John Ravits - Publications, H-index & Citations

John Ravits

university of california

58H指数

179论文数

1.8W被引数

收录论文 62

发表时间

TDP-43 skein-like inclusions are formed by BAG3- and HSP70-guided co-aggregation with actin-binding proteins TDP-43 skein-like inclusions 是由 BAG3 和 HSP70 介导的与肌动蛋白结合蛋白的协同聚集形成的。

Nature Cell Biology

IF19.1

2025-10-31

PREAI

Shan Lu; Sitao Zhang; Spencer Oung; Jolene K. Diedrich; Peng Han; Olatz Arnold-Garcia; Takuya Ohkubo; Olubankole Aladesuyi Arogundade; Sonia Vazquez-Sanchez; Ke Zhang; John Ravits; John R. Yates III; Don W. Cleveland

Shared burden of ultra-rare genetic variants across a spectrum of motor neuron diseases 超罕见遗传变异在一系列运动神经元疾病中的共享负担

Translational Neurodegeneration

IF15.2

2025-10-29

OAAI

Gang Wu; Wenan Chen; Joanne Wuu; Angita Jain; Jason Myers; Isabell Cordts; Evadnie Rampersaud; Jeannine M. Heckmann; Melissa Nel; Volkan Granit; Jeffrey Statland; Andrea Swenson; John Ravits; Corey T. McMillan; Lauren Elman; James Caress; Ted M. Burns; Erik P. Pioro; Jaya Trivedi; Jonathan Katz; Carlayne Jackson; Samuel Maiser; David Walk; Yuen So; Jacob L. McCauley; Matthew C. Baker; J. Paul Taylor; Stephan Zuchner; Rosa Rademakers; Marka van Blitterswijk; Michael Benatar

CK1δ/ε-mediated TDP-43 phosphorylation contributes to early motor neuron disease toxicity in amyotrophic lateral sclerosis

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2024-12-04

OAAI

Ko, Vivian I.; Ong, Kailee; Kwon, Deborah Y.; Li, Xueying; Pietrasiewicz, Alicia; Harvey, James S.; Lulla, Mukesh; Bhat, Guruharsha; Cleveland, Don W.; Ravits, John M.

CK1δ/ε kinases regulate TDP-43 phosphorylation and are therapeutic targets for ALS-related TDP-43 hyperphosphorylation CK1δ/ε 激酶调节TDP-43磷酸化，是ALS相关TDP-43过度磷酸化的治疗靶点

NEUROBIOLOGY OF DISEASE

IF5.6

2024-06-01

OAAI

Ko, Vivian I.; Ong, Kailee; Cleveland, Don W.; Yu, Haiyang; Ravits, John M.

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

ACTA NEUROPATHOLOGICA

IF9.3

2024-05-30

OAAI

Costantino, Isabel; Meng, Alex; Ravits, John

Challenges of profiling motor neuron transcriptomes from human spinal cord

NEURON

IF15

2023-12-01

PREAI

Gautier, Olivia; Blum, Jacob A.; Maksymetz, James; Chen, Derek; Schweingruber, Christoph; Mei, Irene; Hermann, Anita; Hackos, David H.; Hedlund, Eva; Ravits, John; Gitler, Aaron D.

PREDICTORS OF LUNG FUNCTION TRAJECTORY AND NONINVASIVE VENTILATION OUTCOMES IN ALS

CHEST

IF8.6

2023-10-01

OAAI

Chau, Lianne; Ravits, John; Orr, Jeremy E.

Reply: The lower motor neuron homunculus: function matters

BRAIN

IF11.7

2023-02-02

PREAI

Ravits, John; Stack, Julia

Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis 全基因组测序分析揭示了患有肌萎缩性侧索硬化症的单卵双胞胎的合子后突变变异性

NEUROBIOLOGY OF AGING

IF3.5

2023-02-01

OAAI

Tazelaar, Gijs H. P.; Hop, Paul J.; Seelen, Meinie; van Vugt, Joke J. F. A.; van Rheenen, Wouter; Kool, Lindy; van Eijk, Kristel R.; Gijzen, Marleen; Dooijes, Dennis; Moisse, Matthieu; Calvo, Andrea; Moglia, Cristina; Brunetti, Maura; Canosa, Antonio; Nordin, Angelica; Pardina, Jesus S. Mora; Ravits, John; Al-Chalabi, Ammar; Chio, Adriano; McLaughlin, Russell L.; Hardiman, Orla; Van Damme, Philip; de Carvalho, Mamede; Neuwirth, Christoph; Weber, Markus; Andersen, Peter M.; van den Berg, Leonard H.; Veldink, Jan H.; van Es, Michael A.

Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition 热休克伴侣HSPB1调节细胞质TDP-43相分离和液-凝胶转变

NATURE CELL BIOLOGY

IF19.1

2022-09-08

OAAI

Lu, Shan; Hu, Jiaojiao; Arogundade, Olubankole Aladesuyi; Goginashvili, Alexander; Vazquez-Sanchez, Sonia; Diedrich, Jolene K.; Gu, Jinge; Blum, Jacob; Oung, Spencer; Ye, Qiaozhen; Yu, Haiyang; Ravits, John; Liu, Cong; Yates, John R., III; Cleveland, Don W.

The lower motor neuron homunculus

BRAIN

IF11.7

2022-08-27

OAAI

Ravits, John; Stack, Julia

Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis

ACTA NEUROPATHOLOGICA

IF9.3

2022-07-01

OAAI

Krach, Florian; Wheeler, Emily C.; Regensburger, Martin; Boerstler, Tom; Wend, Holger; Vu, Anthony Q.; Wang, Ruth; Reischl, Stephanie; Boldt, Karsten; Batra, Ranjan; Aigner, Stefan; Ravits, John; Winkler, Juergen; Yeo, Gene W.; Winner, Beate

Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response

CELL RESEARCH

IF25.9

2022-06-03

OAAI

Li, Wanjin; Shan, Bing; Zou, Chengyu; Wang, Huibing; Zhang, Meng-Meng; Zhu, Hong; Naito, Masanori Gomi; Xu, Daichao; Manuel, Vica Jean; Mifflin, Lauren; Hou, Zhaodong; Ravits, John; Yuan, Junying

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis 散发性和家族性肌萎缩性侧索硬化症中RNA结合蛋白ELAVL3 (HuC) 的核耗竭

ACTA NEUROPATHOLOGICA

IF9.3

2021-10-07

OAAI

Diaz-Garcia, Sandra; Ko, Vivian I.; Vazquez-Sanchez, Sonia; Chia, Ruth; Arogundade, Olubankole Aladesuyi; Rodriguez, Maria J.; Traynor, Bryan J.; Cleveland, Don; Ravits, John

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination

JOURNAL OF CELL BIOLOGY

IF6.4

2021-08-04

OAAI

Ho, Wan Yun; Chang, Jer-Cherng; Lim, Kenneth; Cazenave-Gassiot, Amaury; Nguyen, Aivi T.; Foo, Juat Chin; Muralidharan, Sneha; Viera-Ortiz, Ashley; Ong, Sarah J. M.; Hor, Jin Hui; Agrawal, Ira; Hoon, Shawn; Arogundade, Olubankole Aladesuyi; Rodriguez, Maria J.; Lim, Su Min; Kim, Seung Hyun; Ravits, John; Ng, Shi-Yan; Wenk, Markus R.; Lee, Edward B.; Tucker-Kellogg, Greg; Ling, Shuo-Chien

Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype 与肌萎缩侧索硬化风险和临床表型相关的新型STMN2变体

FRONTIERS IN AGING NEUROSCIENCE

IF4.5

2021-03-26

OAAI

Theunissen, Frances; Anderton, Ryan S.; Mastaglia, Frank L.; Flynn, Loren L.; Winter, Samantha J.; James, Ian; Bedlack, Richard; Hodgetts, Stuart; Fletcher, Sue; Wilton, Steve D.; Laing, Nigel G.; MacShane, Mandi; Needham, Merrilee; Saunders, Ann; Mackay-Sim, Alan; Melamed, Ze'ev; Ravits, John; Cleveland, Don W.; Akkari, P. Anthony

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

ACTA NEUROPATHOLOGICA COMMUNICATIONS

IF5.7

2021-02-15

OAAI

Aladesuyi Arogundade, Olubankole; Nguyen, Sandra; Leung, Ringo; Wainio, Danielle; Rodriguez, Maria; Ravits, John

Cross-Comparison of Human iPSC Motor Neuron Models of Familial and Sporadic ALS Reveals Early and Convergent Transcriptomic Disease Signatures

CELL SYSTEMS

IF7.7

2021-02-01

OAAI

Ho, Ritchie; Workman, Michael J.; Mathkar, Pranav; Wu, Kathryn; Kim, Kevin J.; O'Rourke, Jacqueline G.; Kellogg, Mariko; Montel, Valerie; Banuelos, Maria G.; Arogundade, Olubankole Aladesuyi; Diaz-Garcia, Sandra; Oheb, Daniel; Huang, Steven; Khrebtukova, Irina; Watson, Lisa; Ravits, John; Taylor, Kevin; Baloh, Robert H.; Svendsen, Clive N.

Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis 机器学习提示肌萎缩性侧索硬化症认知功能障碍的多基因风险

EMBO MOLECULAR MEDICINE

IF8.3

2020-12-03

OAAI

Placek, Katerina; Benatar, Michael; Wuu, Joanne; Rampersaud, Evadnie; Hennessy, Laura; Van Deerlin, Vivianna M.; Grossman, Murray; Irwin, David J.; Elman, Lauren; McCluskey, Leo; Quinn, Colin; Granit, Volkan; Statland, Jeffrey M.; Burns, Ted M.; Ravits, John; Swenson, Andrea; Katz, Jon; Pioro, Erik P.; Jackson, Carlayne; Caress, James; So, Yuen; Maiser, Samuel; Walk, David; Lee, Edward B.; Trojanowski, John Q.; Cook, Philip; Gee, James; Sha, Jin; Naj, Adam C.; Rademakers, Rosa; Chen, Wenan; Wu, Gang; Paul Taylor, J.; McMillan, Corey T.

ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation

CELL DEATH AND DIFFERENTIATION

IF15.4

2020-11-12

OAAI

Hor, Jin-Hui; Santosa, Munirah Mohamad; Lim, Valerie Jing Wen; Ho, Beatrice Xuan; Taylor, Amy; Khong, Zi Jian; Ravits, John; Fan, Yong; Liou, Yih-Cherng; Soh, Boon-Seng; Ng, Shi-Yan

研究方向