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PanDrugs2: prioritizing cancer therapies using integrated individual multi-omics data Jimenez-Santos, Maria Jose; Nogueira-Rodriguez, Alba; Pineiro-Yanez, Elena; Lopez-Fernandez, Hugo; Garcia-Martin, Santiago; Gomez-Plana, Paula; Reboiro-Jato, Miguel; Gomez-Lopez, Gonzalo; Glez-Pena, Daniel; Al-Shahrour, Fatima 分享 收藏
Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A Mouron, S.; Bueno, M. J.; Lluch, A.; Manso, L.; Calvo, I; Cortes, J.; Garcia-Saenz, J. A.; Gil-Gil, M.; Martinez-Janez, N.; Apala, J., V; Caleiras, E.; Ximenez-Embun, Pilar; Munoz, J.; Gonzalez-Cortijo, L.; Murillo, R.; Sanchez-Bayona, R.; Cejalvo, J. M.; Gomez-Lopez, G.; Fustero-Torre, C.; Sabroso-Lasa, S.; Malats, N.; Martinez, M.; Moreno, A.; Megias, D.; Malumbres, M.; Colomer, R.; Quintela-Fandino, M. 分享 收藏
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Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers Martin, Alberto; Epifano, Carolina; Vilaplana-Marti, Borja; Hernandez, Ivan; Macias, Rocio I. R.; Martinez-Ramirez, Angel; Cerezo, Ana; Cabezas-Sainz, Pablo; Garranzo-Asensio, Maria; Amarilla-Quintana, Sandra; Gomez-Dominguez, Deborah; Caleiras, Eduardo; Camps, Jordi; Gomez-Lopez, Gonzalo; Gomez de Cedron, Marta; Ramirez de Molina, Ana; Barderas, Rodrigo; Sanchez, Laura; Velasco-Miguel, Susana; Perez de Castro, Ignacio 分享 收藏
Evaluation in a Cytokine Storm Model In Vivo of the Safety and Efficacy of Intravenous Administration of PRS CK STORM (Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells) Pedro Lapuente, Juan; Gomez, Gonzalo; Marco-Brualla, Joaquin; Fernandez, Pablo; Desportes, Paula; Sanz, Jara; Garcia-Gil, Mario; Bermejo, Fernando; Victor San Martin, Juan; Algaba, Alicia; Carlos De Gregorio, Juan; Lapuente, Daniel; De Gregorio, Almudena; Lapuente, Belen; Gomez, Sergio; de las Vinas Andres, Maria; Anel, Alberto 分享 收藏
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RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness Benitez, Sandra; Cordero, Alex; Santamaria, Patricia G.; Redondo-Pedraza, Jaime; Rocha, Ana S.; Collado-Sole, Alejandro; Jimenez, Maria; Sanz-Moreno, Adrian; Yoldi, Guillermo; Santos, Juliana C.; De Benedictis, Ilaria; Gomez-Aleza, Clara; Da Silva-Alvarez, Sabela; Troule, Kevin; Gomez-Lopez, Gonzalo; Alcazar, Noelia; Palmero, Ignacio; Collado, Manuel; Serrano, Manuel; Gonzalez-Suarez, Eva 分享 收藏
Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia Xiong, Huizhong; Mancini, Maicol; Gobert, Michael; Shen, Shiqian; Furtado, Glaucia C.; Lira, Sergio A.; Parkhurst, Christopher N.; Garambois, Veronique; Brengues, Muriel; Tadokoro, Carlos E.; Trimarchi, Thomas; Gomez-Lopez, Gonzalo; Singh, Amartya; Khiabanian, Hossein; Minuzzo, Sonia; Indraccolo, Stefano; Lobry, Camille; Aifantis, Iannis; Herranz, Daniel; Lafaille, Juan J.; Maraver, Antonio 分享 收藏
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state Cerezo-Wallis, Daniela; Contreras-Alcalde, Marta; Troule, Kevin; Catena, Xavier; Mucientes, Cynthia; Calvo, Tonantzin G.; Canon, Estela; Tejedo, Cristina; Pennacchi, Paula C.; Hogan, Sabrina; Koelblinger, Peter; Tejero, Hector; Chen, Andrew X.; Ibarz, Nuria; Grana-Castro, Osvaldo; Martinez, Lola; Munoz, Javier; Ortiz-Romero, Pablo; Rodriguez-Peralto, Jose L.; Gomez-Lopez, Gonzalo; Al-Shahrour, Fatima; Rabadan, Raul; Levesque, Mitchell P.; Olmeda, David; Soengas, Maria S. 分享 收藏
Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases 增强子的全局超活化通过抑制CDK8/19介质激酶来稳定人类和小鼠的幼稚多能性 Lynch, Cian J.; Bernad, Raquel; Martinez-Val, Ana; Shahbazi, Marta N.; Nobrega-Pereira, Sandrina; Calvo, Isabel; Blanco-Aparicio, Carmen; Tarantino, Carolina; Garreta, Elena; Richart-Gines, Laia; Alcazar, Noelia; Grana-Castro, Osvaldo; Gomez-Lopez, Gonzalo; Aksoy, Irene; Munoz-Martin, Maribel; Martinez, Sonia; Ortega, Sagrario; Prieto, Susana; Simboeck, Elisabeth; Camasses, Alain; Stephan-Otto Attolini, Camille; Fernandez, Agustin F.; Sierra, Marta I.; Fraga, Mario F.; Pastor, Joaquin; Fisher, Daniel; Montserrat, Nuria; Savatier, Pierre; Munoz, Javier; Zernicka-Goetz, Magdalena; Serrano, Manuel 分享 收藏
Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas KRAS/P53突变型肺腺癌中CDK4和RAF1失活后的肿瘤消退和耐药机制 Esteban-Burgos, Laura; Wang, Haiyun; Nieto, Patricia; Zheng, Jie; Blanco-Aparicio, Carmen; Varela, Carmen; Gomez-Lopez, Gonzalo; Fernandez-Garcia, Fernando; Sanclemente, Manuel; Guerra, Carmen; Drosten, Matthias; Galan, Javier; Caleiras, Eduardo; Martinez-Torrecuadrada, Jorge; Fajas, Lluis; Peng, Sheng-Bin; Santamaria, David; Musteanu, Monica; Barbacid, Mariano 分享 收藏
TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion Navarro, Rocio; Tapia-Galisteo, Antonio; Martin-Garcia, Laura; Tarin, Carlos; Corbacho, Cesareo; Gomez-Lopez, Gonzalo; Sanchez-Tirado, Esther; Campuzano, Susana; Gonzalez-Cortes, Araceli; Yanez-Sedeno, Paloma; Compte, Marta; Alvarez-Vallina, Luis; Sanz, Laura 分享 收藏
Autocrine CCL5 Effect Mediates Trastuzumab Resistance by ERK Pathway Activation in HER2-Positive Breast Cancer Zazo, Sandra; Gonzalez-Alonso, Paula; Martin-Aparicio, Ester; Chamizo, Cristina; Luque, Melani; Sanz-Alvarez, Marta; Minguez, Pablo; Gomez-Lopez, Gonzalo; Cristobal, Ion; Carames, Cristina; Garcia-Foncillas, Jesus; Eroles, Pilar; Lluch, Ana; Arpi, Oriol; Rovira, Ana; Albanell, Joan; Madoz-Gurpide, Juan; Rojo, Federico 分享 收藏
MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia Luz Morales, Maria; Arenas, Alicia; Ortiz-Ruiz, Alejandra; Leivas, Alejandra; Rapado, Inmaculada; Rodriguez-Garcia, Alba; Castro, Nerea; Zagorac, Ivana; Quintela-Fandino, Miguel; Gomez-Lopez, Gonzalo; Gallardo, Miguel; Ayala, Rosa; Linares, Maria; Martinez-Lopez, Joaquin 分享 收藏
The correlation between immune subtypes and consensus molecular subtypes in colorectal cancer identifies novel tumour microenvironment profiles, with prognostic and therapeutic implications 结直肠癌中免疫亚型和共有分子亚型之间的相关性确定了新的肿瘤微环境特征，具有预后和治疗意义 Soldevilla, B.; Carretero-Puche, C.; Gomez-Lopez, G.; Al-Shahrour, F.; Riesco, M. C.; Gil-Calderon, B.; Alvarez-Vallina, L.; Espinosa-Olarte, P.; Gomez-Esteves, G.; Rubio-Cuesta, B.; Sarmentero, J.; La Salvia, A.; Garcia-Carbonero, R. 分享 收藏
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High-throughput phosphoproteomics (HTPS) in neoadjuvant (NEO) breast cancer (BC) reveals clusters of extreme sensitivity to paclitaxel (T) Quintela-Fandino, M.; Lluch, A.; Manso, L.; Calvo, I.; Cortes, J.; Garcia-Saenz, J. A.; Zagorac, I.; Tapial-Martinez, P.; Gomez-Lopez, G.; Fustero, C.; Munoz, J.; Gonzalez-Cortijo, L.; Mouron, S. 分享 收藏
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer Zagorac, Ivana; Fernandez-Gaitero, Sara; Penning, Renske; Post, Harm; Bueno, Maria J.; Mouron, Silvana; Manso, Luis; Morente, Manuel M.; Alonso, Soledad; Serra, Violeta; Munoz, Javier; Gomez-Lopez, Gonzalo; Francisco Lopez-Acosta, Jose; Jimenez-Renard, Veronica; Gris-Oliver, Albert; Al-Shahrour, Fatima; Pineiro-Yanez, Elena; Luis Montoya-Suarez, Jose; Apala, Juan V.; Moreno-Torres, Amalia; Colomer, Ramon; Dopazo, Ana; Heck, Albert J. R.; Altelaar, Maarten; Quintela-Fandino, Miguel 分享 收藏
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