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收藏Syndecan 1 is a therapeutic target for KRAS-driven pancreatic cancer
Takeda, Mitsunobu; Yang, Zecheng; Theardy, Madeline S.; Sorokin, Alexey; Coker, Oluwadara; Chen, Shuaitong; Vien, Long T.; Bover, Laura; Ying, Haoqiang; Kopetz, Scott; Yao, Wantong 分享 收藏 Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance共靶向SOS1通过解决内在和获得性耐药增强KRASG12C抑制剂的抗肿瘤作用Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. 分享 收藏 分享 收藏 The PLK1 inhibitor, onvansertib, is active as monotherapy and in combination with cetuximab in RAS wild-type colorectal cancer patient-derived xenograftsRidinger, Maya; Marie, Preeti Kanikarla; Gao, Fengqin; Liu, Zhensheng; Maddalena, Giulia; Menter, David; Sorokin, Alexey; Smeal, Tod; Kopetz, Scott 分享 收藏 Elevated H3K27 trimethylation mediates adaptation to DNA demethylation in BRAFV600E-mutated colorectal cancerLee, Hey Min; Saw, Ajay Kumar; Morris, Van Karlyle; Singh, Anand Kamal; Napolitano, Stefania; Sorokin, Alexey; Marie, Preeti Kanikarla; Coker, Oluwadara; Villarreal, Oscar Eduardo; Anvar, Nazanin Esmaeili; Rai, Kunal; Kopetz, Scott 分享 收藏 YAP-TAZ-TEAD transcriptional program is a prominent driver of acquired resistance to KRASG12C-based therapies in patients with metastatic colorectal cancerCoker, Oluwadara; Sorokin, Alexey; Akhave, Neal; Pan, Kelsey; Gao, Fengqin; Liu, Zhensheng; Kanikarla, Preeti; Lee, HeyMin; Villarreal, Oscar; Alshenaifi, Jumanah; Maddalena, Giulia; Mohamed, Alaa; Prescod, Dionne; Menter, David; Chowdury, Saikat; Corcoran, Ryan; Rai, Kunal; Hong, David; Kopetz, Scott 分享 收藏 分享 收藏 Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal CancerGhosh, Susmita; Fan, Fan; Powell, Reid T.; Roszik, Jason; Park, Yong Sung; Stephan, Clifford; Sebastian, Manu; Tan, Lin; Sorokin, Alexey, V; Lorenzi, Philip L.; Kopetz, Scott; Ellis, Lee M.; Bhattacharya, Rajat 分享 收藏 分享 收藏 Combining bromodomain and extraterminal (BET) protein inhibitor treatment with standard MAPK inhibitors improved MAPK signaling inhibition in colorectal cancerLee, Hey Min; Sorokin, Alexey; Marie, Preeti Kanikarla; Chowdhury, Saikat; Singh, Anand; Anderson, Amanda; Alshenaifi, Jumanah Yousef; Meric-Bernstam, Funda; Rai, Kunal; Kopetz, Scott 分享 收藏 分享 收藏 Autologous humanized mouse models to study combination and single-agent immunotherapy for colorectal cancer patient-derived xenograftsKanikarla Marie, Preeti; Sorokin, Alexey V.; Bitner, Lea A.; Aden, Rebecca; Lam, Michael; Manyam, Ganiraju; Woods, Melanie N.; Anderson, Amanda; Capasso, Anna; Fowlkes, Natalie; Overman, Michael J.; Menter, David G.; Kopetz, Scott 分享 收藏 Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6Sorokin, Alexey V.; Marie, Preeti Kanikarla; Bitner, Lea; Syed, Muddassir; Woods, Melanie; Manyam, Ganiraju; Kwong, Lawrence N.; Johnson, Benny; Morris, Van K.; Jones, Philip; Menter, David G.; Lee, Michael S.; Kopetz, Scott 分享 收藏 KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy野生型RAS的KRASG12C-independent反馈激活限制了KRASG12C抑制剂的功效Ryan, Meagan B.; Coker, Oluwadara; Sorokin, Alexey; Fella, Katerina; Barnes, Haley; Wong, Edmond; Kanikarla, Preeti; Gao, Fengqin; Zhang, Youyan; Zhou, Lian; Kopetz, Scott; Corcoran, Ryan B. 分享 收藏 The Provocative Roles of Platelets in Liver Disease and CancerKanikarla Marie, Preeti; Fowlkes, Natalie W.; Afshar-Kharghan, Vahid; Martch, Stephanie L.; Sorokin, Alexey; Shen, John Paul; Morris, Van K.; Dasari, Arvind; You, Nancy; Sood, Anil K.; Overman, Michael J.; Kopetz, Scott; Menter, David George 分享 收藏 Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpressionEGFR，MEK和PD-L1的三重阻断在结直肠癌模型中具有抗肿瘤活性，MAPK信号转导和PD-L1过表达Napolitano, S.; Matrone, N.; Muddassir, A. L.; Martini, G.; Sorokin, A.; De Falco, V.; Giunta, E. F.; Ciardiello, D.; Martinelli, E.; Belli, V.; Furia, M.; Kopetz, S.; Morgillo, F.; Ciardiello, F.; Troiani, T. 分享 收藏 分享 收藏 分享 收藏 分享 收藏 
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