Brian D. Sykes - Publications, H-index & Citations

Brian D. Sykes

university of alberta

81H指数

645论文数

3.7W被引数

收录论文 126

发表时间

Conversion of a Cardiac Muscle Modulator from an Inhibitor to an Activator

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2023-03-03

OAAI

Cai, Fangze; Kampourakis, Thomas; Parijat, Priyanka; Cockburn, Kieran T.; Sykes, Brian D.

Drugging the Sarcomere, a Delicate Balance: Position of N-Terminal Charge of the Inhibitor W7

ACS CHEMICAL BIOLOGY

IF3.8

2022-06-01

PREAI

Cai, Fangze; Kampourakis, Thomas; Cockburn, Kieran T.; Sykes, Brian D.

A Potent Fluorescent Reversible-Covalent Inhibitor of Cardiac Muscle Contraction

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-08-23

OAAI

Cai, Fangze; Kampourakis, Thomas; Klein, Brittney A.; Sykes, Brian D.

Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-03-11

PREAI

Li, Monica X.; Mercier, Pascal; Hartman, James J.; Sykes, Brian D.

The Role of Electrostatics in the Mechanism of Cardiac Thin Filament Based Sensitizers

ACS CHEMICAL BIOLOGY

IF3.8

2020-07-07

PREAI

Cai, Fangze; Robertson, Ian M.; Kampourakis, Thomas; Klein, Brittney A.; Sykes, Brian D.

Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction

METABOLOMICS

IF3.3

2020-06-12

PREAI

Fu, Ze-Lin; Mercier, Pascal; Eskandari-Sedighi, Ghazaleh; Yang, Jing; Westaway, David; Sykes, Brian D.

Thioimidate Bond Formation between Cardiac Troponin C and Nitrile-containing Compounds

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2019-05-15

OAAI

Klein, Brittney A.; Robertson, Ian M.; Reiz, Bela; Kampourakis, Thomas; Li, Liang; Sykes, Brian D.

Understanding Calcium Sensitization and Desensitization using a Cardiac Troponin Chimera

BIOPHYSICAL JOURNAL

IF3.1

2018-02-01

OAAI

Cai, Fangze; Hwang, Peter; Sykes, Brian

Characterization of a Fluorescent Levosimendan Analog Binding to Cardiac Troponin

BIOPHYSICAL JOURNAL

IF3.1

2018-02-01

OAAI

Klein, Brittney; Sykes, Brian D.

A novel Gerstmann-Straussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles

PLOS PATHOGENS

IF4.9

2018-01-16

OAAI

Mercer, Robert C. C.; Daude, Nathalie; Dorosh, Lyudmyla; Fu, Ze-Lin; Mays, Charles E.; Gapeshina, Hristina; Wohlgemuth, Serene L.; Acevedo-Morantes, Claudia Y.; Yang, Jing; Cashman, Neil R.; Coulthart, Michael B.; Pearson, Dawn M.; Joseph, Jeffrey T.; Wille, Holger; Safar, Jiri G.; Jansen, Gerard H.; Stepanova, Maria; Sykes, Brian D.; Westaway, David

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

NATURE COMMUNICATIONS

IF15.7

2018-01-16

OAAI

Elia, Josephine; Ungal, Grace; Kao, Charlly; Ambrosini, Alexander; De Jesus-Rosario, Nilsa; Larsen, Lene; Chiavacci, Rosetta; Wang, Tiancheng; Kurian, Christine; Titchen, Kanani; Sykes, Brian; Hwang, Sharon; Kumar, Bhumi; Potts, Jacqueline; Davis, Joshua; Malatack, Jeffrey; Slattery, Emma; Moorthy, Ganesh; Zuppa, Athena; Weller, Andrew; Byrne, Enda; Li, Yun R.; Kraft, Walter K.; Hakonarson, Hakon

Dynamics of cryoprotectant permeation in porcine heart valve leaflets

CELL TRANSPLANTATION

IF3.2

2017-06-22

PREAI

Lakey, JRT; Helms, LMH; Moser, G; Lix, B; Slupsky, CM; Rebeyka, IM; Sykes, BD; McGann, LE

Structures reveal details of small molecule binding to cardiac troponin

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2016-12-01

OAAI

Cai, Fangze; Li, Monica X.; Pineda-Sanabria, Sandra E.; Gelozia, Shorena; Lindert, Steffen; West, Frederick; Sykes, Brian D.; Hwang, Peter M.

Probing the mechanism of cardiovascular drugs using a covalent levosimendan analog

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2016-03-01

OAAI

Pineda-Sanabria, Sandra E.; Robertson, Ian M.; Sun, Yin-Biao; Irving, Malcolm; Sykes, Brian D.

Designing a High Affinity Cardiac Troponin Activator

BIOPHYSICAL JOURNAL

IF3.1

2016-02-01

OAAI

Cai, Fangze; Li, Monica; Pineda-Sanabria, Sandra; Gelozia, Shorena; Lindert, Steffen; McCammon, J. Andrew; West, Frederick; Sykes, Brian; Hwang, Peter

The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2015-10-01

OAAI

Robertson, Ian M.; Sevrieva, Ivanka; Li, Monica X.; Irving, Malcolm; Sun, Yin-Biao; Sykes, Brian D.

Targeting the sarcomere to correct muscle function

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2015-04-17

110

PREAI

Hwang, Peter M.; Sykes, Brian D.

UBC9-dependent Association between Calnexin and Protein Tyrosine Phosphatase 1B (PTP1B) at the Endoplasmic Reticulum

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-02-01

OAAI

Lee, Dukgyu; Kraus, Allison; Prins, Daniel; Groenendyk, Jody; Aubry, Isabelle; Liu, Wen-Xin; Li, Hao-Dong; Julien, Olivier; Touret, Nicolas; Sykes, Brian D.; Tremblay, Michel L.; Michalak, Marek

Computer-Aided Drug Discovery Approach Finds Calcium Sensitizer of Cardiac Troponin

BIOPHYSICAL JOURNAL

IF3.1

2015-01-01

OAAI

Lindert, Steffen; Li, Monica X.; Sykes, Brian; McCammon, J. Andrew

The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-09-22

OAAI

Hwang, Peter M.; Cai, Fangze; Pineda-Sanabria, Sandra E.; Corson, David C.; Sykes, Brian D.

研究方向