David L. McKinzie - Publications, H-index & Citations

David L. McKinzie

Purdue University System

49H指数

131论文数

7.5K被引数

收录论文 52

发表时间

Sucla2 Knock-Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type-Specific Phenotypes

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE

IF9.1

2024-10-31

OAAI

Lancaster, Makayla S.; Hafen, Paul; Law, Andrew S.; Matias, Catalina; Meyer, Timothy; Fischer, Kathryn; Miller, Marcus; Hao, Chunhai; Gillespie, Patrick; Mckinzie, David; Brault, Jeffrey J.; Graham, Brett H.

Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy

NEUROBIOLOGY OF AGING

IF3.5

2022-01-01

OAAI

Patel, Henika; Martinez, Pablo; Perkins, Abigail; Taylor, Xavier; Jury, Nur; McKinzie, David; Lasagna-Reeves, Cristian A.

Xanomeline's activity in rodent models of psychosis: Role of central muscarinic receptors and augmentation by antipsychotic drugs

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2021-12-01

PREAI

McKinzie, D.; Fischer, K.; Meyer, T.; Yohn, S.; Popiolek, M.; Felder, C.; Paul, S.

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-06-03

PREAI

McKinzie, David L.; Winneroski, Leonard L.; Green, Steven J.; Hembre, Erik J.; Erickson, Jon A.; Willis, Brian A.; Monk, Scott A.; Aluise, Christopher D.; Baker, Thomas K.; Lopez, Jose E.; Hendle, Jorg; Beck, James P.; Brier, Richard A.; Boggs, Leonard N.; Borders, Anthony R.; Cocke, Patrick J.; Garcia-Losada, Pablo; Lowe, Stephen L.; Mathes, Brian M.; May, Patrick C.; Porter, Warren J.; Stout, Stephanie L.; Timm, David E.; Watson, Brian M.; Yang, Zhixiang; Mergott, Dustin J.

The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain

NEUROPSYCHOPHARMACOLOGY

IF7.1

2020-12-20

OAAI

Montani, Caterina; Canella, Carola; Schwarz, Adam J.; Li, Jennifer; Gilmour, Gary; Galbusera, Alberto; Wafford, Keith; Gutierrez-Barragan, Daniel; McCarthy, Andrew; Shaw, David; Knitowski, Karen; McKinzie, David; Gozzi, Alessandro; Felder, Christian

Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats

PAIN

IF5.5

2018-03-22

OAAI

Cowen, Stephen L.; Phelps, Caroline E.; Navratilova, Edita; McKinzie, David L.; Okun, Alec; Husain, Omar; Gleason, Scott D.; Witkin, Jeffrey M.; Porreca, Frank

Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1S,2S,4S,5R,6S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-01-19

PREAI

Monn, James A.; Henry, Steven S.; Massey, Steven M.; Clawson, David K.; Chen, Qi; Diseroad, Benjamin A.; Bhardwaj, Rajni M.; Atwel, Shane; Lu, Frances; Wang, Jing; Russell, Marijane; Heinz, Beverly A.; Wang, Xu-shan; Carter, Joan H.; Getman, Brian G.; Adragni, Kofi; Broad, Lisa M.; Sanger, Helene E.; Ursu, Daniel; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; Shaw, David B.; McKinzie, David L.; Hao, Junliang

Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2017-04-01

OAAI

Felder, Christian C.; Schober, Douglas A.; Tu, Yuan; Quets, Anne; Xiao, Hongling; Watt, Marla; Siuda, Ed; Nisenbaum, Eric; Xiang, Chuanxi; Heinz, Beverly; Prieto, Lourdes; McKinzie, David L.; Monn, James A.

Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain

PAIN

IF5.5

2016-08-19

OAAI

Okun, Alec; McKinzie, David L.; Witkin, Jeffrey M.; Remeniuk, Bethany; Husein, Omar; Gleason, Scott D.; Oyarzo, Janice; Navratilova, Edita; McElroy, Brian; Cowen, Stephen; Kennedy, Jeffrey D.; Porreca, Frank

Exploratory Analysis for a Targeted Patient Population Responsive to the Metabotropic Glutamate 2/3 Receptor Agonist Pomaglumetad Methionil in Schizophrenia

BIOLOGICAL PSYCHIATRY

IF9

2015-12-01

126

PREAI

Kinon, Bruce J.; Millen, Brian A.; Zhang, Lu; McKinzie, David L.

Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-09-14

PREAI

Monn, James A.; Prieto, Lourdes; Taboada, Lorena; Hao, Junliang; Reinhard, Matthew R.; Hen, Steven S.; Beadle, Christopher D.; Walton, Lesley; Man, Teresa; Rudyk, Helene; Clark, Barry; Tupper, David; Baker, S. Richard; Lamas, Carlos; Montero, Carlos; Marcos, Alicia; Blanco, Jaime; Bures, Mark; Clawson, David K.; Atwell, Shane; Lu, Frances; Wang, Jing; Russell, Marijane; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Getman, Brian G.; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; Shaw, David B.; McKinzie, David L.

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-02-05

PREAI

Monn, James A.; Prieto, Lourdes; Taboada, Lorena; Pedregal, Concepcion; Hao, Junliang; Reinhard, Matt R.; Henry, Steven S.; Goldsmith, Paul J.; Beadle, Christopher D.; Walton, Lesley; Man, Teresa; Rudyk, Helene; Clark, Barry; Tupper, David; Baker, S. Richard; Lamas, Carlos; Montero, Carlos; Marcos, Alicia; Blanco, Jaime; Bures, Mark; Clawson, David K.; Atwell, Shane; Lu, Frances; Wang, Jing; Russell, Marijane; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Xiang, Chuanxi; Catlow, John T.; Swanson, Steven; Sanger, Helen; Broad, Lisa M.; Johnson, Michael P.; Knopp, Kelly L.; Simmons, Rosa M. A.; Johnson, Bryan G.; Shaw, David B.; Mc Kinzie, David L.

Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3-c]pyran) Scaffold

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-04-11

PREAI

Toledo, Miguel A.; Pedregal, Concepcion; Lafuente, Celia; Diaz, Nuria; Angeles Martinez-Grau, Maria; Jimenez, Alma; Benito, Ana; Torrado, Alicia; Mateos, Carlos; Joshi, Elizabeth M.; Kahl, Steven D.; Rash, Karen S.; Mudra, Daniel R.; Barth, Vanessa N.; Shaw, David B.; McKinzie, David; Witkin, Jeffrey M.; Statnick, Michael A.

The Muscarinic Acetylcholine Receptor Agonist BuTAC Mediates Antipsychotic-Like Effects via the M4 Subtype 毒蕈碱型乙酰胆碱受体激动剂BuTAC通过M4亚型介导抗精神病药样作用

NEUROPSYCHOPHARMACOLOGY

IF7.1

2013-08-02

OAAI

Watt, Marla L.; Rorick-Kehn, Linda; Shaw, David B.; Knitowski, Karen M.; Quets, Anne T.; Chesterfield, Amy K.; McKinzie, David L.; Felder, Christian C.

Synthesis and Pharmacological Characterization of 4-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2013-06-03

PREAI

Monn, James A.; Valli, Matthew J.; Massey, Steven M.; Hao, Junliang; Reinhard, Matthew R.; Bures, Mark G.; Heinz, Beverly A.; Wang, Xushan; Carter, Joan H.; Getman, Brian G.; Stephenson, Gregory A.; Herin, Marc; Catlow, John T.; Swanson, Steven; Johnson, Bryan G.; McKinzie, David L.; Henry, Steven S.

The long-lasting effects of JDTic, a kappa opioid receptor antagonist, on the expression of ethanol-seeking behavior and the relapse drinking of female alcohol-preferring (P) rats

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2012-06-01

OAAI

Deehan, Gerald A., Jr.; McKinzie, David L.; Carroll, F. Ivy; McBride, William J.; Rodd, Zachary A.

Reduction of dendritic spines and elevation of GABAergic signaling in the brains of mice treated with an estrogen receptor β ligand

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-01-17

OAAI

Tan, Xin-jie; Dai, Yu-bing; Wu, Wan-fu; Kim, Hyun-Jin; Barros, Rodrigo P. A.; Richardson, Timothy I.; Yaden, Benjamin C.; Warner, Margaret; McKinzie, David L.; Krishnan, Venkatesh; Gustafssona, Jan-Ake

Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2011-10-26

PREAI

Mitch, Charles H.; Quimby, Steven J.; Diaz, Nuria; Pedregal, Concepcion; de la Torre, Marta G.; Jimenez, Alma; Shi, Qing; Canada, Emily J.; Kahl, Steven D.; Statnick, Michael A.; McKinzie, David L.; Benesh, Dana R.; Rash, Karen S.; Barth, Vanessa N.

Effects of a novel mGlu2/3 receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid

PSYCHOPHARMACOLOGY

IF3.3

2011-08-17

PREAI

Lowe, Stephen; Dean, Robert; Ackermann, Bradley; Jackson, Kimberley; Natanegara, Fanni; Anderson, Shelby; Eckstein, James; Yuen, Eunice; Ayan-Oshodi, Mosun; Ho, Mary; McKinzie, David; Perry, Kenneth; Svensson, Kjell

Pharmacological Characterization of LY593093, an M1 Muscarinic Acetylcholine Receptor-Selective Partial Orthosteric Agonist

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2011-08-01

PREAI

Watt, Marla L.; Schober, Douglas A.; Hitchcock, Stephen; Liu, Bin; Chesterfield, Amy K.; McKinzie, David; Felder, Christian C.

研究方向