未登录 Revealing the mechanism of action of a fi rst-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31 P NMR 通过31 p NMR揭示一类共价抑制剂KRASG12C (ON) 的作用机理和致癌KRAS的其他功能特性 Sharma, Alok K.; Pei, Jun; Yang, Yue; Dyba, Marcin; Smith, Brian; Rabara, Dana; Larsen, Erik K.; Lightstone, Felice C.; Esposito, Dominic; Stephen, Andrew G.; Wang, Bin; Beltran, Pedro J.; Wallace, Eli; Nissley, Dwight V.; McCormick, Frank; Maciag, Anna E. 分享 收藏
Use of the natural nucleotide, GTP, is essential for the identification of potent, active-state KRASG12C inhibitors that bind in the switch II pocket Wang, Bin; Sharma, Alok; Stice, James; Smith, Brian; Dyba, Marcin; Singh, Devansh; Denson, John-Paul; Rabara, Dana; Larsen, Erik; Yang, Yue; Lightstone, Felice C.; Stephen, Andrew; Nissley, Dwight; McCormick, Frank; Wallace, Eli; Maciag, Anna E.; Beltran, Pedro J. 分享 收藏
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Expanded RAS proteoform landscape in malignant cell lines revealed by top-down mass spectrometry DeHart, Caroline J.; D'Ippolito, Robert A.; Sharma, Kanika; Fer, Nicole; Smith, Brian; Meyer, Mackenzie; Eury, Scott; Neish, Abigail; Powell, Katie; Wall, Vanessa; Burgan, William; Esposito, Dominic; Maciag, Anna E.; McCormick, Frank; Nissley, Dwight V. 分享 收藏
Phase III Prospectively Randomized Trial of Perioperative 5-FU After Curative Resection for Colon Cancer: An Intergroup Trial of the ECOG-ACRIN Cancer Research Group (E1292) Kemeny, M. Margaret; Zhao, Fengmin; Forastiere, Arlene A.; Catalano, Paul; Hamilton, Stanley R.; Miedema, Brent W.; Dawson, Nancy A.; Weiner, Louis M.; Smith, Brian D.; Mason, Bernard A.; Graziano, Stephen L.; Gilman, Paul B.; Venook, Alan P.; Pinto, Harlan A.; Whitehead, Robert P.; O'Dwyer, Peter J.; Benson, Al B. 分享 收藏
Safeguarding human-wildlife cooperation van der Wal, Jessica E. M.; Spottiswoode, Claire N.; Uomini, Natalie T.; Cantor, Mauricio; Daura-Jorge, Fabio G.; Afan, Anap, I; Attwood, Mairenn C.; Amphaeris, Jenny; Balasani, Fatima; Begg, Colleen M.; Blair, Cameron J.; Bronstein, Judith L.; Buanachique, Iahaia O.; Cuthill, Rion R. T.; Das, Jewel; Deb, Apurba; Dixit, Tanmay; Dlamini, Gcina S.; Dounias, Edmond; Gedi, Isa I.; Gruber, Martin; Hoffmann, Lilian S.; Holzlehner, Tobias; Isack, Hussein A.; Laltaika, Eliupendo A.; Lloyd-Jones, David J.; Lund, Jess; Machado, Alexandre M. S.; Mahadevan, L.; Moreno, Ignacio B.; Nwaogu, Chima J.; Pereira, Valdomiro L.; Pierotti, Raymond; Rucunua, Seliano A.; dos Santos, Wilson F.; Serpa, Nathalia; Smith, Brian D.; Tolkova, Irina; Tun, Tint; Valle-Pereira, Joao V. S.; Wood, Brian M.; Wrangham, Richard W.; Cram, Dominic L. 分享 收藏
Integrative Modeling, Molecular Mechanics, and Molecular Dynamics Evaluation of Genomics Variants in KMT2C (MLL3), a Gene Involved in Kleefstra Syndrome Type 2 Jorge, Salomao D.; Chi, Young-In; de Assuncao, Thiago Milech; Mathison, Angela J.; Volkman, Brian; Smith, Brian; Lomberk, Gwen; Zimmermann, Michael T.; Urrutia, Raul 分享 收藏
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Genomics of Population Differentiation in Humpback Dolphins, Sousa spp. in the Indo-Pacific Ocean Amaral, Ana R.; Chanfana, Catia; Smith, Brian D.; Mansur, Rubaiyat; Collins, Tim; Baldwin, Robert; Minton, Gianna; Parra, Guido J.; Krutzen, Michael; Jefferson, Thomas A.; Karczmarski, Leszek; Guissamulo, Almeida; Brownell, Robert L., Jr.; Rosenbaum, Howard C. 分享 收藏
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Differential Effector Engagement by Oncogenic KRAS 致癌KRAS的差异效应参与 Yuan, Tina L.; Amzallag, Arnaud; Bagni, Rachel; Yi, Ming; Afghani, Shervin; Burgan, William; Fer, Nicole; Strathern, Leslie A.; Powell, Katie; Smith, Brian; Waters, Andrew M.; Drubin, David; Thomson, Ty; Liao, Rosy; Greninger, Patricia; Stein, Giovanna T.; Murchie, Ellen; Cortez, Eliane; Egan, Regina K.; Procter, Lauren; Bess, Matthew; Cheng, Kwong Tai; Lee, Chih-Shia; Lee, Liam Changwoo; Fellmann, Christof; Stephens, Robert; Luo, Ji; Lowe, Scott W.; Benes, Cyril H.; McCormick, Frank 分享 收藏
Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study Rutrick, Daniel; Stein, Dan J.; Subramanian, Ganesan; Smith, Brian; Fava, Maurizio; Hasler, Gregor; Cha, Jang-Ho; Gasparini, Fabrizio; Donchev, Toni; Ocwieja, Magdalena; Johns, Donald; Gomez-Mancilla, Baltazar 分享 收藏
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Uncovering oncogenic KRAS allele specific phenotypes using an isogenic MEF cell line system Fer, Nicole; Smith, Brian; Garvey, Leslie; Burgan, William; Powell, Katie; Sharma, Kanika; Waters, Andrew; Wu, Xiaolin; Soppet, Dan; Stephens, Robert; Nissley, Dwight; Holderfield, Matthew; Bagni, Rachel K. 分享 收藏
Next-generation screen for integrative subtyping and target discovery for KRAS-mutant cancer Yuan, Tina L.; Bagni, Rachel; Yi, Ming; Amzallag, Arnaud; Afghani, Shervin; Beam, Katie; Burgan, William; Fer, Nicole; Garvey, Leslie; Smith, Brian; Waters, Andrew; Stephens, Robert; Benes, Cyril; McCormick, Frank 分享 收藏
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