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Antiviral target compound profile for pandemic preparedness Demarest, James F.; Draghia-Akli, Ruxandra; Cihlar, Tomas; Bradley, Kenneth; Young, John A. T.; Chandra, Richa; Vaidyanathan, Sujata; Chu-Moyer, Margaret; Lynch, Christopher L.; Campbell, Andrew; Saikatendu, Kumar Singh; Bilello, John P.; Murata, Yoshihiko; van Loock, Marnix; Hurt, Aeron C.; Tellinghuisen, Timothy; Ruggiero, Lee; Mackman, Richard; Hill, Nina M.; Pottage, John C.; van Loock, Marnix 分享 收藏
Discovery of GS-7682, a Novel 4′-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys Siegel, Dustin S.; Hui, Hon C.; Pitts, Jared; Vermillion, Meghan S.; Ishida, Kazuya; Rautiola, Davin; Keeney, Michael; Irshad, Hammad; Zhang, Lijun; Chun, Kwon; Chin, Gregory; Goyal, Bindu; Doerffler, Edward; Yang, Hai; Clarke, Michael O.; Palmiotti, Chris; Vijjapurapu, Arya; Riola, Nicholas C.; Stray, Kirsten; Murakami, Eisuke; Ma, Bin; Wang, Ting; Zhao, Xiaofeng; Xu, Yili; Lee, Gary; Marchand, Bruno; Seung, Minji; Nayak, Arabinda; Tomkinson, Adrian; Kadrichu, Nani; Ellis, Scott; Barauskas, Ona; Feng, Joy Y.; Perry, Jason K.; Perron, Michel; Bilello, John P.; Kuehl, Philip J.; Subramanian, Raju; Cihlar, Tomas; Mackman, Richard L. 分享 收藏
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses Martinez, David R.; Moreira, Fernando R.; Catanzaro, Nicholas J.; Diefenbacher, Meghan V.; Zweigart, Mark R.; Gully, Kendra L.; De la Cruz, Gabriela; Brown, Ariane J.; Adams, Lily E.; Yount, Boyd; Baric, Thomas J.; Mallory, Michael L.; Conrad, Helen; May, Samantha R.; Dong, Stephanie; Scobey, D. Trevor; Nguyen, Cameron; Montgomery, Stephanie A.; Perry, Jason K.; Babusis, Darius; Barrett, Kimberly T.; Nguyen, Anh-Hoa; Nguyen, Anh-Quan; Kalla, Rao; Bannister, Roy; Feng, Joy Y.; Cihlar, Tomas; Baric, Ralph S.; Mackman, Richard L.; Bilello, John P.; Schaefer, Alexandra; Sheahan, Timothy P. 分享 收藏
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys Mackman, Richard L.; Kalla, Rao V.; Babusis, Darius; Pitts, Jared; Barrett, Kimberly T.; Chun, Kwon; Du Pont, Venice; Rodriguez, Lauren; Moshiri, Jasmine; Xu, Yili; Lee, Michael; Lee, Gary; Bleier, Blake; Nguyen, Anh-Quan; O'Keefe, B. Michael; Ambrosi, Andrea; Cook, Meredith; Yu, Joy; Dempah, Kassibla Elodie; Bunyan, Elaine; Riola, Nicholas C.; Lu, Xianghan; Liu, Renmeng; Davie, Ashley; Hsiang, Tien-Ying; Dearing, Justin; Vermillion, Meghan; Gale Jr, Michael; Niedziela-Majka, Anita; Feng, Joy Y.; Hedskog, Charlotte; Bilello, John P.; Subramanian, Raju; Cihlar, Tomas 分享 收藏
Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice Schafer, Alexandra; Martinez, David R.; Won, John J.; Meganck, Rita M.; Moreira, Fernando R.; Brown, Ariane J.; Gully, Kendra L.; Zweigart, Mark R.; Conrad, William S.; May, Samantha R.; Dong, Stephanie; Kalla, Rao; Chun, Kwon; Du Pont, Venice; Babusis, Darius; Tang, Jennifer; Murakami, Eisuke; Subramanian, Raju; Barrett, Kimberly T.; Bleier, Blake J.; Bannister, Roy; Feng, Joy Y.; Bilello, John P.; Cihlar, Tomas; Mackman, Richard L.; Montgomery, Stephanie A.; Baric, Ralph S.; Sheahan, Timothy P. 分享 收藏
Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection Vermillion, Meghan S.; Murakami, Eisuke; Ma, Bin; Pitts, Jared; Tomkinson, Adrian; Rautiola, Davin; Babusis, Darius; Irshad, Hammad; Seigel, Dustin; Kim, Cynthia; Zhao, Xiaofeng; Niu, Congrong; Yang, Jesse; Gigliotti, Andrew; Kadrichu, Nani; Bilello, John P.; Ellis, Scott; Bannister, Roy; Subramanian, Raju; Smith, Bill; Mackman, Richard L.; Lee, William A.; Kuehl, Philip J.; Hartke, Jim; Cihlar, Tomas; Porter, Danielle P. 分享 收藏
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Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets Cox, Robert M.; Wolf, Josef D.; Lieber, Carolin M.; Sourimant, Julien; Lin, Michelle J.; Babusis, Darius; DuPont, Venice; Chan, Julie; Barrett, Kim T.; Lye, Diane; Kalla, Rao; Chun, Kwon; Mackman, Richard L.; Ye, Chengjin; Cihlar, Tomas; Martinez-Sobrido, Luis; Greninger, Alexander L.; Bilello, John P.; Plemper, Richard K. 分享 收藏
Reply to Yan and Muller, Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver REPLY Murakami, Eisuke; Bilello, John; Li, Ruidong; Li, Li; Porter, Danielle; Humeniuk, Rita; Mackman, Richard; Cihlar, Tomas; Osinusi, Anu; Feng, Joy 分享 收藏
Prodrugs of a 1′-CN-4-Aza-7,9-dideazaadenosine C-Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV Mackman, Richard L.; Hui, Hon C.; Perron, Michel; Murakami, Eisuke; Palmiotti, Christopher; Lee, Gary; Stray, Kirsten; Zhang, Lijun; Goyal, Bindu; Chun, Kwon; Byun, Daniel; Siegel, Dustin; Simonovich, Scott; Du Pont, Venice; Pitts, Jared; Babusis, Darius; Vijjapurapu, Arya; Lu, Xianghan; Kim, Cynthia; Zhao, Xiaofeng; Chan, Julie; Ma, Bin; Lye, Diane; Vandersteen, Adelle; Wortman, Sarah; Barrett, Kimberly T.; Toteva, Maria; Jordan, Robert; Subramanian, Raju; Bilello, John P.; Cihlar, Tomas 分享 收藏
Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B Daffis, Stephane; Balsitis, Scott; Chamberlain, Jason; Zheng, Jim; Santos, Rex; Rowe, William; Ramakrishnan, Dhivya; Pattabiraman, Divya; Spurlock, Sandra; Chu, Ruth; Kang, Don; Mish, Michael; Ramirez, Ricardo; Li, Li; Li, Bei; Ma, Sarina; Hung, Magdeleine; Voitenleitner, Christian; Yon, Changsuek; Suresh, Manasa; Menne, Stephan; Cote, Paul; Delaney, William E.; Mackman, Richard; Fletcher, Simon P. 分享 收藏
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B Mackman, Richard L.; Mish, Michael; Chin, Gregory; Perry, Jason K.; Appleby, Todd; Aktoudianakis, Vangelis; Metobo, Sammy; Pyun, Peter; Niu, Congrong; Daffis, Stephane; Yu, Helen; Zheng, Jim; Villasenor, Armando G.; Zablocki, Jeff; Chamberlain, Jason; Jin, Haolun; Lee, Gary; Suekawa-Pirrone, Kimberley; Santos, Rex; Delaney, William E.; Fletcher, Simon P. 分享 收藏
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor 结构引导的新型，有效和口服生物可利用的3，5-二甲基异恶唑芳基-苯并咪唑BET溴结构域抑制剂的发现 Sperandio, David; Aktoudianakis, Vangelis; Babaoglu, Kerim; Chen, Xiaowu; Elbel, Kristyna; Chin, Gregory; Corkey, Britton; Du, Jinfa; Jiang, Bob; Kobayashi, Tetsuya; Mackman, Richard; Martinez, Ruben; Yang, Hai; Zablocki, Jeff; Kusam, Saritha; Jordan, Kim; Webb, Heather; Bates, Jamie G.; Lad, Latesh; Mish, Michael; Niedziela-Majka, Anita; Metobo, Sammy; Sapre, Annapurna; Hung, Magdeleine; Jin, Debi; Fung, Wanchi; Kan, Elaine; Eisenberg, Gene; Larson, Nate; Newby, Zachary E. R.; Lansdon, Eric; Tay, Chin; Neve, Richard M.; Shevick, Sophia L.; Breckenridge, David G. 分享 收藏
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle Mackman, Richard L.; Steadman, Victoria A.; Dean, David K.; Jansa, Petr; Poullennec, Karine G.; Appleby, Todd; Austin, Carol; Blakemore, Caroline A.; Cai, Ruby; Cannizzaro, Carina; Chin, Gregory; Chiva, Jean-Yves C.; Dunbar, Neil A.; Fliri, Hans; Highton, Adrian J.; Hui, Hon; Ji, Mingzhe; Jin, Haolun; Karki, Kapil; Keats, Andrew J.; Lazarides, Linos; Lee, Yu-Jen; Liclican, Albert; Mish, Michael; Murray, Bernard; Pettit, Simon B.; Pyun, Peter; Sangi, Michael; Santos, Rex; Sanvoisin, Jonathan; Schmitz, Uli; Schrier, Adam; Siegel, Dustin; Sperandio, David; Stepan, George; Tian, Yang; Watt, Gregory M.; Yang, Hai; Schultz, Brian E. 分享 收藏
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease Agostini, Maria L.; Andres, Erica L.; Sims, Amy C.; Graham, Rachel L.; Sheahan, Timothy P.; Lu, Xiaotao; Smith, Everett Clinton; Case, James Brett; Feng, Joy Y.; Jordan, Robert; Ray, Adrian S.; Cihlar, Tomas; Siegel, Dustin; Mackman, Richard L.; Clarke, Michael O.; Baric, Ralph S.; Denison, Mark R. 分享 收藏
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses Sheahan, Timothy P.; Sims, Amy C.; Graham, Rachel L.; Menachery, Vineet D.; Gralinski, Lisa E.; Case, James B.; Leist, Sarah R.; Pyrc, Krzysztof; Feng, Joy Y.; Trantcheva, Iva; Bannister, Roy; Park, Yeojin; Babusis, Darius; Clarke, Michael O.; Mackman, Richard L.; Spahn, Jamie E.; Palmiotti, Christopher A.; Siegel, Dustin; Ray, Adrian S.; Cihlar, Tomas; Jordan, Robert; Denison, Mark R.; Baric, Ralph S. 分享 收藏
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses Lo, Michael K.; Jordan, Robert; Arvey, Aaron; Sudhamsu, Jawahar; Shrivastava-Ranjan, Punya; Hotard, Anne L.; Flint, Mike; McMullan, Laura K.; Siegel, Dustin; Clarke, Michael O.; Mackman, Richard L.; Hui, Hon C.; Perron, Michel; Ray, Adrian S.; Cihlar, Tomas; Nichol, Stuart T.; Spiropoulou, Christina F. 分享 收藏
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