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Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics 替代多聚腺苷酸化特征可区分肺动脉高压中的不良性右心室重塑：对基于RNA的诊断和治疗的意义 Subramaniam, Janani; Jonnakuti, Venkata; Collum, Scott D.; Martineau, Sandra; Huang, Kai-Lieh; Breuils-Bonnet, Sandra; Frump, Andrea L.; Akkanti, Bindu H.; Patel, Jayeshkumar A.; Patel, Manish K.; Salas De Armas, Ismael; Lefebvre, Isabella N.; Radovancevic, Rajko; Blanco, Elvin; Wagner, Eric J.; Gregoric, Igor; Nathan, Sriram; Kar, Biswajit; Provencher, Steeve; Bonnet, Sebastien; Potus, Francois; Yalamanchili, Hari Krishna; Karmouty-Quintana, Harry 分享 收藏
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Cytochrome P450 1A1 influences obesity-induced pulmonary hypertension 细胞色素P450 1A1影响肥胖诱导的肺动脉高压 Dignam, Joshua P.; Sharma, Smriti; Aitchison, Gregor; Gebril, Ayman; Stasinopoulos, Ioannis; Laforest, Sofia; Coyle, Chelbi; Andrew, Ruth; Homer, Natalie Z. M.; Bonnet, Sebastien; Breuils-bonnet, Sandra; Wabitsch, Martin; Maclean, Margaret R. 分享 收藏
Pharmacological inhibition of Epac1 protects against pulmonary fibrosis by blocking FoxO3a neddylation Epac1的药理学抑制通过阻断FoxO3a的neddylation来保护 against 肺纤维化 Jankowski, Katherine; Lemay, Sarah E.; Lozano-Ojalvo, Daniel; Perez-Rodriguez, Leticia; Sauvaget, Melanie; Breuils-Bonnet, Sandra; Formoso, Karina; Jagana, Vineeta; Ochoa, Maria T.; Zhang, Shihong; Milara, Javier; Cortijo, Julio; Turnbull, Irene C.; Provencher, Steeve; Bonnet, Sebastien; Ochando, Jordi; Lezoualch, Frank; Bisserier, Malik; Hadri, Lahouaria 分享 收藏
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Unraveling AURKB as a potential therapeutic target in pulmonary hypertension using integrated transcriptomic analysis and pre-clinical studies 通过整合转录组学分析和临床前研究，阐明AURKB作为肺动脉高压潜在治疗靶点的价值。 Lemay, Sarah-Eve; Mougin, Manon; Sauvaget, Melanie; El Kabbout, Reem; Valasarajan, Chanil; Yamamoto, Keiko; Martineau, Sandra; Pelletier, Andreanne; Bilodeau, Coralie; Grobs, Yann; Bourgeois, Alice; Romanet, Charlotte; Breuils-Bonnet, Sandra; Montesinos, Monica S.; Lu, Min; Chen, Huidong; Gilbert, Megan; Theberge, Charlie; Potus, Francois; Pullamsetti, Soni; Provencher, Steeve; Bonnet, Sebastien; Boucherat, Oliver 分享 收藏
ATP citrate lyase drives vascular remodeling in systemic and pulmonary vascular diseases through metabolic and epigenetic changes Grobs, Yann; Romanet, Charlotte; Lemay, Sarah-Eve; Bourgeois, Alice; Voisine, Pierre; Theberge, Charlie; Sauvaget, Melanie; Breuils-Bonnet, Sandra; Martineau, Sandra; El Kabbout, Reem; Valasarajan, Chanil; Chelladurai, Prakash; Pelletier, Andreanne; Mougin, Manon; Dumais, Elizabeth; Perron, Jean; Flamand, Nicolas; Potus, Francois; Provencher, Steeve; Pullamsetti, Soni Savai; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Integrin α5β1 represents a novel therapeutic target to improve vascular remodeling in pulmonary arterial hypertension 整合素α5β1是改善肺动脉高压血管重塑的一个新型治疗靶点。 Lemay, Sarah-Eve; Montesinos, Monica; Grobs, Yann; Yokokawa, Tetsuro; Shimauchi, Tsukasa; Romanet, Charlotte; Sauvaget, Melanie; Bonnet, Sandra Breuils; Bourgeois, Alice; Theberge, Charlie; Martineau, Sandra; Lippa, Blaise; Goodwin, Bryan; Lin, Albert; Wang, Hua; Dowling, James; Lu, Min; Qiao, Qi; McTeague, T. Andrew; Moy, Terence I.; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
NLRP3 signaling in rodent and human right ventricular failure is sexually dimorphic and regulated by 17ß-estradiol via estrogen receptor a NLRP3信号在啮齿动物和人类右心室衰竭中呈现性别二态性，并通过雌激素受体α由17β-雌二醇调节。 Fais, Rafael Sobrano; Palotta, Erica Das Neves; Kopf, Katrina; Massad, Karina Mora; Hoffer, Christopher; Walts, Avram; Cook, Todd; Fisher, Amanda; Frump, Andrea; Givens, Sophie; Bourgeois, Alice; Woulfe, K. C.; Pullamsetti, Soni Savai; Boucherat, Olivier; Ogle, Brenda; Bonnet, Sebastien; Lahm, Tim 分享 收藏
Development and characterization of an ex vivo human precision-cut lung slice (hPCLS) system for target validation for pulmonary arterial hypertension 人肺精密切片（hPCLS）系统的建立与表征：用于肺动脉高压靶向验证的离体模型 Kim, Haejin; Jain, Dhawal; Akram, Muzaffar; Zhou, Willa; Provencher, Steeve; Lemay, Sarah-Eve; Bonnet, Sebastien; Potus, Francois; Montesinos, Monica; Lu, Min; Goodwin, Bryan 分享 收藏
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Integrin α5β1 contributes to pathological remodeling of the right ventricle in pulmonary arterial hypertension 整合素α5β1参与肺动脉高压中右心室病理性重塑。 Lemay, Sarah-Eve; Montesinos, Monica; Grobs, Yann; Bourgeois, Alice; Romanet, Charlotte; Sauvaget, Melanie; Bonnet, Sandra Breuils; Theberge, Charlie; Martineau, Sandra; Lippa, Blaise; Goodwin, Bryan; Lin, Albert; Wang, Hua; Dowling, James; Lu, Min; Qiao, Qi; McTeague, T. Andrew; Moy, Terence I.; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Targeting ATP Citrate Lyase: A Novel Therapeutic Strategy for Vascular Remodeling in Pulmonary Hypertension 靶向乙酰辅酶A柠檬酸合酶：肺动脉高压血管重塑的一种新型治疗策略 Grobs, Yann; Romanet, Charlotte; Lemay, Sarah-Eve; Bourgeois, Alice; Voisine, Pierre; Theberge, Charlie; Sauvaget, Melanie; Bonnet, Sandra Breuils; Martineau, Sandra; Reem, EL-Kabbout; Pelletier, Andreanne; Mougin, Manon; Dumais, Elizabeth; Perron, Jean; Flamand, Nicolas; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Targeting NEK2 to Induce Senescence and DNA Damage in Pulmonary Arterial Hypertension 靶向NEK2以诱导肺动脉高压中的衰老和DNA损伤 Martineau, Sandra; Yamamoto, Keiko; Bourgeois, Alice; Lemay, Sarah-Eve; Sauvaget, Melanie; Breuils, Sandra Bonnet; Potus, Francois; Provencher, Steeve; Boucherat, Olivier; Bonnet, Sebastien 分享 收藏
Branched Chain Amino Acids Modulate Lung-Liver Axis in Pulmonary Arterial Hypertension 支链氨基酸调节肺动脉高压中的肺-肝轴 Blake, Madelyn; Moon, Ryan; Blake, Jeffrey; Mendelson, Jenna; Annis, Jeffrey; Prisco, Sasha; Provencher, Steeve; Bonnet, Sandra; Brittain, Evan; Bonnet, Sebastien; Prins, Kurt 分享 收藏
Targeting Aurora Kinase B Improves Vascular Remodeling in Pulmonary Arterial Hypertension 靶向Aurora Kinase B改善肺动脉高压的血管重塑 Lemay, Sarah-Eve; Mougin, Manon; Sauvaget, Melanie; Reem, EL-Kabbout; Valasarajan, Chanil; Yamamoto, Keiko; Martineau, Sandra; Pelletier, Andreanne; Grobs, Yann; Bourgeois, Alice; Romanet, Charlotte; Bonnet, Sandra Breuils; Montesinos, Monica; Lu, Min; Chen, Huidong; Theberge, Charlie; Potus, Francois; Pullamsetti, Soni Savai; Provencher, Steeve; Bonnet, Sebastien; Boucherat, Olivier 分享 收藏
Treatment of pulmonary arterial hypertension by blocking integrin a5b1, a potential disease-modifying strategy 通过阻断整合素α5β1治疗肺动脉高压，一种潜在的改变疾病进程的策略 Montesinos, Monica; Lemay, Sarah-Eve; Kapoor, Parmita; Rapisardi, Hailey; Minh Hai Nguyen; Kim, Haejin; Akram, Muzaffar; Jain, Dhawal; Konopka, Elizabeth; Moy, Terence I.; Smukste, Inese; McTeague, T. Andrew; Dowling, James; Lama, Sujan; Pondish, Jessica; Qiao, Qi; Monroy, Meghan Monroy; Lin, Albert; Wang, Hua; Boucherat, Olivier; Sauvaget, Melanie; Potus, Francois; Breuils, Sandra; Theberge, Charlie; Provencher, Steeve; Ray, Adrian; Lippa, Blaise; Bonnet, Sebastien; Goodwin, Bryan; Lu, Min 分享 收藏
Upregulation of Dynamin 2 (DNM2) Increases Mitochondrial Fission and Cell Proliferation in Pulmonary Arterial Hypertension Dynamin 2 (DNM2)的上调增加肺动脉高压中的线粒体分裂和细胞增殖 Das Gupta, Asish; Chen, Kuang-Hueih; Wu, Danchen; Lima, Patricia; Martin, Ashley; Mewburn, Jeffrey; Al-Qazazi, Ruaa; Emon, Isaac; Colpman, Pierce; Yerramilli, Siddartha; Jones, Oliver; Hindmarch, Charles; Potus, Francois; Bonnet, Sebastien; Archer, Stephen 分享 收藏
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