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Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension Shaw, Duncan E. E.; Smith, Nichola; Beerli, Rene; Cotesta, Simona; D'Alessandro, Pier-Luca; Edwards, Anne-Marie; Lattmann, Rene; Lizos, Dimitrios; Pulz, Robert; Rooney, Lisa; Sohal, Bindi; Rynn, Caroline; Taylor, Jessica; Troxler, Thomas; Williams, Gareth; Guth, Sabine; Rowlands, David 分享 收藏
Development of Enterovirus Antiviral Agents That Target the Viral 2C Protein 开发靶向病毒2C蛋白的肠病毒抗病毒药物 Kejriwal, Rishabh; Evans, Tristan; Calabrese, Joshua; Swistak, Lea; Alexandrescu, Lauren; Cohen, Michelle; Rahman, Nahian; Henriksen, Niel; Dash, Radha Charan; Hadden, M. Kyle; Stonehouse, Nicola J.; Rowlands, David J.; Kingston, Natalie J.; Hartnoll, Madeline; Dobson, Samuel J.; White, Simon J. 分享 收藏
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Deubiquitinase-targeting chimeras for targeted protein stabilization 用于靶向蛋白质稳定的去泛素酶靶向嵌合体 Henning, Nathaniel J.; Boike, Lydia; Spradlin, Jessica N.; Ward, Carl C.; Liu, Gang; Zhang, Erika; Belcher, Bridget P.; Brittain, Scott M.; Hesse, Matthew J.; Dovala, Dustin; McGregor, Lynn M.; Misiolek, Rachel Valdez; Plasschaert, Lindsey W.; Rowlands, David J.; Wang, Feng; Frank, Andreas O.; Fuller, Daniel; Estes, Abigail R.; Randal, Katelyn L.; Panidapu, Anoohya; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K. 分享 收藏
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease Le Grand, Darren; Gosling, Martin; Baettig, Urs; Bahra, Parmjit; Bala, Kamlesh; Brocklehurst, Cara; Budd, Emma; Butler, Rebecca; Cheung, Atwood K.; Choudhury, Hedaythul; Collingwood, Stephen P.; Cox, Brian; Danahay, Henry; Edwards, Lee; Everatt, Brian; Glaenzel, Ulrike; Glotin, Anne-Lise; Groot-Kormelink, Paul; Hall, Edward; Hatto, Julia; Howsham, Catherine; Hughes, Glyn; King, Anna; Koehler, Julia; Kulkarni, Swarupa; Lightfoot, Megan; Nicholls, Ian; Page, Christopher; Pergl-Wilson, Giles; Popa, Mariana Oana; Robinson, Richard; Rowlands, David; Sharp, Tom; Spendiff, Matthew; Stanley, Emily; Steward, Oliver; Taylor, Roger J.; Tranter, Pamela; Wagner, Trixie; Watson, Hazel; Williams, Gareth; Wright, Penny; Young, Alice; Sandham, David A. 分享 收藏
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Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251) Kazani, Shamsah; Rowlands, David J.; Bottoli, Ivan; Milojevic, Julie; Alcantara, Jose; Jones, Ieuan; Kulmatycki, Kenneth; Machineni, Surendra; Mostovy, Lidia; Nicholls, Ian; Nick, Jerry A.; Rowe, Steven M.; Simmonds, Nicholas J.; Vegesna, Raju; Verheijen, Jeroen; Danahay, Henry; Gosling, Martin; Ayalavajjala, Phaninatha Sarma; Salman, Mohammed; Strieter, Robert 分享 收藏
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Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy Shaw, Joseph; Gosain, Rajendra; Kalita, Monoj Mon; Foster, Toshana L.; Kankanala, Jayakanth; Mahato, D. Ram; Abas, Sonia; King, Barnabas J.; Scott, Claire; Brown, Emma; Bentham, Matthew J.; Wetherill, Laura; Bloy, Abigail; Samson, Adel; Harris, Mark; Mankouri, Jamel; Rowlands, David J.; Macdonald, Andrew; Tarr, Alexander W.; Fischer, Wolfgang B.; Foster, Richard; Griffin, Stephen 分享 收藏
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Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates 携带流感病毒LAH结构域的嵌合HBc病毒样颗粒作为疫苗候选物的生产和纯化 Kazaks, Andris; Lu, I-Na; Farinelle, Sophie; Ramirez, Alex; Crescente, Vincenzo; Blaha, Benjamin; Ogonah, Olotu; Mukhopadhyay, Tarit; De Obanos, Mapi Perez; Krimer, Alejandro; Akopjana, Inara; Bogans, Janis; Ose, Velta; Kirsteina, Anna; Kazaka, Tatjana; Stonehouse, Nicola J.; Rowlands, David J.; Muller, Claude P.; Tars, Kaspars; Rosenberg, William M. 分享 收藏
Genetic economy in picornaviruses: Foot-andmouth disease virus replication exploits alternative precursor cleavage pathways Herod, Morgan R.; Gold, Sarah; Lasecka-Dykes, Lidia; Wright, Caroline; Ward, Joseph C.; McLean, Thomas C.; Forrest, Sophie; Jackson, Terry; Tuthill, Tobias J.; Rowlands, David J.; Stonehouse, Nicola J. 分享 收藏