Hiroyuki Sugiyama - Publications, H-index & Citations

Hiroyuki Sugiyama

taisho pharmaceutical holdings co ltd

46H指数

272论文数

8.3K被引数

收录论文 25

发表时间

Current and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant 目前和新型双重食欲素受体拮抗剂在失眠治疗中的应用：沃诺雷桑特的兴起

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

IF3.7

2025-12-01

PREAI

Chino, Yukihiro; Sugiyama, Hiroyuki; Chaki, Shigeyuki; Sato, Yuri

TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae TP0586532，一种新型非异羟肟酸酯LpxC抑制剂: 对美罗培南对耐碳青霉烯肠杆菌科细菌的体外活性的增强作用

MICROBIOLOGY SPECTRUM

IF3.8

2022-06-29

OAAI

Yoshida, Ippei; Takata, Iichiro; Fujita, Kiyoko; Takashima, Hajime; Sugiyama, Hiroyuki

In Vitro and In Vivo Activities of TP0480066, a Novel Topoisomerase Inhibitor, against Neisseria gonorrhoeae 新型拓扑异构酶抑制剂TP0480066对淋病奈瑟氏球菌的体外和体内活性

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2021-03-18

OAAI

Masuko, Aiko; Takata, Iichiro; Fujita, Kiyoko; Okumura, Hirotoshi; Ushiyama, Fumihito; Amada, Hideaki; Sugiyama, Hiroyuki

Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-01-01

PREAI

Ushiyama, Fumihito; Takashima, Hajime; Matsuda, Yohei; Ogata, Yuya; Sasamoto, Naoki; Kurimoto-Tsuruta, Risa; Ueki, Kaori; Tanaka-Yamamoto, Nozomi; Endo, Mayumi; Mima, Masashi; Fujita, Kiyoko; Takata, Iichiro; Tsuji, Satoshi; Yamashita, Haruhiro; Okumura, Hirotoshi; Otake, Katsumasa; Sugiyama, Hiroyuki

Pharmacological Characterization of TP0591816, a Novel Macrocyclic Respiratory Syncytial Virus Fusion Inhibitor with Antiviral Activity against F Protein Mutants

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2020-12-16

OAAI

Yoshida, Ippei; Arikawa, Kaho; Honma, Yusuke; Inatani, Shoko; Yoshinaga, Mitsukane; Sugiyama, Hiroyuki

Discovery of a potent dual inhibitor of wild-type and mutant respiratory syncytial virus fusion proteins through the modulation of atropisomer interconversion properties

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-12-01

PREAI

Yamaguchi-Sasaki, Toru; Kawaguchi, Takanori; Okada, Atsushi; Tokura, Seiken; Tanaka-Yamamoto, Nozomi; Takeuchi, Tomoki; Ogata, Yuya; Takahashi, Ryo; Kurimoto-Tsuruta, Risa; Tamaoki, Tomokazu; Sugaya, Yutaka; Abe-Kumasaka, Tomoko; Arikawa, Kaho; Yoshida, Ippei; Sugiyama, Hiroyuki; Kanuma, Kosuke; Yoshinaga, Mitsukane

Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-11-19

OAAI

Yamada, Yousuke; Takashima, Hajime; Walmsley, David Lee; Ushiyama, Fumihito; Matsuda, Yohei; Kanazawa, Harumi; Yamaguchi-Sasaki, Toru; Tanaka-Yamamoto, Nozomi; Yamagishi, Junya; Kurimoto-Tsuruta, Risa; Ogata, Yuya; Ohtake, Norikazu; Angove, Hayley; Baker, Lisa; Harris, Richard; Macias, Alba; Robertson, Alan; Surgenor, Allan; Watanabe, Hayato; Nakano, Koichiro; Mima, Masashi; Iwamoto, Kunihiko; Okada, Atsushi; Takata, Iichiro; Hitaka, Kosuke; Tanaka, Akihiro; Fujita, Kiyoko; Sugiyama, Hiroyuki; Hubbard, Roderick E.

Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors 作为细菌II型拓扑异构酶抑制剂的8-(甲基氨基)-2-氧代-1，2-二氢喹啉的铅优化

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2020-11-01

PREAI

Ushiyama, Fumihito; Amada, Hideaki; Mihara, Yasuhiro; Takeuchi, Tomoki; Tanaka-Yamamoto, Nozomi; Mima, Masashi; Kamitani, Masafumi; Wada, Reiko; Tamura, Yunoshin; Endo, Mayumi; Masuko, Aiko; Takata, Iichiro; Hitaka, Kosuke; Sugiyama, Hiroyuki; Ohtake, Norikazu

Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation

ACS OMEGA

IF4.3

2020-04-24

OAAI

Ushiyama, Fumihito; Amada, Hideaki; Takeuchi, Tomoki; Tanaka-Yamamoto, Nozomi; Kanazawa, Harumi; Nakano, Koichiro; Mima, Masashi; Masuko, Aiko; Takata, Iichiro; Hitaka, Kosuke; Iwamoto, Kunihiko; Sugiyama, Hiroyuki; Ohtake, Norikazu

Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2020-04-10

OAAI

Yamaguchi-Sasaki, Toru; Tokura, Seiken; Ogata, Yuya; Kawaguchi, Takanori; Sugaya, Yutaka; Takahashi, Ryo; Iwakiri, Kanako; Abe-Kumasaka, Tomoko; Yoshida, Ippei; Arikawa, Kaho; Sugiyama, Hiroyuki; Kanuma, Kosuke

Vibiro vulnificus hemolysin associates with gangliosides

BMC MICROBIOLOGY

IF4.2

2020-03-30

OAAI

Kashimoto, Takashige; Sugiyama, Hiroyuki; Kawamidori, Keigo; Yamazaki, Kohei; Kado, Takehiro; Matsuda, Kaho; Kodama, Toshio; Mukai, Takao; Ueno, Shunji

Antibacterial and antifungal properties of Ag nanoparticle-loaded cellulose nanofiber aerogels prepared by supercritical CO2 drying

JOURNAL OF SUPERCRITICAL FLUIDS

IF4.4

2019-01-01

PREAI

Matsuyama, Kiyoshi; Morotomi, Kanae; Inoue, Sakura; Nakashima, Megumi; Nakashima, Hiroyuki; Okuyama, Tetsuya; Kato, Takafumi; Muto, Hiroyuki; Sugiyama, Hiroyuki

Abaloparatide Exerts Bone Anabolic Effects with Less Stimulation of Bone Resorption-Related Factors: A Comparison with Teriparatide

CALCIFIED TISSUE INTERNATIONAL

IF3.2

2018-05-03

OAAI

Makino, Akito; Takagi, Hideko; Takahashi, Yoshimasa; Hase, Naoki; Sugiyama, Hiroyuki; Yamana, Kei; Kobayashi, Tsunefumi

CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients

LEUKEMIA

IF13.4

2012-03-20

OAAI

Hosen, N.; Matsuoka, Y.; Kishida, S.; Nakata, J.; Mizutani, Y.; Hasegawa, K.; Mugitani, A.; Ichihara, H.; Aoyama, Y.; Nishida, S.; Tsuboi, A.; Fujiki, F.; Tatsumi, N.; Nakajima, H.; Hino, M.; Kimura, T.; Yata, K.; Abe, M.; Oka, Y.; Oji, Y.; Kumanogoh, A.; Sugiyama, H.

LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus

MOLECULAR BRAIN

IF2.9

2010-04-28

OAAI

Kitamura, Takashi; Saitoh, Yoshito; Murayama, Akiko; Sugiyama, Hiroyuki; Inokuchi, Kaoru

Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2009-03-15

OAAI

Sakamoto, Kensuke; Iwasaki, Kenta; Sugiyama, Hiroyuki; Tsuji, Yoshiaki