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Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2 Ewart, Gary; Bobardt, Michael M.; Bentzen, Bo Hjorth; Yan, Yannan; Thomson, Audrey; Klumpp, Klaus; Becker, Stephen; Rosenkilde, Mette; Miller, Michelle; Gallay, Philippe 分享 收藏
Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19 Zheng, Jian; Wong, Lok-Yin Roy; Wilhelmsen, Kevin; Li, Kun; Ortiz, Miguel E.; Schnicker, Nicholas J.; Thurman, Andrew; Pezzulo, Alejandro A.; Szachowicz, Peter J.; Li, Pengfei; Pan, Ruangang; Klumpp, Klaus; Aswad, Fred; Rebo, Justin; Narumiya, Shuh; Murakami, Makoto; Zuniga, Sonia; Sola, Isabel; Enjuanes, Luis; Meyerholz, David K.; Fortney, Kristen; McCray, Paul B.; Perlman, Stanley 分享 收藏
Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection Faure-Dupuy, Suzanne; Delphin, Marion; Aillot, Ludovic; Dimier, Laura; Lebosse, Fanny; Fresquet, Judith; Parent, Romain; Matter, Matthias Sebastian; Rivoire, Michel; Bendriss-Vermare, Nathalie; Salvetti, Anna; Heide, Danijela; Flores, Lalo; Klumpp, Klaus; Lam, Angela; Zoulim, Fabien; Heikenwaelder, Mathias; Durantel, David; Lucifora, Julie 分享 收藏
Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection Yuen, Man Fung; Gane, Edward J.; Kim, Dong Joon; Weilert, Frank; Chan, Henry Lik Yuen; Lalezari, Jacob; Hwang, Seong Gyu; Tuan Nguyen; Flores, Osvaldo; Hartman, George; Liaw, Sandy; Lenz, Oliver; Kakuda, Thomas N.; Talloen, Willem; Schwabe, Christian; Klumpp, Klaus; Brown, Nathaniel 分享 收藏
Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus Lam, Angela M.; Espiritu, Christine; Vogel, Robert; Ren, Suping; Lau, Vincent; Kelly, Mollie; Kuduk, Scott D.; Hartman, George D.; Flores, Osvaldo A.; Klumpp, Klaus 分享 收藏
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection NVR 3-778，单独和联合聚乙二醇化干扰素，与恩替卡韦在具有人源化肝脏和HBV感染的uPA/SCID小鼠中的功效 Klumpp, Klaus; Shimada, Takashi; Allweiss, Lena; Volz, Tassilo; Luetgehetmann, Marc; Hartman, George; Flores, Osvaldo A.; Lam, Angela M.; Dandri, Maura 分享 收藏
Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants Lam, Angela M.; Ren, Suping; Espiritu, Christine; Kelly, Mollie; Lau, Vincent; Zheng, Lingjie; Hartman, George D.; Flores, Osvaldo A.; Klumpp, Klaus 分享 收藏
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Early function modulation and reprogramming of Kupffer cells promote establishment and maintenance of HBV infection Faure-Dupuy, S.; Aillot, L.; Isorce, N.; Dimier, L.; Testoni, B.; Lam, A.; Klumpp, K.; Zanetti, C.; Bendriss-Vermare, N.; Hasan, U.; Zoulim, F.; Lucifora, J.; Durantel, D. 分享 收藏
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NVR 3-778, A FIRST-IN-CLASS HBVCORE INHIBITOR, ALONE AND IN COMBINATION WITH PEG-INTERFERON (PEGIFN), IN TREATMENT-NAIVE HBEAG-POSITIVE PATIENTS: EARLY REDUCTIONS IN HBV DNA AND HBEAG Yuen, M-F.; Kim, D. J.; Weilert, F.; Chan, H. L-Y.; Lalezari, J. P.; Hwang, S. G.; Nguyen, T.; Liaw, S.; Brown, N.; Klumpp, K.; Flores, O.; Hartman, G.; Gane, E. 分享 收藏
High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein 与病毒核心蛋白结合的乙型肝炎病毒复制抑制剂的高分辨率晶体结构 Klumpp, Klaus; Lam, Angela M.; Lukacs, Christine; Vogel, Robert; Ren, Suping; Espiritu, Christine; Baydo, Ruth; Atkins, Kateri; Abendroth, Jan; Liao, Guochun; Efimov, Andrey; Hartman, George; Flores, Osvaldo A. 分享 收藏
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Prevention of Hepatitis C Virus Infection and Spread in Human Liver Chimeric Mice by an Anti-CD81 Monoclonal Antibody Ji, Changhua; Liu, Yang; Pamulapati, Chandra; Bohini, Sandhya; Fertig, Georg; Schraeml, Michael; Rubas, Werner; Brandt, Michael; Ries, Stefan; Ma, Han; Klumpp, Klaus 分享 收藏
A Novel Immuno-Competitive Capture Mass Spectrometry Strategy for Protein-Protein Interaction Profiling Reveals That LATS Kinases Regulate HCV Replication Through NS5A Phosphorylation Meistermann, Helene; Gao, Junjun; Golling, Sabrina; Lamerz, Jens; Le Pogam, Sophie; Tzouros, Manuel; Sankabathula, Sailaja; Gruenbaum, Lore; Najera, Isabel; Langen, Hanno; Klumpp, Klaus; Augustin, Angelique 分享 收藏
Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys Vexler, Vladimir; Yu, Li; Pamulapati, Chandrasena; Garrido, Rosario; Grimm, Hans Peter; Sriraman, Priya; Bohini, Sandhya; Schraeml, Michael; Singh, Usha; Brandt, Michael; Ries, Stefan; Ma, Han; Klumpp, Klaus; Ji, Changhua 分享 收藏
Intracellular Effects of the Hepatitis C Virus Nucleoside Polymerase Inhibitor RO5855 ( Mericitabine Parent) and Ribavirin in Combination Ma, H.; Le Pogam, S.; Fletcher, S.; Hinojosa-Kirschenbaum, F.; Javanbakht, H.; Yan, J. -M.; Jiang, W. -R.; Inocencio, N.; Klumpp, K.; Najera, I. 分享 收藏
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