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Prognostic Utility of ctDNA Detection in The monarchE Trial of Adjuvant Abemaciclib Plus Endocrine therapy (ET) in HR+, HER2-, Node-positive, High-risk Early Breast Cancer (EBC) 在 monarchE 试验中，ctDNA 检测在辅助阿贝西利联合内分泌治疗（ET）于 HR+/HER2-、淋巴结阳性、高危早期乳腺癌（EBC）中的预后价值 Loi, S.; Johnston, S.; Arteaga, C.; Graff, S.; Chandarlapaty, S.; Goetz, M.; Desmedt, C.; Sasano, H.; Liu, D.; Rodrik-Outmezguine, V.; Sireci, A.; Sandoval, C.; Won, H.; Litchfield, L.; Turner, N. 分享 收藏
Genomic And Transcriptomic Profiling of Primary Tumors From Patients with HR+, HER2-, Node-positive, High-risk Early Breast Cancer (EBC) in the monarchE Trial monarchE试验中HR⁺、HER2⁻、淋巴结阳性、高危早期乳腺癌（EBC）患者原发肿瘤的基因组学和转录组学分析 Rubenstein, C. S.; Turner, N.; Reis-Filho, J. S.; Goetz, M. P.; Desmedt, C.; Chandarlapaty, S.; Sasano, H.; Arteaga, C. L.; Loi, S.; Graff, S. L.; Liu, D.; Rodrik-Outmezguine, V.; Sireci, A.; Won, H.; Litchfield, L. M.; Munoz, M.; Johnston, S. 分享 收藏
Results from a pilot study exploring ctDNA detection using a tumor-informed assay in the monarchE trial of adjuvant abemaciclib with endocrine therapy in HR+, HER2-, node-positive, high-risk early breast cancer Loi, Sherene; Johnston, Stephen; Arteaga, Carlos; Graff, Stephanie; Chandarlapaty, Sarat; Goetz, Matthew; Desmedt, Christine; Reis-Filho, Jorge; Sasano, Hironobu; Rodrik-Outmezguine, Vanessa; Sireci, Anthony; Rubenstein, Cynthia Sandoval; Won, Helen; Liu, Deli; Litchfield, Lacey M.; Turner, Nicholas 分享 收藏
Genomic and transcriptomic profiling of primary tumors from patients with HR+, HER2-, node-positive, high-risk early breast cancer in the monarchE trial Turner, Nicholas; Reis-Filho, Jorge; Goetz, Matthew; Desmedt, Christine; Chandarlapaty, Sarat; Sasano, Hironobu; Arteaga, Carlos; Loi, Sherene; Graff, Stephanie; Liu, Deli; Rodrik-Outmezguine, Vanessa; Sireci, Anthony; Rubenstein, Cynthia Sandoval; Won, Helen; Litchfield, Lacey M.; Munoz, Maria; Johnston, Stephen 分享 收藏
Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies Murciano-Goroff, Yonina R.; Schram, Alison M.; Rosen, Ezra Y.; Won, Helen; Gong, Yixiao; Noronha, Anne Marie; Janjigian, Yelena Y.; Stadler, Zsofia K.; Chang, Jason C.; Yang, Soo-Ryum; Mandelker, Diana; Offit, Kenneth; Berger, Michael F.; Donoghue, Mark T. A.; Bandlamudi, Chaitanya; Drilon, Alexander 分享 收藏
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers (vol 13, 1450, 2022) Rosen, Ezra Y.; Won, Helen H.; Zheng, Youyun; Cocco, Emiliano; Selcuklu, Duygu; Gong, Yixiao; Friedman, Noah D.; de Bruijn, Ino; Sumer, Onur; Bielski, Craig M.; Savin, Casey; Bourque, Caitlin; Falcon, Christina; Clarke, Nikeysha; Jing, Xiaohong; Meng, Fanli; Zimel, Catherine; Shifman, Sophie; Kittane, Srushti; Wu, Fan; Ladanyi, Marc; Ebata, Kevin; Kherani, Jennifer; Brandhuber, Barbara J.; Fagin, James; Sherman, Eric J.; Rekhtman, Natasha; Berger, Michael F.; Scaltriti, Maurizio; Hyman, David M.; Taylor, Barry S.; Drilon, Alexander 分享 收藏
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers Rosen, Ezra Y.; Won, Helen H.; Zheng, Youyun; Cocco, Emiliano; Selcuklu, Duygu; Gong, Yixiao; Friedman, Noah D.; de Bruijn, Ino; Sumer, Onur; Bielski, Craig M.; Savin, Casey; Bourque, Caitlin; Falcon, Christina; Clarke, Nikeysha; Jing, Xiaohong; Meng, Fanli; Zimel, Catherine; Shifman, Sophie; Kittane, Srusthi; Wu, Fan; Ladanyi, Marc; Ebata, Kevin; Kherani, Jennifer; Brandhuber, Barbara J.; Fagin, James; Sherman, Eric J.; Rekhtman, Natasha; Berger, Michael F.; Scaltriti, Maurizio; Hyman, David M.; Taylor, Barry S.; Drilon, Alexander 分享 收藏
TERT Copy Number Alterations, Promoter Mutations and Rearrangements in Adrenocortical Carcinomas Gupta, Sounak; Won, Helen; Chadalavada, Kalyani; Nanjangud, Gouri J.; Chen, Ying-Bei; Al-Ahmadie, Hikmat A.; Fine, Samson W.; Sirintrapun, Sahussapont J.; Strong, Vivian E.; Raj, Nitya; Lagunes, Diane Reidy; Vanderbilt, Chad M.; Berger, Michael F.; Ladanyi, Marc; Dogan, Snjezana; Tickoo, Satish K.; Reuter, Victor E.; Gopalan, Anuradha 分享 收藏
Recurrence biomarkers of triple negative breast cancer treated with neoadjuvant chemotherapy and anti-EGFR antibodies Radosevic-Robin, Nina; Selenica, Pier; Zhu, Yingjie; Won, Helen H.; Berger, Michael F.; Ferrando, Lorenzo; Cocco, Emiliano; Privat, Maud; Ponelle-Chachuat, Flora; Abrial, Catherine; Nabholtz, Jean-Marc; Penault-Llorca, Frederique; Reis-Filho, Jorge S.; Scaltriti, Maurizio 分享 收藏
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS 使用msk-access通过配对正常测序增强无细胞DNA中临床高灵敏度肿瘤突变分析的特异性 Rose Brannon, A.; Jayakumaran, Gowtham; Diosdado, Monica; Patel, Juber; Razumova, Anna; Hu, Yu; Meng, Fanli; Haque, Mohammad; Sadowska, Justyna; Murphy, Brian J.; Baldi, Tessara; Johnson, Ian; Ptashkin, Ryan; Hasan, Maysun; Srinivasan, Preethi; Rema, Anoop Balakrishnan; Rijo, Ivelise; Agarunov, Aaron; Won, Helen; Perera, Dilmi; Brown, David N.; Samoila, Aliaksandra; Jing, Xiaohong; Gedvilaite, Erika; Yang, Julie L.; Stephens, Dennis P.; Dix, Jenna-Marie; DeGroat, Nicole; Nafa, Khedoudja; Syed, Aijazuddin; Li, Alan; Lebow, Emily S.; Bowman, Anita S.; Ferguson, Donna C.; Liu, Ying; Mata, Douglas A.; Sharma, Rohit; Yang, Soo-Ryum; Bale, Tejus; Benhamida, Jamal K.; Chang, Jason C.; Dogan, Snjezana; Hameed, Meera R.; Hechtman, Jaclyn F.; Moung, Christine; Ross, Dara S.; Vakiani, Efsevia; Vanderbilt, Chad M.; Yao, JinJuan; Razavi, Pedram; Smyth, Lillian M.; Chandarlapaty, Sarat; Iyer, Gopa; Abida, Wassim; Harding, James J.; Krantz, Benjamin; O'Reilly, Eileen; Yu, Helena A.; Li, Bob T.; Rudin, Charles M.; Diaz, Luis; Solit, David B.; Arcila, Maria E.; Ladanyi, Marc; Loomis, Brian; Tsui, Dana; Berger, Michael F.; Zehir, Ahmet; Benayed, Ryma 分享 收藏
TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors Cocco, Emiliano; Lee, Ji Eun; Kannan, Srinivasaraghavan; Schram, Alison M.; Won, Helen H.; Shifman, Sophie; Kulick, Amanda; Baldino, Laura; Toska, Eneda; Arruabarrena-Aristorena, Amaia; Kittane, Srushti; Wu, Fan; Cai, Yanyan; Arena, Sabrina; Mussolin, Benedetta; Kannan, Ram; Vasan, Neil; Gorelick, Alexander N.; Berger, Michael F.; Novoplansky, Ofra; Jagadeeshan, Sankar; Liao, Yi; Rix, Uwe; Misale, Sandra; Taylor, Barry S.; Bardelli, Alberto; Hechtman, Jaclyn F.; Hyman, David M.; Elkabets, Moshe; de Stanchina, Elisa; Verma, Chandra S.; Ventura, Andrea; Drilon, Alexander; Scaltriti, Maurizio 分享 收藏
TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors Cocco, Emiliano; Lee, Ji Eun; Kannan, Srinivasaraghavan; Schram, Alison M.; Won, Helen H.; Shifman, Sophie; Kulick, Amanda; Baldino, Laura; Toska, Eneda; Arena, Sabrina; Mussolin, Benedetta; Kannan, Ram; Vasan, Neil; Gorelick, Alexander N.; Berger, Michael F.; Liao, Yi; Rix, Uwe; Bardelli, Alberto; Hechtman, Jacklyn; de Stanchina, Elisa; Hyman, David M.; Verma, Chandra; Ventura, Andrea; Drilon, Alexander; Scaltriti, Maurizio 分享 收藏
Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors PTEN和ESR1的改变促进了对alpelisib加芳香酶抑制剂的临床耐药性 Razavi, Pedram; Dickler, Maura N.; Shah, Payal D.; Toy, Weiyi; Brown, David N.; Won, Helen H.; Li, Bob T.; Shen, Ronglai; Vasan, Neil; Modi, Shanu; Jhaveri, Komal; Caravella, Betty Ann; Patil, Sujata; Selenica, Pier; Zamora, Stephen; Cowan, Aimee M.; Comen, Elizabeth; Singh, Andy; Covey, Anne; Berger, Michael F.; Hudis, Clifford A.; Norton, Larry; Nagy, Rebecca J.; Odegaard, Justin I.; Lanman, Richard B.; Solit, David B.; Robson, Mark E.; Lacouture, Mario E.; Brogi, Edi; Reis-Filho, Jorge S.; Moynahan, Mary Ellen; Scaltriti, Maurizio; Chandarlapaty, Sarat 分享 收藏
Neratinib plus trastuzumab plus fulvestrant for HER2-mutant, hormone receptor-positive, metastatic breast cancer: Updated results from the phase 2 SUMMIT 'basket' trial Wildiers, Hans; Boni, Valentina; Saura, Cristina; Oliveira, Mafalda; Jhaveri, Komal; Won, Helen; Bidard, Francois-Clement; Brufsky, Adam M.; Burkard, Mark E.; Cervantes, Andres; Fernandez-Martos, Carlos; Haley, Barbara; Loi, Sherene; Spanggaard, Iben; Panni, Stefano; Lu, Janice; Dujka, Melanie E.; Xu, Feng; Macia, Sonia; Eli, Lisa D.; Lalani, Alshad S.; Piha-Paul, Sarina; Meric-Bernstam, Funda; Solit, David B.; Hyman, David M. 分享 收藏
Efficacy and Determinants of Response to HER Kinase Inhibition in HER2-Mutant Metastatic Breast Cancer Smyth, Lillian M.; Piha-Paul, Sarina A.; Won, Helen H.; Schram, Alison M.; Saura, Cristina; Loi, Sherene; Lu, Janice; Shapiro, Geoffrey I.; Juric, Dejan; Mayer, Ingrid A.; Arteaga, Carlos L.; de la Fuente, Macarena I.; Brufksy, Adam M.; Spanggaard, Iben; Mau-Sorensen, Morten; Arnedos, Monica; Moreno, Victor; Boni, Valentina; Sohn, Joohyuk; Schwartzberg, Lee S.; Gonzalez-Farre, Xavier; Cervantes, Andres; Bidard, Francois-Clement; Gorelick, Alexander N.; Lanman, Richard B.; Nagy, Rebecca J.; Ulaner, Gary A.; Chandarlapaty, Sarat; Jhaveri, Komal; Gavrila, Elena I.; Zimel, Catherine; Selcuklu, S. Duygu; Melcer, Myra; Samoila, Aliaksandra; Cai, Yanyan; Scaltriti, Maurizio; Mann, Grace; Xu, Feng; Eli, Lisa D.; Dujka, Melanie; Lalani, Alshad S.; Bryce, Richard; Baselga, Jose; Taylor, Barry S.; Solit, David B.; Meric-Bernstam, Funda; Hyman, David M. 分享 收藏
Phase 2 study of LY3023414 in patients with advanced endometrial cancer harboring activating mutations in the PI3K pathway LY3023414在具有PI3K通路激活突变的晚期子宫内膜癌患者中的2期研究 Rubinstein, Maria M.; Hyman, David M.; Caird, Imogen; Won, Helen; Soldan, Krysten; Seier, Kenneth; Iasonos, Alexia; Tew, William P.; O'Cearbhaill, Roisin E.; Grisham, Rachel N.; Hensley, Martee L.; Troso-Sandoval, Tiffany; Sabbatini, Paul; Guillen, Joyce; Selcuklu, S. Duygu; Zimel, Catherine; Torrisi, Jean; Aghajanian, Carol; Makker, Vicky 分享 收藏
A rectal cancer organoid platform to study individual responses to chemoradiation Ganesh, Karuna; Wu, Chao; O'Rourke, Kevin P.; Szeglin, Bryan C.; Zheng, Youyun; Sauve, Charles-Etienne Gabriel; Adileh, Mohammad; Wasserman, Isaac; Marco, Michael R.; Kim, Amanda S.; Shady, Maha; Sanchez-Vega, Francisco; Karthaus, Wouter R.; Won, Helen H.; Choi, Seo-Hyun; Pelossof, Raphael; Barlas, Afsar; Ntiamoah, Peter; Pappou, Emmanouil; Elghouayel, Arthur; Strong, James S.; Chen, Chin-Tung; Harris, Jennifer W.; Weiser, Martin R.; Nash, Garrett M.; Guillem, Jose G.; Wei, Iris H.; Kolesnick, Richard N.; Veeraraghavan, Harini; Ortiz, Eduardo J.; Petkovska, Iva; Cercek, Andrea; Manova-Todorova, Katia O.; Saltz, Leonard B.; Lavery, Jessica A.; DeMatteo, Ronald P.; Massague, Joan; Paty, Philip B.; Yaeger, Rona; Chen, Xi; Patil, Sujata; Clevers, Hans; Berger, Michael F.; Lowe, Scott W.; Shia, Jinru; Romesser, Paul B.; Dow, Lukas E.; Garcia-Aguilar, Julio; Sawyers, Charles L.; Smith, J. Joshua 分享 收藏
PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer Nixon, Mellissa J.; Formisano, Luigi; Mayer, Ingrid A.; Estrada, M. Valeria; Gonzalez-Ericsson, Paula, I; Isakoff, Steven J.; Forero-Torres, Andres; Won, Helen; Sanders, Melinda E.; Solit, David B.; Berger, Michael F.; Cantley, Lewis C.; Winer, Eric P.; Arteaga, Carlos L.; Balko, Justin M. 分享 收藏
Resistance to TRK inhibition mediated by convergent MAPK pathway activation Cocco, Emiliano; Schram, Alison M.; Kulick, Amanda; Misale, Sandra; Won, Helen H.; Yaeger, Rona; Razavi, Pedram; Ptashkin, Ryan; Hechtman, Jaclyn F.; Toska, Eneda; Cownie, James; Somwar, Romel; Shifman, Sophie; Mattar, Marissa; Selcuklu, S. Duygu; Samoila, Aliaksandra; Guzman, Sean; Tuch, Brian B.; Ebata, Kevin; de Stanchina, Elisa; Nagy, Rebecca J.; Lanman, Richard B.; Houck-Loomis, Brian; Patel, Juber A.; Berger, Michael F.; Ladanyi, Marc; Hyman, David M.; Drilon, Alexander; Scaltriti, Maurizio 分享 收藏
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