未登录 Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer 缺氧与肺癌对免疫检查点抑制剂的获得性耐药有关 Robles-Oteiza, Camila; Hastings, Katherine; Choi, Jungmin; Sirois, Isabelle; Ravi, Arvind; Exposito, Francisco; de Miguel, Fernando; Knight, James R.; Lopez-Giraldez, Francesc; Choi, Hyejin; Socci, Nicholas D.; Merghoub, Taha; Awad, Mark; Getz, Gad; Gainor, Justin; Hellmann, Matthew D.; Caron, Etienne; Kaech, Susan M.; Politi, Katerina 分享 收藏
Antibiotics are associated with worse outcomes in lung cancer patients treated with chemotherapy and immunotherapy 抗生素与化疗和免疫治疗的肺癌患者预后较差相关 Elkrief, Arielle; Mendez-Salazar, Eder Orlando; Maillou, Jade; Vanderbilt, Chad M.; Gogia, Pooja; Desilets, Antoine; Messaoudene, Meriem; Kelly, Daniel; Ladanyi, Marc; Hellmann, Matthew D.; Zitvogel, Laurence; Rudin, Charles M.; Routy, Bertrand; Derosa, Lisa; Schoenfeld, Adam J. 分享 收藏
Aligning tumor mutational burden (TMB) quantification across diagnostic platforms: phase II of the Friends of Cancer Research TMB Harmonization Project (vol 32, pg 1626, 2021) Vega, D. M.; Yee, L. M.; McShane, L. M.; Williams, P. M.; Chen, L.; Vilimas, T.; Fabrizio, D.; Funari, V.; Newberg, J.; Bruce, L. K.; Chen, S-J; Baden, J.; Barrett, J. Carl; Beer, P.; Butler, M.; Cheng, J-H; Conroy, J.; Cyanam, D.; Eyring, K.; Garcia, E.; Green, G.; Gregersen, V. R.; Hellmann, M. D.; Keefer, L. A.; Lasiter, L.; Lazar, A. J.; Li, M. -C; MacConaill, L. E.; Meier, K.; Mellert, H.; Pabla, S.; Pallavajjalla, A.; Pestano, G.; Salgado, R.; Samara, R.; Sokol, E. S.; Stafford, P.; Budczies, J.; Stenzinger, A.; Tom, W.; Valkenburg, K. C.; Wang, X. Z.; Weigman, V.; Xie, M.; Xie, Q.; Zehir, A.; Zhao, C.; Zhao, Y.; Stewart, M. D.; Allen, J. 分享 收藏
Biomarker-directed, pembrolizumab-based combination therapy in non-small cell lung cancer: phase 2 KEYNOTE-495/KeyImPaCT trial interim results Gutierrez, Martin; Lam, Wei-Sen; Hellmann, Matthew D.; Gubens, Matthew A.; Aggarwal, Charu; Tan, Daniel Shao Weng; Felip, Enriqueta; Chiu, Joanne W. Y.; Lee, Jong-Seok; Yang, James Chih-Hsin; Garon, Edward B.; Finocchiaro, Giovanna; Ahn, Myung-Ju; Luft, Alexander; Landers, Gregory A.; Basso, Andrea; Ma, Hua; Kobie, Julie; Palcza, John; Cristescu, Razvan; Fong, Lawrence; Snyder, Alexandra; Yuan, Jianda; Herbst, Roy S. 分享 收藏
Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer Ravi, Arvind; Hellmann, Matthew D.; Arniella, Monica B.; Holton, Mark; Freeman, Samuel S.; Naranbhai, Vivek; Stewart, Chip; Leshchiner, Ignaty; Kim, Jaegil; Akiyama, Yo; Griffin, Aaron T.; Vokes, Natalie I.; Sakhi, Mustafa; Kamesan, Vashine; Rizvi, Hira; Ricciuti, Biagio; Forde, Patrick M.; Anagnostou, Valsamo; Riess, Jonathan W.; Gibbons, Don L.; Pennell, Nathan A.; Velcheti, Vamsidhar; Digumarthy, Subba R.; Mino-Kenudson, Mari; Califano, Andrea; Heymach, John V.; Herbst, Roy S.; Brahmer, Julie R.; Schalper, Kurt A.; Velculescu, Victor E.; Henick, Brian S.; Rizvi, Naiyer; Jaenne, Pasi A.; Awad, Mark M.; Chow, Andrew; Greenbaum, Benjamin D.; Luksza, Marta; Shaw, Alice T.; Wolchok, Jedd; Hacohen, Nir; Getz, Gad; Gainor, Justin F. 分享 收藏
Intratumoral Escherichia is associated with response to single-agent immune checkpoint inhibition in patients with advanced non-small cell lung cancer Elkrief, Arielle; Bowman, Anita S.; Bektas, Ayyuce Begum; Kang, Wenfei; Manova-Todorova, Katia; Egger, Jacklynn V.; Rizvi, Hira; Kelly, Daniel; Chan, Eric; Rosiek, Eric; Ning, Fan; Riely, Gregory J.; Villalonga, Alvaro Quintanal; Dogan, Snjezana; Bhanot, Umesh; Gonen, Mithat; Hellmann, Matthew D.; Schoenfeld, Adam J.; Rudin, Charles M.; Ladanyi, Marc; Vanderbilt, Chad M. 分享 收藏
Immunoproteasome expression and checkpoint blockade response in advanced non-small cell lung cancer Naranbhai, Vivek; Ravi, Arvind; Hellmann, Matthew; Arniella, Monica; Holton, Mark; Freeman, Samuel; Stewart, Chip; Leshchiner, Ignaty; Kim, Jaegil; Akiyama, Yo; Griffin, Aaron; Vokes, Natalie; Sakhi, Mustafa; Kamesan, Vashine; Rizvi, Hira; Ricciuti, Biagio; Forde, Patrick; Anagnostou, Valsamo; Riess, Jonathan; Gibbons, Don; Pennell, Nathan; Velcheti, Vamsidhar; Digumarthy, Subba; Mino-Kenudson, Mari; Califano, Andrea; Heymach, John; Herbst, Roy; Brahmer, Julie; Schalper, Kurt; Velculescu, Victor; Henick, Brian; Rizvi, Naiyer; Janne, Pasi; Awad, Mark; Chow, Andrew; Greenbaum, Benjamin; Luksza, Marta; Shaw, Alice; Wolchok, Jedd; Hacohen, Nir; Getz, Gad; Gainor, Justin 分享 收藏
Background variability in plasma ctDNA levels in patients with advanced lung cancer in the absence of treatment Vega, Diana M.; Markovets, Aleksandra; Abbosh, Christopher; Quinn, Katie; Chang, Kyle; Wienke, Sara; Hartmaier, Ryan; Hellmann, Matthew; Barrett, J. Carl; Hodgson, Darren 分享 收藏
Misclassification of clonal hematopoietic mutations as tumor-derived confound accurate ctDNA-response assessment in patients with metastatic non-small-cell lung cancer: analyses from the phase 3 MYSTIC trial Abbosh, Chris; Kuziora, Michael; Stetson, Daniel; Lai, Zhongwu; Shrestha, Yashaswi; Labrousse, Paul; Shi, Xiaojin; Mann, Helen; Vega, Diana Merino; Hellmann, Matthew D.; Peters, Solange; Barrett, J. Carl; Hodgson, Darren 分享 收藏
Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors with chemotherapy 癌症免疫治疗协会 (SITC) 对免疫检查点抑制剂联合化疗耐药的共识定义 Rizvi, Naiyer; Ademuyiwa, Foluso O.; Cao, Z. Alexander; Chen, Helen X.; Ferris, Robert L.; Goldberg, Sarah B.; Hellmann, Matthew D.; Mehra, Ranee; Rhee, Ina; Park, Jong Chul; Kluger, Harriet; Tawbi, Hussein; Sullivan, Ryan J. 分享 收藏
Long-term survival with first-line nivolumab plus ipilimumab in patients with advanced non-small-cell lung cancer: a pooled analysis Borghaei, H.; Ciuleanu, T. -E.; Lee, J. -S; Pluzanski, A.; Caro, R. Bernabe; Gutierrez, M.; Ohe, Y.; Nishio, M.; Goldman, J.; Ready, N.; Spigel, D. R.; Ramalingam, S. S.; Paz-Ares, L. G.; Gainor, J. F.; Ahmed, S.; Reck, M.; Maio, M.; O'Byrne, K. J.; Memaj, A.; Nathan, F.; Tran, P.; Hellmann, M. D.; Brahmer, J. R. 分享 收藏
The ectonucleotidase CD39 identifies tumor-reactive CD8+T cells predictive of immune checkpoint blockade efficacy in human lung cancer 外核酸酶CD39识别肿瘤反应性CD8 T细胞，预测人类肺癌中免疫检查点阻断功效 Chow, Andrew; Uddin, Fathema Z.; Liu, Michael; Dobrin, Anton; Nabet, Barzin Y.; Mangarin, Levi; Lavin, Yonit; Rizvi, Hira; Tischfield, Sam E.; Quintanal-Villalonga, Alvaro; Chan, Joseph M.; Shah, Nisargbhai; Allaj, Viola; Manoj, Parvathy; Mattar, Marissa; Meneses, Maximiliano; Landau, Rebecca; Ward, Mariana; Kulick, Amanda; Kwong, Charlene; Wierzbicki, Matthew; Yavner, Jessica; Egger, Jacklynn; Chavan, Shweta S.; Farillas, Abigail; Holland, Aliya; Sridhar, Harsha; Ciampricotti, Metamia; Hirschhorn, Daniel; Guan, Xiangnan; Richards, Allison L.; Heller, Glenn; Mansilla-Soto, Jorge; Sadelain, Michel; Klebanoff, Christopher A.; Hellmann, Matthew D.; Sen, Triparna; de Stanchina, Elisa; Wolchok, Jedd D.; Merghoub, Taha; Rudin, Charles M. 分享 收藏
Widespread hypertranscription in aggressive human cancers Zatzman, Matthew; Fuligni, Fabio; Ripsman, Ryan; Suwal, Tannu; Comitani, Federico; Edward, Lisa-Monique; Denroche, Rob; Jang, Gun Ho; Notta, Faiyaz; Gallinger, Steven; Selvanathan, Saravana P.; Toretsky, Jeffrey A.; Hellmann, Matthew D.; Tabori, Uri; Huang, Annie; Shlien, Adam 分享 收藏
Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer 循环肿瘤DNA指导治疗晚期非小细胞肺癌的总生存期 Jee, Justin; Lebow, Emily S.; Yeh, Randy; Das, Jeeban P.; Namakydoust, Azadeh; Paik, Paul K.; Chaft, Jamie E.; Jayakumaran, Gowtham; Brannon, A. Rose; Benayed, Ryma; Zehir, Ahmet; Donoghue, Mark; Schultz, Nikolaus; Chakravarty, Debyani; Kundra, Ritika; Madupuri, Ramyasree; Murciano-Goroff, Yonina R.; Tu, Hai-Yan; Xu, Chong-Rui; Martinez, Andres; Wilhelm, Clare; Galle, Jesse; Daly, Bobby; Yu, Helena A.; Offin, Michael; Hellmann, Matthew D.; Lito, Piro; Arbour, Kathryn C.; Zauderer, Marjorie G.; Kris, Mark G.; Ng, Kenneth K.; Eng, Juliana; Preeshagul, Isabel; Lai, W. Victoria; Fiore, John J.; Iqbal, Afsheen; Molena, Daniela; Rocco, Gaetano; Park, Bernard J.; Lim, Lee P.; Li, Mark; Tong-Li, Candace; De Silva, Madhawa; Chan, David L.; Diakos, Connie, I; Itchins, Malinda; Clarke, Stephen; Pavlakis, Nick; Lee, Adrian; Rekhtman, Natasha; Chang, Jason; Travis, William D.; Riely, Gregory J.; Solit, David B.; Gonen, Mithat; Rusch, Valerie W.; Rimner, Andreas; Gomez, Daniel; Drilon, Alexander; Scher, Howard, I; Shah, Sohrab P.; Berger, Michael F.; Arcila, Maria E.; Ladanyi, Marc; Levine, Ross L.; Shen, Ronglai; Razavi, Pedram; Reis-Filho, Jorge S.; Jones, David R.; Rudin, Charles M.; Isbell, James M.; Li, Bob T. 分享 收藏
Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer Coffey, David G.; Xu, Yuexin; Towlerton, Andrea M. H.; Kowanetz, Marcin; Hegde, Priti; Darwish, Martine; Yadav, Mahesh; Blanchette, Craig; Ruppert, Shannon M.; Bertino, Sarah; Xu, Qikai; Ferretti, Andrew; Weinheimer, Adam; Hellmann, Matthew; Qin, Angel; Thomas, Dafydd; Warren, Edus H.; Ramnath, Nithya 分享 收藏
Genetic Ancestry Correlates with Somatic Differences in a Real-World Clinical Cancer Sequencing Cohort Arora, Kanika; Tran, Thinh N.; Kemel, Yelena; Mehine, Miika; Liu, Ying L.; Nandakumar, Subhiksha; Smith, Shaleigh A.; Brannon, A. Rose; Ostrovnaya, Irina; Stopsack, Konrad H.; Razavi, Pedram; Safonov, Anton; Rizvi, Hira A.; Hellmann, Matthew D.; Vijai, Joseph; Reynolds, Thomas C.; Fagin, James A.; Carrot-Zhang, Jian; Offit, Kennet; Solit, David B.; Ladanyil, Marc; Schultz, Nikolaus; Zehir, Ahmet; Brown, Carol L.; Stadler, Zsofia K.; Chakravarty, Debyani; Bandlamudi, Chaitanya; Berger, Michael F. 分享 收藏
Multimodal integration of radiology, pathology and genomics for prediction of response to PD-(L)1 blockade in patients with non-small cell lung cancer 放射学、病理学和基因组学的多模态整合预测非小细胞肺癌患者对PD-(L)1阻断的反应 Vanguri, Rami S.; Luo, Jia; Aukerman, Andrew T.; Egger, Jacklynn, V; Fong, Christopher J.; Horvat, Natally; Pagano, Andrew; Araujo-Filho, Jose De Arimateia Batista; Geneslaw, Luke; Rizvi, Hira; Sosa, Ramon; Boehm, Kevin M.; Yang, Soo-Ryum; Bodd, Francis M.; Ventura, Katia; Hollmann, Travis J.; Ginsberg, Michelle S.; Gao, Jianjiong; Hellmann, Matthew D.; Sauter, Jennifer L.; Shah, Sohrab P. 分享 收藏
Deciphering radiological stable disease to immune checkpoint inhibitors Luo, J.; Wu, S.; Rizvi, H.; Zhang, Q.; Egger, J., V; Osorio, J. C.; Schoenfeld, A. J.; Plodkowski, A. J.; Ginsberg, M. S.; Callahan, M. K.; Maher, C.; Shoushtari, A. N.; Postow, M. A.; Voss, M. H.; Kotecha, R. R.; Gupta, A.; Raja, R.; Kris, M. G.; Hellmann, M. D. 分享 收藏
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions Schad, Sara E.; Chow, Andrew; Mangarin, Levi; Pan, Heng; Zhang, Jiajia; Ceglia, Nicholas; Caushi, Justina X.; Malandro, Nicole; Zappasodi, Roberta; Gigoux, Mathieu; Hirschhorn, Daniel; Budhu, Sadna; Amisaki, Masataka; Arniella, Monica; Redmond, David; Chaft, Jamie; Forde, Patrick M.; Gainor, Justin F.; Hellmann, Matthew D.; Balachandran, Vinod; Shah, Sohrab; Smith, Kellie N.; Pardoll, Drew; Elemento, Olivier; Wolchok, Jedd D.; Merghoub, Taha 分享 收藏
Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer Mukherjee, Semanti; Bandlamudi, Chaitanya; Hellmann, Matthew D.; Kemel, Yelena; Drill, Esther; Rizvi, Hira; Tkachuk, Kaitlyn; Khurram, Aliya; Walsh, Michael F.; Zauderer, Marjorie G.; Mandelker, Diana; Topka, Sabine; Zehir, Ahmet; Srinivasan, Preethi; Selvan, Myvizhi Esai; Carlo, Maria I.; Cadoo, Karen A.; Latham, Alicia; Hamilton, Jada G.; Liu, Ying L.; Lipkin, Steven M.; Belhadj, Sami; Bond, Gareth L.; Gumus, Zeynep H.; Klein, Robert J.; Ladanyi, Marc; Solit, David B.; Robson, Mark E.; Jones, David R.; Kris, Mark G.; Vijai, Joseph; Stadler, Zsofia K.; Amos, Christopher I.; Taylor, Barry S.; Berger, Michael F.; Rudin, Charles M.; Offit, Kenneth 分享 收藏
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