李

李伯良 (Bo-Liang Li)

China Nuclear Power Engineering Co., Ltd.

H指数:32

被引数:5,766

个人简介

1979年毕业于北京大学生物系生化专业，1983年在中科院原上海生化所研究生毕业并获硕士学位。1989年晋升为副研究员，1993年特聘为研究员，1994年批准为博导。曾在美国Dartmouth医学院和New Jersey-UMDNJ从事研究。2000年至今在中科院上海生化与细胞所从事研究，首任所长（2000-2003）、研究组长、博导、研究员、学位委员（2000-2014）和学术委员。曾在中科院原上海生化所任所长（1997-2000）、常务副所长（1995-1997）、学术委员会主任（1995-2000）等职。兼任国家基金委生命科学部咨询委员会委员（2014-2020）等。

教育背景

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工作经历

暂无内容

荣誉奖项

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Development of an EAM potential for nuclear-grade Mo–Re alloys via a particle swarm optimization(PSO)-driven three-stage refinement strategy

通过粒子群优化(PSO)驱动的三阶段精炼策略开发用于核级Mo–Re合金的嵌入原子法(EAM)势

Computational Materials Science

IF3.3

2025-09-100

PRE

Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma (vol 394, pg 617, 2006)

BIOCHEMICAL JOURNAL

IF4.3

2020-12-241

Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2019-10-0123

OAAI

Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance

NATURE METABOLISM

IF20.8

2019-05-0655

PREAI

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation (vol 19, pg 808, 2017)

NATURE CELL BIOLOGY

IF19.1

2017-12-013

OAAI

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation

NATURE CELL BIOLOGY

IF19.1

2017-06-12102

OAAI

The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes

CELL REPORTS

IF6.9

2017-06-0138

OAAI

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling

MOLECULAR CELL

IF16.6

2017-04-01202

OAAI

AAV9-NPC1 significantly ameliorates Purkinje cell death and behavioral abnormalities in mouse NPC disease

JOURNAL OF LIPID RESEARCH

IF4.1

2017-03-0145

OAAI

Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

IF3.4

2016-11-271

OAAI

The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

IF3.4

2016-11-273

OAAI

Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome

CELL RESEARCH

IF25.9

2016-08-30104

OAAI

Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif

Numb通过结合YxNxxF基序指导EAAT3的亚细胞定位

JOURNAL OF CELL SCIENCE

IF3.6

2016-01-019

OAAI

ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-α-processing alteration

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

IF3.4

2015-12-0111

OAAI

Excess TNF-α in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

IF3.4

2015-11-0115

PREAI

The Clathrin Adaptor Proteins ARH, Dab2, and Numb Play Distinct Roles in Niemann-Pick C1-Like 1 Versus Low Density Lipoprotein Receptor-mediated Cholesterol Uptake

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2014-11-0134

OAAI

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1

NATURE MEDICINE

IF50

2013-12-1593

PREAI

MiR-9 reduces human acyl-coenzyme A:cholesterol acyltransferase-1 to decrease THP-1 macrophage-derived foam cell formation

ACTA BIOCHIMICA ET BIOPHYSICA SINICA

IF3.4

2013-11-0145

PREAI

Production of ACAT1 56-kDa isoform in human cells via trans-splicing involving the ampicillin resistance gene

CELL RESEARCH

IF25.9

2013-07-0917

OAAI

Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine

JOURNAL OF LIPID RESEARCH

IF4.1

2012-10-0165

OAAI

研究方向

实验室一直从事生化分子生物学等方面工作，研究方向先为基因的表达功能固醇代谢平衡生理病理调控靶标系统创建胆固醇代谢关键酶表达功能固醇转运调控酰基辅酶A:胆固醇酰基转移酶(ACAT)的表达功能转录剪接翻译修饰表达调控功能模式及其与胆固醇代谢平衡的生理功能病理变化等关系，包括与细胞质膜游离胆固醇的动态平衡细胞胆固醇及其代谢物固醇的载运特异脂蛋白分泌外排和转运调控动脉粥样硬化(AS)病神经退行性疾病(如老年痴呆症，AD)癌症研究ACAT靶标系统新药研发

宋

宋保亮

H 指数:62论文数:189被引数:1.5万

Ta‐Yuan Chang

H 指数:61论文数:208被引数:2.0万

Catherine C.Y. Chang

H 指数:49论文数:143被引数:8,138

Ying Xiong

H 指数:34论文数:168被引数:5,186

杨

杨新颖

H 指数:30论文数:150被引数:2,308