未登录 Performance of a modular robotic cluster matches skilled human operators for complex cell therapy manufacturing tasks 模块化机器人集群在复杂细胞治疗制造任务中的性能与熟练人类操作员相当 Sadhu, Sudeshna; Schmittlein, Brigitte; Lares, Angela; Cheng, Christopher; Chen, Xiaojie; Bhatia, Varun; Zha, Winston; Wah, Sebastien; Nayak, Sunaina; Uboldi, Marco; Yu, Yifan; Wang, Jiawei; Zhang, Wei; Bhanap, Prajakta P.; Ji, Yongchang; Scheffler, Andrew; Wilson, John; Welch, Dan; Gkitsas-Long, Nikolaos; Retherford, Aidan Jeffrey; Tunuguntla, Ramya; Melocchi, Alice; Girard, Alexandre; Parietti, Federico; Feldman, Steven A.; Esensten, Jonathan H. 分享 收藏
HUMANIZED ANTI-CAR ANTIBODIES AFFECT DURABLE RESPONSE TO GD2-CAR T-CELLS IN DIFFUSE MIDLINE GLIOMA 人源化抗CAR抗体影响弥漫性中线胶质瘤中GD2-CAR T细胞的持久应答 Chen, Yiyun; Song, Kun-Wei; Huang, Ying-Wen; Iswari, Nadya; Desai, Moksha; Ehlinger, Zachary; Daghagh, Hossein; Reynolds, Kevin; Mahdi, Jasia; Majzner, Robbie; Richards, Becky; Kamens, Jennifer; Barsan, Valentin; Campen, Cynthia; Partap, Sonia; Madhav, Divya; Moon, Jennifer; Baggott, Christina; Fujimoto, Michelle; Li, Amy; Jariwala, Sneha; Mavroukakis, Sharon; Egeler, Emily; Jacobs, Ashley; Erickson, Courtney; Kaur, Aanchal Preet; Soundaranayagi, Smriti; Rietberg, Skyler; Schultz, Liora; Davis, Kara; Feldman, Steven; Heitzeneder, Sabine; Yamada-Hunter, Sean; Sotillo, Elena; Good, Zinaida; Sahaf, Bita; Monje, Michelle; Ramakrishna, Sneha; Mackall, Crystal 分享 收藏
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MYELOID POPULATIONS MODULATE GD2 CAR T CELL ACTIVITY IN DIFFUSE MIDLINE GLIOMA Ramakrishna, Sneha; Geraghty, Anna; Good, Zinaida; Desai, Moksha; Mancusi, Rebecca; Mahdi, Jasia; Song, Kun Wei; Ehlinger, Zachary; Chen, Yiyun; Hamilton, Mark; Rietberg, Skyler; Majzner, Robbie; Schultz, Liora; Richards, Becky; Kamens, Jennifer; Barsan, Vali; Campen, Cynthia; Partap, Sonia; Moon, Jennifer; Baggott, Christina; Kunick, Michael; Fujimoto, Michelle; Li, Amy; Jariwala, Sneha; Mavroukakis, Sharon; Egeler, Emily; Jacobs, Ashley; Erickson, Courtney; Prabhu, Snehit; Davis, Kara; Feldman, Steven; Sahaf, Bita; Mackall, Crystal; Monje, Michelle 分享 收藏
GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency Car-t细胞中GLUT1过表达诱导代谢重编程并增强效力 Guerrero, Justin A.; Klysz, Dorota D.; Chen, Yiyun; Malipatlolla, Meena; Lone, Jameel; Fowler, Carley; Stuani, Lucille; May, Audre; Bashti, Malek; Xu, Peng; Huang, Jing; Michael, Basil; Contrepois, Kevin; Dhingra, Shaurya; Fisher, Chris; Svensson, Katrin J.; Davis, Kara L.; Kasowski, Maya; Feldman, Steven A.; Sotillo, Elena; Mackall, Crystal L. 分享 收藏
CD22-directed CART-cell therapy for large B-cell lymphomas progressing after CD19-directed CART-cell therapy: a dose- finding phase 1 study Frank, Matthew J.; Baird, John H.; Kramer, Anne Marijn; Srinagesh, Hrishikesh K.; Patel, Shabnum; Brown, Annie Kathleen; Oak, Jean S.; Younes, Sheren F.; Natkunam, Yasodha; Hamilton, Mark P.; Su, Yi-Jiun; Agarwal, Neha; Chinnasamy, Harshini; Egeler, Emily; Mavroukakis, Sharon; Feldman, Steven A.; Sahaf, Bita; Mackall, Crystal L.; Muffly, Lori; Miklos, David B. 分享 收藏
SEQUENTIAL INTRAVENOUS AND INTRACEREBROVENTRICULAR GD2-CAR T-CELL THERAPY FOR H3K27M-MUTATED DIFFUSE MIDLINE GLIOMAS Monje, Michelle; Mahdi, Jasia; Majzner, Robbie G.; Yeom, Kristen; Schultz, Liora M.; Richards, Rebecca; Barsan, Valentin; Song, Kun-Wei; Kamens, Jennifer; Baggott, Christina; Kunicki, Michael; Lim, Alexandria Sung; Reschke, Agnes; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Patel, Shabnum; Chinnasamy, Harshini; Erickson, Courtney; Jacobs, Ashley; Duh, Allison K.; Rietberg, Skyler P.; Tunuguntla, Ramya; Klysz, Dorota Danuta; Fowler, Carley; Green, Sean; Beebe, Barbara; Carr, Casey; Fujimoto, Michelle; Brown, Annie Kathleen; Peterson, Ann-Louise G.; Mcintyre, Catherine; Siddiqui, Aman; Lepori-Bui, Nadia; Villar, Katlin; Pham, Kymhuynh; Bove, Rachel; Musa, Eric; Reynolds, Warren; Kuo, Adam; Prabhu, Snehit; Rasmussen, Lindsey; Cornell, Timothy T.; Partap, Soni; Fisher, Paul G.; Campen, Cynthia J.; Grant, Gerald; Prolo, Laura; Ye, Xiaobu; Sahaf, Bita; Davis, Kara L.; Feldman, Steven A.; Ramakrishna, Sneha; Mackall, Crystal L. 分享 收藏
CD22 CAR T cells demonstrate high response rates and safety in pediatric and adult B-ALL: Phase 1b results Schultz, Liora M.; Jeyakumar, Nikeshan; Kramer, Anne Marijn; Sahaf, Bita; Srinagesh, Hrishi; Shiraz, Parveen; Agarwal, Neha; Hamilton, Mark; Erickson, Courtney; Jacobs, Ashley; Moon, Jennifer; Baggott, Christina; Arai, Sally; Bharadwaj, Sushma; Johnston, Laura J.; Liedtke, Michaela; Lowsky, Robert; Meyer, Everett; Negrin, Robert; Rezvani, Andrew; Shizuru, Judy; Sidana, Surbhi; Egeler, Emily; Mavroukakis, Sharon; Tunuguntla, Ramya; Gkitsas-Long, Nikolaos; Retherford, Aidan; Brown, Annie Kathleen; Gramstrap-Petersen, Anne-Louise; Ibanez, Raquel Martin; Feldman, Steven A.; Miklos, David B.; Mackall, Crystal L.; Davis, Kara L.; Frank, Matthew; Ramakrishna, Sneha; Muffly, Lori 分享 收藏
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing Balke-Want, Hyatt; Keerthi, Vimal; Gkitsas, Nikolaos; Mancini, Andrew G.; Kurgan, Gavin L.; Fowler, Carley; Xu, Peng; Liu, Xikun; Asano, Kyle; Patel, Sunny; Fisher, Christopher J.; Brown, Annie K.; Tunuguntla, Ramya H.; Patel, Shabnum; Sotillo, Elena; Mackall, Crystal L.; Feldman, Steven A. 分享 收藏
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Inosine endows CAR T cells with features of increased stemness and anti-tumor potency Klysz, Dorota; Freitas, Katie; Malipatlolla, Meena; Maier, Stefanie; Fowler, Carley; Labanieh, Louai; Stuani, Lucille; Daniel, Bence; Sandor, Katalin; Xu, Peng; Huang, Jing; Leruste, Amaury; Keerthi, Vimal; Gkitsas, Nikolaos; Patel, Shabnum; Arredondo-Guerrero, Justin; Fisher, Chris; Asano, Kyle; Patel, Sunny; Satpathy, Ansuman; Davis, Kara; Sotillo, Elena; Feldman, Steven; Mackall, Crystal 分享 收藏
Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy Good, Zinaida; Spiegel, Jay Y.; Sahaf, Bita; Malipatlolla, Meena B.; Ehlinger, Zach J.; Kurra, Sreevidya; Desai, Moksha H.; Reynolds, Warren D.; Lin, Anita Wong; Vandris, Panayiotis; Wu, Fang; Prabhu, Snehit; Hamilton, Mark P.; Tamaresis, John S.; Hanson, Paul J.; Patel, Shabnum; Feldman, Steven A.; Frank, Matthew J.; Baird, John H.; Muffly, Lori; Claire, Gursharan K.; Craig, Juliana; Kong, Katherine A.; Wagh, Dhananjay; Coller, John; Bendall, Sean C.; Tibshirani, Robert J.; Plevritis, Sylvia K.; Miklos, David B.; Mackall, Crystal L. 分享 收藏
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CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial CD19和CD22双重靶向CAR T细胞治疗复发性或难治性b细胞恶性肿瘤的1期临床试验 Spiegel, Jay Y.; Patel, Shabnum; Muffly, Lori; Hossain, Nasheed M.; Oak, Jean; Baird, John H.; Frank, Matthew J.; Shiraz, Parveen; Sahaf, Bita; Craig, Juliana; Iglesias, Maria; Younes, Sheren; Natkunam, Yasodha; Ozawa, Michael G.; Yang, Eric; Tamaresis, John; Chinnasamy, Harshini; Ehlinger, Zach; Reynolds, Warren; Lynn, Rachel; Rotiroti, Maria Caterina; Gkitsas, Nikolaos; Arai, Sally; Johnston, Laura; Lowsky, Robert; Majzner, Robbie G.; Meyer, Everett; Negrin, Robert S.; Rezvani, Andrew R.; Sidana, Surbhi; Shizuru, Judith; Weng, Wen-Kai; Mullins, Chelsea; Jacob, Allison; Kirsch, Ilan; Bazzano, Magali; Zhou, Jing; Mackay, Sean; Bornheimer, Scott J.; Schultz, Liora; Ramakrishna, Sneha; Davis, Kara L.; Kong, Katherine A.; Shah, Nirali N.; Qin, Haiying; Fry, Terry; Feldman, Steven; Mackall, Crystal L.; Miklos, David B. 分享 收藏
GD2 CAR T-CELLS MEDIATE CLINICAL ACTIVITY AND MANAGEABLE TOXICITY IN CHILDREN AND YOUNG ADULTS WITH H3K27M-MUTATED DIPG AND SPINAL CORD DMG Majzner, Robbie; Ramakrishna, Sneha; Mochizuki, Aaron; Patel, Shabnum; Chinnasamy, Harshini; Yeom, Kristen; Schultz, Liora; Richards, Rebecca; Campen, Cynthia; Reschke, Agnes; Mahdi, Jasia; Martin, Angus; Toland, Shaw; Baggott, Christina; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Landrum, Kayla; Erickson, Courtney; Rasmussen, Lindsay; Barsan, Valentin; Tamaresis, John; Marcy, Anne; Kunicki, Michael; Fujimoto, Michelle; Ehlinger, Zach; Kurra, Sreevidya; Cornell, Timothy; Partap, Sonia; Fisher, Paul; Grant, Gerald; Vogel, Hannes; Sahaf, Bita; Davis, Kara; Feldman, Steven; Mackall, Crystal; Monje, Michelle 分享 收藏
SINGLE CELL RNA SEQUENCING FROM THE CSF OF SUBJECTS WITH H3K27M+DIPG/DMG TREATED WITH GD2 CAR T-CELLULAR THERAPY Mochizuki, Aaron; Ramakrishna, Sneha; Good, Zina; Patel, Shabnum; Chinnasamy, Harshini; Yeom, Kristen; Schultz, Liora; Richards, Rebecca; Campen, Cynthia; Reschke, Agnes; Mahdi, Jasia; Toland, Angus; Baggot, Christina; Mavroukakis, Sharon; Egeler, Emily; Moon, Jennifer; Landrum, Kayla; Erickson, Courtney; Rasmussen, Lindsey; Barsan, Valentin; Tamaresis, John; Marcy, Anne; Kunicki, Michael; Celones, Michelle; Ehlinger, Zach; Kurra, Sreevidya; Cornell, Timothy; Partap, Sonia; Fisher, Paul; Grant, Gerald; Vogel, Hannes; Davis, Kara; Feldman, Steven; Sahaf, Bita; Majzner, Robbie; Mackall, Crystal; Monje, Michelle 分享 收藏
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery Chiou, Shin-Heng; Tseng, Diane; Reuben, Alexandre; Mallajosyula, Vamsee; Molina, Irene S.; Conley, Stephanie; Wilhelmy, Julie; McSween, Alana M.; Yang, Xinbo; Nishimiya, Daisuke; Sinha, Rahul; Nabet, Barzin Y.; Wang, Chunlin; Shrager, Joseph B.; Berry, Mark F.; Backhus, Leah; Lui, Natalie S.; Wakelee, Heather A.; Neal, Joel W.; Padda, Sukhmani K.; Berry, Gerald J.; Delaidelli, Alberto; Sorensen, Poul H.; Sotillo, Elena; Tran, Patrick; Benson, Jalen A.; Richards, Rebecca; Labanieh, Louai; Klysz, Dorota D.; Louis, David M.; Feldman, Steven A.; Diehn, Maximilian; Weissman, Irving L.; Zhang, Jianjun; Wistuba, Ignacio I.; Futreal, P. Andrew; Heymach, John, V; Garcia, K. Christopher; Mackall, Crystal L.; Davis, Mark M. 分享 收藏
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Tumor infiltrating lymphocytes (TIL) recognize a unique and diverse number of non-synonymous somatic mutations in patients with metastatic breast cancer Zacharakis, Nikolaos; Kim, Peter; Robbins, Paul; Gartner, Jared; Prickett, Todd; Hill, Victoria; Paria, Biman; Feldman, Steven; Goff, Stephanie; Rosenberg, Steven 分享 收藏
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