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Yiheng Chen

Merck & Co. Inc.
H指数:18
被引数:2,251

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Discovery Process of Enlicitide; a Highly Engineered Macrocyclic Peptide Therapeutic; through Issue-Driven Fragment-Based Synthetic Assembly and SAR

通过问题驱动的片段基础合成组装和构效关系研究发现的恩利西肽；一种高度工程化的大环肽治疗药物

Journal of Medicinal Chemistry
IF6.8
2026-05-270
PRE
Hubert Josien; Anilkumar G. Nair; Fa-Xiang Ding; Yan Guo; Yi-Heng Chen; Ashwin U. Rao; Jian Liu; Ling Tong; Zhongxiang Sun; Michael M.-C. Lo; Thomas J. Tucker; Mark W. Embrey; Aurash Shahripour; Chengwei Wu; Elisabetta Bianchi; Danila Branca; Jeffrey T. Kuethe; Joshua Lee; David A. Thaisrivongs; Paul G. Bulger; Xiaohong Zhu; Sookhee N. Ha; Jennifer M. Johnston; Daniel J. Klein; Peter Orth; Mee Ra Hong; Alexei V. Buevich; Qi Gao; Hratch J. Zokian; Kenneth A. Koeplinger; Rodger W. Tracy; Michael J. Hafey; Nicole Buist; Tjerk Bueters; Candice Alleyne; Alan Bass; Louis-Charles Campeau; Douglas G. Johns; Robert M. Garbaccio; Petr Vachal; Abbas Walji; Harold B. Wood
A genetic variant associated with aquaporin 3 expression is correlated to in-hospital death in COVID-19 patients with extracellular hyperosmolality

与水通道蛋白3表达相关的遗传变异与外渗高渗性COVID-19患者的院内死亡相关。

PHYSIOLOGICAL GENOMICS
IF2.5
2025-06-010
PRE
Marks-Hultstrom, Michael; Marks, Amanda M.; Butler-Laporte, Guillaume; Yoshiji, Satoshi; Lu, Tianyuan; Morrison, Dave R.; Nakanishi, Tomoko; Chen, Yiheng; Forgetta, Vincenzo; Farjoun, Yossi; Frithiof, Robert; Lipcsey, Miklos; Zeberg, Hugo; Richards, J. Brent
Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-040
PRE
Logan, Kaitlyn M.; Kaplan, Will; Simov, Vladimir; Zhou, Hua; Li, Derun; Torres, Luis; Morriello, Gregori J.; Acton, John J.; Pio, Barbara; Chen, Yi-Heng; Keylor, Mitchell H.; Johnson, Rebecca; Kattar, Solomon D.; Chau, Ryan; Yan, Xin; Ardolino, Michael; Zarate, Cayetana; Otte, Karin M.; Palte, Rachel L.; Xiong, Tina; McMinn, Spencer E.; Lin, Shishi; Neelamkavil, Santhosh F.; Liu, Ping; Su, Jing; Hegde, Laxminarayan G.; Woodhouse, Janice D.; Moy, Lily Y.; Ciaccio, Paul J.; Piesvaux, Jennifer; Zebisch, Matthias; Henry, Clare; Barker, John; Wood, Harold B.; Kennedy, Matthew E.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.
Integrating genetics and metabolomics from multi- ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration

整合来自多种族和多流体数据的遗传学和代谢组学揭示了年龄相关性黄斑变性的推定机制

CELL REPORTS MEDICINE
IF10.6
2023-07-0114
OAAI
Han, Xikun; Lains, Ines; Li, Jun; Li, Jinglun; Chen, Yiheng; Yu, Bing; Qi, Qibin; Boerwinkle, Eric; Kaplan, Robert; Thyagarajan, Bharat; Daviglus, Martha; Joslin, Charlotte E.; Cai, Jianwen; Guasch-Ferre, Marta; Tobias, Deirdre K.; Rimm, Eric; Ascherio, Alberto; Costenbader, Karen; Karlson, Elizabeth; Mucci, Lorelei; Eliassen, A. Heather; Zeleznik, Oana; Miller, John; Vavvas, Demetrios G.; Kim, Ivana K.; Silva, Rufino; Miller, Joan; Hu, Frank; Willett, Walter; Lasky-Su, Jessica; Kraft, Peter; Richards, J. Brent; MacGregor, Stuart; Husain, Deeba; Liang, Liming
Circulating proteins to predict COVID-19 severity

循环蛋白质预测新型冠状病毒肺炎严重程度

SCIENTIFIC REPORTS
IF3.9
2023-04-177
OAAI
Su, Chen-Yang; Zhou, Sirui; Gonzalez-Kozlova, Edgar; Butler-Laporte, Guillaume; Brunet-Ratnasingham, Elsa; Nakanishi, Tomoko; Jeon, Wonseok R.; Morrison, David; Laurent, Laetitia; Afilalo, Jonathan; Afilalo, Marc; Henry, Danielle; Chen, Yiheng; Carrasco-Zanini, Julia; Farjoun, Yossi; Pietzner, Maik; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Bouab, Meriem; Petitjean, Louis; Guzman, Charlotte; Xue, Xiaoqing; Tselios, Chris; Vulesevic, Branka; Adeleye, Olumide; Abdullah, Tala; Almamlouk, Noor; Moussa, Yara; DeLuca, Chantal; Duggan, Naomi; Schurr, Erwin; Brassard, Nathalie; Durand, Madeleine; Del Valle, Diane Marie; Thompson, Ryan A.; Cedillo, Mario; Schadt, Eric; Nie, Kai W.; Simons, Nicole; Mouskas, Konstantinos; Zaki, Nicolas; Patel, Manishkumar; Xie, Hui; Harris, Jocelyn; Marvin, Robert; Cheng, Esther; Tuballes, Kevin; Argueta, Kimberly; Scott, Ieisha; Greenwood, Celia M. T.; Paterson, Clare A.; Hinterberg, Michael; Langenberg, Claudia; Forgetta, Vincenzo; Pineau, Joelle; Mooser, Vincent; Marron, Thomas D.; Beckmann, Noam; Kim-schulze, Seunghee W.; Charney, Alexander; Gnjatic, Sacha E.; Kaufmann, Daniel; Merad, Miriam; Richards, J. Brent
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
NATURE METABOLISM
IF20.8
2023-02-2027
OAAI
Yoshiji, Satoshi; Butler-Laporte, Guillaume; Lu, Tianyuan; Willett, Julian Daniel Sunday; Su, Chen-Yang; Nakanishi, Tomoko; Morrison, David R.; Chen, Yiheng; Liang, Kevin; Hultstrom, Michael; Ilboudo, Yann; Afrasiabi, Zaman; Lan, Shanshan; Duggan, Naomi; DeLuca, Chantal; Vaezi, Mitra; Tselios, Chris; Xue, Xiaoqing; Bouab, Meriem; Shi, Fangyi; Laurent, Laetitia; Munter, Hans Markus; Afilalo, Marc; Afilalo, Jonathan; Mooser, Vincent; Timpson, Nicholas J.; Zeberg, Hugo; Zhou, Sirui; Forgetta, Vincenzo; Farjoun, Yossi; Richards, J. Brent
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases

血浆代谢组的基因组图谱优先考虑与人类疾病有关的代谢物

NATURE GENETICS
IF31.8
2023-01-12241
OA
Chen, Yiheng; Lu, Tianyuan; Pettersson-Kymmer, Ulrika; Stewart, Isobel D.; Butler-Laporte, Guillaume; Nakanishi, Tomoko; Cerani, Agustin; Liang, Kevin Y. H.; Yoshiji, Satoshi; Willett, Julian Daniel Sunday; Su, Chen-Yang; Raina, Parminder; Greenwood, Celia M. T.; Farjoun, Yossi; Forgetta, Vincenzo; Langenberg, Claudia; Zhou, Sirui; Ohlsson, Claes; Richards, J. Brent
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
NATURE MEDICINE
IF50
2021-02-25164
OAAI
Zhou, Sirui; Butler-Laporte, Guillaume; Nakanishi, Tomoko; Morrison, David R.; Afilalo, Jonathan; Afilalo, Marc; Laurent, Laetitia; Pietzner, Maik; Kerrison, Nicola; Zhao, Kaiqiong; Brunet-Ratnasingham, Elsa; Henry, Danielle; Kimchi, Nofar; Afrasiabi, Zaman; Rezk, Nardin; Bouab, Meriem; Petitjean, Louis; Guzman, Charlotte; Xue, Xiaoqing; Tselios, Chris; Vulesevic, Branka; Adeleye, Olumide; Abdullah, Tala; Almamlouk, Noor; Chen, Yiheng; Chasse, Michael; Durand, Madeleine; Paterson, Clare; Normark, Johan; Frithiof, Robert; Lipcsey, Miklos; Hultstrom, Michael; Greenwood, Celia M. T.; Zeberg, Hugo; Langenberg, Claudia; Thysell, Elin; Pollak, Michael; Mooser, Vincent; Forgetta, Vincenzo; Kaufmann, Daniel E.; Richards, J. Brent

研究方向

暂未获取到该数据
J
J. Brent Richards
H 指数:86论文数:378被引数:3.8万
V
Vincenzo Forgetta
H 指数:47论文数:144被引数:1.2万
G
Guillaume Butler‐Laporte
H 指数:32论文数:121被引数:6,048
S
Satoshi Yoshiji
H 指数:12论文数:75被引数:1,430
S
Sirui Zhou
H 指数:34论文数:184被引数:4,974
Y
Yossi Farjoun
H 指数:28论文数:104被引数:1.9万
T
Tomoko Nakanishi
H 指数:50论文数:482被引数:1.0万
K
Kevin Y. H. Liang
H 指数:12论文数:37被引数:5,821
T
Tianyuan Lu
H 指数:22论文数:167被引数:2,625
C
Claudia Langenberg
H 指数:157论文数:773被引数:11.3万