andrew B.; Lim, Emerson A.; Manji, Gulam A.; Mckhann, Guy M.; Mckiernan, James M.; Neugut, Alfred I.; Olive, Kenneth P.; Rosenblat, Todd; Schwartz, Gary K.; Shu, Catherine A.; Sisti, Michael B.; Tergas, Ana; Vattakalam, Reena M.; Welch, Mary; Wenske, Sven; Wright, Jason D.; Canoll, Peter; Hibshoosh, Hanina; Kalinsky, Kevin; Aburi, Mahalaxmi; Sims, Peter A.; Alvarez, Mariano J.; Kung, Andrew L.; Califano, Andrea 分享 收藏
Relief of chromosomal instability-induced cGAS-STING signaling sensitizes STK11-mutant non-small cell lung cancer to immune checkpoint blockade Caprio, Lindsay A.; Hong, Christy; Amin, Amit Dipak; Tagore, Somnath; Melms, Johannes; Cai, Luke; Wang, Yiping; Ho, Patricia; Mu, Michael; Hibshoosh, Hanina; Henick, Brian; Wong, Kwok K.; Bakhoum, Samuel F.; Izar, Benjamin 分享 收藏
Multi-modal single-cell and spatial genomics reveals genomic, adaptive and microenvironmental features of human non-small cell lung cancer brain metastasis Tagore, Somnath; Caprio, Lindsay; Amin, Amit Dipak; Barrera, Irving; Melms, Johannes; Luthria, Karan; Wang, Yiping; Georgis, Yohanna; Jaiswal, Abhi; Lagos, Galina G.; Walsh, Zachary; Shah, Parin; Biermann, Jana; Sheikh, Neha; Ramaradj, Priyanka; Anandasabapathy, Niroshana; Hibshoosh, Hanina; Schwartz, Gary; Henick, Brian; Taylor, Alison; Chen, Fei; Izar, Benjamin 分享 收藏
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